LOCUS       NM_001411827             858 bp    mRNA    linear   ROD 12-AUG-2024
DEFINITION  Mus musculus RAB2A, member RAS oncogene family (Rab2a), transcript
            variant 2, mRNA.
ACCESSION   NM_001411827 XM_006538126
VERSION     NM_001411827.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 858)
  AUTHORS   Wang,H., Iida-Norita,R., Mashiko,D., Pham,A.H., Miyata,H. and
            Ikawa,M.
  TITLE     Golgi associated RAB2 interactor protein family contributes to
            murine male fertility to various extents by assuring correct
            morphogenesis of sperm heads
  JOURNAL   PLoS Genet 20 (6), e1011337 (2024)
   PUBMED   38935810
  REMARK    GeneRIF: Golgi associated RAB2 interactor protein family
            contributes to murine male fertility to various extents by assuring
            correct morphogenesis of sperm heads.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 858)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 858)
  AUTHORS   Morohoshi,A., Miyata,H., Oyama,Y., Oura,S., Noda,T. and Ikawa,M.
  TITLE     FAM71F1 binds to RAB2A and RAB2B and is essential for acrosome
            formation and male fertility in mice
  JOURNAL   Development 148 (21) (2021)
   PUBMED   34714330
REFERENCE   4  (bases 1 to 858)
  AUTHORS   Matsunaga,K., Taoka,M., Isobe,T. and Izumi,T.
  TITLE     Rab2a and Rab27a cooperatively regulate the transition from granule
            maturation to exocytosis through the dual effector Noc2
  JOURNAL   J Cell Sci 130 (3), 541-550 (2017)
   PUBMED   27927751
  REMARK    GeneRIF: These results suggest that the dual effector, Noc2,
            regulates the transition from Rab2a-mediated granule biogenesis to
            Rab27a-mediated granule exocytosis.
REFERENCE   5  (bases 1 to 858)
  AUTHORS   Fujita,N., Huang,W., Lin,T.H., Groulx,J.F., Jean,S., Nguyen,J.,
            Kuchitsu,Y., Koyama-Honda,I., Mizushima,N., Fukuda,M. and
            Kiger,A.A.
  TITLE     Genetic screen in Drosophila muscle identifies autophagy-mediated
            T-tubule remodeling and a Rab2 role in autophagy
  JOURNAL   Elife 6, e23367 (2017)
   PUBMED   28063257
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 858)
  AUTHORS   Fukuda,M., Kuroda,T.S. and Mikoshiba,K.
  TITLE     Slac2-a/melanophilin, the missing link between Rab27 and myosin Va:
            implications of a tripartite protein complex for melanosome
            transport
  JOURNAL   J Biol Chem 277 (14), 12432-12436 (2002)
   PUBMED   11856727
REFERENCE   7  (bases 1 to 858)
  AUTHORS   Kuroda,T.S., Fukuda,M., Ariga,H. and Mikoshiba,K.
  TITLE     The Slp homology domain of synaptotagmin-like proteins 1-4 and
            Slac2 functions as a novel Rab27A binding domain
  JOURNAL   J Biol Chem 277 (11), 9212-9218 (2002)
   PUBMED   11773082
REFERENCE   8  (bases 1 to 858)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
REFERENCE   9  (bases 1 to 858)
  AUTHORS   Alavizadeh,A., Kiernan,A.E., Nolan,P., Lo,C., Steel,K.P. and
            Bucan,M.
  TITLE     The Wheels mutation in the mouse causes vascular, hindbrain, and
            inner ear defects
  JOURNAL   Dev Biol 234 (1), 244-260 (2001)
   PUBMED   11356033
REFERENCE   10 (bases 1 to 858)
  AUTHORS   Bell,A.W., Ward,M.A., Blackstock,W.P., Freeman,H.N.,
            Choudhary,J.S., Lewis,A.P., Chotai,D., Fazel,A., Gushue,J.N.,
            Paiement,J., Palcy,S., Chevet,E., Lafreniere-Roula,M., Solari,R.,
            Thomas,D.Y., Rowley,A. and Bergeron,J.J.
  TITLE     Proteomics characterization of abundant Golgi membrane proteins
  JOURNAL   J Biol Chem 276 (7), 5152-5165 (2001)
   PUBMED   11042173
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL806521.9 and AL732627.14.
            
            On Sep 6, 2022 this sequence version replaced XM_006538126.5.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR13422601.1565412.1,
                                           SRR10662772.734815.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384, SAMN00849387
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-248               AL806521.9         159400-159647
            249-320             AL806521.9         184891-184962
            321-388             AL732627.14        11199-11266
            389-471             AL732627.14        16628-16710
            472-564             AL732627.14        17144-17236
            565-676             AL732627.14        21055-21166
            677-858             AL732627.14        28068-28249
FEATURES             Location/Qualifiers
     source          1..858
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 3.63 cM"
     gene            1..858
                     /gene="Rab2a"
                     /gene_synonym="9330148M11Rik; Rab2"
                     /note="RAB2A, member RAS oncogene family"
                     /db_xref="GeneID:59021"
                     /db_xref="MGI:MGI:1928750"
     exon            1..248
                     /gene="Rab2a"
                     /gene_synonym="9330148M11Rik; Rab2"
                     /inference="alignment:Splign:2.1.0"
     CDS             203..853
                     /gene="Rab2a"
                     /gene_synonym="9330148M11Rik; Rab2"
                     /EC_number="3.6.5.2"
                     /note="isoform 2 is encoded by transcript variant 2;
                     GTP-binding protein; ras-related protein Rab-2A; RAB2,
                     member RAS oncogene family"
                     /codon_start=1
                     /product="ras-related protein Rab-2A isoform 2"
                     /protein_id="NP_001398756.1"
                     /db_xref="GeneID:59021"
                     /db_xref="MGI:MGI:1928750"
                     /translation="MAYAYLFKYIIIGDTGVGKSCLLLQFTDKRFQPVHDLTIGVEFG
                     ARMITIDGKQIKLQIWDTAGQESFRSITRSYYRGAAGALLVYDITRRDTFNHLTTWLE
                     DARQHSNSNMVIMLIGNKSDLESRREVKKEEGEAFAREHGLIFMETSAKTASNVEEVM
                     NAESTVQMNHCQDAGGCCMGGSVKTIKRQHLRVYLSHCSIAVKRFCDQGNPLKKII"
     exon            249..320
                     /gene="Rab2a"
                     /gene_synonym="9330148M11Rik; Rab2"
                     /inference="alignment:Splign:2.1.0"
     exon            321..388
                     /gene="Rab2a"
                     /gene_synonym="9330148M11Rik; Rab2"
                     /inference="alignment:Splign:2.1.0"
     exon            389..471
                     /gene="Rab2a"
                     /gene_synonym="9330148M11Rik; Rab2"
                     /inference="alignment:Splign:2.1.0"
     exon            472..564
                     /gene="Rab2a"
                     /gene_synonym="9330148M11Rik; Rab2"
                     /inference="alignment:Splign:2.1.0"
     exon            565..676
                     /gene="Rab2a"
                     /gene_synonym="9330148M11Rik; Rab2"
                     /inference="alignment:Splign:2.1.0"
     exon            677..858
                     /gene="Rab2a"
                     /gene_synonym="9330148M11Rik; Rab2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      835..840
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rab2a"
                     /gene_synonym="9330148M11Rik; Rab2"
                     /note="hexamer: ATTAAA"
     polyA_site      858
                     /gene="Rab2a"
                     /gene_synonym="9330148M11Rik; Rab2"
                     /note="major polyA site"
ORIGIN      
        1 attgttccga agggctgggc cgctgtgctc cgcgctcggc gctgtcagtt cgtcccgctg
       61 cccctcggcc tttgctgctg gctctgacgg cgaccgacgg cgggcggggc ccgggttcgc
      121 ggccgagcgg cgccggtgag ggcgcggagg aggcgcacag cgggaggagg agccgtgagc
      181 ctggcacgga gcggccgcgg ccatggcgta cgcctatctc ttcaagtaca tcatcatcgg
      241 cgacacaggt gttggtaaat cgtgcttatt gctacagttt acagacaaga ggtttcagcc
      301 ggtgcatgac ctcacaattg gtgtagagtt tggtgctcgg atgataacga ttgatgggaa
      361 acagataaaa ctccagatct gggatacagc agggcaggag tcctttcgtt ctatcacacg
      421 gtcatattac agaggtgcag cgggggcttt actagtgtat gatattacaa ggagagacac
      481 gttcaaccac ttgacaacct ggttagaaga tgcccgtcag cattccaatt ccaacatggt
      541 catcatgctt attggaaata aaagtgactt agaatctagg agagaagtga aaaaggaaga
      601 aggtgaagct tttgcacgag agcatggact tatcttcatg gaaacttctg ccaagactgc
      661 gtctaatgta gaggaggtga tgaacgcaga gtccacagta cagatgaatc actgccagga
      721 cgcaggaggg tgttgcatgg gaggaagtgt taagactata aaaagacaac acttaagagt
      781 ctatcttagt cactgttcta ttgctgtgaa gagattctgt gaccaaggca acccattaaa
      841 aaaaatcatt tgatcgga
//
