LOCUS       NM_027295               1663 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus RAB28, member RAS oncogene family (Rab28), transcript
            variant 1, mRNA.
ACCESSION   NM_027295 XM_132086
VERSION     NM_027295.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1663)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1663)
  AUTHORS   Collin,G.B., Gogna,N., Chang,B., Damkham,N., Pinkney,J., Hyde,L.F.,
            Stone,L., Naggert,J.K., Nishina,P.M. and Krebs,M.P.
  TITLE     Mouse Models of Inherited Retinal Degeneration with Photoreceptor
            Cell Loss
  JOURNAL   Cells 9 (4), 931 (2020)
   PUBMED   32290105
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1663)
  AUTHORS   Castro,J.P., Yancoskie,M.N., Marchini,M., Belohlavy,S.,
            Hiramatsu,L., Kucka,M., Beluch,W.H., Naumann,R., Skuplik,I.,
            Cobb,J., Barton,N.H., Rolian,C. and Chan,Y.F.
  TITLE     An integrative genomic analysis of the Longshanks selection
            experiment for longer limbs in mice
  JOURNAL   Elife 8, e42014 (2019)
   PUBMED   31169497
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1663)
  AUTHORS   Ying,G., Boldt,K., Ueffing,M., Gerstner,C.D., Frederick,J.M. and
            Baehr,W.
  TITLE     The small GTPase RAB28 is required for phagocytosis of cone outer
            segments by the murine retinal pigmented epithelium
  JOURNAL   J Biol Chem 293 (45), 17546-17558 (2018)
   PUBMED   30228185
  REMARK    GeneRIF: these findings reveal that RAB28 is required for shedding
            and phagocytosis of cone OS discs.
REFERENCE   5  (bases 1 to 1663)
  AUTHORS   Zhou,Z., Menzel,F., Benninghoff,T., Chadt,A., Du,C., Holman,G.D.
            and Al-Hasani,H.
  TITLE     Rab28 is a TBC1D1/TBC1D4 substrate involved in GLUT4 trafficking
  JOURNAL   FEBS Lett 591 (1), 88-96 (2017)
   PUBMED   27929607
  REMARK    GeneRIF: Rab28 is a substrate for the GAP domains of both TBC1D1
            and TBC1D4 in vitro.
REFERENCE   6  (bases 1 to 1663)
  AUTHORS   Verzi,M.P., Stanfel,M.N., Moses,K.A., Kim,B.M., Zhang,Y.,
            Schwartz,R.J., Shivdasani,R.A. and Zimmer,W.E.
  TITLE     Role of the homeodomain transcription factor Bapx1 in mouse distal
            stomach development
  JOURNAL   Gastroenterology 136 (5), 1701-1710 (2009)
   PUBMED   19208343
REFERENCE   7  (bases 1 to 1663)
  AUTHORS   Itoh,T., Satoh,M., Kanno,E. and Fukuda,M.
  TITLE     Screening for target Rabs of TBC (Tre-2/Bub2/Cdc16)
            domain-containing proteins based on their Rab-binding activity
  JOURNAL   Genes Cells 11 (9), 1023-1037 (2006)
   PUBMED   16923123
REFERENCE   8  (bases 1 to 1663)
  AUTHORS   Fukuda,M.
  TITLE     Distinct Rab binding specificity of Rim1, Rim2, rabphilin, and
            Noc2. Identification of a critical determinant of Rab3A/Rab27A
            recognition by Rim2
  JOURNAL   J Biol Chem 278 (17), 15373-15380 (2003)
   PUBMED   12578829
REFERENCE   9  (bases 1 to 1663)
  AUTHORS   Fukuda,M., Kuroda,T.S. and Mikoshiba,K.
  TITLE     Slac2-a/melanophilin, the missing link between Rab27 and myosin Va:
            implications of a tripartite protein complex for melanosome
            transport
  JOURNAL   J Biol Chem 277 (14), 12432-12436 (2002)
   PUBMED   11856727
REFERENCE   10 (bases 1 to 1663)
  AUTHORS   Kuroda,T.S., Fukuda,M., Ariga,H. and Mikoshiba,K.
  TITLE     The Slp homology domain of synaptotagmin-like proteins 1-4 and
            Slac2 functions as a novel Rab27A binding domain
  JOURNAL   J Biol Chem 277 (11), 9212-9218 (2002)
   PUBMED   11773082
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC102858.11, BB850234.1, AK159493.1 and BY591132.1.
            
            On Jul 16, 2015 this sequence version replaced NM_027295.2.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC004580.1, AK159493.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164134
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-13                AC102858.11        132334-132346
            14-158              BB850234.1         2-146
            159-1654            AK159493.1         136-1631
            1655-1663           BY591132.1         462-470
FEATURES             Location/Qualifiers
     source          1..1663
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 22.58 cM"
     gene            1..1663
                     /gene="Rab28"
                     /gene_synonym="2700023P08Rik"
                     /note="RAB28, member RAS oncogene family"
                     /db_xref="GeneID:100972"
                     /db_xref="MGI:MGI:1917285"
     exon            1..275
                     /gene="Rab28"
                     /gene_synonym="2700023P08Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             201..866
                     /gene="Rab28"
                     /gene_synonym="2700023P08Rik"
                     /note="isoform 1 is encoded by transcript variant 1;
                     ras-related protein Rab-28"
                     /codon_start=1
                     /product="ras-related protein Rab-28 isoform 1"
                     /protein_id="NP_081571.1"
                     /db_xref="CCDS:CCDS19258.1"
                     /db_xref="GeneID:100972"
                     /db_xref="MGI:MGI:1917285"
                     /translation="MSDSEEESQDRQLKIVVLGDGTSGKTSLATCFAQETFGKQYKQT
                     IGLDFFLRRITLPGNLNVTLQVWDIGGQTIGGKMLDKYIYGAQGILLVYDITNYQSFE
                     NLEDWYSVVKTVSEESETQPLVALVGNKIDLEHMRTVKADKHLRFCQENGFSSHFVSA
                     KTGDSVFLCFQKVAAEILGIKLNKAEIEQSQRVVKADIVNYNQEPLSRTVNPPRSSMC
                     AVQ"
     exon            276..372
                     /gene="Rab28"
                     /gene_synonym="2700023P08Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            373..461
                     /gene="Rab28"
                     /gene_synonym="2700023P08Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            462..591
                     /gene="Rab28"
                     /gene_synonym="2700023P08Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            592..695
                     /gene="Rab28"
                     /gene_synonym="2700023P08Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            696..773
                     /gene="Rab28"
                     /gene_synonym="2700023P08Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            774..1663
                     /gene="Rab28"
                     /gene_synonym="2700023P08Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1642..1647
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rab28"
                     /gene_synonym="2700023P08Rik"
                     /note="hexamer: AATAAA"
     polyA_site      1660
                     /gene="Rab28"
                     /gene_synonym="2700023P08Rik"
                     /note="major polyA site"
ORIGIN      
        1 ggggggcgga gccctgctgg gggaggggag gagggcaaga tggcggccgg tgagtgattc
       61 tccctggctt ccttcagggc ggaggagacg ccggggcggg ggacccgctc gtgcagcccg
      121 ccggcctcct cacccccgcc cccggaggcc tcctctttcc cgtcctccac ctcgggggca
      181 ggccagcatc ctcggacacc atgtcagact ctgaggagga gagccaggac cggcaactga
      241 aaatcgtcgt gctgggggac ggcacctcgg ggaagacctc cttagctacg tgttttgctc
      301 aagagacatt tgggaagcag tacaagcaga cgataggact ggatttcttt ttgagaagga
      361 ttaccttacc aggaaatttg aatgttactc ttcaagtttg ggatatagga gggcagacaa
      421 taggtggcaa gatgttggat aaatacatct atggagcaca gggaatcctc ttggtatatg
      481 atattacaaa ctaccaaagc tttgagaatt tggaagattg gtattctgtg gtgaagacag
      541 taagtgaaga gtcagaaact cagcccctgg ttgctttagt gggcaataaa attgacttgg
      601 agcatatgcg aacagtaaaa gctgataagc acttacgatt ttgccaggaa aatggtttta
      661 gtagccactt tgtttcagcc aagacaggag actctgtctt cctgtgtttt cagaaagttg
      721 cagcagaaat cctgggaatc aaattaaaca aagcagaaat agaacagtca cagagagtgg
      781 tgaaggcaga tattgtaaac tacaaccagg agcccttgtc aagaactgtt aaccctcctc
      841 ggagctccat gtgtgcagtg cagtgagcac acactgtatt gatagttctg gctgctcttc
      901 ccctgaattg ggccccagct gcctaggaac gtgttttatc agtgactgtc tccgtagcca
      961 gctcacactt cctcctgctc tgctccttca tcctttagtt gcctgaggga tcaggcagct
     1021 ccctggaccg gaaggagtgc gatttggaac cacacgtttt gaaatccgaa tggagagtcc
     1081 attctctgga ttgagactgc ctcctcactc cagaagaacc atgttgcttc cttctctctt
     1141 cacttctttg tttcccagat ataaaaaatt taaccagata tgaagctgct ccaagctttg
     1201 atgatcattt tctatctgaa cttgtgtatg tgaaagtgta cttcagagcg ctgatggtga
     1261 aagcctctca agaaggtgtt cctttgctgg ctattgagag tacaatatac aaagctgtat
     1321 ctaattgaaa gtgcttcaaa tgaggctgta atagaaatat tttttcattt ttaaaggagc
     1381 ctaatgtgtt tatattgtag tttataactc acaagtagtg agtatttgat attgtatttt
     1441 tattactgta tcatggtcat tgcatatttt atcatatttg gcttagatgg ctttatggat
     1501 tttgataaat ggttcagctg atcctccaca tggaatttct cctacagact gtatgagagt
     1561 gcttccagat gagtcatgat ctccttggat cattggggat cgatcacact ggacctgttg
     1621 tgcagatggt tttctcagat aaataaattt atttaaaata tgt
//
