LOCUS       NM_023635               3066 bp    mRNA    linear   ROD 09-JUL-2024
DEFINITION  Mus musculus RAB27A, member RAS oncogene family (Rab27a),
            transcript variant 2, mRNA.
ACCESSION   NM_023635 XM_988908 XM_988941 XM_988982
VERSION     NM_023635.6
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3066)
  AUTHORS   Soucy,A., Potts,C., Kaija,A., Harrington,A., McGilvrey,M.,
            Sutphin,G.L., Korstanje,R., Tero,B., Seeker,J., Pinz,I., Vary,C.,
            Ryzhova,L. and Liaw,L.
  TITLE     Effects of a Global Rab27a Null Mutation on Murine PVAT and
            Cardiovascular Function
  JOURNAL   Arterioscler Thromb Vasc Biol 44 (7), 1601-1616 (2024)
   PUBMED   38660803
  REMARK    GeneRIF: Effects of a Global Rab27a Null Mutation on Murine PVAT
            and Cardiovascular Function.
REFERENCE   2  (bases 1 to 3066)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 3066)
  AUTHORS   Richard,A.C., Ma,C.Y., Marioni,J.C. and Griffiths,G.M.
  TITLE     Cytotoxic T lymphocytes require transcription for infiltration but
            not target cell lysis
  JOURNAL   EMBO Rep 24 (11), e57653 (2023)
   PUBMED   37860838
REFERENCE   4  (bases 1 to 3066)
  AUTHORS   Bastos,N., Castaldo,S.A., Adem,B., Machado,J.C., Melo,C.A. and
            Melo,S.A.
  TITLE     SMC3 epigenetic silencing regulates Rab27a expression and drives
            pancreatic cancer progression
  JOURNAL   J Transl Med 21 (1), 578 (2023)
   PUBMED   37641131
  REMARK    GeneRIF: SMC3 epigenetic silencing regulates Rab27a expression and
            drives pancreatic cancer progression.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3066)
  AUTHORS   Munafo,D.B., Johnson,J.L., Ellis,B.A., Rutschmann,S., Beutler,B.
            and Catz,S.D.
  TITLE     Rab27a is a key component of the secretory machinery of azurophilic
            granules in granulocytes
  JOURNAL   Biochem J 402 (2), 229-239 (2007)
   PUBMED   17090228
  REMARK    GeneRIF: Rab27a and JFC1/Slp1 permit myeloperoxidase release into
            the surrounding milieu and constitute key components of the
            secretory machinery of azurophilic granules in granulocytes
REFERENCE   6  (bases 1 to 3066)
  AUTHORS   Barral,D.C., Ramalho,J.S., Anders,R., Hume,A.N., Knapton,H.J.,
            Tolmachova,T., Collinson,L.M., Goulding,D., Authi,K.S. and
            Seabra,M.C.
  TITLE     Functional redundancy of Rab27 proteins and the pathogenesis of
            Griscelli syndrome
  JOURNAL   J Clin Invest 110 (2), 247-257 (2002)
   PUBMED   12122117
  REMARK    GeneRIF: Rab27b is functionally redundant with Rab27a and the
            pathogenesis of Griscelli syndrome is determined by the relative
            expression of Rab27a and Rab27b in specialized cell types.
            Erratum:[J Clin Invest 2002 Oct;110(8):1213]
REFERENCE   7  (bases 1 to 3066)
  AUTHORS   Wilson,S.M., Yip,R., Swing,D.A., O'Sullivan,T.N., Zhang,Y.,
            Novak,E.K., Swank,R.T., Russell,L.B., Copeland,N.G. and
            Jenkins,N.A.
  TITLE     A mutation in Rab27a causes the vesicle transport defects observed
            in ashen mice
  JOURNAL   Proc Natl Acad Sci U S A 97 (14), 7933-7938 (2000)
   PUBMED   10859366
REFERENCE   8  (bases 1 to 3066)
  AUTHORS   Moore,K.J., Swing,D.A., Copeland,N.G. and Jenkins,N.A.
  TITLE     Interaction of the murine dilute suppressor gene (dsu) with
            fourteen coat color mutations
  JOURNAL   Genetics 125 (2), 421-430 (1990)
   PUBMED   2379821
  REMARK    Erratum:[Genetics 1990 Sep;126(1):285]
REFERENCE   9  (bases 1 to 3066)
  AUTHORS   Moore,K.J., Swing,D.A., Rinchik,E.M., Mucenski,M.L., Buchberg,A.M.,
            Copeland,N.G. and Jenkins,N.A.
  TITLE     The murine dilute suppressor gene dsu suppresses the coat-color
            phenotype of three pigment mutations that alter melanocyte
            morphology, d, ash and ln
  JOURNAL   Genetics 119 (4), 933-941 (1988)
   PUBMED   3410303
REFERENCE   10 (bases 1 to 3066)
  AUTHORS   Langdon,W.Y., Theodore,T.S., Buckler,C.E., Stimpfling,J.H.,
            Martin,M.A. and Morse,H.C. 3rd.
  TITLE     Relationship between a retroviral germ line reintegration and a new
            mutation at the ashen locus in B10.F mice. Retroviral integration
            and an ashen mutation
  JOURNAL   Virology 133 (1), 183-190 (1984)
   PUBMED   6322428
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CJ077071.1, AK010373.1,
            AK008798.1, BE948607.1 and BP769437.1.
            
            On Jul 29, 2014 this sequence version replaced NM_023635.5.
            
            Summary: The protein encoded by this gene is a member of the Rab
            family of proteins, which is the largest family within the Ras
            superfamily of GTPases. This gene product is thought to regulate
            vesicular transport, together with its specific effectors.
            Mutations in this gene cause several defects, including actin-based
            melanosome transport defects and immunodeficiency. Mutations in the
            human ortholog of this gene are associated with Griscelli syndrome
            type 2. Alternative splicing results in multiple transcript
            variants. [provided by RefSeq, Jul 2014].
            
            Transcript Variant: This variant (2) lacks an exon in the 5' UTR
            compared to variant 1. Variants 1, 2, and 3 encode the same
            protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK030529.1, AK010373.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-83                CJ077071.1         1-83
            84-1876             AK010373.1         2-1794
            1877-2045           AK008798.1         50-218
            2046-2046           BE948607.1         17-17
            2047-2919           AK008798.1         219-1091
            2920-3066           BP769437.1         1-147               c
FEATURES             Location/Qualifiers
     source          1..3066
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 40.08 cM"
     gene            1..3066
                     /gene="Rab27a"
                     /gene_synonym="2210402C08Rik; 2410003M20Rik;
                     4933437C11Rik; ash"
                     /note="RAB27A, member RAS oncogene family"
                     /db_xref="GeneID:11891"
                     /db_xref="MGI:MGI:1861441"
     exon            1..202
                     /gene="Rab27a"
                     /gene_synonym="2210402C08Rik; 2410003M20Rik;
                     4933437C11Rik; ash"
                     /inference="alignment:Splign:2.1.0"
     exon            203..377
                     /gene="Rab27a"
                     /gene_synonym="2210402C08Rik; 2410003M20Rik;
                     4933437C11Rik; ash"
                     /inference="alignment:Splign:2.1.0"
     exon            378..463
                     /gene="Rab27a"
                     /gene_synonym="2210402C08Rik; 2410003M20Rik;
                     4933437C11Rik; ash"
                     /inference="alignment:Splign:2.1.0"
     exon            464..567
                     /gene="Rab27a"
                     /gene_synonym="2210402C08Rik; 2410003M20Rik;
                     4933437C11Rik; ash"
                     /inference="alignment:Splign:2.1.0"
     exon            568..691
                     /gene="Rab27a"
                     /gene_synonym="2210402C08Rik; 2410003M20Rik;
                     4933437C11Rik; ash"
                     /inference="alignment:Splign:2.1.0"
     exon            692..3048
                     /gene="Rab27a"
                     /gene_synonym="2210402C08Rik; 2410003M20Rik;
                     4933437C11Rik; ash"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1850..1855
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rab27a"
                     /gene_synonym="2210402C08Rik; 2410003M20Rik;
                     4933437C11Rik; ash"
                     /note="hexamer: ATTAAA"
     polyA_site      1879
                     /gene="Rab27a"
                     /gene_synonym="2210402C08Rik; 2410003M20Rik;
                     4933437C11Rik; ash"
                     /note="major polyA site"
ORIGIN      
        1 gctctcctct acgggaagtg atgtggggcc agacggaaaa tagcgccaag cacccaaaaa
       61 aggccagtcg cacggggtcc cgagctccat ttggaaggga gtacctaagg gatagagcac
      121 agcgaggacg cggcacgttg ggaatctagc actgcaggga cgcaacaccg cagggacagc
      181 accggacaga gcaccaaacc gggtgaggca cagagttctc catcatgtcg gatggagatt
      241 acgattacct catcaagttc ttggccttgg gagactctgg ggtagggaag accagtgtac
      301 tctaccagta cactgatggc aagttcaact ccaaattcat caccacagtg ggcattgatt
      361 tcagggaaaa gagagtggtg tacagagcca atgggccaga tggagctgtg ggccgaggcc
      421 agagaatcca cctgcagtta tgggacacgg cggggcagga gaggtttcgt agcttaacca
      481 ctgcattctt cagggacgct atgggtttcc tgcttctgtt cgacctgaca aatgagcaaa
      541 gtttcctcaa tgtccgaaac tggataagcc agctacagat gcacgcgtac tgtgaaaacc
      601 cagatatagt gctgtgtgga aataagagtg acctggaaga ccagagggca gtgaaagagg
      661 aggaggcccg ggaacttgcc gagaagtacg gaatccccta ttttgaaacc agtgctgcca
      721 acgggacaaa cataagccac gcgattgaga tgctcctgga cctgatcatg aagcggatgg
      781 agcggtgtgt ggacaagtcc tggattccgg agggagtggt acggtccaac ggccatacct
      841 ctgcggatca gctaagtgag gagaaggaga aggggttgtg tggctgttga gacgccaagc
      901 gagccccgtg gcagcagcgc atgacccctg gttgccgcca gctccgctgt agagaccaag
      961 ccggcagctc gatgagatga gcaaacagcc cctcctatgc caggtgcctc tcctcgcctc
     1021 caggagggtc acctcgggca tccatctgta acgcgctgca gctttgtatg atttagtcca
     1081 tgaatcggaa gaaatacttc acagagccaa aagtgtctta taaaagccca cggtggcggg
     1141 tcatttaggg atccaagatt tcagccatga aagatttcat ctgttatgta gaacgctgat
     1201 ggtcctgtcg cctgccttaa cacagtcgcc tgcctcaaca caggacagcc ctagagtctc
     1261 attgaagaca ttaagatctt tgagcaagga aaagctagca cggtcttgag aatccagatt
     1321 tcaaaatcca tactgtagac tatcactctc aaacacgtga atgtcaataa gtgtgtacac
     1381 acagatcaat gtctttcagc attgcttttt aacatagcct ttcctttgac atgagcataa
     1441 acagatggcg gccataccta tagactctga atagatcgga ttgactcact gtgagtttgg
     1501 gggtgggggg aagggtttat ggagcagggg tgggtgaagt agggatcagt cagattgtct
     1561 gctgttagcc gaggggtcat gaagactctt gtgtctatcc atggtctgtt gggttcagtg
     1621 cacctctgaa catcgctcat gcttctacag tatgtatgtt tgcatgtatg tatgtatggt
     1681 ctcttcatat gtacgtatgt ttggtctggc acctcaggat ctgctttcac ttgtctggag
     1741 actgccaatc tgacttttcc catcaagttt tggtggtggt ggtgtttccc agtttgtttt
     1801 ctcccccccc cccttccccc attaatgtaa ctgaaggaat ctctttttaa ttaaacggcg
     1861 tgtttatttg ctatctggag ggagggagtt cactgtctgt atttaagcag tcacatttgt
     1921 gggccagttt aagagaagtg ttttgtagcc tgtagctttc actgggaatg tggggcactg
     1981 atgttttttg atagtggaaa acatactttg catggtagtt tcaagtggct tttttttttt
     2041 ttttttgaga cagggtcttt tcatatagtt tctagctggc ccaaaactcc ctttgtagac
     2101 taggctggcc tcaaactcac agagatccac ctgtctcagc accctaagca ctggggatta
     2161 aaggtgtagt tgtcacacct ggctctcaga agacttttaa aaaattgcac atctatcatt
     2221 tattgccatt gtcctttgac ccctcctcag aaaaaaatag ccatggccac taagctttta
     2281 ctgtttttga aataagggac tctttgaaac accaaactca tcattgaggc ctatacatct
     2341 gaatcctata tacccaggac atgaggccca tcatagccgt gccttccagc gttgttctaa
     2401 gacttcagtg gagcatactg cttgtttggc acatttctta atgtctctct tgtaaataca
     2461 tcaagtcaat atgccagaca ggtattggtg gttcgttctt ttcatctccc atacttgaga
     2521 agcagaggca ggcgatgagt ttgaagctag gcttcactat agagtgagtt tcaggacagc
     2581 caaagataca tagtgaagtc ctgtttcaaa aaacaaacac acactaggca gtggaggccc
     2641 atgcctttca tcccagcact caggaggcag aggcaggtgg atttctgagt tcgaggccag
     2701 cctggtctac agagtgagtt ccaggacagc caagactaca cataaaaaag tgaatgtttg
     2761 cacagtggca tagtgcgggt tttgagaagt gagatgccgc tcctgttggc tccacaccag
     2821 gcacggggct taatgtgtgt gatagttgcc caacacaaga gctgccttga attgttgaaa
     2881 caaaacaaaa ctgagttctc tgaaaatggt ttaaatttga taaaaaaaaa aaaataaccg
     2941 tactttttgt cactgtattt ttctatttac aaatctgtat aaaaaatgct ctttagtgaa
     3001 ctttgtgcca attaaaccat aataataata aaaaaaaata ataaaagaaa aaaaaaaaaa
     3061 aaaaaa
//
