LOCUS       NM_177375               1399 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus RAB26, member RAS oncogene family (Rab26), mRNA.
ACCESSION   NM_177375 XM_283428 XM_914497
VERSION     NM_177375.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1399)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1399)
  AUTHORS   Gong,D., Liu,X., Wu,P., Chen,Y., Xu,Y., Gao,Z., Qian,H., Wang,G.
            and He,B.
  TITLE     Rab26 alleviates sepsis-induced immunosuppression as a master
            regulator of macrophage ferroptosis and polarization shift
  JOURNAL   Free Radic Biol Med 212, 271-283 (2024)
   PUBMED   38169213
  REMARK    GeneRIF: Rab26 alleviates sepsis-induced immunosuppression as a
            master regulator of macrophage ferroptosis and polarization shift.
REFERENCE   3  (bases 1 to 1399)
  AUTHORS   Wu,D., Wang,Y., Hu,J., Xu,Y., Gong,D., Wu,P., Dong,J., He,B.,
            Qian,H. and Wang,G.
  TITLE     Rab26 promotes macrophage phagocytosis through regulation of MFN2
            trafficking to mitochondria
  JOURNAL   FEBS J 290 (16), 4023-4039 (2023)
   PUBMED   37060270
  REMARK    GeneRIF: Rab26 promotes macrophage phagocytosis through regulation
            of MFN2 trafficking to mitochondria.
REFERENCE   4  (bases 1 to 1399)
  AUTHORS   Zhuang,R., Zhou,Y., Wang,Z., Cao,Y., Chen,J., Xu,L., Ren,Y.,
            Zheng,Y., Wei,Z., Qiu,H., Li,L., Han,Y., Yun,Y., Chen,X., Hong,W.
            and Wang,T.
  TITLE     Rab26 restricts insulin secretion via sequestering Synaptotagmin-1
  JOURNAL   PLoS Biol 21 (6), e3002142 (2023)
   PUBMED   37289842
  REMARK    GeneRIF: Rab26 restricts insulin secretion via sequestering
            Synaptotagmin-1.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1399)
  AUTHORS   Zhang,W., Wang,Y., Li,C., Xu,Y., Wang,X., Wu,D., Gao,Z., Qian,H.,
            You,Z., Zhang,Z., He,B. and Wang,G.
  TITLE     Extracellular CIRP-Impaired Rab26 Restrains EPOR-Mediated
            Macrophage Polarization in Acute Lung Injury
  JOURNAL   Front Immunol 12, 768435 (2021)
   PUBMED   34925338
  REMARK    GeneRIF: Extracellular CIRP-Impaired Rab26 Restrains EPOR-Mediated
            Macrophage Polarization in Acute Lung Injury.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1399)
  AUTHORS   Tian,X., Jin,R.U., Bredemeyer,A.J., Oates,E.J., Blazewska,K.M.,
            McKenna,C.E. and Mills,J.C.
  TITLE     RAB26 and RAB3D are direct transcriptional targets of MIST1 that
            regulate exocrine granule maturation
  JOURNAL   Mol Cell Biol 30 (5), 1269-1284 (2010)
   PUBMED   20038531
  REMARK    GeneRIF: MIST1 binds to highly conserved CATATG E-boxes to directly
            activate transcription of 6 genes, including those encoding the
            small GTPases RAB26 and RAB3D.
REFERENCE   7  (bases 1 to 1399)
  AUTHORS   Itoh,T., Satoh,M., Kanno,E. and Fukuda,M.
  TITLE     Screening for target Rabs of TBC (Tre-2/Bub2/Cdc16)
            domain-containing proteins based on their Rab-binding activity
  JOURNAL   Genes Cells 11 (9), 1023-1037 (2006)
   PUBMED   16923123
REFERENCE   8  (bases 1 to 1399)
  AUTHORS   Fukuda,M.
  TITLE     Distinct Rab binding specificity of Rim1, Rim2, rabphilin, and
            Noc2. Identification of a critical determinant of Rab3A/Rab27A
            recognition by Rim2
  JOURNAL   J Biol Chem 278 (17), 15373-15380 (2003)
   PUBMED   12578829
REFERENCE   9  (bases 1 to 1399)
  AUTHORS   Fukuda,M., Kuroda,T.S. and Mikoshiba,K.
  TITLE     Slac2-a/melanophilin, the missing link between Rab27 and myosin Va:
            implications of a tripartite protein complex for melanosome
            transport
  JOURNAL   J Biol Chem 277 (14), 12432-12436 (2002)
   PUBMED   11856727
REFERENCE   10 (bases 1 to 1399)
  AUTHORS   Kuroda,T.S., Fukuda,M., Ariga,H. and Mikoshiba,K.
  TITLE     The Slp homology domain of synaptotagmin-like proteins 1-4 and
            Slac2 functions as a novel Rab27A binding domain
  JOURNAL   J Biol Chem 277 (11), 9212-9218 (2002)
   PUBMED   11773082
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC132367.3.
            
            On Mar 11, 2022 this sequence version replaced NM_177375.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC094931.1, AB232621.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-346               AC132367.3         110763-111108
            347-457             AC132367.3         112163-112273
            458-499             AC132367.3         113658-113699
            500-566             AC132367.3         113776-113842
            567-619             AC132367.3         114042-114094
            620-685             AC132367.3         114365-114430
            686-742             AC132367.3         114515-114571
            743-819             AC132367.3         114668-114744
            820-1399            AC132367.3         114842-115421
FEATURES             Location/Qualifiers
     source          1..1399
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 12.4 cM"
     gene            1..1399
                     /gene="Rab26"
                     /gene_synonym="A830020M03Rik"
                     /note="RAB26, member RAS oncogene family"
                     /db_xref="GeneID:328778"
                     /db_xref="MGI:MGI:2443284"
     exon            1..346
                     /gene="Rab26"
                     /gene_synonym="A830020M03Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             140..922
                     /gene="Rab26"
                     /gene_synonym="A830020M03Rik"
                     /codon_start=1
                     /product="ras-related protein Rab-26"
                     /protein_id="NP_796349.1"
                     /db_xref="CCDS:CCDS50016.1"
                     /db_xref="GeneID:328778"
                     /db_xref="MGI:MGI:2443284"
                     /translation="MSRKKTPKSKGGSEPATSTLPAAAAATNGPRLAHPRTVRPGPEA
                     PPNGPPQSIRPSLGSTGDFYDVAFKVMLVGDSGVGKTCLLVRFKDGAFLAGTFISTVG
                     IDFRNKVLDVDGMKVKLQIWDTAGQERFRSVTHAYYRDAHALLLLYDITNKDSFDNIQ
                     AWLTEIQEYAQQDVVLMLLGNKVDSTQDRVVKREDGEKLAKEYGLPFMETSARTGLNV
                     DLAFTAIAKELKQRSAKAPSEPRFRLHDYVKREGRGVSCCRL"
     exon            347..457
                     /gene="Rab26"
                     /gene_synonym="A830020M03Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            458..499
                     /gene="Rab26"
                     /gene_synonym="A830020M03Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            500..566
                     /gene="Rab26"
                     /gene_synonym="A830020M03Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            567..619
                     /gene="Rab26"
                     /gene_synonym="A830020M03Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            620..685
                     /gene="Rab26"
                     /gene_synonym="A830020M03Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            686..742
                     /gene="Rab26"
                     /gene_synonym="A830020M03Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            743..819
                     /gene="Rab26"
                     /gene_synonym="A830020M03Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            820..1399
                     /gene="Rab26"
                     /gene_synonym="A830020M03Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1382..1387
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rab26"
                     /gene_synonym="A830020M03Rik"
                     /note="hexamer: AATAAA"
     polyA_site      1399
                     /gene="Rab26"
                     /gene_synonym="A830020M03Rik"
                     /note="major polyA site"
ORIGIN      
        1 actgagtgct ggagatgctg ctgctactgc cgccgccgct gccgctgcgg gacgggttcg
       61 ggtccgagtc ggtcttggcg ggcacggggc gtgggacaac ccgggacaca gcggtagcag
      121 caggagcaca ctgagaacca tgtccaggaa gaagaccccc aagagcaagg gggggagtga
      181 gccggctacc tctacgctgc ccgccgccgc cgccgccacc aatgggccac gtctggcaca
      241 tccgaggact gtgcgccctg gcccagaggc accgcccaat gggcccccgc agtccatccg
      301 gccctcactt ggtagcactg gagacttcta cgatgttgct ttcaaggtca tgctggtggg
      361 ggattccggt gtggggaaga cctgcctgct tgtgcgcttc aaggatgggg ctttcctggc
      421 tggtaccttc atctccactg tgggcatcga cttccggaat aaagttctgg atgtggatgg
      481 catgaaggtg aagctgcaga tctgggacac agctggtcag gagcggttcc gaagtgtcac
      541 ccatgcctac taccgagatg ctcacgcact gttgctgctc tacgacatca ccaacaaaga
      601 ttccttcgac aacattcagg cctggttgac agagatccag gaatatgccc agcaggatgt
      661 ggtgctcatg ctgctaggga acaaggttga ctctactcaa gaccgtgtgg taaagaggga
      721 agatggggag aaattagcca aggagtatgg gctacctttc atggagacca gcgcaaggac
      781 tggcctcaac gtggacttgg cttttacagc catagcaaag gagctgaaac agagatcagc
      841 caaggctccc agcgagccgc gcttcaggct gcatgactat gttaagaggg agggccgagg
      901 ggtctcctgc tgtcgactct gaaccttgct gaaactcagt tccacgctgg aggaagcagt
      961 tctgcctttg agaattgccc gagtctatag acttgtcctc aaaggatgga tgccctagtg
     1021 tcttctcaaa gacaccagag gctaatgctt accctttgcc ccagtggcca ccagaaatgg
     1081 tcttgaagca taaaaaccag gccacagcac attgctgccc tcttctgggc actcccagaa
     1141 gtgaggaggg ggaccacacg cagcacactg ctcagacagg accccactca aggctatgtc
     1201 agtcactgtc catttgttgg actgcttccg actcactagg aggctgatat agggacgcac
     1261 agcaaggtca gaatgataga acccagtcac aacttagcag gctggcccag tccgttccac
     1321 tttgtactaa agtcaccaag ccacaaatgt tgagtgaaaa cctgtcctct aagtccctat
     1381 taataaaggt gtttctgga
//
