LOCUS       NM_016899               1060 bp    mRNA    linear   ROD 12-NOV-2024
DEFINITION  Mus musculus RAB25, member RAS oncogene family (Rab25), mRNA.
ACCESSION   NM_016899
VERSION     NM_016899.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1060)
  AUTHORS   Zhang,Q., Zhang,Z., Liu,Z., Wang,C., Chen,H., Shen,L., Long,C.,
            Wei,G. and Liu,X.
  TITLE     Deficiency in the Rab25 gene leads to a decline in male fertility
            and testicular injury: Impact on the regulation of germ cell
            proliferation and apoptosis
  JOURNAL   Exp Cell Res 442 (2), 114285 (2024)
   PUBMED   39424096
  REMARK    GeneRIF: Deficiency in the Rab25 gene leads to a decline in male
            fertility and testicular injury: Impact on the regulation of germ
            cell proliferation and apoptosis.
REFERENCE   2  (bases 1 to 1060)
  AUTHORS   Zhang,Z., Zhang,Q., Liu,Z., Wang,C., Chen,H., Luo,X., Shen,L.,
            Long,C., Wei,G. and Liu,X.
  TITLE     Rab25 is involved in hypospadias via the beta1 integrin/EGFR
            pathway
  JOURNAL   Exp Cell Res 436 (2), 113980 (2024)
   PUBMED   38401686
  REMARK    GeneRIF: Rab25 is involved in hypospadias via the beta1
            integrin/EGFR pathway.
REFERENCE   3  (bases 1 to 1060)
  AUTHORS   Kohil,A., Amir,S.S., Behrens,A. and Khan,O.M.
  TITLE     A small Rho GTPase RAB25 with a potential role in chemotherapy
            resistance in pancreatic cancer
  JOURNAL   Cancer Biomark 36 (2), 133-145 (2023)
   PUBMED   36565104
  REMARK    GeneRIF: A small Rho GTPase RAB25 with a potential role in
            chemotherapy resistance in pancreatic cancer.
REFERENCE   4  (bases 1 to 1060)
  AUTHORS   Jeong,H., Lim,K.M., Kim,K.H., Cho,Y., Lee,B., Knowles,B.C.,
            Roland,J.T., Zwerner,J.P., Goldenring,J.R. and Nam,K.T.
  TITLE     Loss of Rab25 promotes the development of skin squamous cell
            carcinoma through the dysregulation of integrin trafficking
  JOURNAL   J Pathol 249 (2), 227-240 (2019)
   PUBMED   31144312
  REMARK    GeneRIF: Loss of Rab25 promotes the development and neoplastic
            transition of skin squamous cell carcinoma through dysregulation of
            integrin trafficking.
REFERENCE   5  (bases 1 to 1060)
  AUTHORS   Hinze,C., Ruffert,J., Walentin,K., Himmerkus,N., Nikpey,E.,
            Tenstad,O., Wiig,H., Mutig,K., Yurtdas,Z.Y., Klein,J.D.,
            Sands,J.M., Branchi,F., Schumann,M., Bachmann,S., Bleich,M. and
            Schmidt-Ott,K.M.
  TITLE     GRHL2 Is Required for Collecting Duct Epithelial Barrier Function
            and Renal Osmoregulation
  JOURNAL   J Am Soc Nephrol 29 (3), 857-868 (2018)
   PUBMED   29237740
REFERENCE   6  (bases 1 to 1060)
  AUTHORS   Fukuda,M.
  TITLE     Distinct Rab binding specificity of Rim1, Rim2, rabphilin, and
            Noc2. Identification of a critical determinant of Rab3A/Rab27A
            recognition by Rim2
  JOURNAL   J Biol Chem 278 (17), 15373-15380 (2003)
   PUBMED   12578829
REFERENCE   7  (bases 1 to 1060)
  AUTHORS   Fukuda,M., Kuroda,T.S. and Mikoshiba,K.
  TITLE     Slac2-a/melanophilin, the missing link between Rab27 and myosin Va:
            implications of a tripartite protein complex for melanosome
            transport
  JOURNAL   J Biol Chem 277 (14), 12432-12436 (2002)
   PUBMED   11856727
REFERENCE   8  (bases 1 to 1060)
  AUTHORS   Kuroda,T.S., Fukuda,M., Ariga,H. and Mikoshiba,K.
  TITLE     The Slp homology domain of synaptotagmin-like proteins 1-4 and
            Slac2 functions as a novel Rab27A binding domain
  JOURNAL   J Biol Chem 277 (11), 9212-9218 (2002)
   PUBMED   11773082
REFERENCE   9  (bases 1 to 1060)
  AUTHORS   Suzuki,H., Fukunishi,Y., Kagawa,I., Saito,R., Oda,H., Endo,T.,
            Kondo,S., Bono,H., Okazaki,Y. and Hayashizaki,Y.
  TITLE     Protein-protein interaction panel using mouse full-length cDNAs
  JOURNAL   Genome Res 11 (10), 1758-1765 (2001)
   PUBMED   11591653
REFERENCE   10 (bases 1 to 1060)
  AUTHORS   Bhartur,S.G., Calhoun,B.C., Woodrum,J., Kurkjian,J., Iyer,S.,
            Lai,F. and Goldenring,J.R.
  TITLE     Genomic structure of murine Rab11 family members
  JOURNAL   Biochem Biophys Res Commun 269 (2), 611-617 (2000)
   PUBMED   10708602
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AC145168.5.
            
            On May 1, 2007 this sequence version replaced NM_016899.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK003260.1, BC006624.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-247               AC145168.5         114120-114366       c
            248-443             AC145168.5         111148-111343       c
            444-637             AC145168.5         109407-109600       c
            638-718             AC145168.5         108788-108868       c
            719-1060            AC145168.5         108116-108457       c
FEATURES             Location/Qualifiers
     source          1..1060
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 38.87 cM"
     gene            1..1060
                     /gene="Rab25"
                     /note="RAB25, member RAS oncogene family"
                     /db_xref="GeneID:53868"
                     /db_xref="MGI:MGI:1858203"
     exon            1..247
                     /gene="Rab25"
                     /inference="alignment:Splign:2.1.0"
     exon            248..443
                     /gene="Rab25"
                     /inference="alignment:Splign:2.1.0"
     exon            444..637
                     /gene="Rab25"
                     /inference="alignment:Splign:2.1.0"
     exon            638..718
                     /gene="Rab25"
                     /inference="alignment:Splign:2.1.0"
     exon            719..1060
                     /gene="Rab25"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agctcccaca gagtagctaa acgtgccaga gctgagcctc tggggctctt cctggcctca
       61 actgagccct cttgtccttt tcccccaatg agagaggagc caggtgcagg tctcttaaaa
      121 gctgagagtt gaggccattt aaacaataaa cagactcgtg acctctgcac ctgcaaacgt
      181 cttcactctc catgctgagc caagatgggg aatcgaacag atgaagatta taactttgtc
      241 tttaaggtgg tgctgatcgg cgagtcaggc gtgggcaaga ccaatctgct gtcccggttc
      301 acccgcaatg agttcagcca cgacagtcgc accaccatcg gggttgagtt ctccacccgc
      361 actgtaatgc tgggcaccgc tgctgtcaag gcacagatct gggacacggc cggcctggag
      421 agatacagag ccatcacctc tgcgtactat cgtggggccg tgggggcact cctggtattt
      481 gacctgacca agcaccagac ctacgctgtg gtggagcgct ggctaaagga gctgtatgac
      541 catgccgaag ccacgattgt tgtcatgctc gtggggaaca aaagtgacct cagccaggcc
      601 cgagaggtcc ctactgagga ggcctgcatg tttgctgaaa acaatggcct gctgttcctg
      661 gagacgtcag ccctcgactc caccaatgtt gagctagcct tccagactgt cctcaaagag
      721 atctttgcaa aggtgtccaa gcagaagcag aacagcaccc ggaccagtgc catcaccctg
      781 ggcaatgccc aagctggaca ggatcctggc cctggggaaa agagggcctg ttgcatcagc
      841 ctctgacttc agctatggcc agccctgtgt cctgccttca gctttcagat atctccacct
      901 cccttactgc aggacttctc cctaccctgg agtccctgat cactagcacg cagggtcatc
      961 atgccctacc atgtgatctg cccaccatat tcctctccat cacctggacc ccttacaggc
     1021 gagggccgga aaataaagct gttttgtatt gtgcctggcc
//
