LOCUS       NM_008999               4321 bp    mRNA    linear   ROD 11-APR-2023
DEFINITION  Mus musculus RAB23, member RAS oncogene family (Rab23), transcript
            variant 1, mRNA.
ACCESSION   NM_008999
VERSION     NM_008999.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4321)
  AUTHORS   Hasan MR, Koskenranta A, Alakurtti K, Takatalo M and Rice DP.
  TITLE     RAB23 regulates musculoskeletal development and patterning
  JOURNAL   Front Cell Dev Biol 11, 1049131 (2023)
   PUBMED   36910145
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4321)
  AUTHORS   Hor CHH, Lo JCW, Cham ALS, Leong WY and Goh ELK.
  TITLE     Multifaceted Functions of Rab23 on Primary Cilium-Mediated and
            Hedgehog Signaling-Mediated Cerebellar Granule Cell Proliferation
  JOURNAL   J Neurosci 41 (32), 6850-6863 (2021)
   PUBMED   34210780
  REMARK    GeneRIF: Multifaceted Functions of Rab23 on Primary Cilium-Mediated
            and Hedgehog Signaling-Mediated Cerebellar Granule Cell
            Proliferation.
REFERENCE   3  (bases 1 to 4321)
  AUTHORS   Hasan MR, Takatalo M, Ma H, Rice R, Mustonen T and Rice DP.
  TITLE     RAB23 coordinates early osteogenesis by repressing FGF10-pERK1/2
            and GLI1
  JOURNAL   Elife 9, e55829 (2020)
   PUBMED   32662771
  REMARK    GeneRIF: RAB23 coordinates early osteogenesis by repressing
            FGF10-pERK1/2 and GLI1.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4321)
  AUTHORS   Wang HH, Zhang Y, Tang F, Pan MH, Wan X, Li XH and Sun SC.
  TITLE     Rab23/Kif17 regulate meiotic progression in oocytes by modulating
            tubulin acetylation and actin dynamics
  JOURNAL   Development 146 (3) (2019)
   PUBMED   30696709
  REMARK    GeneRIF: results demonstrate that the Rab23-Kif17-cargo complex
            regulates tubulin acetylation for spindle organization and drives
            actin-mediated spindle migration during meiosis.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4321)
  AUTHORS   Hor CHH and Goh ELK.
  TITLE     Rab23 Regulates Radial Migration of Projection Neurons via
            N-cadherin
  JOURNAL   Cereb Cortex 28 (4), 1516-1531 (2018)
   PUBMED   29420702
  REMARK    GeneRIF: These studies suggest that cortical neuron migration is
            mediated by a molecular hierarchy downstream of Rab23 via
            N-cadherin.
REFERENCE   6  (bases 1 to 4321)
  AUTHORS   Qian X, Davis AA, Goderie SK and Temple S.
  TITLE     FGF2 concentration regulates the generation of neurons and glia
            from multipotent cortical stem cells
  JOURNAL   Neuron 18 (1), 81-93 (1997)
   PUBMED   9010207
REFERENCE   7  (bases 1 to 4321)
  AUTHORS   Sporle R, Gunther T, Struwe M and Schughart K.
  TITLE     Severe defects in the formation of epaxial musculature in open
            brain (opb) mutant mouse embryos
  JOURNAL   Development 122 (1), 79-86 (1996)
   PUBMED   8565855
REFERENCE   8  (bases 1 to 4321)
  AUTHORS   Gunther T, Struwe M, Aguzzi A and Schughart K.
  TITLE     Open brain, a new mouse mutant with severe neural tube defects,
            shows altered gene expression patterns in the developing spinal
            cord
  JOURNAL   Development 120 (11), 3119-3130 (1994)
   PUBMED   7720556
REFERENCE   9  (bases 1 to 4321)
  AUTHORS   Olkkonen VM, Peterson JR, Dupree P, Lutcke A, Zerial M and Simons
            K.
  TITLE     Isolation of a mouse cDNA encoding Rab23, a small novel GTPase
            expressed predominantly in the brain
  JOURNAL   Gene 138 (1-2), 207-211 (1994)
   PUBMED   8125302
REFERENCE   10 (bases 1 to 4321)
  AUTHORS   Chavrier P, Simons K and Zerial M.
  TITLE     The complexity of the Rab and Rho GTP-binding protein subfamilies
            revealed by a PCR cloning approach
  JOURNAL   Gene 112 (2), 261-264 (1992)
   PUBMED   1555775
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK047068.1 and AC163668.5.
            
            [WARNING] On May 6, 2023 this sequence was replaced by NM_008999.5.
            
            On Apr 30, 2009 this sequence version replaced NM_008999.3.
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Both variants encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK047068.1, AK082017.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2502              AK047068.1         2-2503
            2503-4321           AC163668.5         151465-153283       c
FEATURES             Location/Qualifiers
     source          1..4321
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 12.8 cM"
     gene            1..4321
                     /gene="Rab23"
                     /gene_synonym="opb; opb2"
                     /note="RAB23, member RAS oncogene family"
                     /db_xref="GeneID:19335"
                     /db_xref="MGI:MGI:99833"
     exon            1..278
                     /gene="Rab23"
                     /gene_synonym="opb; opb2"
                     /inference="alignment:Splign:2.1.0"
     exon            279..370
                     /gene="Rab23"
                     /gene_synonym="opb; opb2"
                     /inference="alignment:Splign:2.1.0"
     exon            371..590
                     /gene="Rab23"
                     /gene_synonym="opb; opb2"
                     /inference="alignment:Splign:2.1.0"
     exon            591..676
                     /gene="Rab23"
                     /gene_synonym="opb; opb2"
                     /inference="alignment:Splign:2.1.0"
     exon            677..833
                     /gene="Rab23"
                     /gene_synonym="opb; opb2"
                     /inference="alignment:Splign:2.1.0"
     exon            834..916
                     /gene="Rab23"
                     /gene_synonym="opb; opb2"
                     /inference="alignment:Splign:2.1.0"
     exon            917..1009
                     /gene="Rab23"
                     /gene_synonym="opb; opb2"
                     /inference="alignment:Splign:2.1.0"
     exon            1010..4321
                     /gene="Rab23"
                     /gene_synonym="opb; opb2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agcgcggcgg gcgggagtcc ggcgcgccct ccatccccgg cggcgtcggc aaggagtagc
       61 tcggtgaacc cggatactaa taaagttcgc tagagactca taatcgttct gaaagagcgg
      121 agcgggtacg aggcgtccgc ggggaggagc cgggctcggt gctgcgggct gtgcgttccg
      181 ggctcggtgt tgcggactgt gcgttccggg ctcagcgctg cgggttgtgc gttccgggct
      241 gcgggctccg cgctgagggt tccgggctgc gggcagaggg tgaagaattg tttagattga
      301 gaagaggaag tcgacttccc aaaactgagc cagtgtgaaa cacaagctgg atgaacacgg
      361 tcagatcttg gtttgaggga gacagtgtgg tctcctggag ttagagctgc tgcagaaact
      421 cttcctgttt caaaaatgtt ggaggaagat atggaagtgg ccatcaagat ggtggtggtg
      481 gggaatgggg cggttggaaa gtcgagcatg attcagcgct actgcaaagg cattttcaca
      541 aaagactaca agaaaaccat cggcgtagac tttttggagc gacagattca ggttaacgat
      601 gaagatgtaa ggctaatgtt atgggacact gcaggtcaag aggagtttga tgcaatcacg
      661 aaggcctact atcgaggagc ccaggcttgt gtgcttgtgt tttctaccac agacagggaa
      721 tcttttgaag cgatttccag ctggagagaa aaagtagtag cggaggttgg agatatacca
      781 accgcactgg tgcaaaacaa gatcgatctg ctggatgatt catgcatcaa aaatgaggaa
      841 gcggagggac tggccaaaag gctaaagctg aggttctacc ggacgtccgt gaaggaggac
      901 ctcaacgtga gtgaagtttt taaatatttg gctgagaaac acctacaaaa actcaaacaa
      961 caaataaccg aagatccaga acagacacac tcaagtagta acaagattgg tgtctttaat
     1021 gcatcggtca gaagtcactt gggccagaat tcaagttccc ttaatggtgg cgatgtcatc
     1081 aaccttagac ctaacaaaca aaggaccaag agaaccagaa accctttcag cagctgtagt
     1141 gtaccctaaa ctgtttcatg gaggacaaag ctgaattgca ccgtgcagtt aacggcactg
     1201 tgtgcgggct gtcctgcgtg tgtcgtgggc ctctcaccac gctctgaaag ctgacattgt
     1261 aacgctgctc tgctgtgctc ctcagaatgt agatggcgcc ctctgctgga gaattactgc
     1321 tctgtggact cactctagtt ttttacctta gacgaggctt ctcctgtttt tgaacggaca
     1381 ccagtggaaa tgtcaaaaac aggttttgct gaattttaaa ttctgaagac aaaaacaaca
     1441 tgactaacta catcggtaac cattttaccc tgatggacca tgagggatgg caagcattgt
     1501 tctgacactg ggcgtcgagc ttttctggaa tgttcagtct gaatgcttaa agaacatatg
     1561 gaagggaaac ccggactatg tcagactgcc ctggtgtgtg tgttgtcaga ggtactcgtg
     1621 caatatccgt gatgtgcgga ctgtgggggt gtgcatgcag actcctggct caggcagtag
     1681 gcctgtgccc tgggaaaggg gatgcagatt ctagtcagtt cgctcgctcg tacaaccatt
     1741 gcgtatgttt ctggtctcac ctgaggcgtc cggacatact ttacagaaag aacttggacc
     1801 caagtgtgcc aaacactacc gctaattttt acactacttt cctattcaaa tttgtattta
     1861 tgacatcttg tagaggcagt ttcctctccg acaggtagat gaaaggaatg taaatgtctg
     1921 actgctcggg cctgtccctc ctgggattct cccagagcct tctccatagc cactgtaagc
     1981 aatgtgcccg gtacacacag cagcctgcag ccactcagaa ggccctgtgg agcgcgtgca
     2041 caccagcttc tggctgctga cctgagacca aactctgaac ttccaagctg aaggggacca
     2101 tctttgcaga gtgatggtct ttggtcctga tcacagattt tctgaagccc tgcaactcta
     2161 aggcatcctt ttgtttacac tcttagtata gcatttacca ttattgctta agtttttctg
     2221 tggcctttgg tgtacgtgga ccttatcagg aacgatcggt aagaagcgcc tgtaaagacc
     2281 cggtatggga aagaagggga aacgtgtgag ctgggcacca gcctgcctgc caaagagata
     2341 atatcatgag ttctactaaa aactcattat ccttaatcag tcattttact tagaaaatat
     2401 caataacccg tttccacagt cctggttttc atgtacttca aaatatataa aagtgatatt
     2461 tcttggaacg tgtgcttttc ctttcttttt ttttcttttt tttactaaaa tatataaata
     2521 gttcctatat ttctcttgtc ttttttttct ttaaagttta cccttggcgt accacccatc
     2581 ctgcccagca caggttcctg ttgcgagcag aggtcgctga gcgccctccc tccatggtgg
     2641 tccacatgct tgcttttccc attggcatcc caagcaggca ggatcatctg tgtggtcagc
     2701 tgttagcgcc cctggtgcag ggtaaggtgg gggacttgga tccacacagt ggtgcctgct
     2761 gtgagacgtg atttttttcc tcttcaaaca cagactcctc agtttttaca caaagtaaat
     2821 ttgttggcaa ataaattagt tgaccctttt aatggcattg gcagaaaatt cattccttat
     2881 agaacattgt agctttattt gtagccacta aatgcatggt aaaaaggtgt gtggtctgtc
     2941 tctttaaaac agtgtctggt gatggctgcc gtttccttaa tatttgttag cttgtctccc
     3001 cgtccccctc cctctccctc tcctggagct gaggactgaa cccaggtaag tgctctacca
     3061 ctgagctaaa ccccagcccc ttccttaata tttgtaacag aagtttatgt gttttgtttt
     3121 atccattttt tatgggagca tttgttacac atttggtttt tactttgcac cactgtattt
     3181 tctacctaac ttaaaaaggt ctaaaatcag ccacaggtaa tattaattta tcaatatatt
     3241 caattctgaa accctcaaag gtcacgttat tggtttcttc tgtgactgta acgtttatga
     3301 actctgggcc accagacctt tgtgctctaa gtaacttttg cagtgtcacc ggttcttagt
     3361 ggcgggcaca gagctgtgaa gtcattgcta tatctaagag ttcctcaggt ttctgcagtc
     3421 tcggcctaag aaggagatag tttataaaac agcccatata catacagcag ttcaaataaa
     3481 agcaggttga actgtttctt ctccactcaa ggtgaccata cacatggaga tttcaaattc
     3541 cagcactacc acagggagca tgtgtgaccc ctccactgcc gagtgaagtg gggcggatgc
     3601 tcctgacttg tcttggcaga gctgagaact cgggtatggc cctcctgtct ttctgagggt
     3661 ttaggatggg gagttggcct tagaacccga tgctgccccc tgaggtgctc ttgtaatctg
     3721 agatgctgct tgcctctgga ggatcctggt ggctgtggtg agtgccctgg gagcacctca
     3781 gagagatgtg tgggctgcag ggagcccaca agggcagagc tttggcttcc atagccttag
     3841 gtgagcagat ggctttagtc acactaacag ttacgtcgaa cgtgctgttg ctcctaagag
     3901 tttcacgtat aaagctgaaa aatacatcat acaaatgaag ctgtctgcac acaggtaaac
     3961 aaaaccccag cagggtctga aatgcccagg tagccagcgc ccagatggca gactgattcg
     4021 gccaaaagag tcttggttac tgccactttt ctgttgtcac ttgaagtatc tatagtagga
     4081 tgttgataaa tggtatttta aaaataaaat ctttgggtca aaggaaaaac ttaacccctt
     4141 ctatattttt gttactaata aataatgctt ttgtaaatcc gaatagaaaa ctacttgtat
     4201 gttttcctat tgagtggtac ttaacgcctt tggggttaat tttaaaatgt actacttgat
     4261 taaaatttcc acaaagttga attccaataa ctcaaaaaaa taaaacattt caaagctaga
     4321 a
//
