LOCUS       NM_024436               1909 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus RAB22A, member RAS oncogene family (Rab22a), mRNA.
ACCESSION   NM_024436
VERSION     NM_024436.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1909)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1909)
  AUTHORS   Gao,Y., Zheng,X., Chang,B., Lin,Y., Huang,X., Wang,W., Ding,S.,
            Zhan,W., Wang,S., Xiao,B., Huo,L., Yu,Y., Chen,Y., Gong,R., Wu,Y.,
            Zhang,R., Zhong,L., Wang,X., Chen,Q., Gao,S., Jiang,Z., Wei,D. and
            Kang,T.
  TITLE     Intercellular transfer of activated STING triggered by
            RAB22A-mediated non-canonical autophagy promotes antitumor immunity
  JOURNAL   Cell Res 32 (12), 1086-1104 (2022)
   PUBMED   36280710
  REMARK    GeneRIF: Intercellular transfer of activated STING triggered by
            RAB22A-mediated non-canonical autophagy promotes antitumor
            immunity.
REFERENCE   3  (bases 1 to 1909)
  AUTHORS   Shakya,S., Sharma,P., Bhatt,A.M., Jani,R.A., Delevoye,C. and
            Setty,S.R.
  TITLE     Rab22A recruits BLOC-1 and BLOC-2 to promote the biogenesis of
            recycling endosomes
  JOURNAL   EMBO Rep 19 (12) (2018)
   PUBMED   30404817
  REMARK    GeneRIF: Rab22A promotes the assembly of a BLOC-1-BLOC-2-KIF13A
            complex on early/sorting endosomes.
REFERENCE   4  (bases 1 to 1909)
  AUTHORS   Cebrian,I., Croce,C., Guerrero,N.A., Blanchard,N. and Mayorga,L.S.
  TITLE     Rab22a controls MHC-I intracellular trafficking and antigen
            cross-presentation by dendritic cells
  JOURNAL   EMBO Rep 17 (12), 1753-1765 (2016)
   PUBMED   27861124
  REMARK    GeneRIF: findings provide compelling evidence that Rab22a plays a
            central role in the MHC-I endocytic trafficking, which is crucial
            for efficient cross-presentation by dendritic cells
REFERENCE   5  (bases 1 to 1909)
  AUTHORS   Woller,B., Luiskandl,S., Popovic,M., Prieler,B.E., Ikonge,G.,
            Mutzl,M., Rehmann,H. and Herbst,R.
  TITLE     Rin-like, a novel regulator of endocytosis, acts as guanine
            nucleotide exchange factor for Rab5a and Rab22
  JOURNAL   Biochim Biophys Acta 1813 (6), 1198-1210 (2011)
   PUBMED   21419809
  REMARK    GeneRIF: Data show that Rinl is closely associated with the
            cytoskeleton and thus contributes to the spatial control of Rab5a
            and Rab22 signaling at actin-positive compartments.
REFERENCE   6  (bases 1 to 1909)
  AUTHORS   Eathiraj,S., Pan,X., Ritacco,C. and Lambright,D.G.
  TITLE     Structural basis of family-wide Rab GTPase recognition by
            rabenosyn-5
  JOURNAL   Nature 436 (7049), 415-419 (2005)
   PUBMED   16034420
REFERENCE   7  (bases 1 to 1909)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   8  (bases 1 to 1909)
  AUTHORS   Barbosa,M.D., Johnson,S.A., Achey,K., Gutierrez,M.J.,
            Wakeland,E.K., Zerial,M. and Kingsmore,S.F.
  TITLE     The Rab protein family: genetic mapping of six Rab genes in the
            mouse
  JOURNAL   Genomics 30 (3), 439-444 (1995)
   PUBMED   8825628
REFERENCE   9  (bases 1 to 1909)
  AUTHORS   Olkkonen,V.M., Dupree,P., Killisch,I., Lutcke,A., Zerial,M. and
            Simons,K.
  TITLE     Molecular cloning and subcellular localization of three GTP-binding
            proteins of the rab subfamily
  JOURNAL   J Cell Sci 106 (Pt 4), 1249-1261 (1993)
   PUBMED   8126105
REFERENCE   10 (bases 1 to 1909)
  AUTHORS   Chavrier,P., Simons,K. and Zerial,M.
  TITLE     The complexity of the Rab and Rho GTP-binding protein subfamilies
            revealed by a PCR cloning approach
  JOURNAL   Gene 112 (2), 261-264 (1992)
   PUBMED   1555775
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AK146594.1.
            
            On Jun 10, 2007 this sequence version replaced NM_024436.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK146594.1, AK150617.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1909
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 97.26 cM"
     gene            1..1909
                     /gene="Rab22a"
                     /gene_synonym="3732413A17Rik; E130120E14Rik; Rab22"
                     /note="RAB22A, member RAS oncogene family"
                     /db_xref="GeneID:19334"
                     /db_xref="MGI:MGI:105072"
     exon            1..297
                     /gene="Rab22a"
                     /gene_synonym="3732413A17Rik; E130120E14Rik; Rab22"
                     /inference="alignment:Splign:2.1.0"
     CDS             262..846
                     /gene="Rab22a"
                     /gene_synonym="3732413A17Rik; E130120E14Rik; Rab22"
                     /note="RAB22, member RAS oncogene family; rab-14; rab-22"
                     /codon_start=1
                     /product="ras-related protein Rab-22A"
                     /protein_id="NP_077756.2"
                     /db_xref="CCDS:CCDS38352.1"
                     /db_xref="GeneID:19334"
                     /db_xref="MGI:MGI:105072"
                     /translation="MALRELKVCLLGDTGVGKSSIVWRFVEDSFDPNINPTIGASFMT
                     KTVQYQNELHKFLIWDTAGQERFRALAPMYYRGSAAAIIVYDITKEETFSTLKNWVRE
                     LRQHGPPSIVVAIAGNKCDLTDVREVMERDAKDYADSIHAIFVETSAKNAININELFI
                     EISRRIPSTDANPASGGKGFKLRRQPSEPKRSCC"
     exon            298..377
                     /gene="Rab22a"
                     /gene_synonym="3732413A17Rik; E130120E14Rik; Rab22"
                     /inference="alignment:Splign:2.1.0"
     exon            378..459
                     /gene="Rab22a"
                     /gene_synonym="3732413A17Rik; E130120E14Rik; Rab22"
                     /inference="alignment:Splign:2.1.0"
     exon            460..531
                     /gene="Rab22a"
                     /gene_synonym="3732413A17Rik; E130120E14Rik; Rab22"
                     /inference="alignment:Splign:2.1.0"
     exon            532..638
                     /gene="Rab22a"
                     /gene_synonym="3732413A17Rik; E130120E14Rik; Rab22"
                     /inference="alignment:Splign:2.1.0"
     exon            639..748
                     /gene="Rab22a"
                     /gene_synonym="3732413A17Rik; E130120E14Rik; Rab22"
                     /inference="alignment:Splign:2.1.0"
     exon            749..1909
                     /gene="Rab22a"
                     /gene_synonym="3732413A17Rik; E130120E14Rik; Rab22"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      1909
                     /gene="Rab22a"
                     /gene_synonym="3732413A17Rik; E130120E14Rik; Rab22"
                     /note="putative"
ORIGIN      
        1 aggtgaccca gctggcgtcc caagatggcg gcggcggtag cgcccgggag gccaaggcgg
       61 tgtcccggct gttgaggtga ctccgccgga caagtgacgg ggtcggccgg accggagggc
      121 ggcggcggac gcacggccgc ccggagtgct cggccgggac ttggcggtga ggcggcggcg
      181 ccgggggatg ctggtgctgg gccgggcctc tccctcctca acttagggcg gcggcgggcc
      241 cgcacccctg gttcccgggc catggcgctg agggaactta aagtgtgcct gctcggggat
      301 acgggtgtgg gtaaatcgag catcgtgtgg cggtttgtgg aagacagttt tgatccgaat
      361 atcaatccaa ccataggggc atcttttatg accaagactg tccagtacca aaatgagcta
      421 cataaattcc taatctggga tacagctgga caagaacgat ttcgtgcatt ggcaccaatg
      481 tactatcgag ggtcagcagc agccatcatc gtttacgaca tcacaaaaga agagacgttt
      541 tcaactctga agaactgggt gagagagctc cgccagcacg gcccccccag cattgtcgtt
      601 gccatcgcag ggaacaagtg cgatcttact gatgtcagag aagtcatgga gagagatgct
      661 aaggactacg cagattccat tcatgccatc tttgtagaga ccagcgcaaa aaatgcaata
      721 aacataaatg aactctttat agaaattagt cgaagaattc catccactga tgccaaccca
      781 gcgtctggcg gcaagggctt caaactccga agacagccat cggagccaaa gcgaagctgc
      841 tgctgacgac ccagggcctg accttgagga agaagcaggt ggtcctggag gctgcaggag
      901 agccgtgccc tgccactgga cgccacctca tgctctttat gcaaaaagga ctcagagaac
      961 cggctgttgg gttctcttgg aagactgcag caggtgtctg tgtctgcaca cttctgtcag
     1021 tggactctgg cgtgcaaagg gaccatgcat gcccttggct gtttacccag ctgaaaggag
     1081 cgtctgacgt atggctatgg atggtaggat tgaattgctg gtgcctctgt ggtcaggatt
     1141 tcatgtgtta tttgtaaggg aaatgagcac tttcatggat ataagggaaa agctgtgggg
     1201 atggtcatct ccttggtcct cgtctctagt gtcagagtcg tatcagtaag atgtgggaaa
     1261 tgatcacaag tagagggatg ggtgttccta ggacagcttc cgccatctct aaagcacttt
     1321 gccacacagt ggctgccggt tcaccttggg tttgcttctg accttgtatg tgtcagaacc
     1381 cacgcacatt agttatggtc acctttctac agaagctctc atgctccagg cgatggggta
     1441 cagaagctac ctggagccag ttgagttgca tgtgtctaaa ctgacgggca gtggcttagg
     1501 agaggagagg aaaggagagg acaaagcaaa tgaatctttt ggtgagattg ttttttgttt
     1561 atggtttgtt ttggtttttt tgttttttgc ccagtttgtt ttggtgggaa aaacaactgt
     1621 gagctgccta gcatatgtaa atttgtagtc tatatttatg agaccattgc ttaaaaatta
     1681 taaattatgt aaatacatta ataacttctg aattcctttc agtattcact tagtcctgtg
     1741 cccagtctcc tgtgtgccca cccagttttc agcctgtcca caggaacctc tgaagcccat
     1801 ttatcttgtg caggagcacg gagcgcttag ctcacagctt ccttccttcc ttctccctct
     1861 cccttctgca tcccatctgg aaatggtaat aaagacatat gcctccgtg
//
