LOCUS       NM_024454               1856 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus RAB21, member RAS oncogene family (Rab21), mRNA.
ACCESSION   NM_024454
VERSION     NM_024454.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1856)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1856)
  AUTHORS   Liu,P., Wu,A., Li,H., Zhang,J., Ni,J., Quan,Z. and Qing,H.
  TITLE     Rab21 Protein Is Degraded by Both the Ubiquitin-Proteasome Pathway
            and the Autophagy-Lysosome Pathway
  JOURNAL   Int J Mol Sci 23 (3), 1131 (2022)
   PUBMED   35163051
  REMARK    GeneRIF: Rab21 Protein Is Degraded by Both the Ubiquitin-Proteasome
            Pathway and the Autophagy-Lysosome Pathway.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1856)
  AUTHORS   Wang,N., Meng,W., Jia,R. and Xiang,S.
  TITLE     Rab GTPase 21 mediates caerulin-induced TRAF3-MKK3-p38 activation
            and acute pancreatitis response
  JOURNAL   Biochem Biophys Res Commun 518 (1), 50-58 (2019)
   PUBMED   31402118
  REMARK    GeneRIF: Rab21 mediates caerulin-induced MKK3-p38 activation and
            pro-inflammatory responses.
REFERENCE   4  (bases 1 to 1856)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1856)
  AUTHORS   Li,P., Wu,Y.H., Zhu,Y.T., Li,M.X. and Pei,H.H.
  TITLE     Requirement of Rab21 in LPS-induced TLR4 signaling and
            pro-inflammatory responses in macrophages and monocytes
  JOURNAL   Biochem Biophys Res Commun 508 (1), 169-176 (2019)
   PUBMED   30471852
  REMARK    GeneRIF: Rab21 regulates LPS-induced pro-inflammatory responses by
            promoting TLR4 endosomal traffic and downstream signaling
            activation
REFERENCE   6  (bases 1 to 1856)
  AUTHORS   Fukuda,M.
  TITLE     Distinct Rab binding specificity of Rim1, Rim2, rabphilin, and
            Noc2. Identification of a critical determinant of Rab3A/Rab27A
            recognition by Rim2
  JOURNAL   J Biol Chem 278 (17), 15373-15380 (2003)
   PUBMED   12578829
REFERENCE   7  (bases 1 to 1856)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   8  (bases 1 to 1856)
  AUTHORS   Fukuda,M., Kuroda,T.S. and Mikoshiba,K.
  TITLE     Slac2-a/melanophilin, the missing link between Rab27 and myosin Va:
            implications of a tripartite protein complex for melanosome
            transport
  JOURNAL   J Biol Chem 277 (14), 12432-12436 (2002)
   PUBMED   11856727
REFERENCE   9  (bases 1 to 1856)
  AUTHORS   Kuroda,T.S., Fukuda,M., Ariga,H. and Mikoshiba,K.
  TITLE     The Slp homology domain of synaptotagmin-like proteins 1-4 and
            Slac2 functions as a novel Rab27A binding domain
  JOURNAL   J Biol Chem 277 (11), 9212-9218 (2002)
   PUBMED   11773082
REFERENCE   10 (bases 1 to 1856)
  AUTHORS   Chavrier,P., Simons,K. and Zerial,M.
  TITLE     The complexity of the Rab and Rho GTP-binding protein subfamilies
            revealed by a PCR cloning approach
  JOURNAL   Gene 112 (2), 261-264 (1992)
   PUBMED   1555775
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC055042.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC055042.1, BU520717.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849377, SAMN00849379
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1856
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 63.51 cM"
     gene            1..1856
                     /gene="Rab21"
                     /gene_synonym="9630024B22"
                     /note="RAB21, member RAS oncogene family"
                     /db_xref="GeneID:216344"
                     /db_xref="MGI:MGI:894308"
     exon            1..398
                     /gene="Rab21"
                     /gene_synonym="9630024B22"
                     /inference="alignment:Splign:2.1.0"
     CDS             246..914
                     /gene="Rab21"
                     /gene_synonym="9630024B22"
                     /EC_number="3.6.5.2"
                     /note="rab-12"
                     /codon_start=1
                     /product="ras-related protein Rab-21"
                     /protein_id="NP_077774.1"
                     /db_xref="CCDS:CCDS24177.1"
                     /db_xref="GeneID:216344"
                     /db_xref="MGI:MGI:894308"
                     /translation="MAAAGGGAAAAAGRAYSFKVVLLGEGCVGKTSLVLRYCENKFND
                     KHITTLQASFLTKKLNIGGKRVNLAIWDTAGQERFHALGPIYYRDSNGAILVYDVTDE
                     DSFQKVKNWVKELRKMLGNEICLCIVGNKIDLEKERHVSIQEAESYAESVGAKHYHTS
                     AKQNKGIEELFLDLCKRMIETAQVDERAKGNGSSQAGAARRGVQIIDDEPQAQSSGGC
                     CSSG"
     exon            399..458
                     /gene="Rab21"
                     /gene_synonym="9630024B22"
                     /inference="alignment:Splign:2.1.0"
     exon            459..566
                     /gene="Rab21"
                     /gene_synonym="9630024B22"
                     /inference="alignment:Splign:2.1.0"
     exon            567..630
                     /gene="Rab21"
                     /gene_synonym="9630024B22"
                     /inference="alignment:Splign:2.1.0"
     exon            631..685
                     /gene="Rab21"
                     /gene_synonym="9630024B22"
                     /inference="alignment:Splign:2.1.0"
     exon            686..774
                     /gene="Rab21"
                     /gene_synonym="9630024B22"
                     /inference="alignment:Splign:2.1.0"
     exon            775..1824
                     /gene="Rab21"
                     /gene_synonym="9630024B22"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1474..1479
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rab21"
                     /gene_synonym="9630024B22"
                     /note="hexamer: ATTAAA"
     polyA_site      1517
                     /gene="Rab21"
                     /gene_synonym="9630024B22"
     regulatory      1802..1807
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rab21"
                     /gene_synonym="9630024B22"
                     /note="hexamer: ATTAAA"
     polyA_site      1824
                     /gene="Rab21"
                     /gene_synonym="9630024B22"
                     /note="major polyA site"
ORIGIN      
        1 ggagacgcca ttagagggag gagaggcagc tctcccctag cctcgggtcc ctgacgtggt
       61 ggccggggcc cttcattctg ggactttctc tcggccctcg caggcctcgc ccgcggaagg
      121 acgcggcgag caccgggctc ggcggggcgt gaaagagccg ggcccgggag gagcgggcgc
      181 cccggcggcg gcggtgcggg gttcggcgcg gcgctgggct cgggcggcgg ggtagcggcg
      241 gcgggatggc tgcggccggc ggcggggcgg cggcggcggc gggccgagcc tactccttca
      301 aggtggtgct gctcggggaa ggctgcgtgg ggaagacgtc gctggtgctg cgctactgcg
      361 agaacaagtt caacgacaag cacatcacca ccctgcaggc atctttctta acaaagaagt
      421 taaatattgg tggaaaaaga gtaaaccttg ccatatggga cacagcaggt caggagagat
      481 tccacgcact gggcccaatt tactaccgag attcgaacgg agctatttta gtttatgatg
      541 taacggatga agattccttt cagaaggtaa aaaactgggt caaagaatta cgaaaaatgt
      601 tgggaaatga gatctgtttg tgtatagttg gtaataaaat agacttggaa aaggagaggc
      661 acgtctctat tcaagaagca gaatcgtatg cagagtctgt gggagccaag cattaccata
      721 cttccgctaa acagaacaaa ggcattgagg agctctttct cgacctttgt aaaagaatga
      781 tagagacagc ccaggtggat gagagagcaa aaggcaatgg ctcgagtcaa gccggggctg
      841 caaggcgagg tgtgcagatc atcgacgacg agcctcaagc tcagagcagc ggagggtgct
      901 gttcctccgg ctaactgctc agcctgtgac cctcaaaaca taagagaact gtggatcatt
      961 gccctcaaca tgaagactgc catattccaa gtcacatcat tttaccaatg gagttataga
     1021 attaacagta ttttcaatta cgtttataac actgcagaga ccttaagtgc taaacttagt
     1081 ggagtttgtg accagagaat tggcattttc tacaaatgtt aacaaagcaa ttaccaatgg
     1141 cctttttaca tattttttct ttaatgagga ataatatgca tgtagaaaag acctacttaa
     1201 aggcttcatt tatattcttt taaatcagat ctttatttaa taacttatat atgatgttgg
     1261 aatggtatac atttttgcag tcctttgtat tttgtggtag tttgaattgt atcacttcta
     1321 aacagcatac tgtttttgtt tttgtttttt gattagcaga tacgtgaagt tctatttttg
     1381 cagggtttgc acaggcccct aactgtctac tactttgata taatctataa acatcctgta
     1441 tgctgagctg gtaaaataca ttgtaaatta catattaaat attttatctg cttttacaag
     1501 cgcaaggtgc aaaaatatat acaattgtca tcttgatgac tgtgaggtga attaaccgtt
     1561 ggtgataaca cctaagcttt tgactctgtt atagcgctca ccaccccttc ccttgtctta
     1621 acgtggaagt gcgcacttac gtgttcacag acttacctga ctcgcttact taccggctgc
     1681 tgtcaccttc cccttcccct ttttctgttt cttttttcct ttctttttct tttttctttt
     1741 cttttttttt ggcctctgta tgtcccagtg atccaaaagc agcgtttgcc tttttattgt
     1801 tattaaacaa gtttccttct gccaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaa
//
