LOCUS       NM_011227               1450 bp    mRNA    linear   ROD 09-JUN-2024
DEFINITION  Mus musculus RAB20, member RAS oncogene family (Rab20), mRNA.
ACCESSION   NM_011227 XM_134046
VERSION     NM_011227.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1450)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1450)
  AUTHORS   Schnettger,L., Rodgers,A., Repnik,U., Lai,R.P., Pei,G., Verdoes,M.,
            Wilkinson,R.J., Young,D.B. and Gutierrez,M.G.
  TITLE     A Rab20-Dependent Membrane Trafficking Pathway Controls M.
            tuberculosis Replication by Regulating Phagosome Spaciousness and
            Integrity
  JOURNAL   Cell Host Microbe 21 (5), 619-628 (2017)
   PUBMED   28494243
REFERENCE   3  (bases 1 to 1450)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643. PMID: 29144450]
REFERENCE   4  (bases 1 to 1450)
  AUTHORS   Segawa,T., Hazeki,K., Nigorikawa,K., Morioka,S., Guo,Y.,
            Takasuga,S., Asanuma,K. and Hazeki,O.
  TITLE     Inpp5e increases the Rab5 association and phosphatidylinositol
            3-phosphate accumulation at the phagosome through an interaction
            with Rab20
  JOURNAL   Biochem J 464 (3), 365-375 (2014)
   PUBMED   25269936
  REMARK    GeneRIF: Inpp5e, through functional interactions with Rab20 on the
            phagosome, activates Rab5, which, in turn, increases PtdIns3P and
            delays phagosome acidification.
REFERENCE   5  (bases 1 to 1450)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   6  (bases 1 to 1450)
  AUTHORS   Kuroda,T.S., Fukuda,M., Ariga,H. and Mikoshiba,K.
  TITLE     The Slp homology domain of synaptotagmin-like proteins 1-4 and
            Slac2 functions as a novel Rab27A binding domain
  JOURNAL   J Biol Chem 277 (11), 9212-9218 (2002)
   PUBMED   11773082
REFERENCE   7  (bases 1 to 1450)
  AUTHORS   McMurtrie,E.B., Barbosa,M.D.F.S., Zerial,M. and Kingsmore,S.F.
  TITLE     Genetic mapping of Rab20 on mouse chromosome 8
  JOURNAL   Mamm Genome 8 (4), 291-292 (1997)
   PUBMED   9096117
REFERENCE   8  (bases 1 to 1450)
  AUTHORS   Murphy,C. and Zerial,M.
  TITLE     Expression of Rab proteins during mouse embryonic development
  JOURNAL   Methods Enzymol 257, 324-332 (1995)
   PUBMED   8583936
REFERENCE   9  (bases 1 to 1450)
  AUTHORS   Lutcke,A., Parton,R.G., Murphy,C., Olkkonen,V.M., Dupree,P.,
            Valencia,A., Simons,K. and Zerial,M.
  TITLE     Cloning and subcellular localization of novel rab proteins reveals
            polarized and cell type-specific expression
  JOURNAL   J Cell Sci 107 (Pt 12), 3437-3448 (1994)
   PUBMED   7706395
REFERENCE   10 (bases 1 to 1450)
  AUTHORS   Chavrier,P., Simons,K. and Zerial,M.
  TITLE     The complexity of the Rab and Rho GTP-binding protein subfamilies
            revealed by a PCR cloning approach
  JOURNAL   Gene 112 (2), 261-264 (1992)
   PUBMED   1555775
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC124475.3.
            
            On Jun 18, 2019 this sequence version replaced NM_011227.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC089570.1, AK152454.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-313               AC124475.3         90754-91066         c
            314-1450            AC124475.3         65816-66952         c
FEATURES             Location/Qualifiers
     source          1..1450
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 5.73 cM"
     gene            1..1450
                     /gene="Rab20"
                     /gene_synonym="D8Ertd350e"
                     /note="RAB20, member RAS oncogene family"
                     /db_xref="GeneID:19332"
                     /db_xref="MGI:MGI:102789"
     exon            1..313
                     /gene="Rab20"
                     /gene_synonym="D8Ertd350e"
                     /inference="alignment:Splign:2.1.0"
     exon            314..1450
                     /gene="Rab20"
                     /gene_synonym="D8Ertd350e"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1301..1306
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rab20"
                     /gene_synonym="D8Ertd350e"
                     /note="hexamer: ATTAAA"
     polyA_site      1322
                     /gene="Rab20"
                     /gene_synonym="D8Ertd350e"
                     /note="major polyA site"
     regulatory      1431..1436
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rab20"
                     /gene_synonym="D8Ertd350e"
                     /note="hexamer: ATTAAA"
     polyA_site      1450
                     /gene="Rab20"
                     /gene_synonym="D8Ertd350e"
ORIGIN      
        1 gcgcttcctc tttggcactt catcgagttc ggatctcagg ccagggccac tagagttcgg
       61 ggtccctgga ggccggggtc cgcgtcccct ggcatcctgg gcgggtgacc gagaagcgca
      121 ggggtcatct cctccgcggc tatgcggaag ccggatggga agatcgtact gctgggggac
      181 atgaacgtgg gtaaaacgtc gctgctgcag cgctacatgg agcgtcgctt cccggacacg
      241 gtcagcaccg tgggcggcgc cttctacctg aagcagtggc gttccttcaa catctccata
      301 tgggacaccg cagggcggga gcagtttcat ggtctgggct ccctgtactg ccgcggagcg
      361 gccgctatca tccttacata cgatgtgaac cacccacaga gcctgtttga gctggaggac
      421 agattcctgg gcctgacaga aacagccaac aatgactgcc tgtttgccat tgtggggaac
      481 aaagtggacc tgacctcgga gcgggacacc gagggcgggg agaaggaagg accggcctct
      541 ggcaaggtgg gcagctgtgt ctccaccaag gtacccaagc aggtgcagcc agaggatgca
      601 gtggcccttt acaagaagat cctgaagtac aagatgctgg atgagaggga gatgccagct
      661 gctgagcaga tgtgcttcga gaccagtgcc aagactggat acaatgtgga cctcctcttt
      721 gaaaccttgt ttgacctggt ggtacctatg atcatgcggc agagggctga ggagtcagat
      781 cagactgtgg atatagccag ctgcaaaaca cccaaacaga ctagatccgg gtgttgtgcc
      841 taatggcagg aggtctgtct tggcatgtgt gtgtgtgagc cactgggcta agaagtctca
      901 cacagcactg ggtaccgagg acaataggca gagtgaccac cagctgctaa tacaggccag
      961 agtgcccagc aacctctggg catccggagg tggcactcaa accccctgtg gagcctgcct
     1021 ggtgccacct catctactgc cctatgcatc tatctctcat ggagatacca ccatggagcc
     1081 tgcagtctga agacctgcct tggactggtc ttgactctgc agtcactacg tcctgcactg
     1141 tgtctgtcct cagaggcctg tgtccactgt gattcatata tggtcttcct gtttgatacc
     1201 tgtaccttga tatgttatga taatgatact ccacttttaa tttatataaa atcaggaatg
     1261 gctgttttta tactgggtga ggccagatgg gctatacatt attaaaaagg atttggggaa
     1321 aagccttgtt cttgggaatg tttgacttta tttgaaccac aggaaattcc ttaattctgg
     1381 gaggtgtaat gggggctgtt ggtggggatg atggttacca tgaagctgtc attaaatgtg
     1441 tgacagtgaa
//
