LOCUS       NM_029576               1835 bp    mRNA    linear   ROD 01-MAR-2025
DEFINITION  Mus musculus RAB1B, member RAS oncogene family (Rab1b), mRNA.
ACCESSION   NM_029576
VERSION     NM_029576.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1835)
  AUTHORS   Solano-Collado,V., Colamarino,R.A., Calderwood,D.A., Baldassarre,M.
            and Spano,S.
  TITLE     A Small-Scale shRNA Screen in Primary Mouse Macrophages Identifies
            a Role for the Rab GTPase Rab1b in Controlling Salmonella Typhi
            Growth
  JOURNAL   Front Cell Infect Microbiol 11, 660689 (2021)
   PUBMED   33898333
  REMARK    GeneRIF: A Small-Scale shRNA Screen in Primary Mouse Macrophages
            Identifies a Role for the Rab GTPase Rab1b in Controlling
            Salmonella Typhi Growth.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1835)
  AUTHORS   Maruyama,T., Jiang,M., Abbott,A., Yu,H.I., Huang,Q.,
            Chrzanowska-Wodnicka,M., Chen,E.I. and Hsu,W.
  TITLE     Rap1b Is an Effector of Axin2 Regulating Crosstalk of Signaling
            Pathways During Skeletal Development
  JOURNAL   J Bone Miner Res 32 (9), 1816-1828 (2017)
   PUBMED   28520221
  REMARK    GeneRIF: identify Rap1b acting downstream of Axin2 as a signaling
            interrogator for FGF and BMP. Genetic analysis reveals that Rap1b
            is essential for development of craniofacial and body skeletons.
            Axin2 regulates Rap1b through modulation of canonical BMP
            signaling.
REFERENCE   3  (bases 1 to 1835)
  AUTHORS   Valkova,C., Albrizio,M., Roder,I.V., Schwake,M., Betto,R.,
            Rudolf,R. and Kaether,C.
  TITLE     Sorting receptor Rer1 controls surface expression of muscle
            acetylcholine receptors by ER retention of unassembled
            alpha-subunits
  JOURNAL   Proc Natl Acad Sci U S A 108 (2), 621-625 (2011)
   PUBMED   21187406
REFERENCE   4  (bases 1 to 1835)
  AUTHORS   Yokoyama,S., Ito,Y., Ueno-Kudoh,H., Shimizu,H., Uchibe,K.,
            Albini,S., Mitsuoka,K., Miyaki,S., Kiso,M., Nagai,A., Hikata,T.,
            Osada,T., Fukuda,N., Yamashita,S., Harada,D., Mezzano,V., Kasai,M.,
            Puri,P.L., Hayashizaki,Y., Okado,H., Hashimoto,M. and Asahara,H.
  TITLE     A systems approach reveals that the myogenesis genome network is
            regulated by the transcriptional repressor RP58
  JOURNAL   Dev Cell 17 (6), 836-848 (2009)
   PUBMED   20059953
REFERENCE   5  (bases 1 to 1835)
  AUTHORS   Li,Y.H., Werner,H. and Puschel,A.W.
  TITLE     Rheb and mTOR regulate neuronal polarity through Rap1B
  JOURNAL   J Biol Chem 283 (48), 33784-33792 (2008)
   PUBMED   18842593
  REMARK    GeneRIF: Inhibition of PI3K or mTOR reduced the level of Rap1B,
            which acts downstream of Rheb and mTOR. The ubiquitin E3 ligase
            Smurf2 mediates the restriction of Rap1B by initiating its
            degradation.
REFERENCE   6  (bases 1 to 1835)
  AUTHORS   Itoh,T., Satoh,M., Kanno,E. and Fukuda,M.
  TITLE     Screening for target Rabs of TBC (Tre-2/Bub2/Cdc16)
            domain-containing proteins based on their Rab-binding activity
  JOURNAL   Genes Cells 11 (9), 1023-1037 (2006)
   PUBMED   16923123
REFERENCE   7  (bases 1 to 1835)
  AUTHORS   Fukuda,M.
  TITLE     Distinct Rab binding specificity of Rim1, Rim2, rabphilin, and
            Noc2. Identification of a critical determinant of Rab3A/Rab27A
            recognition by Rim2
  JOURNAL   J Biol Chem 278 (17), 15373-15380 (2003)
   PUBMED   12578829
REFERENCE   8  (bases 1 to 1835)
  AUTHORS   Fukuda,M., Kuroda,T.S. and Mikoshiba,K.
  TITLE     Slac2-a/melanophilin, the missing link between Rab27 and myosin Va:
            implications of a tripartite protein complex for melanosome
            transport
  JOURNAL   J Biol Chem 277 (14), 12432-12436 (2002)
   PUBMED   11856727
REFERENCE   9  (bases 1 to 1835)
  AUTHORS   Kuroda,T.S., Fukuda,M., Ariga,H. and Mikoshiba,K.
  TITLE     The Slp homology domain of synaptotagmin-like proteins 1-4 and
            Slac2 functions as a novel Rab27A binding domain
  JOURNAL   J Biol Chem 277 (11), 9212-9218 (2002)
   PUBMED   11773082
REFERENCE   10 (bases 1 to 1835)
  AUTHORS   Antony,C., Huchet,M., Changeux,J.P. and Cartaud,J.
  TITLE     Developmental regulation of membrane traffic organization during
            synaptogenesis in mouse diaphragm muscle
  JOURNAL   J Cell Biol 130 (4), 959-968 (1995)
   PUBMED   7642711
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC124502.4.
            
            On Apr 30, 2007 this sequence version replaced NM_029576.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK003609.1, AK156726.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134, SAMN01164141
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-72                AC124502.4         16592-16663
            73-145              AC124502.4         18338-18410
            146-241             AC124502.4         18660-18755
            242-337             AC124502.4         18852-18947
            338-469             AC124502.4         22790-22921
            470-1835            AC124502.4         23016-24381
FEATURES             Location/Qualifiers
     source          1..1835
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 4.25 cM"
     gene            1..1835
                     /gene="Rab1b"
                     /gene_synonym="1110011F09Rik"
                     /note="RAB1B, member RAS oncogene family"
                     /db_xref="GeneID:76308"
                     /db_xref="MGI:MGI:1923558"
     exon            1..72
                     /gene="Rab1b"
                     /gene_synonym="1110011F09Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             59..664
                     /gene="Rab1b"
                     /gene_synonym="1110011F09Rik"
                     /EC_number="3.6.5.2"
                     /codon_start=1
                     /product="ras-related protein Rab-1B"
                     /protein_id="NP_083852.1"
                     /db_xref="CCDS:CCDS29452.1"
                     /db_xref="GeneID:76308"
                     /db_xref="MGI:MGI:1923558"
                     /translation="MNPEYDYLFKLLLIGDSGVGKSCLLLRFADDTYTESYISTIGVD
                     FKIRTIELDGKTIKLQIWDTAGQERFRTITSSYYRGAHGIIVVYDVTDQESYANVKQW
                     LQEIDRYASENVNKLLVGNKSDLTTKKVVDNTTAKEFADSLGVPFLETSAKNATNVEQ
                     AFMTMAAEIKKRMGPGAASGGERPNLKIDSTPVKPASGGCC"
     exon            73..145
                     /gene="Rab1b"
                     /gene_synonym="1110011F09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            146..241
                     /gene="Rab1b"
                     /gene_synonym="1110011F09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            242..337
                     /gene="Rab1b"
                     /gene_synonym="1110011F09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            338..469
                     /gene="Rab1b"
                     /gene_synonym="1110011F09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            470..1835
                     /gene="Rab1b"
                     /gene_synonym="1110011F09Rik"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggaacgggag gcggagcaga gccgactggg agcgaccgag cgggccaccg ctgccgccat
       61 gaaccccgaa tatgactacc tgtttaagct gcttttgatt ggtgactccg gcgtgggcaa
      121 gtcgtgcctg ctcctgcggt ttgctgatga cacttacaca gagagctaca tcagcaccat
      181 cggtgtggat ttcaagattc gaaccattga gctggacggc aaaaccatca aactgcagat
      241 ttgggacaca gctggtcagg agcggttcag gaccatcact tccagctact atcgcggggc
      301 tcatggcatc attgtggtgt atgacgtcac tgaccaggag tcctacgcca acgtgaaaca
      361 gtggctgcag gagatagatc gctacgccag tgagaatgtc aataaactcc tggtaggcaa
      421 caagagtgac ctcaccacca agaaggtcgt ggacaacacc acggccaagg aatttgcaga
      481 ctctctgggt gtccccttcc tcgagacaag tgccaagaat gccaccaatg ttgagcaggc
      541 attcatgaca atggctgcag agatcaaaaa gcggatgggg ccaggagcag cgtctggggg
      601 tgaacggccc aacctgaaga tcgacagcac ccctgtgaag cctgctagcg gtggctgctg
      661 ctaggagggg cacttggggg agggcacctt gtccagatga tgcccctgga gcgggcagga
      721 agtgcctccc tctcctaggg catttgagtc tgtagctttg gggtgtcctg ggctccccat
      781 cttcctctgg cccatctgcc ttctgctctg agtcccagtc ctgtcagggc ccccgtggag
      841 gacatgcaga gcctgtggct ggggtggtca cagggacagc tccgctgctg cctctgggta
      901 ccttgaaaag atgcccacca cgcacctttc tttggaatga gggctccgct gtctgtcact
      961 cacccccatg tatgctgcac tgggtttctc tttcctttct tcccaatagc aagggcctcc
     1021 ctgcctctgc tgcccctggg tgcaggcagt agccagggga tccagggcct cagatccagg
     1081 gtcctgcatc ggacctcagg acaggtgcca gggctgcgag agccccatag ccaccttttc
     1141 ctcatctctg cctcactcca tcgctcccac acagcttgag ccgtccagct gcggttaggt
     1201 cttgagcaca tctagggtag gtgggcggat ggctgcgggg cctgtgtctc aagccgggag
     1261 ggagcctgct cctgcctccc cctgccctgc ctgagccagg cccatgtgct gcctgcccac
     1321 cgagcccctt tgtccctgag gaaagcggag gcggaaggcc caccttgcca aaggccgggc
     1381 accagcctta accctcactc tgccagcacc acctcccttt tccgaggcag cacatctggc
     1441 ttgttcttcc tccattcctc agagcctgac agggccagac ctgcttctct ggggaatgtg
     1501 ggtgcagctt ggggttgtgg ggctcttccc cctcccaact cagaatcctg gcccccaccc
     1561 tctggcacag cttcctgtag aaaacctttg gtctttacct aagaagccat gtcctttgtg
     1621 ctgtctcttg ccagtctcac cctacaacct gtcctccccc tccagtgtgt atttaagtcc
     1681 ctgggctgcc cctctgggag ggagcctctt ctcccaggtt cccctctgat gtcacatcag
     1741 gcatcttgca aggaaaagcc acttggggga agatggaaaa ggatgaaaaa ataaatttcc
     1801 actggccctt ggataagcca agggtttttg caagg
//
