LOCUS       NM_008996               2871 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus RAB1A, member RAS oncogene family (Rab1a), mRNA.
ACCESSION   NM_008996
VERSION     NM_008996.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2871)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2871)
  AUTHORS   Wu,Y., Yang,D. and Chen,G.Y.
  TITLE     Targeted disruption of Rab1a causes early embryonic lethality
  JOURNAL   Int J Mol Med 49 (4) (2022)
   PUBMED   35137917
REFERENCE   3  (bases 1 to 2871)
  AUTHORS   Strong,E.J., Ng,T.W., Porcelli,S.A. and Lee,S.
  TITLE     Mycobacterium tuberculosis PE_PGRS20 and PE_PGRS47 Proteins Inhibit
            Autophagy by Interaction with Rab1A
  JOURNAL   mSphere 6 (4), e0054921 (2021)
   PUBMED   34346699
  REMARK    GeneRIF: Mycobacterium tuberculosis PE_PGRS20 and PE_PGRS47
            Proteins Inhibit Autophagy by Interaction with Rab1A.
REFERENCE   4  (bases 1 to 2871)
  AUTHORS   Zhang,X., Wang,X., Yuan,Z., Radford,S.J., Liu,C., Libutti,S.K. and
            Zheng,X.F.S.
  TITLE     Amino acids-Rab1A-mTORC1 signaling controls whole-body glucose
            homeostasis
  JOURNAL   Cell Rep 34 (11), 108830 (2021)
   PUBMED   33730578
REFERENCE   5  (bases 1 to 2871)
  AUTHORS   Iwaki,A., Moriwaki,K., Sobajima,T., Taniguchi,M., Yoshimura,S.I.,
            Kunii,M., Kanda,S., Kamada,Y., Miyoshi,E. and Harada,A.
  TITLE     Loss of Rab6a in the small intestine causes lipid accumulation and
            epithelial cell death from lactation
  JOURNAL   FASEB J 34 (7), 9450-9465 (2020)
   PUBMED   32496646
REFERENCE   6  (bases 1 to 2871)
  AUTHORS   Chavrier,P., Simons,K. and Zerial,M.
  TITLE     The complexity of the Rab and Rho GTP-binding protein subfamilies
            revealed by a PCR cloning approach
  JOURNAL   Gene 112 (2), 261-264 (1992)
   PUBMED   1555775
REFERENCE   7  (bases 1 to 2871)
  AUTHORS   Wichmann,H., Jockusch,H., Guenet,J.L., Gallwitz,D. and Kaupmann,K.
  TITLE     The mouse homolog to the ras-related yeast gene YPT1 maps on
            chromosome 11 close to the wobbler (wr) locus
  JOURNAL   Mamm Genome 3 (8), 467-468 (1992)
   PUBMED   1643310
REFERENCE   8  (bases 1 to 2871)
  AUTHORS   Le Roy,H., Simon-Chazottes,D., Montagutelli,X. and Guenet,J.L.
  TITLE     A set of anonymous DNA clones as markers for mouse gene mapping
  JOURNAL   Mamm Genome 3 (4), 244-246 (1992)
   PUBMED   1351769
REFERENCE   9  (bases 1 to 2871)
  AUTHORS   Wichmann,H., Disela,C., Haubruck,H. and Gallwitz,D.
  TITLE     Nucleotide sequence of the mouse ypt1 gene encoding a ras-related
            GTP-binding protein
  JOURNAL   Nucleic Acids Res 17 (16), 6737-6738 (1989)
   PUBMED   2506528
REFERENCE   10 (bases 1 to 2871)
  AUTHORS   Fawell,E., Hook,S. and Armstrong,J.
  TITLE     Nucleotide sequence of a gene encoding a YPT1-related protein from
            Schizosaccharomyces pombe
  JOURNAL   Nucleic Acids Res 17 (11), 4373 (1989)
   PUBMED   2740223
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY283776.1, AK167150.1, AK034408.1, AK159425.1 and CB723426.1.
            
            On Feb 22, 2018 this sequence version replaced NM_008996.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF226873.1, AK152978.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-22                BY283776.1         2-23
            23-1452             AK167150.1         1-1430
            1453-2370           AK034408.1         1431-2348
            2371-2777           AK159425.1         2348-2754
            2778-2871           CB723426.1         380-473
FEATURES             Location/Qualifiers
     source          1..2871
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 12.92 cM"
     gene            1..2871
                     /gene="Rab1a"
                     /gene_synonym="Gtbp; mKIAA3012; Rab-1; Rab1; Ypt1"
                     /note="RAB1A, member RAS oncogene family"
                     /db_xref="GeneID:19324"
                     /db_xref="MGI:MGI:97842"
     exon            1..241
                     /gene="Rab1a"
                     /gene_synonym="Gtbp; mKIAA3012; Rab-1; Rab1; Ypt1"
                     /inference="alignment:Splign:2.1.0"
     CDS             219..836
                     /gene="Rab1a"
                     /gene_synonym="Gtbp; mKIAA3012; Rab-1; Rab1; Ypt1"
                     /EC_number="3.6.5.2"
                     /note="YPT1-related protein; ras-related YPT1 protein;
                     RAB1, member RAS oncogene family"
                     /codon_start=1
                     /product="ras-related protein Rab-1A"
                     /protein_id="NP_033022.1"
                     /db_xref="CCDS:CCDS36115.1"
                     /db_xref="GeneID:19324"
                     /db_xref="MGI:MGI:97842"
                     /translation="MSSMNPEYDYLFKLLLIGDSGVGKSCLLLRFADDTYTESYISTI
                     GVDFKIRTIELDGKTIKLQIWDTAGQERFRTITSSYYRGAHGIIVVYDVTDQESFNNV
                     KQWLQEIDRYASENVNKLLVGNKCDLTTKKVVDYTTAKEFADSLGIPFLETSAKNATN
                     VEQSFMTMAAEIKKRMGPGATAGGAEKSNVKIQSTPVKQSGGGCC"
     exon            242..314
                     /gene="Rab1a"
                     /gene_synonym="Gtbp; mKIAA3012; Rab-1; Rab1; Ypt1"
                     /inference="alignment:Splign:2.1.0"
     exon            315..410
                     /gene="Rab1a"
                     /gene_synonym="Gtbp; mKIAA3012; Rab-1; Rab1; Ypt1"
                     /inference="alignment:Splign:2.1.0"
     exon            411..506
                     /gene="Rab1a"
                     /gene_synonym="Gtbp; mKIAA3012; Rab-1; Rab1; Ypt1"
                     /inference="alignment:Splign:2.1.0"
     exon            507..638
                     /gene="Rab1a"
                     /gene_synonym="Gtbp; mKIAA3012; Rab-1; Rab1; Ypt1"
                     /inference="alignment:Splign:2.1.0"
     exon            639..2847
                     /gene="Rab1a"
                     /gene_synonym="Gtbp; mKIAA3012; Rab-1; Rab1; Ypt1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1422..1427
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rab1a"
                     /gene_synonym="Gtbp; mKIAA3012; Rab-1; Rab1; Ypt1"
                     /note="hexamer: AATAAA"
     polyA_site      1448
                     /gene="Rab1a"
                     /gene_synonym="Gtbp; mKIAA3012; Rab-1; Rab1; Ypt1"
                     /note="major polyA site"
     regulatory      2819..2824
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rab1a"
                     /gene_synonym="Gtbp; mKIAA3012; Rab-1; Rab1; Ypt1"
                     /note="hexamer: AATAAA"
     polyA_site      2847
                     /gene="Rab1a"
                     /gene_synonym="Gtbp; mKIAA3012; Rab-1; Rab1; Ypt1"
ORIGIN      
        1 agttcctggt tcgccggcgg ccattttggg tggaagcgat cactgagtgg cggcggctgc
       61 tgattgtgtt ctaagggtcg gagtggggtc gacgtttgct ctaccggaac agcttagctc
      121 attcctccct ttccattacc tgtggcgcgg agagttgggg cggcggctgc gtcagcaagg
      181 gcggtggtgg cggcggcggc ggcggcagct gcagtgacat gtccagcatg aatcccgaat
      241 atgattattt attcaagtta cttctgattg gcgattctgg ggttggaaag tcctgccttc
      301 tccttaggtt tgcagatgat acgtatacgg aaagctacat cagcacaatt ggtgtggatt
      361 tcaagatacg aactatagag ttagatggga aaacaatcaa gctacagata tgggacacag
      421 caggccagga aagatttcga acaatcactt ccagttatta cagaggagcc catggcatca
      481 tagttgtgta tgatgtgaca gatcaggagt ccttcaataa cgttaaacag tggctgcagg
      541 agatagatcg ctacgccagt gaaaatgtca acaagttgtt ggtagggaac aaatgtgacc
      601 tgaccacaaa gaaagtagta gactacacaa cagcaaagga atttgcagat tcccttggaa
      661 ttccattttt ggaaaccagt gctaagaacg caacgaatgt agaacagtct ttcatgacga
      721 tggcagctga gattaaaaag cgaatgggtc ctggagctac agctggtggt gccgagaagt
      781 ccaatgttaa aatccagagc actccagtca agcagtcagg tggaggctgc tgctaaaatc
      841 tgcctccgtc cttttctcac agcaatgaat tcgcaatctg aacccaagtg aaaaaacaaa
      901 attgcctgaa ttgtactgta tgtagctgca ctacaacaga ttcttaccgt ttccacaagg
      961 tcagagattg taaatggtca atactgactt ttttttttat tcccttgact caagaccgct
     1021 aacttcattt tcagaactgt tttaaacctt tgtgtgctgg tttataaaat aatgtgtgta
     1081 atccttgttg ctttcctgat accagatcgt ttcccgtggt tggttagaat atattttgtt
     1141 ttgatgttta tattggcatg tttagatgtt gggtttagtc ttctgaagat gaagttcagc
     1201 cattttgtat cacacagcac aaccagtgtc tgtcagtttc cacgcataaa gtttagtgag
     1261 acgttatatg taagatctga tttgctagtt cttcctggta gagttataaa tggaaagatt
     1321 acactatctg attaatagtt tcttcatact ctgcatataa tttgtggctg cagaatattg
     1381 taatttgttg cacactatgt aacaaaactg aagatatgtt taataaatat tgtacttatt
     1441 ggaagtaata tcaaactgta tggtgataag tattgtttta attcctatga ttaaagggaa
     1501 atagagcttt gcattctact cagcagccac gtgtgtgcag caagggcact gtagacctat
     1561 cttaatagca cagcatccag ggtttgcttt ctagtaatag gtctgatgag tgacctagag
     1621 aagcttttgt gctgtgtaga gacttcacca ccttcattgg ttcaaggaac tcaaactcta
     1681 gtgcttcatc tccagcccag gccacctgaa gtggcttcac cagcaaccct tttttccctc
     1741 atctgtggta gagatggaga gcagcccatg cttcctccca ggcagtgatc tggtaatagt
     1801 gctggtgttt cttcatgctc agtctgatgg cgcacacacc tttttctttc ttttttcttt
     1861 ttggctattg gagatagggt ttctctgtgt atccctggct gtcctggaac tctctctgta
     1921 gaccaggctg gcctcgaact cagggatcca cctagctctg tctctgagtg ctgagactga
     1981 aggtgtgcgc cgccacgcct ggcttttttc ccctttcttt tttgagacag ggtcttacta
     2041 tgtagccctg gctagcctgg aacttaagta tgtacaacag gctgcctccc cctcccccat
     2101 tcacctgcct tttcctcaaa agtgctggga ttaaatgatg tcccagactg cacctatttt
     2161 ttgagacaat gtctcatata gctcaagagg cctcaaattc acttgtaacc aaggatgccc
     2221 ttgaactcct gatcctcctg cctccacttc caggtgtcaa ctttattctt tccaattgta
     2281 tgaatcatgt tggtggagag tttaagcatt agaatagaaa gcaggaaatg tgattgccct
     2341 aattgtagaa attctatctc cccccccccc caaattaaat gaaaacatga acgctagatg
     2401 ggaatgatgg gagaaataat atatttattt cggtgaaatt ttgcatgtgt gaaagtttgt
     2461 taactaggat cttcgaaatc ctagactttg cttttgtctt actgtgggaa acaaagtctc
     2521 ttgcagacac tagcatttta aggtgacaaa ggtcagagat tgtttccttt ggtttaagga
     2581 gcagccaagc attcttcaat tgggggctag ggtagggtat ggctgttgat aacacatttt
     2641 atcatggggt ctttaatgat aaaatattaa actaaaaata agccagaaat tacaggttta
     2701 tttttcacta aacagacaat tgaaatacat ggtacaaaaa taagtggtaa gattattgta
     2761 aattgaaaaa tggacagaat aaatattcaa tttaattttc catctatgag aatttcacaa
     2821 taaaatcata gtttactttg tattataaaa aaaaaaaaaa aaaaaaaaaa a
//
