LOCUS       NM_011226               1427 bp    mRNA    linear   ROD 11-FEB-2025
DEFINITION  Mus musculus RAB19, member RAS oncogene family (Rab19), mRNA.
ACCESSION   NM_011226
VERSION     NM_011226.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1427)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1427)
  AUTHORS   Gao,Q., Liu,G., Huang,L., Zhang,Y., Zhang,X., Song,X. and Xing,X.
  TITLE     WDR38, a novel equatorial segment protein, interacts with the
            GTPase protein RAB19 and Golgi protein GM130 to play roles in
            acrosome biogenesis
  JOURNAL   Acta Biochim Biophys Sin (Shanghai) 55 (10), 1561-1570 (2023)
   PUBMED   37635409
  REMARK    GeneRIF: WDR38, a novel equatorial segment protein, interacts with
            the GTPase protein RAB19 and Golgi protein GM130 to play roles in
            acrosome biogenesis.
REFERENCE   3  (bases 1 to 1427)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   4  (bases 1 to 1427)
  AUTHORS   Itoh,T., Satoh,M., Kanno,E. and Fukuda,M.
  TITLE     Screening for target Rabs of TBC (Tre-2/Bub2/Cdc16)
            domain-containing proteins based on their Rab-binding activity
  JOURNAL   Genes Cells 11 (9), 1023-1037 (2006)
   PUBMED   16923123
REFERENCE   5  (bases 1 to 1427)
  AUTHORS   Fukuda,M.
  TITLE     Distinct Rab binding specificity of Rim1, Rim2, rabphilin, and
            Noc2. Identification of a critical determinant of Rab3A/Rab27A
            recognition by Rim2
  JOURNAL   J Biol Chem 278 (17), 15373-15380 (2003)
   PUBMED   12578829
REFERENCE   6  (bases 1 to 1427)
  AUTHORS   VanBuren,V., Piao,Y., Dudekula,D.B., Qian,Y., Carter,M.G.,
            Martin,P.R., Stagg,C.A., Bassey,U.C., Aiba,K., Hamatani,T.,
            Kargul,G.J., Luo,A.G., Kelso,J., Hide,W. and Ko,M.S.
  TITLE     Assembly, verification, and initial annotation of the NIA mouse
            7.4K cDNA clone set
  JOURNAL   Genome Res 12 (12), 1999-2003 (2002)
   PUBMED   12466305
REFERENCE   7  (bases 1 to 1427)
  AUTHORS   Fukuda,M., Kuroda,T.S. and Mikoshiba,K.
  TITLE     Slac2-a/melanophilin, the missing link between Rab27 and myosin Va:
            implications of a tripartite protein complex for melanosome
            transport
  JOURNAL   J Biol Chem 277 (14), 12432-12436 (2002)
   PUBMED   11856727
REFERENCE   8  (bases 1 to 1427)
  AUTHORS   Kuroda,T.S., Fukuda,M., Ariga,H. and Mikoshiba,K.
  TITLE     The Slp homology domain of synaptotagmin-like proteins 1-4 and
            Slac2 functions as a novel Rab27A binding domain
  JOURNAL   J Biol Chem 277 (11), 9212-9218 (2002)
   PUBMED   11773082
REFERENCE   9  (bases 1 to 1427)
  AUTHORS   Lutcke,A., Olkkonen,V.M., Dupree,P., Lutcke,H., Simons,K. and
            Zerial,M.
  TITLE     Isolation of a murine cDNA clone encoding Rab19, a novel
            tissue-specific small GTPase
  JOURNAL   Gene 155 (2), 257-260 (1995)
   PUBMED   7721101
REFERENCE   10 (bases 1 to 1427)
  AUTHORS   Chavrier,P., Simons,K. and Zerial,M.
  TITLE     The complexity of the Rab and Rho GTP-binding protein subfamilies
            revealed by a PCR cloning approach
  JOURNAL   Gene 112 (2), 261-264 (1992)
   PUBMED   1555775
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BQ562779.1 and BC032936.1.
            
            On Feb 24, 2018 this sequence version replaced NM_011226.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC032936.1, AK017590.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849376
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-75                BQ562779.1         179-253
            76-1427             BC032936.1         1-1352
FEATURES             Location/Qualifiers
     source          1..1427
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 18.16 cM"
     gene            1..1427
                     /gene="Rab19"
                     /note="RAB19, member RAS oncogene family"
                     /db_xref="GeneID:19331"
                     /db_xref="MGI:MGI:103292"
     exon            1..157
                     /gene="Rab19"
                     /inference="alignment:Splign:2.1.0"
     exon            158..370
                     /gene="Rab19"
                     /inference="alignment:Splign:2.1.0"
     CDS             170..823
                     /gene="Rab19"
                     /codon_start=1
                     /product="ras-related protein Rab-19"
                     /protein_id="NP_035356.1"
                     /db_xref="CCDS:CCDS20021.1"
                     /db_xref="GeneID:19331"
                     /db_xref="MGI:MGI:103292"
                     /translation="MQFSSSSRTSDENVDYLFKVILIGDSNVGKTCVVQHFKSGVYSE
                     SQQNTIGVDFTVRSLEIDGKKVKMQVWDTAGQERFRTITQSYYRSAHAAIIAYDLTRR
                     STFESVPHWIHEIEKYGAANLVIMLIGNKSDLWEKRHVLFEDACTLAEKHGLLAVLET
                     SAKESRNIDEVFVLMAKELIARNSLHLYGESAQQGLSQDSSPVLVAQVPNESTRCTC"
     exon            371..554
                     /gene="Rab19"
                     /inference="alignment:Splign:2.1.0"
     exon            555..1397
                     /gene="Rab19"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1370..1375
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rab19"
                     /note="hexamer: ATTAAA"
     polyA_site      1397
                     /gene="Rab19"
                     /note="major polyA site"
ORIGIN      
        1 gctttctctg tccaccgaac ttgactccag gggccggaac ttgagttccc actgcgctgc
       61 aagacaagag gacgaaggag acgacggagg gctgcagagg aaagcagaag aaaaagcaaa
      121 aactacctgc tcaccagaga ggtgaaagag tgcccaggaa gccagagcta tgcagttctc
      181 cagctcatcc aggacatcag atgagaatgt ggactatttg ttcaaggtca tccttattgg
      241 ggactccaac gtggggaaga catgtgtggt tcagcatttc aaatctggag tctacagtga
      301 gtcccagcag aacaccattg gggtggactt caccgtgcgc tccctcgaga tagacggcaa
      361 gaaagtgaag atgcaggtgt gggacacggc aggccaggag cgcttccgta ccatcaccca
      421 aagctactac cggagtgccc acgcagctat catcgcttat gatctcacac ggcggtccac
      481 attcgaatct gtccctcact ggatccacga gatagaaaaa tatggagctg ccaacttggt
      541 catcatgctg atcgggaaca aatcagacct gtgggagaag cggcatgtcc tgtttgagga
      601 tgcctgcaca ctggctgaga agcatggcct cctggctgtc ttggagacat ccgccaagga
      661 gtccaggaac atagatgaag tctttgtgct catggcgaag gagttaattg cccgcaacag
      721 cctgcacctg tatggggaga gtgcccagca aggtctttcc caggattcca gcccagttct
      781 tgtggcccag gtccccaatg agagcacccg ctgtacttgt tgaacatgtg tgggaggcca
      841 gcacaaaagc cagggtattc agacaccagt gtctccagta gtgttgccca gctgagcctg
      901 atgggcagta cagactctta aggaaagggg ataccactgc cctcaaggac tccattaaag
      961 tgaggacttc aggccctgga ggaagagggc taggatggat tctcctcata ctgatctgtc
     1021 tccccaacat ccagctgttt tatagtggag tttgcgtctc tgttgtacaa agacagtaaa
     1081 gtgaggagca ggaagatgca aagagggtat ttggaacatt ctagatttgg agtcagccca
     1141 ggcactgttg gggaaggcct gaaatgaaaa gccagcctcc ttccaacagt cacagccagg
     1201 cctgttacct agaggccaga aatgctttct tgccaaatgg tcaggaacca ggaggcagat
     1261 ggaactggct tgccctttgt cactctgact acaagggtgg aagaaatgcc tactatgaat
     1321 tcttaaaaca tcgaattatc tcttgtacag aagtcagacc taagttgaaa ttaaattgtc
     1381 cttatattat taacaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaa
//
