LOCUS       NM_181070               3670 bp    mRNA    linear   ROD 29-OCT-2024
DEFINITION  Mus musculus RAB18, member RAS oncogene family (Rab18), transcript
            variant 2, mRNA.
ACCESSION   NM_181070 NM_011225
VERSION     NM_181070.6
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3670)
  AUTHORS   Deng,Y., Hahn,Q., Yu,L., Zhu,Z., Boyer,J.A., Wang,J., Kong,D.,
            Carey,L.M., Hepperla,A.J., Simon,J.M., Temple,B., Zhang,Z.,
            Zhang,Y., Santos,C., Frank,J.E., Herring,L.E., Wang,X.,
            Dokholyan,N.V., Campbell,S.L., Baldwin,A.S., Damania,B., Zhang,Q.
            and Liu,P.
  TITLE     2'3'-cGAMP interactome identifies 2'3'-cGAMP/Rab18/FosB signaling
            in cell migration control independent of innate immunity
  JOURNAL   Sci Adv 10 (42), eado7024 (2024)
   PUBMED   39413198
  REMARK    GeneRIF: 2'3'-cGAMP interactome identifies 2'3'-cGAMP/Rab18/FosB
            signaling in cell migration control independent of innate immunity.
REFERENCE   2  (bases 1 to 3670)
  AUTHORS   Liu,J., Li,L., Xu,D., Li,Y., Chen,T., Liu,Y., Bao,Y., Wang,Y.,
            Yang,L., Li,P. and Xu,L.
  TITLE     Rab18 maintains homeostasis of subcutaneous adipose tissue to
            prevent obesity-induced metabolic disorders
  JOURNAL   Sci China Life Sci 67 (6), 1170-1182 (2024)
   PUBMED   38523235
  REMARK    GeneRIF: Rab18 maintains homeostasis of subcutaneous adipose tissue
            to prevent obesity-induced metabolic disorders.
REFERENCE   3  (bases 1 to 3670)
  AUTHORS   Martin,S., Driessen,K., Nixon,S.J., Zerial,M. and Parton,R.G.
  TITLE     Regulated localization of Rab18 to lipid droplets: effects of
            lipolytic stimulation and inhibition of lipid droplet catabolism
  JOURNAL   J Biol Chem 280 (51), 42325-42335 (2005)
   PUBMED   16207721
  REMARK    GeneRIF: results show that a Rab protein localizes directly to the
            monolayer surface of lipid droplets
REFERENCE   4  (bases 1 to 3670)
  AUTHORS   Ozeki,S., Cheng,J., Tauchi-Sato,K., Hatano,N., Taniguchi,H. and
            Fujimoto,T.
  TITLE     Rab18 localizes to lipid droplets and induces their close
            apposition to the endoplasmic reticulum-derived membrane
  JOURNAL   J Cell Sci 118 (Pt 12), 2601-2611 (2005)
   PUBMED   15914536
  REMARK    GeneRIF: Rab18 regulates lipid droplet-associated membrane
            formation
REFERENCE   5  (bases 1 to 3670)
  AUTHORS   Brasaemle,D.L., Dolios,G., Shapiro,L. and Wang,R.
  TITLE     Proteomic analysis of proteins associated with lipid droplets of
            basal and lipolytically stimulated 3T3-L1 adipocytes
  JOURNAL   J Biol Chem 279 (45), 46835-46842 (2004)
   PUBMED   15337753
REFERENCE   6  (bases 1 to 3670)
  AUTHORS   McMurtrie,E.B., Barbosa,M.D., Zerial,M. and Kingsmore,S.F.
  TITLE     Rab17 and rab18, small GTPases with specificity for polarized
            epithelial cells: genetic mapping in the mouse
  JOURNAL   Genomics 45 (3), 623-625 (1997)
   PUBMED   9367688
REFERENCE   7  (bases 1 to 3670)
  AUTHORS   Murphy,C. and Zerial,M.
  TITLE     Expression of Rab proteins during mouse embryonic development
  JOURNAL   Methods Enzymol 257, 324-332 (1995)
   PUBMED   8583936
REFERENCE   8  (bases 1 to 3670)
  AUTHORS   Lutcke,A., Parton,R.G., Murphy,C., Olkkonen,V.M., Dupree,P.,
            Valencia,A., Simons,K. and Zerial,M.
  TITLE     Cloning and subcellular localization of novel rab proteins reveals
            polarized and cell type-specific expression
  JOURNAL   J Cell Sci 107 (Pt 12), 3437-3448 (1994)
   PUBMED   7706395
REFERENCE   9  (bases 1 to 3670)
  AUTHORS   Yu,H., Leaf,D.S. and Moore,H.P.
  TITLE     Gene cloning and characterization of a GTP-binding Rab protein from
            mouse pituitary AtT-20 cells
  JOURNAL   Gene 132 (2), 273-278 (1993)
   PUBMED   7916717
REFERENCE   10 (bases 1 to 3670)
  AUTHORS   Chavrier,P., Simons,K. and Zerial,M.
  TITLE     The complexity of the Rab and Rho GTP-binding protein subfamilies
            revealed by a PCR cloning approach
  JOURNAL   Gene 112 (2), 261-264 (1992)
   PUBMED   1555775
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC131796.2, BC056351.1 and
            AK034242.1.
            
            On Jun 7, 2013 this sequence version replaced NM_181070.5.
            
            Summary: This gene encodes a member of the Ras-related small
            GTPases, which regulate membrane trafficking in organelles and
            transport vesicles. This protein is expressed predominantly in
            lipid droplets, organelles that store neutral lipids, and is
            proposed to play a role in lipolysis and lipogenesis. In humans
            mutations in this gene are associated with Warburg micro syndrome
            type 3. A pseudogene of this gene is located on chromosome X.
            Alternative splicing results in multiple transcript variants
            encoding different isoforms. [provided by RefSeq, Jun 2013].
            
            Transcript Variant: This variant (2) uses an alternate in-frame
            acceptor splice site in the coding region compared to variant 1. It
            encodes isoform 2 which is shorter compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK140901.1, BC056351.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-46                AC131796.2         99532-99577
            47-2249             BC056351.1         1-2203
            2250-3665           AK034242.1         942-2357
            3666-3670           AC131796.2         125967-125971
FEATURES             Location/Qualifiers
     source          1..3670
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 4.53 cM"
     gene            1..3670
                     /gene="Rab18"
                     /note="RAB18, member RAS oncogene family"
                     /db_xref="GeneID:19330"
                     /db_xref="MGI:MGI:102790"
     exon            1..166
                     /gene="Rab18"
                     /inference="alignment:Splign:2.1.0"
     exon            167..222
                     /gene="Rab18"
                     /inference="alignment:Splign:2.1.0"
     exon            223..284
                     /gene="Rab18"
                     /inference="alignment:Splign:2.1.0"
     exon            285..357
                     /gene="Rab18"
                     /inference="alignment:Splign:2.1.0"
     exon            358..476
                     /gene="Rab18"
                     /inference="alignment:Splign:2.1.0"
     exon            477..543
                     /gene="Rab18"
                     /inference="alignment:Splign:2.1.0"
     exon            544..3670
                     /gene="Rab18"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1786..1791
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rab18"
                     /note="hexamer: AATAAA"
     polyA_site      1805
                     /gene="Rab18"
     regulatory      2227..2232
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rab18"
                     /note="hexamer: ATTAAA"
     polyA_site      2247
                     /gene="Rab18"
                     /note="major polyA site"
     regulatory      2270..2275
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rab18"
                     /note="hexamer: AACAAG"
     polyA_site      2296
                     /gene="Rab18"
     regulatory      2367..2372
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rab18"
                     /note="hexamer: AATATA"
     polyA_site      2387
                     /gene="Rab18"
     regulatory      3650..3655
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rab18"
                     /note="hexamer: AAGAAA"
     polyA_site      3655
                     /gene="Rab18"
     polyA_site      3668
                     /gene="Rab18"
ORIGIN      
        1 ggcggtggtc acagaggtgc gcatgcgctg gccgcctttg ccgacacagg gcagcgctga
       61 cgggcacggg ggctgggtcg gagtagagcg ggcgcaggat ggacgaggac gtgctgacca
      121 ctctgaagat actcatcatc ggcgagagtg gggtgggcaa gtccagcctg ctcctgaggt
      181 tcacagatga tacctttgat ccagaacttg cagcaacaat aggtgttgac tttaaggtga
      241 aaacgatttc agtggatgga aataaggcta aacttgcaat atgggataca gctggtcaag
      301 agaggttcag aacattaact cccagctatt atagaggtgc acagggagtt atattagtct
      361 atgatgtcac aagaagagac acctttgtta aactggataa ctggttaaat gaattggaaa
      421 catactgtac aagaaatgac atagtaaaca tgctagttgg aaataaaatt gataaggaaa
      481 accgtgaagt cgatagaaat gaaggcttga aatttgcacg caagcattct atgttgttca
      541 tagaggcaag tgcaaaaacc tgtgatggtg tacagtgtgc ctttgaggag cttgttgaga
      601 agatcattca gacacctggc ctgtgggaaa gtgagaacca gaacaaagga gtcaagctgt
      661 cacacaggga agagagccgc ggaggaggcg cctgcggcgg ttactgctct gtgctataaa
      721 ctctgggaat tccatctctt gcatatttga tcagatagtg acatctttct gtatataaac
      781 tcttaactgc tattagggac cttgcagttt gcacataagt gtttttatca tggcagtgag
      841 tatttgcaag aaactccctc attggctttc ccaggtgaaa tggtatggta agcatgcagt
      901 tttcagtctg tagagttttt ttggggggag gggaggggat tgctgttgtt ttgttttggg
      961 cttttttttt taatgtaacg taaaatcgat gtcgcttcat ggcacatgtg attttatggt
     1021 ttgcatttat catgtcattt taaaacatca tctgtctgta tgtgttgctg caagtctgct
     1081 tttgttctcc cttctgctta attactgaat tacttgttat gtagaactat aaccatggga
     1141 aggtttccct tgaggaataa caaagcatga ttcacagctt ttctaggatg ctttagactc
     1201 ttagtactaa gtaaaattct cagttcagaa tacagcccag gccaattcat aattaaacct
     1261 ctatttgttc tgatgatgct tccaaaatag aattgctaag ttaaggaagt ttggtatgtt
     1321 aatttacacc agtgatgaac tcagctacgc agggcactaa ccctatgttg cacacgctgg
     1381 gttcctgatc ttggtgcgat gttttggtta catggcatct ggcaggcttt ctgccatttg
     1441 ggtttcagaa gaacatgaac agtatattat tatagctcct ttaattcttc cacttttaaa
     1501 accaacatgt tttttcacaa gtgttggtag tgtttgtccg ggtgcctcag ttgtaacttg
     1561 ttgtataatg actgtctgta tcttaatggc ttccataaat gactagttgc tattcaaaac
     1621 atatttttgt gatttgaaga tggggaagga aaacactaaa tgacaatttg agaaaggtgt
     1681 attgttccaa attctgactg gaggggagag gctcttgcag tgagatcgtt gataagttac
     1741 tgcaaaagta gccactagtt tattaaaaac caaactgtac agattaataa accttttcca
     1801 caatattcag ttttctaact ccttgttgcc gtacagtgta tgttttctta ctcatacatt
     1861 atttaatttc tttaacctct gctatttatg ctccacaagt aaaatgtact tagactggtc
     1921 actgtattgt cccttattaa gatgctgata ttaattttta cagtttatta tctatgtaca
     1981 atggtaaatg ataaacattt tgtgtacctt tgcaatatgt gtgttactgg gtttacttcg
     2041 gattgatttc tttctgaata gggtgtcttc atatggaaac ctcacattac atcatttata
     2101 tttggtggtc tacatgtgat tagagctttt atacattctg tatattttta ttaaatgtaa
     2161 gacttttgct tctataatgt tagaggaagg tagctcacac atgtatttat aatttagtca
     2221 cattacatta aattttagat ttatgtacat tttgtgtctt gtctgtctta acaagacttc
     2281 tgcttgttct tgctgagtca tgctgtcgtt attaccatta gatcatcatc ttgatttgag
     2341 cagaacttga gtatatgagt cgcatgaata tagctttgaa aatttgattg ttgtgtctag
     2401 agaggtggtt cattgggcaa agtacttgtt tcagagtttg aagactggca tttgcatccc
     2461 agaactcacc taaaatggca ggtgacatgg cagtcaactc tcactctcca aacagaagat
     2521 agagatagag gctccagaat caagcaggca agctagagta gtcatgttgg caagctttgg
     2581 gctcagctga tactttgctt caaagctaca gtgaaaagca gtataagaag cctcagtgtc
     2641 aactgtgggt ctgtatacac atatggacat acatgtacac ccccacatac ttgagcacac
     2701 acacacacac aaattaattt tgacagattt attttagaac cttctatttg ttatatctag
     2761 gtggatttga tcagtgtttc ttagtgaagg ttttgaaagt gattaacaca tagaatcagg
     2821 cacctatata acagctttgc tagttatttc agaattccat aatctccagc tctttgcaga
     2881 tgctgttaga acataaaaac ccagcataga cttaaagtac tagattcttt cactgagtag
     2941 tagtgagcat ttatttattg atttatttat tgaagcgtct ttggtgcctg gtgttctatg
     3001 tactaaatta tcttctaaag ccttagaatg acttagtgat aatttgtact actattgtgc
     3061 ctattttatt actatttttt taagtcagtt ttgttgaagt ttgggatttt atttatttat
     3121 tttttggtgg tttttgtttt tgtctgtttg tttctttgtt ttcttttaga tcatctcact
     3181 gtgtgtccca gactggcttc aaactctgtc tccctggtgc atcctccagg gggttggatt
     3241 gtgtatgtgt ccagcatctc aggatatgtc cattctaatg aggaaggtga tcagacaggt
     3301 atgtaatgca atttctctga ggttatatgc tcagtgatgc agctggattc ctgtcaagga
     3361 gattttactc atgaccctga attcttggtc tcctcattgg ttagttacta gcagcttaac
     3421 ccagctgagc tgagtttgcc catatttcat cacaatatgt ttggctatat gtagtagaag
     3481 tatttcagat ctgttctttg tgaaatgaat cctatagata gcaacctatc cctagcatca
     3541 ttgacctaaa aaatctaggc agcagagcag gtagaataaa ggtctgagac ttaggaaaga
     3601 taccaaggct tacagtgaca gcactcccta tttgttttgg ctaataaaaa agaaatgtag
     3661 tctggaaatg
//
