LOCUS       NM_008998               1825 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus RAB17, member RAS oncogene family (Rab17), transcript
            variant 1, mRNA.
ACCESSION   NM_008998 XM_907560 XM_920475 XM_920479
VERSION     NM_008998.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1825)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1825)
  AUTHORS   Butterfield,N.C., Curry,K.F., Steinberg,J., Dewhurst,H.,
            Komla-Ebri,D., Mannan,N.S., Adoum,A.T., Leitch,V.D., Logan,J.G.,
            Waung,J.A., Ghirardello,E., Southam,L., Youlten,S.E.,
            Wilkinson,J.M., McAninch,E.A., Vancollie,V.E., Kussy,F.,
            White,J.K., Lelliott,C.J., Adams,D.J., Jacques,R., Bianco,A.C.,
            Boyde,A., Zeggini,E., Croucher,P.I., Williams,G.R. and
            Bassett,J.H.D.
  TITLE     Accelerating functional gene discovery in osteoarthritis
  JOURNAL   Nat Commun 12 (1), 467 (2021)
   PUBMED   33473114
  REMARK    Erratum:[Nat Commun. 2021 May 28;12(1):3302. doi:
            10.1038/s41467-021-23768-8.. PMID: 34050183]
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1825)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1825)
  AUTHORS   Striz,A.C. and Tuma,P.L.
  TITLE     The GTP-bound and Sumoylated Form of the rab17 Small Molecular
            Weight GTPase Selectively Binds Syntaxin 2 in Polarized Hepatic
            WIF-B Cells
  JOURNAL   J Biol Chem 291 (18), 9721-9732 (2016)
   PUBMED   26957544
  REMARK    GeneRIF: The selectivity in syntaxin binding and apical protein
            redistribution further suggests that rab17 and syntaxin 2 mediate
            fusion of transcytotic vesicles at the apical surface.
REFERENCE   5  (bases 1 to 1825)
  AUTHORS   Mori,Y., Fukuda,M. and Henley,J.M.
  TITLE     Small GTPase Rab17 regulates the surface expression of kainate
            receptors but not
            alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)
            receptors in hippocampal neurons via dendritic trafficking of
            Syntaxin-4 protein
  JOURNAL   J Biol Chem 289 (30), 20773-20787 (2014)
   PUBMED   24895134
REFERENCE   6  (bases 1 to 1825)
  AUTHORS   Zacchi,P., Stenmark,H., Parton,R.G., Orioli,D., Lim,F., Giner,A.,
            Mellman,I., Zerial,M. and Murphy,C.
  TITLE     Rab17 regulates membrane trafficking through apical recycling
            endosomes in polarized epithelial cells
  JOURNAL   J Cell Biol 140 (5), 1039-1053 (1998)
   PUBMED   9490718
REFERENCE   7  (bases 1 to 1825)
  AUTHORS   McMurtrie,E.B., Barbosa,M.D., Zerial,M. and Kingsmore,S.F.
  TITLE     Rab17 and rab18, small GTPases with specificity for polarized
            epithelial cells: genetic mapping in the mouse
  JOURNAL   Genomics 45 (3), 623-625 (1997)
   PUBMED   9367688
REFERENCE   8  (bases 1 to 1825)
  AUTHORS   Murphy,C. and Zerial,M.
  TITLE     Expression of Rab proteins during mouse embryonic development
  JOURNAL   Methods Enzymol 257, 324-332 (1995)
   PUBMED   8583936
REFERENCE   9  (bases 1 to 1825)
  AUTHORS   Lutcke,A., Jansson,S., Parton,R.G., Chavrier,P., Valencia,A.,
            Huber,L.A., Lehtonen,E. and Zerial,M.
  TITLE     Rab17, a novel small GTPase, is specific for epithelial cells and
            is induced during cell polarization
  JOURNAL   J Cell Biol 121 (3), 553-564 (1993)
   PUBMED   8486736
REFERENCE   10 (bases 1 to 1825)
  AUTHORS   Chavrier,P., Simons,K. and Zerial,M.
  TITLE     The complexity of the Rab and Rho GTP-binding protein subfamilies
            revealed by a PCR cloning approach
  JOURNAL   Gene 112 (2), 261-264 (1992)
   PUBMED   1555775
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK075591.1 and BC051071.1.
            
            On Apr 30, 2009 this sequence version replaced NM_008998.3.
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Both variants encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC051071.1, AK075591.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1362              AK075591.1         2-1363
            1363-1825           BC051071.1         1339-1801
FEATURES             Location/Qualifiers
     source          1..1825
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 45.84 cM"
     gene            1..1825
                     /gene="Rab17"
                     /note="RAB17, member RAS oncogene family"
                     /db_xref="GeneID:19329"
                     /db_xref="MGI:MGI:104640"
     exon            1..391
                     /gene="Rab17"
                     /inference="alignment:Splign:2.1.0"
     exon            392..551
                     /gene="Rab17"
                     /inference="alignment:Splign:2.1.0"
     CDS             395..1039
                     /gene="Rab17"
                     /codon_start=1
                     /product="ras-related protein Rab-17"
                     /protein_id="NP_033024.1"
                     /db_xref="CCDS:CCDS15156.1"
                     /db_xref="GeneID:19329"
                     /db_xref="MGI:MGI:104640"
                     /translation="MAQAAGLPQASTASGQPYVSKLVLLGSSSVGKTSLALRYMKQDF
                     SNVLPTVGCAFFTKVLDLGSSSLKLEIWDTAGQEKYQSVCHLYFRGANAALLVYDITR
                     KDSFHKAQQWLEDLEKEFQPGEVVVMLVGNKTDLGEEREVTFQEGKEFAESKSLLFME
                     TSAKLNYQVSEIFNTVAQELLQRAGDTGSSRPQEGEAVALNQEPPIRQRQCCAR"
     exon            552..703
                     /gene="Rab17"
                     /inference="alignment:Splign:2.1.0"
     exon            704..829
                     /gene="Rab17"
                     /inference="alignment:Splign:2.1.0"
     exon            830..923
                     /gene="Rab17"
                     /inference="alignment:Splign:2.1.0"
     exon            924..1790
                     /gene="Rab17"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1768..1773
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rab17"
                     /note="hexamer: ATTAAA"
     polyA_site      1790
                     /gene="Rab17"
                     /note="major polyA site"
ORIGIN      
        1 agaagagctg ttctctaagt ctgtgatgct ttctggtaca ggtgagacct ggaaagggct
       61 gaaattcagg gctgcagctc ggtgaggagg cagagagcca ccaagtgtga cttctagctt
      121 actctgaccc agctgatcac atgatcatgt ggggactttg caccggagtt tacaggaaga
      181 gtcctgccgg ctggggcctt ggtgggagca gggggcctgc tcacttcatt tgctcggctg
      241 ctggtagtca gtgtgcactg ctctgcccac cccgcccctg gcaggaccct gacgagtcat
      301 acagcaccca ggggaagcac agccagggga agagaggggt gcctgcggcc ctgtgggatg
      361 gtggtctgta gcactcttct aaagtgaaca ggccatggcg caggctgctg ggctgccaca
      421 ggccagcact gcttctggcc agccctacgt gagcaagctg gttctgcttg gaagcagttc
      481 tgtgggcaag accagcctgg ccctccggta catgaagcag gacttcagca atgtcttgcc
      541 gactgtgggg tgtgccttct tcacaaaggt gctggacttg ggctcctcat ctctgaagct
      601 tgagatctgg gacacagccg gccaggagaa gtaccaaagc gtctgccacc tctacttcag
      661 gggtgccaat gctgcgctcc tggtttatga catcactcgg aaggattcct ttcacaaggc
      721 ccagcagtgg ctggaagacc tggagaagga attccagcca ggagaggtgg tggtgatgct
      781 ggtcggcaac aaaacggatc tgggcgagga gcgggaagtg accttccagg aaggaaaaga
      841 gtttgcagag agcaaaagct tgctgttcat ggaaacctcc gccaagctga actaccaggt
      901 gtctgagatc ttcaacactg ttgctcagga gcttctgcag agagcaggag acacggggag
      961 cagccgccca caggaaggtg aggctgtggc tctgaaccag gaacctccca tcaggcagcg
     1021 ccagtgctgt gcacgatagc cgctgccact gcaggagagc tggcggagga cacatctcag
     1081 cctgtgcttc agagggtccc cagcccaagc tactacgtct ttgtggcaaa tctgccgggg
     1141 ctgcctcttt gtccattcat gttctgtgtc ggagatggct tatgcttgag ccctggaggc
     1201 ttccaggcgt tggttttctc tgtaatcact gcttgccaaa gctgatgaga actgtctcag
     1261 ggaagatcca gtgtcaaatg gctcccagaa gactgtcagc cctaccttac ctgataccca
     1321 gatacttgga tgccctgagc caagtgtgcc tgctcctcct gggctgtccc tttcagcttc
     1381 cttgtgacca gcacagagag ctaaatgaag cagagaagca gcatggactg ggaaaagcct
     1441 ttgatccgtg ggatgggagg acagatgctt cctcctgggg cagcatccat aactggacca
     1501 ctttcgttct gggaactgtc agggggagag aaggggcatc aatgcaagga aaaatgcaga
     1561 gatgagccca agagaaaaac gagcccaagg tgctaagtct cagtgaggtg acgcaggaga
     1621 gacagagtct gaaagggtgg ctgggatgga agtgtccccc ttccagcggt ggatggacag
     1681 agccaggttt ctacctagtg atctgaggac tctaaaaccc ctgtcccgag atgaacaccg
     1741 tgttgtctca tgtccttctc tccaaatatt aaacgtcttg acaatccgaa aaaaaaaaaa
     1801 aaaaaaaaaa aaaaaaaaaa aaaaa
//
