LOCUS       NM_134050               3145 bp    mRNA    linear   ROD 11-FEB-2025
DEFINITION  Mus musculus RAB15, member RAS oncogene family (Rab15), transcript
            variant 1, mRNA.
ACCESSION   NM_134050
VERSION     NM_134050.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3145)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3145)
  AUTHORS   Wu,J., Moriwaki,K., Asuka,T., Nakai,R., Kanda,S., Taniguchi,M.,
            Sugiyama,T., Yoshimura,S.I., Kunii,M., Nagasawa,T., Hosen,N.,
            Miyoshi,E. and Harada,A.
  TITLE     EHBP1L1, an apicobasal polarity regulator, is critical for nuclear
            polarization during enucleation of erythroblasts
  JOURNAL   Blood Adv 7 (14), 3382-3394 (2023)
   PUBMED   37042948
  REMARK    Erratum:[Blood Adv. 2024 Mar 12;8(5):1151. doi:
            10.1182/bloodadvances.2023011838.. PMID: 38421726]
REFERENCE   3  (bases 1 to 3145)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3145)
  AUTHORS   Walentin,K., Hinze,C., Werth,M., Haase,N., Varma,S., Morell,R.,
            Aue,A., Potschke,E., Warburton,D., Qiu,A., Barasch,J., Purfurst,B.,
            Dieterich,C., Popova,E., Bader,M., Dechend,R., Staff,A.C.,
            Yurtdas,Z.Y., Kilic,E. and Schmidt-Ott,K.M.
  TITLE     A Grhl2-dependent gene network controls trophoblast branching
            morphogenesis
  JOURNAL   Development 142 (6), 1125-1136 (2015)
   PUBMED   25758223
REFERENCE   5  (bases 1 to 3145)
  AUTHORS   Lai,H.C., Klisch,T.J., Roberts,R., Zoghbi,H.Y. and Johnson,J.E.
  TITLE     In vivo neuronal subtype-specific targets of Atoh1 (Math1) in
            dorsal spinal cord
  JOURNAL   J Neurosci 31 (30), 10859-10871 (2011)
   PUBMED   21795538
REFERENCE   6  (bases 1 to 3145)
  AUTHORS   Sherwood,R.I., Jitianu,C., Cleaver,O., Shaywitz,D.A., Lamenzo,J.O.,
            Chen,A.E., Golub,T.R. and Melton,D.A.
  TITLE     Prospective isolation and global gene expression analysis of
            definitive and visceral endoderm
  JOURNAL   Dev Biol 304 (2), 541-555 (2007)
   PUBMED   17328885
REFERENCE   7  (bases 1 to 3145)
  AUTHORS   Itoh,T., Satoh,M., Kanno,E. and Fukuda,M.
  TITLE     Screening for target Rabs of TBC (Tre-2/Bub2/Cdc16)
            domain-containing proteins based on their Rab-binding activity
  JOURNAL   Genes Cells 11 (9), 1023-1037 (2006)
   PUBMED   16923123
REFERENCE   8  (bases 1 to 3145)
  AUTHORS   Fukuda,M.
  TITLE     Distinct Rab binding specificity of Rim1, Rim2, rabphilin, and
            Noc2. Identification of a critical determinant of Rab3A/Rab27A
            recognition by Rim2
  JOURNAL   J Biol Chem 278 (17), 15373-15380 (2003)
   PUBMED   12578829
REFERENCE   9  (bases 1 to 3145)
  AUTHORS   Fukuda,M., Kuroda,T.S. and Mikoshiba,K.
  TITLE     Slac2-a/melanophilin, the missing link between Rab27 and myosin Va:
            implications of a tripartite protein complex for melanosome
            transport
  JOURNAL   J Biol Chem 277 (14), 12432-12436 (2002)
   PUBMED   11856727
REFERENCE   10 (bases 1 to 3145)
  AUTHORS   Kuroda,T.S., Fukuda,M., Ariga,H. and Mikoshiba,K.
  TITLE     The Slp homology domain of synaptotagmin-like proteins 1-4 and
            Slac2 functions as a novel Rab27A binding domain
  JOURNAL   J Biol Chem 277 (11), 9212-9218 (2002)
   PUBMED   11773082
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY237353.1, AK158768.1, AK158637.1 and AI840042.1.
            
            On Nov 26, 2016 this sequence version replaced NM_134050.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC027769.1, AK158768.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164139
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-110               BY237353.1         2-111
            111-490             AK158768.1         65-444
            491-2330            AK158637.1         413-2252
            2331-3126           AK158768.1         2285-3080
            3127-3145           AI840042.1         1-19                c
FEATURES             Location/Qualifiers
     source          1..3145
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 33.73 cM"
     gene            1..3145
                     /gene="Rab15"
                     /gene_synonym="2310012G06Rik"
                     /note="RAB15, member RAS oncogene family"
                     /db_xref="GeneID:104886"
                     /db_xref="MGI:MGI:1916865"
     exon            1..331
                     /gene="Rab15"
                     /gene_synonym="2310012G06Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             208..846
                     /gene="Rab15"
                     /gene_synonym="2310012G06Rik"
                     /note="isoform 1 is encoded by transcript variant 1;
                     ras-related protein Rab-15"
                     /codon_start=1
                     /product="ras-related protein Rab-15 isoform 1"
                     /protein_id="NP_598811.3"
                     /db_xref="CCDS:CCDS25997.1"
                     /db_xref="GeneID:104886"
                     /db_xref="MGI:MGI:1916865"
                     /translation="MAKQYDVLFRLLLIGDSGVGKTCLLCRFTDNEFHSSHISTIGVD
                     FKMKTIEVDGIKVRIQIWDTAGQERYQTITKQYYRRAQGIFLVYDISSERSYQHIMKW
                     VSDVDEYAPEGVQKILIGNKADEEQKRQVGREQGQQLAKEYGMDFYETSACTNLNIKE
                     SFTRLTELVLQAHRKELDGLRTRASNELALAELEEDEGKPEGPANSSKTCWC"
     exon            332..392
                     /gene="Rab15"
                     /gene_synonym="2310012G06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            393..453
                     /gene="Rab15"
                     /gene_synonym="2310012G06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            454..531
                     /gene="Rab15"
                     /gene_synonym="2310012G06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            532..621
                     /gene="Rab15"
                     /gene_synonym="2310012G06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            622..687
                     /gene="Rab15"
                     /gene_synonym="2310012G06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            688..3129
                     /gene="Rab15"
                     /gene_synonym="2310012G06Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3107..3112
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rab15"
                     /gene_synonym="2310012G06Rik"
                     /note="hexamer: AATAAA"
     polyA_site      3127
                     /gene="Rab15"
                     /gene_synonym="2310012G06Rik"
                     /note="major polyA site"
ORIGIN      
        1 gagcttcccc gcgacgcgct cccgccgcag ccgcgcttcc ccgcgccagc gagccagcga
       61 gcgagcgggc gaggccagcg cgggggccgg gccgcttcct tctcgccacc gcggcgtcct
      121 ggggctggct ccagccgcga tggcagaggc tgagcggggc tgagcccgca gccgcccgca
      181 gccctcgggc ccccttgagt ccctgccatg gcgaaacagt acgatgtgct gttccggcta
      241 ctgctgatcg gggactccgg ggttggcaag acatgcctgc tgtgccgctt caccgacaac
      301 gagttccact cctcgcatat ctccaccatc ggtgttgact ttaagatgaa gactatcgaa
      361 gtagacggca tcaaagtgag aatacagatt tgggacacag cagggcagga gaggtaccag
      421 actatcacaa agcagtacta tcggcgagcc cagggaatat ttttagtcta cgacattagc
      481 agtgagcgct cctatcagca tatcatgaag tgggtcagtg acgtggatga gtacgctcca
      541 gaaggagtcc agaagatcct aattgggaat aaggctgatg aagagcagaa acggcaggtg
      601 gggagagagc aggggcagca gctggctaag gagtacggca tggacttcta cgaaacaagt
      661 gcctgcacca accttaatat taaagagtcc ttcactcgtc tgacggagct ggtgctgcag
      721 gcccacagga aagagctgga tggtctccga acacgtgcca gcaacgagct cgcactggcc
      781 gagctggagg aggacgaagg caaacctgag ggcccagcaa actcttcaaa gacctgctgg
      841 tgctgagggt tctgagtgga gtccccccag cccccttccc tcaggaggcc cgtggaggca
      901 gggagtctgg gctttgccca ccaccgtcct ttcatttgac aatcctgttg aaaaccagta
      961 gctgctactc ccctgcctgg ccctgcgagc agctctgctg tggtctctga gcagcctctg
     1021 cccccagccc ctctaattct ggagtggtga cctttcagcc tgtttcccag ccgcaggcct
     1081 cctgtgaccc cagaatgtgc tgcgaccacc ccaggctcct gggacgacgg tcaaggctgg
     1141 agtcaaggcc acttcaagat tccttagtgc atctcgtggg ctctctgctt tttctcttct
     1201 ttcttctctt tctccactcc ctcccctccc ttgtaattcg catcccctat catcccagtc
     1261 tctcctccct tgtctgtgtg tcctgccaag cgctgctact gcagttcctt ccttttttcc
     1321 ttcctgattc tgcctaaggg aatggaccca ggctctgccc cagggaggac tgttcaccct
     1381 gctccggggt gggctgaagg ctaagggtgc ttcttcctcc ttgtgccgtg ggctgcctcc
     1441 ccagtggcct gggaaggtag agcactgagg taggaaggaa acactactag gtggccctca
     1501 agcctggact ggcctcttct gcctttgcct tctgctgacg ttctggcctt gcctggctgc
     1561 ctctgtgcct ctgtgaggaa ctgagtccag aggcaggcac agcagagaag gaaaacgaaa
     1621 gaaacgatgg ggtggcaggg attaagtcac ctctgttctc tacctcccat gcctctctcc
     1681 tcacctggat tcacaaattt aaagatgggg atcgaggtct gaggacacca aagggcaagg
     1741 ggagccctgg ggtcagatac tgtatagtca gctgtgaact ccagatagag gcaagagcgg
     1801 atgcgaaggg cgggctccta gaaccagggt tagagcaaga gcagagggag cttcgcagaa
     1861 cagcgagtgc tgtggcgact acagggcatc agaggtgaca agtaatcaac cactcctctt
     1921 tcactgaacc cagccttagg gagttagggt ttccccagag tctggacaac aggccttaag
     1981 acaagggaag agaagggtgg gtatgatgga aatacttggt gctgttctgc cttccaggac
     2041 tccctccccc tggttccctt atttctaagt cggctttgcc aactgctgtg tggctaccaa
     2101 gggagggaaa gagacaccct cctccagagt tctatgctca ggaagtttct ttaaccctgt
     2161 ggttcaagag tagcttgaag gaggcccctg aaaaacaaac aaacaaacaa acaaacaaag
     2221 ccaaccctgg tagggttcat ccttacattc ccaaggtggg aggagctcag gtaagagaag
     2281 agtcccaaga tgcacttcaa gcctggggct ggagccaaag cagaggaaga actaggcact
     2341 gaccgagcat tcaaggacca aggtcctttc aaatccaggg cacagctgtg atgacagaga
     2401 gccccacacc tctttagtcc tctaaaaagg gagatggggg tgaaatcaat ggggatttct
     2461 ccctgactta gcaaacaagg aagcaggcag aagagaacag ctcaggattt actggtggag
     2521 ggaaaaggag ccgggaacaa tagtccattg ttcgctaaag agaaacagtg ttgtgaagac
     2581 tggaccatga ctggctgagg tggcttcctt ggggactgac tcctgggtag tagtaagcct
     2641 tcggtagcag acctgccttc agccagggac ctgaggggag cttctacagg gcacaggctg
     2701 tcccaagtgt cactgtcttg tcccagcctc ttaagaaagg acttgatttt ttttattacc
     2761 ttgaggattc tgggagggaa ttcggggctg tgactctgta ccgtggtcac cctgaagtat
     2821 agcaacagaa ggaggctggg ctatgaagaa cacctgtgct tgctctgttc tggagtttgc
     2881 ctcaccctaa ctgccagtct gggatgtggc ttgggctgtg tcattggcct tgactgttca
     2941 gcaggctttc ctggcctgtc tgcccatgac ctgagatcaa ctcaccctgg tacaccacct
     3001 gagtcccact atctccctgt gatgggtgac ctttgtgtac tgtgtcttgg gtccattata
     3061 tgaattgtga gcagggttca tctattttaa acacaaatgt ttacaaaata aagaatattt
     3121 caaaccataa aaaaaaaaaa aaaaa
//
