LOCUS       NM_026677               1548 bp    mRNA    linear   ROD 16-FEB-2025
DEFINITION  Mus musculus RAB13, member RAS oncogene family (Rab13), transcript
            variant 1, mRNA.
ACCESSION   NM_026677
VERSION     NM_026677.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1548)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1548)
  AUTHORS   Wu,J., Moriwaki,K., Asuka,T., Nakai,R., Kanda,S., Taniguchi,M.,
            Sugiyama,T., Yoshimura,S.I., Kunii,M., Nagasawa,T., Hosen,N.,
            Miyoshi,E. and Harada,A.
  TITLE     EHBP1L1, an apicobasal polarity regulator, is critical for nuclear
            polarization during enucleation of erythroblasts
  JOURNAL   Blood Adv 7 (14), 3382-3394 (2023)
   PUBMED   37042948
  REMARK    Erratum:[Blood Adv. 2024 Mar 12;8(5):1151. doi:
            10.1182/bloodadvances.2023011838.. PMID: 38421726]
REFERENCE   3  (bases 1 to 1548)
  AUTHORS   Huang,X.Y., Zhang,J.T., Li,F., Li,T.T., Shi,X.J., Huang,J.,
            Huang,X.Y., Zhou,J., Tang,Z.Y. and Huang,Z.L.
  TITLE     Exosomal proteomics identifies RAB13 as a potential regulator of
            metastasis for HCC
  JOURNAL   Hepatol Commun 7 (1), e0006 (2023)
   PUBMED   36633475
  REMARK    GeneRIF: Exosomal proteomics identifies RAB13 as a potential
            regulator of metastasis for HCC.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1548)
  AUTHORS   Nishikimi,A., Ishihara,S., Ozawa,M., Etoh,K., Fukuda,M., Kinashi,T.
            and Katagiri,K.
  TITLE     Rab13 acts downstream of the kinase Mst1 to deliver the integrin
            LFA-1 to the cell surface for lymphocyte trafficking
  JOURNAL   Sci Signal 7 (336), ra72 (2014)
   PUBMED   25074980
  REMARK    GeneRIF: Rab13 acts with Mst1 to regulate the spatial distribution
            of LFA-1 and the motility and trafficking of lymphocytes
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1548)
  AUTHORS   Sato,T., Iwano,T., Kunii,M., Matsuda,S., Mizuguchi,R., Jung,Y.,
            Hagiwara,H., Yoshihara,Y., Yuzaki,M., Harada,R. and Harada,A.
  TITLE     Rab8a and Rab8b are essential for several apical transport pathways
            but insufficient for ciliogenesis
  JOURNAL   J Cell Sci 127 (Pt 2), 422-431 (2014)
   PUBMED   24213529
REFERENCE   6  (bases 1 to 1548)
  AUTHORS   Terai,T., Nishimura,N., Kanda,I., Yasui,N. and Sasaki,T.
  TITLE     JRAB/MICAL-L2 is a junctional Rab13-binding protein mediating the
            endocytic recycling of occludin
  JOURNAL   Mol Biol Cell 17 (5), 2465-2475 (2006)
   PUBMED   16525024
REFERENCE   7  (bases 1 to 1548)
  AUTHORS   Morimoto,S., Nishimura,N., Terai,T., Manabe,S., Yamamoto,Y.,
            Shinahara,W., Miyake,H., Tashiro,S., Shimada,M. and Sasaki,T.
  TITLE     Rab13 mediates the continuous endocytic recycling of occludin to
            the cell surface
  JOURNAL   J Biol Chem 280 (3), 2220-2228 (2005)
   PUBMED   15528189
  REMARK    Erratum:[J Biol Chem. 2005 Sep 9;280(36):32048]
REFERENCE   8  (bases 1 to 1548)
  AUTHORS   Fukuda,M.
  TITLE     Distinct Rab binding specificity of Rim1, Rim2, rabphilin, and
            Noc2. Identification of a critical determinant of Rab3A/Rab27A
            recognition by Rim2
  JOURNAL   J Biol Chem 278 (17), 15373-15380 (2003)
   PUBMED   12578829
REFERENCE   9  (bases 1 to 1548)
  AUTHORS   Bell,A.W., Ward,M.A., Blackstock,W.P., Freeman,H.N.,
            Choudhary,J.S., Lewis,A.P., Chotai,D., Fazel,A., Gushue,J.N.,
            Paiement,J., Palcy,S., Chevet,E., Lafreniere-Roula,M., Solari,R.,
            Thomas,D.Y., Rowley,A. and Bergeron,J.J.
  TITLE     Proteomics characterization of abundant Golgi membrane proteins
  JOURNAL   J Biol Chem 276 (7), 5152-5165 (2001)
   PUBMED   11042173
REFERENCE   10 (bases 1 to 1548)
  AUTHORS   Sheth,B., Fontaine,J.J., Ponza,E., McCallum,A., Page,A., Citi,S.,
            Louvard,D., Zahraoui,A. and Fleming,T.P.
  TITLE     Differentiation of the epithelial apical junctional complex during
            mouse preimplantation development: a role for rab13 in the early
            maturation of the tight junction
  JOURNAL   Mech Dev 97 (1-2), 93-104 (2000)
   PUBMED   11025210
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC119825.11, BB867138.1, AK002303.1, AK080805.1 and AI529508.1.
            
            On Jun 18, 2014 this sequence version replaced NM_026677.3.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC027214.1, AK002303.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-12                AC119825.11        116227-116238
            13-100              BB867138.1         16-103
            101-791             AK002303.1         68-758
            792-1526            AK080805.1         662-1396
            1527-1548           AI529508.1         457-478
FEATURES             Location/Qualifiers
     source          1..1548
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 39.21 cM"
     gene            1..1548
                     /gene="Rab13"
                     /gene_synonym="0610007N03Rik; B230212B15Rik"
                     /note="RAB13, member RAS oncogene family"
                     /db_xref="GeneID:68328"
                     /db_xref="MGI:MGI:1927232"
     exon            1..239
                     /gene="Rab13"
                     /gene_synonym="0610007N03Rik; B230212B15Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             116..724
                     /gene="Rab13"
                     /gene_synonym="0610007N03Rik; B230212B15Rik"
                     /EC_number="3.6.5.2"
                     /note="isoform 1 is encoded by transcript variant 1;
                     ras-related protein Rab-13"
                     /codon_start=1
                     /product="ras-related protein Rab-13 isoform 1"
                     /protein_id="NP_080953.1"
                     /db_xref="CCDS:CCDS17522.1"
                     /db_xref="GeneID:68328"
                     /db_xref="MGI:MGI:1927232"
                     /translation="MAKAYDHLFKLLLIGDSGVGKTCLIIRFAEDNFNSTYISTIGID
                     FKIRTVDIEGKRIKLQVWDTAGQERFKTITTAYYRGAMGIILVYDITDEKSFENIQNW
                     MKSIKENASAGVERLLLGNKCDMEAKRQVQREQAEKLAREHRIRFFETSAKSSVNVDE
                     AFSSLARDILLKTGGRRSGTNSKPSSTGLKTSDKKKNKCLLG"
     exon            240..300
                     /gene="Rab13"
                     /gene_synonym="0610007N03Rik; B230212B15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            301..361
                     /gene="Rab13"
                     /gene_synonym="0610007N03Rik; B230212B15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            362..439
                     /gene="Rab13"
                     /gene_synonym="0610007N03Rik; B230212B15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            440..529
                     /gene="Rab13"
                     /gene_synonym="0610007N03Rik; B230212B15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            530..595
                     /gene="Rab13"
                     /gene_synonym="0610007N03Rik; B230212B15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            596..649
                     /gene="Rab13"
                     /gene_synonym="0610007N03Rik; B230212B15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            650..1528
                     /gene="Rab13"
                     /gene_synonym="0610007N03Rik; B230212B15Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1088..1093
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rab13"
                     /gene_synonym="0610007N03Rik; B230212B15Rik"
                     /note="hexamer: ATTAAA"
     polyA_site      1112
                     /gene="Rab13"
                     /gene_synonym="0610007N03Rik; B230212B15Rik"
                     /note="major polyA site"
     regulatory      1505..1510
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rab13"
                     /gene_synonym="0610007N03Rik; B230212B15Rik"
                     /note="hexamer: AATACA"
     polyA_site      1528
                     /gene="Rab13"
                     /gene_synonym="0610007N03Rik; B230212B15Rik"
ORIGIN      
        1 gagggaggaa aacttcctgg ctgggactcc ggcggtttct gcctgccaac cctcggatcc
       61 cgcctaccag tgttggctct tcccgacccc tcccccggcg cccccagtgt ccgccatggc
      121 caaagcctac gaccacctct tcaagttgct gctcatcggg gactcggggg tgggcaagac
      181 ttgtctgatc attcgctttg cagaggacaa cttcaacagc acttacatct ctaccatcgg
      241 aattgatttc aagatccgaa ccgtggacat agaggggaag aggatcaaac tgcaagtgtg
      301 ggacacggct ggccaagaac gattcaagac aataactacc gcctattacc gtggagccat
      361 gggcattatc ctcgtatatg acatcacaga tgagaaatcc ttcgagaata ttcagaactg
      421 gatgaaaagc atcaaagaga atgcctctgc gggagtggag cgcctcctgc tgggaaacaa
      481 gtgtgacatg gaggccaagc ggcaggtgca gagagagcag gcggagaagt tggctcgaga
      541 gcacagaatc cgattttttg agacgagtgc caaatccagt gtgaatgtgg atgaggcttt
      601 cagttccctg gcccgtgaca tcttgctcaa gacaggaggc cggagatcgg gaaccaacag
      661 taagccctca agcactggcc tgaaaacatc tgacaagaag aagaacaagt gcttgttagg
      721 ctgagagcat ttcttgcctc ctattcaccc tgaacctgga ggctagacct gagggagtcg
      781 gactgaggga ttgcagatgg gagaactgtg gtggcacctc aaggggagat gaggggaata
      841 aggagaccgg cgaggacgag acggaagaaa ggggcaggga aaggaggggg aggaaccaag
      901 gatgtgaaag gtgaacagaa gggatttgag aagaggaaag gaagaagaaa tgaatggctc
      961 aggccttgga cagtccaaca ttaaagtcaa catgctgatc tctccattcc tggttcaggg
     1021 ttagggtcct gagaggctgg ctcggcacta ctccgagggt ccctcactct acaaggtctt
     1081 tgttagtatt aaaggccact gttttgcatg aatgtcccat ttgcattact ttcattattg
     1141 tcagaattgc tcttcactca aatcctattt ttgtcacgcc aagatattgg ttcacctgaa
     1201 tgtggctggg ttccccttcc ttgccccaac tctttcactg gtgatgaaaa cagcatgggg
     1261 cagcctgaag gacggacatc ctgtttccac tgtgggttcc caaggactac aagagtggac
     1321 ggaaccttgc cttgagcaca cagtaaccca aggacaaagg atttgaacca ggcttcagta
     1381 aacagcagca cttagtatgg tttatccaag gagatgtggg acatctttga ttctgatgta
     1441 gtcagcttag gtgttgggta ctgttagctg cttttgttag agtattctca gtgttgcaca
     1501 aagaaataca tgaacaaggt gagagtaaaa aaaaaaaaaa aaaaaaaa
//
