LOCUS       NM_024448               2057 bp    mRNA    linear   ROD 24-OCT-2024
DEFINITION  Mus musculus RAB12, member RAS oncogene family (Rab12), mRNA.
ACCESSION   NM_024448 XM_128792
VERSION     NM_024448.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2057)
  AUTHORS   Heaton,G.R., Li,X., Zhou,X., Zhang,Y., Vu,D.T., Oeller,M.,
            Karayel,O., Hoang,Q.Q., Kars,M.E., Wang,M., Tarassishin,L.,
            Mann,M., Peter,I. and Yue,Z.
  TITLE     Targeting Specific Kinase Substrates Rescues Increased Colitis
            Severity Induced by the Crohn's Disease-Linked LRRK2-N2081D Variant
  JOURNAL   bioRxiv (2024)
   PUBMED   39282291
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2057)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 2057)
  AUTHORS   Dhekne,H.S., Tonelli,F., Yeshaw,W.M., Chiang,C.Y., Limouse,C.,
            Jaimon,E., Purlyte,E., Alessi,D.R. and Pfeffer,S.R.
  TITLE     Genome-wide screen reveals Rab12 GTPase as a critical activator of
            Parkinson's disease-linked LRRK2 kinase
  JOURNAL   Elife 12, e87098 (2023)
   PUBMED   37874635
  REMARK    GeneRIF: Genome-wide screen reveals Rab12 GTPase as a critical
            activator of Parkinson's disease-linked LRRK2 kinase.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2057)
  AUTHORS   Efergan,A., Azouz,N.P., Klein,O., Noguchi,K., Rothenberg,M.E.,
            Fukuda,M. and Sagi-Eisenberg,R.
  TITLE     Rab12 Regulates Retrograde Transport of Mast Cell Secretory
            Granules by Interacting with the RILP-Dynein Complex
  JOURNAL   J Immunol 196 (3), 1091-1101 (2016)
   PUBMED   26740112
  REMARK    GeneRIF: we identified the small GTPase Rab12 as a novel regulator
            of mast cell secretory granule transport
REFERENCE   5  (bases 1 to 2057)
  AUTHORS   Matsui,T., Noguchi,K. and Fukuda,M.
  TITLE     Dennd3 functions as a guanine nucleotide exchange factor for small
            GTPase Rab12 in mouse embryonic fibroblasts
  JOURNAL   J Biol Chem 289 (20), 13986-13995 (2014)
   PUBMED   24719330
  REMARK    GeneRIF: Dennd3 not only functions as a Rab12-GEF but also
            modulates Akt signaling in mouse embryonic fibroblast cells
REFERENCE   6  (bases 1 to 2057)
  AUTHORS   Fukuda,M., Kuroda,T.S. and Mikoshiba,K.
  TITLE     Slac2-a/melanophilin, the missing link between Rab27 and myosin Va:
            implications of a tripartite protein complex for melanosome
            transport
  JOURNAL   J Biol Chem 277 (14), 12432-12436 (2002)
   PUBMED   11856727
REFERENCE   7  (bases 1 to 2057)
  AUTHORS   Kuroda,T.S., Fukuda,M., Ariga,H. and Mikoshiba,K.
  TITLE     The Slp homology domain of synaptotagmin-like proteins 1-4 and
            Slac2 functions as a novel Rab27A binding domain
  JOURNAL   J Biol Chem 277 (11), 9212-9218 (2002)
   PUBMED   11773082
REFERENCE   8  (bases 1 to 2057)
  AUTHORS   Matsumoto,K., Asano,T. and Endo,T.
  TITLE     Novel small GTPase M-Ras participates in reorganization of actin
            cytoskeleton
  JOURNAL   Oncogene 15 (20), 2409-2417 (1997)
   PUBMED   9395237
REFERENCE   9  (bases 1 to 2057)
  AUTHORS   Olkkonen,V.M., Dupree,P., Killisch,I., Lutcke,A., Zerial,M. and
            Simons,K.
  TITLE     Molecular cloning and subcellular localization of three GTP-binding
            proteins of the rab subfamily
  JOURNAL   J Cell Sci 106 (Pt 4), 1249-1261 (1993)
   PUBMED   8126105
REFERENCE   10 (bases 1 to 2057)
  AUTHORS   Chavrier,P., Simons,K. and Zerial,M.
  TITLE     The complexity of the Rab and Rho GTP-binding protein subfamilies
            revealed by a PCR cloning approach
  JOURNAL   Gene 112 (2), 261-264 (1992)
   PUBMED   1555775
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CT010496.14.
            
            On Nov 10, 2020 this sequence version replaced NM_024448.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7652917.516008.1,
                                           SRR11927938.2644447.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849386, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-370               CT010496.14        165796-166165       c
            371-431             CT010496.14        152481-152541       c
            432-570             CT010496.14        146758-146896       c
            571-660             CT010496.14        144467-144556       c
            661-765             CT010496.14        143792-143896       c
            766-2057            CT010496.14        140960-142251       c
FEATURES             Location/Qualifiers
     source          1..2057
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 37.88 cM"
     gene            1..2057
                     /gene="Rab12"
                     /gene_synonym="2900054P15Rik"
                     /note="RAB12, member RAS oncogene family"
                     /db_xref="GeneID:19328"
                     /db_xref="MGI:MGI:894284"
     exon            1..370
                     /gene="Rab12"
                     /gene_synonym="2900054P15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            371..431
                     /gene="Rab12"
                     /gene_synonym="2900054P15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            432..570
                     /gene="Rab12"
                     /gene_synonym="2900054P15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            571..660
                     /gene="Rab12"
                     /gene_synonym="2900054P15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            661..765
                     /gene="Rab12"
                     /gene_synonym="2900054P15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            766..2057
                     /gene="Rab12"
                     /gene_synonym="2900054P15Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2031..2036
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rab12"
                     /gene_synonym="2900054P15Rik"
                     /note="hexamer: AATAAA"
     polyA_site      2057
                     /gene="Rab12"
                     /gene_synonym="2900054P15Rik"
                     /note="major polyA site"
ORIGIN      
        1 gggatgctgc taccgctgct gcggagaagc tgcttccctt cctctactcc cggcggcggc
       61 ggcggcggcg gtagcgcgga gcgggtggag ggtgcgcggg ggcccggggc gcgcggacgg
      121 cggcccgagc gcgagccgta tgcgtgcatg gatcccagcg ccgcgctgca ccggcggccc
      181 gcgggcggca gcctgggcgc ggtctccccg gcgctgtcgg gcggccaggc ccgccggagg
      241 aagcagcccc ccaggccggc cgacttcaag ctgcaggtca tcatcatcgg ctcccgcggc
      301 gtgggcaaga ccagcctgat ggagcgcttc accgacgaca cgttctgcga ggcctgcaag
      361 tccaccgtgg gtgttgactt taaaatcaag actgtagaac taagagggaa gaaaattaga
      421 ttacagatct gggacacagc agggcaggag cgatttaaca gcattacctc agcctattac
      481 agaagtgcca aggggatcat actcgtatat gacatcacca agaaggagac gttcgatgac
      541 ttgccaaagt ggatgaagat gattgacaag tatgcttcag aagacgccga gctcctcctg
      601 gttggaaata agctggactg tgagacagac agagaaatct caaggcagca aggagaaaag
      661 tttgcacagc agataaccgg gatgcgcttc tgcgaagcca gtgccaagga caatttcaat
      721 gtggacgaga tctttctgaa acttgttgat gatattctga aaaagatgcc tcttgatgtt
      781 ttgagaaacg agttatccaa tagcatcctt tctctacaac cagagcctga gatcccacca
      841 gagctgcctc ctcccagacc acacgtccga tgctgttgat ttgatacttt ggagatggtg
      901 caagcgattc ctagaagggg gaaacgttct gttctgcact acaatcacgt gacaatttcc
      961 tttcgcactt tgtaacccaa gtcagctata cactaacttg taaatatgca aatatgcaat
     1021 cctgggtaag gtcgggttat ataagttaca cacttccctt caaattatat ttcctcatta
     1081 ccccagtgtc tagtgtacgc acactgggag gcgtagtact tctaatacga agactgggag
     1141 agaagaaaga tgtaatattt cctgagtact ataaatgtcc ttgttaatta cactacaagg
     1201 cagacgctcc gatgagaaga gaggacctgg tgcttcgctt gctgtttcaa cgaaaatcta
     1261 caaaactgaa gttttttgaa aaggaagaca tgacagccac cttttcttta tttatgggct
     1321 ttccccacac ggcacctcaa ggtttggagt gtctctgcac caaagcagag ctccctcacg
     1381 gccacagtga gagcacacat gggccatgta gtgagagggt tcctggatag gggactggac
     1441 ttagtcccga ggctgcagaa ccctgggtgt ttcccgttgg ctgtgacctg cttttaagaa
     1501 tgaaaaggtt caatagagaa agaacggaag ggctgggatt gcagctcagc atttgagcat
     1561 ctgtccagcg tacgtgaggc tctggcttca atccccgtca tcgcaaggaa agaaagaaaa
     1621 agaagcgttt ttgaaactat agaaaagatt ttaaaatcac actgctgtcc tacacaaatc
     1681 ctgtttaaag ggattttaag agttaccttt tagtatatca aagaatacac atgcatttgc
     1741 ctaaacatcc tgtatctttg taatgacaaa cttctcccct tgatggtgag gcttattcct
     1801 attaagccta gactgtgttc tttaagtttt cttggtcccc accccccctt gagggttttt
     1861 ttttttcctg gtctgataag gaatttgtga actctatctt tggtatatct tttattaagc
     1921 tgcactgttt tgtttagtca aggtaaataa gtatgtattt gaataacttg gcgtgtcctg
     1981 agtgttgtgc tatgagaagc atcatggtct ttctacacta atgaagtgca aataaaattt
     2041 tgtatttatg aatgaca
//
