LOCUS       NM_016676               3531 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus RAB10, member RAS oncogene family (Rab10), mRNA.
ACCESSION   NM_016676
VERSION     NM_016676.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3531)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3531)
  AUTHORS   Singh,V., Menard,M.A., Serrano,G.E., Beach,T.G., Zhao,H.T.,
            Riley-DiPaolo,A., Subrahmanian,N., LaVoie,M.J. and
            Volpicelli-Daley,L.A.
  TITLE     Cellular and subcellular localization of Rab10 and phospho-T73
            Rab10 in the mouse and human brain
  JOURNAL   Acta Neuropathol Commun 11 (1), 201 (2023)
   PUBMED   38110990
  REMARK    GeneRIF: Cellular and subcellular localization of Rab10 and
            phospho-T73 Rab10 in the mouse and human brain.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3531)
  AUTHORS   Wu,J., Moriwaki,K., Asuka,T., Nakai,R., Kanda,S., Taniguchi,M.,
            Sugiyama,T., Yoshimura,S.I., Kunii,M., Nagasawa,T., Hosen,N.,
            Miyoshi,E. and Harada,A.
  TITLE     EHBP1L1, an apicobasal polarity regulator, is critical for nuclear
            polarization during enucleation of erythroblasts
  JOURNAL   Blood Adv 7 (14), 3382-3394 (2023)
   PUBMED   37042948
  REMARK    Erratum:[Blood Adv. 2024 Mar 12;8(5):1151. doi:
            10.1182/bloodadvances.2023011838.. PMID: 38421726]
REFERENCE   4  (bases 1 to 3531)
  AUTHORS   Bunner,W., Wang,J., Cohen,S., Bashtovyy,D., Perry,R., Shookster,D.,
            Landry,T., Harris,E.M., Stackman,R., Tran,T.D., Yasuda,R. and
            Szatmari,E.M.
  TITLE     Behavioral and Transcriptome Profiling of Heterozygous Rab10
            Knock-Out Mice
  JOURNAL   eNeuro 10 (5) (2023)
   PUBMED   37156612
  REMARK    GeneRIF: Behavioral and Transcriptome Profiling of Heterozygous
            Rab10 Knock-Out Mice.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3531)
  AUTHORS   Lazo,O.M. and Schiavo,G.
  TITLE     Rab10 regulates the sorting of internalised TrkB for retrograde
            axonal transport
  JOURNAL   Elife 12, e81532 (2023)
   PUBMED   36897066
  REMARK    GeneRIF: Rab10 regulates the sorting of internalised TrkB for
            retrograde axonal transport.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3531)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   7  (bases 1 to 3531)
  AUTHORS   Fukuda,M., Kuroda,T.S. and Mikoshiba,K.
  TITLE     Slac2-a/melanophilin, the missing link between Rab27 and myosin Va:
            implications of a tripartite protein complex for melanosome
            transport
  JOURNAL   J Biol Chem 277 (14), 12432-12436 (2002)
   PUBMED   11856727
REFERENCE   8  (bases 1 to 3531)
  AUTHORS   Kuroda,T.S., Fukuda,M., Ariga,H. and Mikoshiba,K.
  TITLE     The Slp homology domain of synaptotagmin-like proteins 1-4 and
            Slac2 functions as a novel Rab27A binding domain
  JOURNAL   J Biol Chem 277 (11), 9212-9218 (2002)
   PUBMED   11773082
REFERENCE   9  (bases 1 to 3531)
  AUTHORS   Bell,A.W., Ward,M.A., Blackstock,W.P., Freeman,H.N.,
            Choudhary,J.S., Lewis,A.P., Chotai,D., Fazel,A., Gushue,J.N.,
            Paiement,J., Palcy,S., Chevet,E., Lafreniere-Roula,M., Solari,R.,
            Thomas,D.Y., Rowley,A. and Bergeron,J.J.
  TITLE     Proteomics characterization of abundant Golgi membrane proteins
  JOURNAL   J Biol Chem 276 (7), 5152-5165 (2001)
   PUBMED   11042173
REFERENCE   10 (bases 1 to 3531)
  AUTHORS   Barbosa,M.D., Johnson,S.A., Achey,K., Gutierrez,M.J.,
            Wakeland,E.K., Zerial,M. and Kingsmore,S.F.
  TITLE     The Rab protein family: genetic mapping of six Rab genes in the
            mouse
  JOURNAL   Genomics 30 (3), 439-444 (1995)
   PUBMED   8825628
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ092612.1, AK028320.1 and BC052735.1.
            
            On May 13, 2009 this sequence version replaced NM_016676.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK146357.1, AK159383.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-534               CJ092612.1         2-535
            535-3215            AK028320.1         506-3186
            3216-3531           BC052735.1         3300-3615
FEATURES             Location/Qualifiers
     source          1..3531
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 1.71 cM"
     gene            1..3531
                     /gene="Rab10"
                     /note="RAB10, member RAS oncogene family"
                     /db_xref="GeneID:19325"
                     /db_xref="MGI:MGI:105066"
     exon            1..678
                     /gene="Rab10"
                     /inference="alignment:Splign:2.1.0"
     CDS             552..1154
                     /gene="Rab10"
                     /EC_number="3.6.5.2"
                     /codon_start=1
                     /product="ras-related protein Rab-10"
                     /protein_id="NP_057885.1"
                     /db_xref="CCDS:CCDS25782.1"
                     /db_xref="GeneID:19325"
                     /db_xref="MGI:MGI:105066"
                     /translation="MAKKTYDLLFKLLLIGDSGVGKTCVLFRFSDDAFNTTFISTIGI
                     DFKIKTVELQGKKIKLQIWDTAGQERFHTITTSYYRGAMGIMLVYDITNGKSFENISK
                     WLRNIDEHANEDVERMLLGNKCDMDDKRVVPKGKGEQIAREHGIRFFETSAKANINIE
                     KAFLTLAEDILRKTPVKEPNSENVDISSGGGVTGWKSKCC"
     exon            679..739
                     /gene="Rab10"
                     /inference="alignment:Splign:2.1.0"
     exon            740..878
                     /gene="Rab10"
                     /inference="alignment:Splign:2.1.0"
     exon            879..968
                     /gene="Rab10"
                     /inference="alignment:Splign:2.1.0"
     exon            969..1070
                     /gene="Rab10"
                     /inference="alignment:Splign:2.1.0"
     exon            1071..3513
                     /gene="Rab10"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1209..1214
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rab10"
                     /note="hexamer: AATAAA"
     polyA_site      1240
                     /gene="Rab10"
     regulatory      3496..3501
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rab10"
                     /note="hexamer: AACAAA"
     polyA_site      3513
                     /gene="Rab10"
                     /note="major polyA site"
ORIGIN      
        1 gtccttgcgt gcgtctcagg ctgcgcgcac gccggcgtga gagggcacgg ggaaaaaggt
       61 ggctctggcc ggggcggctc tgtttcctgg ggttatgtag cagggcttgt cggctcgcga
      121 gacctcccgc tgccctcgcc cgtgtcctag cgcggggttt ctgctccggg cggaggccgt
      181 gttcaagccc gccgcgctcc ctcgacgtag agctcgctcg tccgcccgtg ggagcgtccc
      241 ggccgagctg cgctgagggg ggaggggagg ccattttgtc ccgaccgact ccccggaacc
      301 gggcggagcg gctgggagag gctgcggagc cgcgggcgcc gcccctcgga ggcacgggcg
      361 ccgccaccgt cggggcttcc tcgacgaggc cgttcggaag gtctcctgct ccgtctcgag
      421 agctgctttc tccttccgca cacgctaccc ggctgctgcg gccccagaac gcccgggtga
      481 ggagttggtt gtagtgagca gttccgatcc cttggggcta ccggcggcga gcgcccgagc
      541 cgctcctccc aatggcgaag aagacgtacg acctgctttt caagctgctc ctgatcgggg
      601 actcgggagt gggcaagacc tgcgtccttt ttcgtttttc ggacgatgcc ttcaatacca
      661 cctttatttc caccatagga atagacttta agatcaaaac agtggaacta caaggaaaga
      721 agatcaagct acagatatgg gacacagcag gccaggagcg atttcacacc atcacaacct
      781 cctactacag aggagcaatg ggcatcatgc tagtgtatga catcaccaac ggtaaaagct
      841 ttgagaacat cagcaagtgg cttagaaaca tagatgagca tgccaatgaa gatgtggaaa
      901 gaatgttact agggaacaag tgtgacatgg acgacaagag agttgtaccg aaaggcaaag
      961 gagaacagat tgcaagggag catggtatta ggttttttga gactagtgca aaagcaaata
     1021 taaacatcga aaaggcgttc ctcacattag ctgaagacat cctccgaaag acccctgtaa
     1081 aagaacccaa cagtgaaaac gtagatatca gcagtggagg aggcgtgacg ggctggaaga
     1141 gcaagtgctg ctgagtgctc tcctgtccat ctgctgccat ccaccatccg gttctcttct
     1201 tgctgcaaaa taaaacactc tgtccatttt taactctaaa cagatatttt tgtttctcat
     1261 cttaactatt caatccacct attttatttg ttctttcatc tgtgactgct tgcggactat
     1321 tataattttc ttcaaacaaa caaacaaaaa tgtatagaga aatcatgtct gtgagttcat
     1381 tttgagattt acttgctcac tcagccctgc acttcagttg tattatagtc cagttcttat
     1441 caacattaaa ctagagcaat catttcaact attctgcaaa ttgtataaga ataaaagtta
     1501 gaattaacaa ttttattttg tacaacagtg ggattttctg tcatgaataa tgtgcttgat
     1561 ccctataatc tatagacgtg atagcaaaga aacaaaagcc aggaaaacac tcattttcgc
     1621 cttgaactgt atgtgggtta atttgtcctg tgccttatgt ggaaaggaac gtctttggtt
     1681 ttcttttttt gttttggtgg aagcatgagc aggagacatt tcatcccagc ataaactcct
     1741 tcagatgctt gtggtttgct tggctgtatc tttcacgata gttaactgag gacaaagggt
     1801 aatgcagaag tgatatttga tttccattct cattcccagt ggccttgata tttaaactga
     1861 ttcctgccac caggtccttg ggccaccctg tccctgcgtc tcatctttct gcatgctgct
     1921 ttgtttgccc ctactactcc tggtgtgagt tatttaaaga tgaaaggttt gtcaagttta
     1981 acatacagca ctgattttac cttgctaagt aaacagaaag ataaattcta actgcctatt
     2041 aactgtcagt taattcgggt cagcccctca tttactctct ccccaaacct gccccgctgt
     2101 tggccttctg tcccccaccc cttcctgtct atccatggag tttatgaaat ggaagagtta
     2161 attgcatgca ctagtgtttg gagggtgttg tggcttgtct ttctaattag gtatatatcc
     2221 tattcacttt cctagagtaa acctcctaac ctggatttga ctagtctcca ttatgccagc
     2281 tcctctggca gttcggcagc ccaggaaaga ctggttttaa aaaagagcaa gaaggagtgg
     2341 gtcttagtag cgtttgtcaa atgtattgag atttggcctt tgaagaacac atttggtatt
     2401 aagttgtctt tactgtaaga tttagaaatg cattataata ttattaattt caagtcctat
     2461 ctttacatcc tctcagaaaa cttctgatac catgaatatt ttaaaaaaga aaaaggaccg
     2521 caaaaggctt ctcgtgtaaa gctgagcact ctggctctgt ctgacccgcc cttctctccc
     2581 ctttctagtt tggcttcatt gcttctcatt aggatagggt aggctaagtt ccctatgctg
     2641 ctagcatcct aagatgatac ctttgtggaa ataattgtga atagcatgat tcatttcaag
     2701 cagaggctga gtttaggaca gcagctacca ttgagaagat ttctgtgaca tgcattttaa
     2761 tgacctcttg gctcacataa acaatatagg gacatatctg ctaaaagaac ccatgaattt
     2821 ttcagatagt gtcccacaga caattctaca tgcctcactg gtggctctta gggtttcttc
     2881 cctcacttga ctttatcatt gtttactagt aaaaagcagc attgccaaat aacccctgat
     2941 tttccactat gaaaaatgcg atgtgtaagc ttttaaagtt gtaggttaaa cctcctgttg
     3001 ttatctttgc tgtttgtgtt gcttccttct atctggaatg tggtagccac ctctttaaac
     3061 tttttttaac ccttaattca gtgacttaag gtttggagat acacactggg attttggcta
     3121 acagactgac agttttgttg tttgcataat tataatcgac attgtacaga gaaaggataa
     3181 ggctaccttt gttaaatctg cactttctga atatcaaaaa aaaaaacaaa aaaaacaaaa
     3241 aaacccacca aaagggaaat ggaagtataa atcaattttt gtataatctg tttgaaacct
     3301 gagttttatt tgcttactat tagggctttg tcccctttct gtaagtctct tgggatcctg
     3361 tgtaggagct gttctcatta aacatcaaca gttcagtcca ttctctggta ctagctacaa
     3421 attcggtttc atactctact taacaattta aataaactga aatatttcta gatggtctac
     3481 ttctgttcat ataaaaacaa acctgatttc caaaaaaaaa aaaaaaaaaa a
//
