LOCUS       NM_001099331            1094 bp    mRNA    linear   ROD 30-JUL-2024
DEFINITION  Mus musculus R3H domain containing-like (R3hdml), mRNA.
ACCESSION   NM_001099331 XM_001481189
VERSION     NM_001099331.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1094)
  AUTHORS   Sakamoto,K., Furuichi,Y., Yamamoto,M., Takahashi,M., Akimoto,Y.,
            Ishikawa,T., Shimizu,T., Fujimoto,M., Takada-Watanabe,A.,
            Hayashi,A., Mita,Y., Manabe,Y., Fujii,N.L., Ishibashi,R.,
            Maezawa,Y., Betsholtz,C., Yokote,K. and Takemoto,M.
  TITLE     R3hdml regulates satellite cell proliferation and differentiation
  JOURNAL   EMBO Rep 20 (11), e47957 (2019)
   PUBMED   31524320
  REMARK    GeneRIF: Our results indicate that R3hdml is required for skeletal
            muscle development, regeneration, and, in particular, satellite
            cell proliferation and differentiation.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL591488.7.
            
            On Apr 23, 2009 this sequence version replaced NM_001099331.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7345562.1255249.1,
                                           SRR17784650.722877.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849377
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-435               AL591488.7         57602-58036
            436-554             AL591488.7         60973-61091
            555-687             AL591488.7         63579-63711
            688-803             AL591488.7         65099-65214
            804-1094            AL591488.7         67606-67896
FEATURES             Location/Qualifiers
     source          1..1094
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 84.31 cM"
     gene            1..1094
                     /gene="R3hdml"
                     /note="R3H domain containing-like"
                     /db_xref="GeneID:100043899"
                     /db_xref="MGI:MGI:3650937"
     exon            1..435
                     /gene="R3hdml"
                     /inference="alignment:Splign:2.1.0"
     CDS             175..936
                     /gene="R3hdml"
                     /note="peptidase inhibitor R3HDML; novel SCP-like
                     extracellular protein domain containing protein;
                     cysteine-rich secretory protein R3HDML"
                     /codon_start=1
                     /product="peptidase inhibitor R3HDML precursor"
                     /protein_id="NP_001092801.1"
                     /db_xref="CCDS:CCDS38316.1"
                     /db_xref="GeneID:100043899"
                     /db_xref="MGI:MGI:3650937"
                     /translation="MPLLSSIVGLTGLLLWMGHTVGALRMPNTTLVQGRPKNTAVWPL
                     SGLGVPRHRRKRHISARDMSALLDYHNHIRASVHPPAANMEYMVWDEQLARSAEAWAT
                     QCIWTHGPSQLMKYVGQNLSIHSGRFRSVVDLVRSWSEEKRHYSFPAPKDCTPHCPWL
                     CSGPVCSHYTQMVWASSSRLGCAINTCSSINVWGNTWQQAVYLVCNYAIKGNWIGEAP
                     YKAGKPCSACPPSYQGNCNSNMCFSGLKSNRLPWV"
     exon            436..554
                     /gene="R3hdml"
                     /inference="alignment:Splign:2.1.0"
     exon            555..687
                     /gene="R3hdml"
                     /inference="alignment:Splign:2.1.0"
     exon            688..803
                     /gene="R3hdml"
                     /inference="alignment:Splign:2.1.0"
     exon            804..1094
                     /gene="R3hdml"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1071..1076
                     /regulatory_class="polyA_signal_sequence"
                     /gene="R3hdml"
                     /note="hexamer: ATTAAA"
     polyA_site      1090
                     /gene="R3hdml"
                     /note="major polyA site"
ORIGIN      
        1 aaggattgag tatcgggacg agagctgggt cagaggatct ctgccaagtt cccaaggagc
       61 attctccaga ctggcagtgc tcaaggagag ttctcagggt ttggccttct catacccacc
      121 tcttctaggc agcagctcta actgcaccag acaggtacac catcccagac agctatgcct
      181 cttctgtcca gcatcgtggg cctcacaggc cttctccttt ggatgggtca cacagtgggg
      241 gccttacgga tgcccaacac cacactggtc cagggccgac ccaagaacac agctgtgtgg
      301 cccctgtctg gcctgggggt gccccggcac cgccggaagc gccacatctc tgctcgggac
      361 atgagcgctt tactggatta tcacaaccac atccgggcca gcgtacaccc acctgctgcc
      421 aacatggagt atatggtttg ggatgagcag ctggccaggt ctgctgaagc ctgggccacc
      481 cagtgcatct ggacccatgg accctcacag ctgatgaagt acgtgggcca gaacctctct
      541 atccattccg gccggttccg ttctgtggta gaccttgtga ggtcttggtc tgaggagaag
      601 cgccattact cattcccggc tccaaaggat tgcaccccac actgcccttg gctctgcagt
      661 ggtcctgtct gctcccacta tacccagatg gtgtgggcat cctccagtcg gctgggctgt
      721 gccattaaca cctgtagcag catcaatgtg tggggcaaca cctggcagca ggctgtctac
      781 ctggtctgca actacgccat taagggcaac tggatcggag aggcacccta caaggccggg
      841 aagccatgtt ctgcctgtcc tcccagttac caaggcaact gcaacagcaa catgtgcttc
      901 tctgggctca aatccaacag gctcccatgg gtctgaactg gcccaatgtt atgtcacccc
      961 tagctgggcc tgacccttga aagattcctc ccccaaaata agagggagaa caggaattgg
     1021 gcagccccta ccattcttta taaatgtctt ttctttaatg tcctgcatgc attaaaggag
     1081 tctcctcttc cttc
//
