LOCUS       NP_001161764            1044 aa            linear   ROD 27-APR-2025
DEFINITION  R3H domain-containing protein 2 isoform 1 [Mus musculus].
ACCESSION   NP_001161764
VERSION     NP_001161764.1
DBSOURCE    REFSEQ: accession NM_001168292.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 1044)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 1044)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Aizawa,H., Yuasa,S.,
            Nakajima,D., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: II. The complete nucleotide sequences of 400 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (1), 35-48 (2003)
   PUBMED   12693553
REFERENCE   3  (residues 1 to 1044)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ078477.1, AK122416.1, AK043545.1 and BC053099.1.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN00849375,
                              SAMN00849381 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1044
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 74.5 cM"
     Protein         1..1044
                     /product="R3H domain-containing protein 2 isoform 1"
                     /note="R3H domain-containing protein 2"
                     /calculated_mol_wt=114453
     Region          23..71
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q80TM6.2)"
     Site            37
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9Y2K5; propagated from
                     UniProtKB/Swiss-Prot (Q80TM6.2)"
     Region          106..147
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q80TM6.2)"
     Site            143
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q80TM6.2)"
     Region          168..229
                     /region_name="R3H_encore_like"
                     /note="R3H domain of encore-like and DIP1-like proteins.
                     Drosophila encore is involved in the germline exit after
                     four mitotic divisions, by facilitating
                     SCF-ubiquitin-proteasome-dependent proteolysis. Maize
                     DBF1-interactor protein 1 (DIP1) containing an R3H...;
                     cd02642"
                     /db_xref="CDD:100071"
     Site            order(201,205)
                     /site_type="other"
                     /note="RxxxH motif"
                     /db_xref="CDD:100071"
     Region          250..303
                     /region_name="SUZ"
                     /note="SUZ domain; pfam12752"
                     /db_xref="CDD:463689"
     Region          261..288
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q80TM6.2)"
     Region          320..408
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q80TM6.2)"
     Site            362
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9Y2K5; propagated from
                     UniProtKB/Swiss-Prot (Q80TM6.2)"
     Site            365
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q80TM6.2)"
     Site            381
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9Y2K5; propagated from
                     UniProtKB/Swiss-Prot (Q80TM6.2)"
     Region          433..485
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q80TM6.2)"
     Region          451..>800
                     /region_name="Med15"
                     /note="ARC105 or Med15 subunit of Mediator complex
                     non-fungal; pfam09606"
                     /db_xref="CDD:312941"
     Region          502..533
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q80TM6.2)"
     Region          551..600
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q80TM6.2)"
     Region          729..770
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q80TM6.2)"
     Region          807..848
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q80TM6.2)"
     Site            921
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9Y2K5; propagated from
                     UniProtKB/Swiss-Prot (Q80TM6.2)"
     Site            923
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9Y2K5; propagated from
                     UniProtKB/Swiss-Prot (Q80TM6.2)"
     Site            924
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q80TM6.2)"
     Site            928
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q80TM6.2)"
     CDS             1..1044
                     /gene="R3hdm2"
                     /gene_synonym="1300003K24Rik; mKIAA1002"
                     /coded_by="NM_001168292.1:221..3355"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS48717.1"
                     /db_xref="GeneID:71750"
                     /db_xref="MGI:MGI:1919000"
ORIGIN      
        1 msnsnttqet leimkesekk lveesvnknk fisktpsked vekegeengl rqetqrrtss
       61 hgharkraks nsklklvrsl avceesstpf vdgpldtqdi iqlhiscpsd keeekstkdv
      121 sekedkdksk ekvprkmlsr dssqeytdst gidlheflvn tlkknprdrm mllkleqeil
      181 dfindnnnqf kkfpqmtsyh rmllhrvaay fgmdhnvdqt gkaviinkts stripeqrfs
      241 ehikdeknte fqqrfilkrd dasmdrddnq mrvplqdgrr sksieereee yqrvrerifa
      301 retgqngyln dirlskeafs ssshkrrqif rgnreglsrt sssrqsstds elksleprpw
      361 sstdsdgsvr smrppvtkas sfsgisiltr gdsigsskgg sagrlsrpgm algapevcnq
      421 vtspqsvrgl lpctaqqqqq qqqqqqqlpa lpptpqhqpp lnnhmisqpv palqpspqpv
      481 qfspsscpqv llpvsppqqy nmaedlsnpf gqmslsrqgs teaadpssal fqpplisqhp
      541 qqasfimasa gqplptsnys tsshapptqq vlppqgymqp pqqiqvsyyp pgqypnsnqq
      601 yrplshpvay spqrgqqlpq asqqpglqpm msnqqqtayq gmlgvqqpqn qgllsnqrss
      661 mggqmqglvv qytplpsyqv pvgsdsqnvv qpsfqqpmlv pasqsvqggl ptggvpvyys
      721 mippaqqngt spsvgflqpp gseqyqmpqs pspcsppqms qqysgvspsg pgvvvmqlnv
      781 pngpqapqnp smvqwshcky ysveqrgqkp gdlyspdgsp qanaqmgssp vtsptqspap
      841 spvtslsnvc tglsplpvlt pfprpggpaq gdgrysllgq plqynlsicp pllhgqstyt
      901 vhqgqsglkh gnrgkrqalk sastdlgtad vvlgrvlevt dlpegitrte adklftqlam
      961 sgakiqwlkd aqglpgaggg dnsgtaengr hpdlaalyti vavfpsplaa qnaslrlnns
     1021 vsrfklrvak knydlriler assq
//
