LOCUS       NM_181750               4812 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus R3H domain containing 1 (R3hdm1), transcript variant
            1, mRNA.
ACCESSION   NM_181750 XM_484907
VERSION     NM_181750.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4812)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4812)
  AUTHORS   Nakano,Y., Wiechert,S. and Banfi,B.
  TITLE     Overlapping Activities of Two Neuronal Splicing Factors Switch the
            GABA Effect from Excitatory to Inhibitory by Regulating REST
  JOURNAL   Cell Rep 27 (3), 860-871 (2019)
   PUBMED   30995482
REFERENCE   3  (bases 1 to 4812)
  AUTHORS   Rehfeld,F., Maticzka,D., Grosser,S., Knauff,P., Eravci,M., Vida,I.,
            Backofen,R. and Wulczyn,F.G.
  TITLE     The RNA-binding protein ARPP21 controls dendritic branching by
            functionally opposing the miRNA it hosts
  JOURNAL   Nat Commun 9 (1), 1235 (2018)
   PUBMED   29581509
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4812)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   5  (bases 1 to 4812)
  AUTHORS   Hackler,L. Jr., Wan,J., Swaroop,A., Qian,J. and Zack,D.J.
  TITLE     MicroRNA profile of the developing mouse retina
  JOURNAL   Invest Ophthalmol Vis Sci 51 (4), 1823-1831 (2010)
   PUBMED   19933188
REFERENCE   6  (bases 1 to 4812)
  AUTHORS   Kalsotra,A., Xiao,X., Ward,A.J., Castle,J.C., Johnson,J.M.,
            Burge,C.B. and Cooper,T.A.
  TITLE     A postnatal switch of CELF and MBNL proteins reprograms alternative
            splicing in the developing heart
  JOURNAL   Proc Natl Acad Sci U S A 105 (51), 20333-20338 (2008)
   PUBMED   19075228
REFERENCE   7  (bases 1 to 4812)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Aizawa,H., Yuasa,S.,
            Nakajima,D., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: II. The complete nucleotide sequences of 400 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (1), 35-48 (2003)
   PUBMED   12693553
REFERENCE   8  (bases 1 to 4812)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY017957.1, BC049181.1 and BC032160.1.
            
            On or before Sep 3, 2004 this sequence version replaced
            XM_484907.1, NM_181750.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN00849384,
                              SAMN01164131 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-18                BY017957.1         13-30
            19-2053             BC049181.1         1-2035
            2054-4812           BC032160.1         945-3703
FEATURES             Location/Qualifiers
     source          1..4812
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="FVB/N"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 55.8 cM"
     gene            1..4812
                     /gene="R3hdm1"
                     /gene_synonym="R3hdm"
                     /note="R3H domain containing 1"
                     /db_xref="GeneID:226412"
                     /db_xref="MGI:MGI:2448514"
     exon            1..178
                     /gene="R3hdm1"
                     /gene_synonym="R3hdm"
                     /inference="alignment:Splign:2.1.0"
     exon            179..387
                     /gene="R3hdm1"
                     /gene_synonym="R3hdm"
                     /inference="alignment:Splign:2.1.0"
     exon            388..598
                     /gene="R3hdm1"
                     /gene_synonym="R3hdm"
                     /inference="alignment:Splign:2.1.0"
     CDS             428..3835
                     /gene="R3hdm1"
                     /gene_synonym="R3hdm"
                     /note="R3H domain (binds single-stranded nucleic acids);
                     R3H domain 1 (binds single-stranded nucleic acids)"
                     /codon_start=1
                     /product="R3H domain-containing protein 1"
                     /protein_id="NP_861415.2"
                     /db_xref="CCDS:CCDS15250.1"
                     /db_xref="GeneID:226412"
                     /db_xref="MGI:MGI:2448514"
                     /translation="MRMSDIVIIKDETETMKDLEAEMRDTTRVENLIKSENYGKISAE
                     KNEHCIDNNIDLQRPPQSFGQTGKRSKSSSKLKLVRSLAVCEESPPPPAAEISQETQE
                     KIQIQLTQSFEKEEKPSKDETDKEKASDKLPRKMLSRDSSQEYTDSTGIDLHEFLVNT
                     LKNNPRDRMMLLKLEQEILDFIGNNESPRKKFPPMTSYHRMLLHRVAAYFGLDHNVDQ
                     SGKSVIVNKTSNTRIPDQKFNEHIKDDRGEDFQKRYILKRDNSSFDKDDSQMRIRLKD
                     DRRSKSIEEREEEYQRARDRIFSQDSLCSQENYIIDKRIQDEDTIGTQQRRQIFRVNK
                     DASGRSTNSHQSSTENELKYSEPRPWSSTDSDSSLRNLKPAVTKASSFSGISVLTRGD
                     SSGSSKSIGRLSKTGSESSGSVGSSTGSLSHTQQPLPGSALSQSSHGAPVIYPAASNH
                     SSLSFDGGLSGQGASPSTSFLLLPLEATGIPPGSILINPQTGQPFLNPDGSPVVYNPP
                     MTQQPVRTQVPGPPQPPLPPPPPQQPAASHMFSQPVGPLQSSSQPVQCSPAPYPSPLL
                     PVSPTQQYSVDNLGAQFSHMSLARQPSADGSDPHATMFQSTVVLQSPQQSGYIVTTAP
                     PHPPPPPPPPPPPPSLPPGQSVPTASFSASGHPVSQPVLQQQGFLPQPSPQMPACYCA
                     PGHYHSSQPQYRPIPSVHHSSHLNQPLPQPAQHTGYQVMPNQQQNYQGIVGVQSPQSQ
                     SLMGGQPNSTGPHIQGVVIPYPSVPSYQVSLPQGSQGIAHQTYQQPVVFPNQSNQGSL
                     PTTGMPVYYSVIPPGQQSNLSSAVGYLQHPGSEQVQFPRTTSPCSSQQLQGHQCAAVP
                     QQPPGGGMVMMQLNLPNNPQSRTHSPPQWKQNKHYCDHQRGQKCMDFSNMDNIVQPSP
                     QLSSPILSPVQSPAPAQLSTLKTIRPSGPPLSIMSQFARPFVPGQGDARYPLLGQPLQ
                     YNPPTLLHGHIPHQQGQSGSRHGNRGRRQAKKAASTDLGAGEAVVGKVLEITELPDGI
                     TRVEAEKLFGELFKIGAKIRWLRDPQSQPQLRRHALCCGSGDNTVNPEHSKPSDLAST
                     YTVLATFPSISAAQSALKKQIHSVNKFKLRMSKKHYDFHILERASSQ"
     exon            599..640
                     /gene="R3hdm1"
                     /gene_synonym="R3hdm"
                     /inference="alignment:Splign:2.1.0"
     exon            641..730
                     /gene="R3hdm1"
                     /gene_synonym="R3hdm"
                     /inference="alignment:Splign:2.1.0"
     exon            731..845
                     /gene="R3hdm1"
                     /gene_synonym="R3hdm"
                     /inference="alignment:Splign:2.1.0"
     exon            846..924
                     /gene="R3hdm1"
                     /gene_synonym="R3hdm"
                     /inference="alignment:Splign:2.1.0"
     exon            925..984
                     /gene="R3hdm1"
                     /gene_synonym="R3hdm"
                     /inference="alignment:Splign:2.1.0"
     exon            985..1125
                     /gene="R3hdm1"
                     /gene_synonym="R3hdm"
                     /inference="alignment:Splign:2.1.0"
     exon            1126..1234
                     /gene="R3hdm1"
                     /gene_synonym="R3hdm"
                     /inference="alignment:Splign:2.1.0"
     exon            1235..1330
                     /gene="R3hdm1"
                     /gene_synonym="R3hdm"
                     /inference="alignment:Splign:2.1.0"
     exon            1331..1368
                     /gene="R3hdm1"
                     /gene_synonym="R3hdm"
                     /inference="alignment:Splign:2.1.0"
     exon            1369..1419
                     /gene="R3hdm1"
                     /gene_synonym="R3hdm"
                     /inference="alignment:Splign:2.1.0"
     exon            1420..1646
                     /gene="R3hdm1"
                     /gene_synonym="R3hdm"
                     /inference="alignment:Splign:2.1.0"
     exon            1647..1901
                     /gene="R3hdm1"
                     /gene_synonym="R3hdm"
                     /inference="alignment:Splign:2.1.0"
     exon            1902..2053
                     /gene="R3hdm1"
                     /gene_synonym="R3hdm"
                     /inference="alignment:Splign:2.1.0"
     exon            2054..2155
                     /gene="R3hdm1"
                     /gene_synonym="R3hdm"
                     /inference="alignment:Splign:2.1.0"
     exon            2156..2452
                     /gene="R3hdm1"
                     /gene_synonym="R3hdm"
                     /inference="alignment:Splign:2.1.0"
     exon            2453..2576
                     /gene="R3hdm1"
                     /gene_synonym="R3hdm"
                     /inference="alignment:Splign:2.1.0"
     exon            2577..2731
                     /gene="R3hdm1"
                     /gene_synonym="R3hdm"
                     /inference="alignment:Splign:2.1.0"
     exon            2732..2883
                     /gene="R3hdm1"
                     /gene_synonym="R3hdm"
                     /inference="alignment:Splign:2.1.0"
     exon            2884..2987
                     /gene="R3hdm1"
                     /gene_synonym="R3hdm"
                     /inference="alignment:Splign:2.1.0"
     exon            2988..3160
                     /gene="R3hdm1"
                     /gene_synonym="R3hdm"
                     /inference="alignment:Splign:2.1.0"
     exon            3161..3305
                     /gene="R3hdm1"
                     /gene_synonym="R3hdm"
                     /inference="alignment:Splign:2.1.0"
     exon            3306..3388
                     /gene="R3hdm1"
                     /gene_synonym="R3hdm"
                     /inference="alignment:Splign:2.1.0"
     exon            3389..3473
                     /gene="R3hdm1"
                     /gene_synonym="R3hdm"
                     /inference="alignment:Splign:2.1.0"
     exon            3474..4812
                     /gene="R3hdm1"
                     /gene_synonym="R3hdm"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtgcgtggt gggaaggggc gggattctgc cgccgcggct gccgctggag ccggtgtccg
       61 ggctggtgat ggggttaatt cccttccgtg agactctacc ttgcaaccag ccggccccgc
      121 cgtcgccccg ctgtgccgcg ctcccgccac ctcctcctgc tccttctcag taacgcgggc
      181 cactgaaagg tatgatatat ttgatccaag acagtccatt tcagcccagg aatctacagt
      241 ggtgacaagg acatgggact cctcccgcca gattactgtt ggttcaatac atttgacatc
      301 ctggctgaca actgtgaaga ggaaccttgg gttattttat tttatttttg tggaacacca
      361 caatctcaga tccataggac acatcaggct tcaagttccc tgtagaattc taaaataacc
      421 tttgctaatg aggatgtctg atattgttat tataaaagat gaaactgaaa caatgaagga
      481 tttggaggca gaaatgagag atacaaccag agttgaaaat cttatcaaat cagaaaacta
      541 tgggaagatt tcggcagaga agaatgaaca ttgtattgac aacaatattg atttgcagcg
      601 gcccccgcag tcatttggac agacaggaaa aaggtctaag tcaagctcaa agttaaagct
      661 agttcggagc cttgcagtat gtgaagaatc tccaccaccc cctgcagcag agatatcaca
      721 ggagacccag gagaaaattc agatacagtt aacacaatca tttgaaaaag aggaaaagcc
      781 ctcaaaagat gaaacagata aagaaaaagc cagtgataag ttacccagaa aaatgttatc
      841 aagagattcc agccaagaat acactgattc aactggcata gatctacatg aatttttagt
      901 aaatacatta aaaaacaatc ccagggacag aatgatgctg ctgaaattgg aacaagaaat
      961 tttagatttc attggtaata atgagtcccc acgtaagaag tttcccccga tgacatctta
     1021 ccacaggatg ctgttacaca gagtggctgc ctactttgga ttagaccaca atgttgatca
     1081 gagtgggaag tctgtcatag tgaacaaaac tagcaacaca agaatacctg atcagaaatt
     1141 taatgaacat ataaaggatg atagaggtga agactttcag aaacgataca tccttaagag
     1201 agataactct agctttgaca aagatgatag ccagatgaga atacgtttga aagatgacag
     1261 aagaagcaaa tctatagaag aaagagaaga agaataccag agagctagag accgaatatt
     1321 ttcccaagat tccctgtgtt cccaagaaaa ctacattatt gacaaaagaa tccaagatga
     1381 ggacactatt ggtacccagc agaggcgcca gatatttaga gttaataaag atgcttcagg
     1441 ccgatcgaca aacagccatc agagcagcac tgaaaatgag ttgaaatact cagagccacg
     1501 accctggagc agcaccgatt cagacagctc cctcagaaac ctgaaacccg ctgtcaccaa
     1561 agccagcagc tttagcggaa tctcagtcct gacaagaggt gatagctctg gaagcagcaa
     1621 aagcataggc aggctttcaa aaacaggatc tgagtcttca ggtagtgtag ggtcctctac
     1681 aggctctctt tctcacaccc agcagcctct cccaggttca gctcttagcc agtcttctca
     1741 tggcgcacct gtcatctacc cggcagccag caatcacagt tctctttcct ttgatggtgg
     1801 cctcagtggt caaggtgcat ctcctagcac tagcttcctt ttgcttccct tggaagcaac
     1861 tggcatacca cctggcagta ttctgatcaa cccacaaaca ggtcagccct tcttaaaccc
     1921 agatggaagt ccagttgtgt acaatcctcc tatgactcaa cagccagttc gaacccaagt
     1981 gcctggtcct ccacagccac ctctgccacc cccaccacct cagcagccag cagccagtca
     2041 catgttctca cagcctgttg gtcctctgca gtcctcttct cagcctgttc agtgctctcc
     2101 agccccctac ccatccccgc tcctgccagt ctcacccacc cagcagtact ccgtggataa
     2161 ccttggcgct cagttcagcc atatgagtct tgcccgccag ccatcagctg atggttctga
     2221 ccctcatgcc accatgttcc agtccactgt tgtactacag tctccacagc agtctggtta
     2281 catcgtgacg acagcacctc cacatccgcc accaccacct ccaccacctc cccctcctcc
     2341 ttccctacca cctgggcagt cagtccccac tgccagtttc tctgcctctg ggcatcctgt
     2401 cagccagcct gtgctccagc agcaggggtt tcttcctcag ccctcaccac agatgccagc
     2461 ctgttactgt gctccaggcc actatcactc cagccaacct cagtaccgcc ctatcccttc
     2521 tgtccatcac agttcacacc taaaccaacc actgccacag cctgcacagc acacaggtta
     2581 tcaagttatg cccaaccagc agcaaaacta ccaaggaata gttggagttc agtcaccgca
     2641 gagtcagagc ctcatgggag gccagccaaa cagcactgga cctcatatcc aaggagtggt
     2701 catcccctac ccctcagtgc catcatatca ggtttcactg cctcaaggtt ctcaaggaat
     2761 tgcccatcag acttatcaac agcctgttgt gttccctaat cagtctaatc aaggatctct
     2821 gcccacaaca ggaatgccag tctattacag tgtcattcca cctggccaac aaagtaattt
     2881 aagctctgca gttggttact tacaacatcc agggtcagaa caagtacagt ttcctcgaac
     2941 cacgtcacca tgcagctctc aacagctcca aggccaccag tgtgcagctg tgccacagca
     3001 gccacctggt ggaggaatgg taatgatgca gctcaaccta ccaaataacc cacagtctcg
     3061 gacccactca cccccacagt ggaaacagaa caagcactac tgtgaccacc agagaggaca
     3121 gaagtgtatg gactttagca acatggataa tattgttcag cccagccctc agctcagcag
     3181 ccccatcctt tctccagtgc agtcgccagc accagctcag ctgtccactc tgaagaccat
     3241 ccgtccctca ggaccaccgc tttccatcat gtcccagttt gctagacctt ttgttcctgg
     3301 acagggagat gccaggtatc cgctgcttgg ccagcccctg cagtacaacc ctcctactct
     3361 tctgcatgga cacattccac atcaacaggg tcagtctggc agcaggcatg gaaaccgagg
     3421 acgtagacaa gctaagaaag ctgcatccac agaccttgga gcaggagaag cagttgtcgg
     3481 caaggtcttg gaaatcacag aactaccaga cggaataact cgagtggaag ccgagaagct
     3541 ttttggggaa ctctttaaaa ttggcgccaa gatccgatgg ctccgggacc cccagtctca
     3601 gcctcagctg cgtcgtcacg ctctctgctg tggtagtggg gataacactg tcaaccctga
     3661 gcactctaaa cccagtgacc tggcctctac gtacactgtc ctagctacgt tcccctccat
     3721 ttcagctgca cagagtgcac tgaagaagca gatccattca gtgaacaagt ttaagctgag
     3781 aatgagcaag aagcactacg atttccacat tttggaaagg gcaagttctc agtaaaccag
     3841 ccgctacctt tggacccctc actctataat tccctgccct ctcccatctg attggcttgt
     3901 taagtggagc gtatgtaata tagagactcc tgggatgttt ggccatatgt taccgctttt
     3961 ggaagaaagt ccagggaccc agaaaaggga gggggaagat acccatttca ccccagcgtc
     4021 tataggaatc cacacgggaa tggttcagag ttagcagctg tttctaagga aatgctgttc
     4081 agatgcctcc taacttttat agttattttg ttttatattt ctgaattctt gtatcagatc
     4141 caaagctcta ttgtacagca aattattctt caaagtgatt ataaccagtt acaacctgta
     4201 tttctttttg cagccagcac agtgtgaacc aactcagact ttgagagaaa aagaatgcag
     4261 gagtggaata accaagtcaa aaaccatgtc aaaactatcc tctggggggt gctgagggtg
     4321 ctatggagac ccacaaataa acaattactc ctccactgaa ttgctaaaca cagaaaaatt
     4381 tccaggaaat ccagaactcc ccaacagggt ccttcttctt catttaggta gtgtggccgt
     4441 taagtgtaag gtaaattatg ttctcgatgc ctcctaatca aaccacttag gttagaaaga
     4501 aacaggaatc atcctaggca ggaaaattac tccacttttt tttaagtgtc cttccaataa
     4561 ctaatgccac tcatcagcat tgtcctcttt ggaaattttg tcctcctgag gaaatgcact
     4621 tgacgagtgc tgaaaacttc ttaagtggtt taaattttgt tttcattgtt tgcagcggat
     4681 tactggacat caaagattca ttgcacttat gaacaaggaa ccttattttc aatttctgtg
     4741 taattttgca aggctgtaca atgtgctgat gcaagccttt ttcagttcaa gagaataaat
     4801 gtttacaaat gt
//
