LOCUS       NM_001146012            1749 bp    mRNA    linear   ROD 13-AUG-2022
DEFINITION  Mus musculus R3H domain and coiled-coil containing 1 (R3hcc1),
            transcript variant 2, mRNA.
ACCESSION   NM_001146012 XM_001479474 XM_913986
VERSION     NM_001146012.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1749)
  AUTHORS   Lee S, Liu B, Lee S, Huang SX, Shen B and Qian SB.
  TITLE     Global mapping of translation initiation sites in mammalian cells
            at single-nucleotide resolution
  JOURNAL   Proc Natl Acad Sci U S A 109 (37), E2424-E2432 (2012)
   PUBMED   22927429
  REMARK    GeneRIF: Ribosome profiling indicates that this gene can use a
            non-AUG (CUG) start codon in both human HEK293 and mouse embryonic
            fibroblast cells.
REFERENCE   2  (bases 1 to 1749)
  AUTHORS   Gaudet P, Livstone MS, Lewis SE and Thomas PD.
  TITLE     Phylogenetic-based propagation of functional annotations within the
            Gene Ontology consortium
  JOURNAL   Brief Bioinform 12 (5), 449-462 (2011)
   PUBMED   21873635
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC160639.2, AK032854.1 and BQ747890.1.
            
            [WARNING] On Jan 10, 2025 this sequence was replaced by
            NM_001146012.3.
            
            On Aug 28, 2014 this sequence version replaced NM_001146012.1.
            
            Transcript Variant: This variant (2) contains an alternate 5'
            terminal exon, and it thus differs in the 5' UTR and initiates
            translation at a downstream in-frame start codon, compared to
            variant 1. The encoded isoform (b) is shorter at the N-terminus,
            compared to isoform a. Both variants 2 and 3 encode isoform b.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK156843.1, AK032854.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164138, SAMN01164139
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            non-AUG initiation codon :: PMID: 22927429
            RefSeq Select criteria   :: based on expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-31                AC160639.2         9029-9059
            32-1726             AK032854.1         2-1696
            1727-1749           BQ747890.1         591-613
FEATURES             Location/Qualifiers
     source          1..1749
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 36.08 cM"
     gene            1..1749
                     /gene="R3hcc1"
                     /gene_synonym="1700020M16Rik"
                     /note="R3H domain and coiled-coil containing 1"
                     /db_xref="GeneID:71843"
                     /db_xref="MGI:MGI:1919093"
     exon            1..79
                     /gene="R3hcc1"
                     /gene_synonym="1700020M16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            80..207
                     /gene="R3hcc1"
                     /gene_synonym="1700020M16Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             98..1564
                     /gene="R3hcc1"
                     /gene_synonym="1700020M16Rik"
                     /note="isoform b is encoded by transcript variant 2;
                     non-AUG (CUG) translation initiation codon; R3H and
                     coiled-coil domain-containing protein 1"
                     /codon_start=1
                     /product="R3H and coiled-coil domain-containing protein 1
                     isoform b"
                     /protein_id="NP_001139484.2"
                     /db_xref="CCDS:CCDS49533.2"
                     /db_xref="GeneID:71843"
                     /db_xref="MGI:MGI:1919093"
                     /translation="MALLCLDGVFLSSAENDFVHRVQEELDRFLLQKQLSKVLLFPPV
                     SSRLRYLIHRTAENFDLLSSFSVGEGWKRRTVICHLDIRVPSSDGPSGPCRPPASHPS
                     KYRGPRYTSHQGAAAGPRGAPAGRWHRGRKPDQPLYVPRVLRRQGGPVAASIPGIKGE
                     DPAGAVSEEEPREAGAGDAEADQGIAMLVTQELLKSPDPGHANEPQMGLGDTEPSENP
                     EKEQGAETAVQQGSGAQLAMEEENRSHGMRSLVDQEEEEIEGEEEEKVDEKEEDTGKQ
                     KERVDEEEEKTDAQEGKVDSEGERMDEGEDKVDAEEEDEDEADADHGDFSELLQEITA
                     NLTEKEIKIEKIHLDTSAFTEELPGERDLTHLVEIYDFKPTLKTEDLLATFSEFQEKG
                     FRIQWVDDTHAIGIFPCPASALEALAKDFSVLKIRPLTQGTKQSKLKALQRPKFLRLS
                     KERPQTDSAVARRLVARALGLQHNRKKELPTPPSVLPS"
     exon            208..345
                     /gene="R3hcc1"
                     /gene_synonym="1700020M16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            346..1090
                     /gene="R3hcc1"
                     /gene_synonym="1700020M16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1091..1263
                     /gene="R3hcc1"
                     /gene_synonym="1700020M16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1264..1334
                     /gene="R3hcc1"
                     /gene_synonym="1700020M16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1335..1430
                     /gene="R3hcc1"
                     /gene_synonym="1700020M16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1431..1729
                     /gene="R3hcc1"
                     /gene_synonym="1700020M16Rik"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgctaattcc gctgggaaga aggggacgct caggctcttg gggaccctga gcgcggcggc
       61 aactttccga gctgccgcgg ctctgccatc tgtcaccctg gcccttctct gcttggacgg
      121 tgtcttcctc tcctcggccg aaaatgactt tgtccaccgg gtccaagagg agctcgatcg
      181 tttcctgctg cagaagcagc tatccaaggt cctacttttt cccccagtct ccagccgcct
      241 gcggtacctg atccatcgaa cggcggagaa ttttgatctt ttgagcagct tctctgttgg
      301 ggagggctgg aagaggagga cagtcatttg tcacctggac atcagagtac ccagttcaga
      361 tggcccctct ggtccctgcc gccctcctgc ctcccatccc agcaagtacc gtggtcctcg
      421 gtatacctca catcagggag cagctgctgg tccccgaggt gctccagcag gacgctggca
      481 tcgtggacgg aagccggatc agcctctgta tgtgccccgg gtgctacgca ggcaaggtgg
      541 accggtggca gcctccatcc caggcatcaa gggagaggac ccagctggtg cagtgtcaga
      601 agaagagcct agagaggctg gtgctgggga cgctgaggct gatcagggaa ttgccatgtt
      661 ggtgactcaa gagctcctga agagccccga cccaggccat gcaaatgagc cacagatggg
      721 gttgggtgac acggagccct ctgagaatcc tgaaaaggaa caaggggctg agacagctgt
      781 gcagcagggg tccggcgcac aactggccat ggaggaggaa aataggagtc atgggatgcg
      841 gagcctggtg gaccaagagg aggaggagat agagggagag gaggaagaga aggtggacga
      901 gaaggaagag gacacaggca agcagaaaga gcgggtcgat gaggaggaag agaagactga
      961 tgcgcaggaa gggaaggtgg attcggaggg agagaggatg gatgaaggtg aagacaaggt
     1021 ggatgcggag gaagaggacg aggatgaggc cgatgctgac cacggtgatt tcagtgagct
     1081 gctgcaggag atcacagcca acctgaccga aaaggagatt aaaatagaga agatccacct
     1141 ggacacatcc gccttcacag aagagctgcc cggggagagg gacttgaccc acctggtgga
     1201 gatctatgac tttaagccaa cactcaagac cgaggacctg ttggccactt tctctgagtt
     1261 ccaagagaag ggattcagaa tccagtgggt ggatgacact catgctatcg gcatctttcc
     1321 ctgccctgcc tcagcactcg aggcactggc caaggatttc tccgtgctca agatccgccc
     1381 gctcacacag gggaccaagc agtccaagct gaaagccttg cagaggccaa agttcctgcg
     1441 actatcgaag gagaggccgc agacagattc agcggtggcc cgcaggctgg tggcccgggc
     1501 cttgggactc caacacaaca gaaagaaaga gctgcctact cccccaagtg ttctgccatc
     1561 ttgaggcccc ggacccagct ctccgaatta ggctggggcc cagtaccaca cgcctttaca
     1621 gataccagga cagccccttt gccctcactg gagctgctat ggggcacagc aggctttagt
     1681 tggtctgctc tcagaaattg agaagaaata aaaatttaaa gttggtgtaa aaaaaaaaaa
     1741 aaaaaaaaa
//
