LOCUS       NM_001356329            2863 bp    mRNA    linear   ROD 07-AUG-2023
DEFINITION  Mus musculus queuine tRNA-ribosyltransferase accessory subunit 2
            (Qtrt2), transcript variant 1, mRNA.
ACCESSION   NM_001356329 XM_006521668
VERSION     NM_001356329.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2863)
  AUTHORS   Sebastiani M, Behrens C, Dorr S, Gerber HD, Benazza R,
            Hernandez-Alba O, Cianferani S, Klebe G, Heine A and Reuter K.
  TITLE     Structural and Biochemical Investigation of the Heterodimeric
            Murine tRNA-Guanine Transglycosylase
  JOURNAL   ACS Chem Biol 17 (8), 2229-2247 (2022)
   PUBMED   35815944
  REMARK    GeneRIF: Structural and Biochemical Investigation of the
            Heterodimeric Murine tRNA-Guanine Transglycosylase.
REFERENCE   2  (bases 1 to 2863)
  AUTHORS   Behrens C, Biela I, Petiot-Becard S, Botzanowski T, Cianferani S,
            Sager CP, Klebe G, Heine A and Reuter K.
  TITLE     Homodimer Architecture of QTRT2, the Noncatalytic Subunit of the
            Eukaryotic tRNA-Guanine Transglycosylase
  JOURNAL   Biochemistry 57 (26), 3953-3965 (2018)
   PUBMED   29862811
  REMARK    GeneRIF: In the crystal, QTRT2 is clearly present as a homodimer
            that is strikingly similar to that formed by bacterial TGT. In
            particular, a cluster of four aromatic residues within the
            interface of the bacterial TGT, which constitutes a 'hot spot' for
            dimer stability, is present in a similar constellation in QTRT2.
REFERENCE   3  (bases 1 to 2863)
  AUTHORS   Boland C, Hayes P, Santa-Maria I, Nishimura S and Kelly VP.
  TITLE     Queuosine formation in eukaryotic tRNA occurs via a
            mitochondria-localized heteromeric transglycosylase
  JOURNAL   J Biol Chem 284 (27), 18218-18227 (2009)
   PUBMED   19414587
  REMARK    GeneRIF: TGT weakly interacts with the outer mitochondrial membrane
            possibly through association with Qv1(QTRD1 variant 1), which was
            found to be stably associated with the organelle
REFERENCE   4  (bases 1 to 2863)
  AUTHORS   Stryke D, Kawamoto M, Huang CC, Johns SJ, King LA, Harper CA, Meng
            EC, Lee RE, Yee A, L'Italien L, Chuang PT, Young SG, Skarnes WC,
            Babbitt PC and Ferrin TE.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CT025520.10.
            
            [WARNING] On Sep 12, 2023 this sequence was replaced by
            NM_001356329.3.
            
            On Apr 22, 2022 this sequence version replaced NM_001356329.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR13422598.657486.1,
                                           SRR17253013.732103.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164137, SAMN01164138
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-90                CT025520.10        84819-84908
            91-311              CT025520.10        93262-93482
            312-367             CT025520.10        94121-94176
            368-444             CT025520.10        96442-96518
            445-657             CT025520.10        97634-97846
            658-857             CT025520.10        102655-102854
            858-1009            CT025520.10        105378-105529
            1010-1127           CT025520.10        106948-107065
            1128-2863           CT025520.10        111174-112909
FEATURES             Location/Qualifiers
     source          1..2863
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 28.44 cM"
     gene            1..2863
                     /gene="Qtrt2"
                     /gene_synonym="3110012M05Rik; 4930470H18Rik; Qrtr2;
                     Qtrtd1"
                     /note="queuine tRNA-ribosyltransferase accessory subunit
                     2"
                     /db_xref="GeneID:106248"
                     /db_xref="MGI:MGI:1922194"
     exon            1..90
                     /gene="Qtrt2"
                     /gene_synonym="3110012M05Rik; 4930470H18Rik; Qrtr2;
                     Qtrtd1"
                     /inference="alignment:Splign:2.1.0"
     exon            91..311
                     /gene="Qtrt2"
                     /gene_synonym="3110012M05Rik; 4930470H18Rik; Qrtr2;
                     Qtrtd1"
                     /inference="alignment:Splign:2.1.0"
     exon            312..367
                     /gene="Qtrt2"
                     /gene_synonym="3110012M05Rik; 4930470H18Rik; Qrtr2;
                     Qtrtd1"
                     /inference="alignment:Splign:2.1.0"
     exon            368..444
                     /gene="Qtrt2"
                     /gene_synonym="3110012M05Rik; 4930470H18Rik; Qrtr2;
                     Qtrtd1"
                     /inference="alignment:Splign:2.1.0"
     exon            445..657
                     /gene="Qtrt2"
                     /gene_synonym="3110012M05Rik; 4930470H18Rik; Qrtr2;
                     Qtrtd1"
                     /inference="alignment:Splign:2.1.0"
     exon            658..857
                     /gene="Qtrt2"
                     /gene_synonym="3110012M05Rik; 4930470H18Rik; Qrtr2;
                     Qtrtd1"
                     /inference="alignment:Splign:2.1.0"
     exon            858..1009
                     /gene="Qtrt2"
                     /gene_synonym="3110012M05Rik; 4930470H18Rik; Qrtr2;
                     Qtrtd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1010..1127
                     /gene="Qtrt2"
                     /gene_synonym="3110012M05Rik; 4930470H18Rik; Qrtr2;
                     Qtrtd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1128..2863
                     /gene="Qtrt2"
                     /gene_synonym="3110012M05Rik; 4930470H18Rik; Qrtr2;
                     Qtrtd1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtgggccaa gggttctacg agtcggaaca cgtgttatct cttgcgaaga gtttaagggt
       61 cctgagggtg cggagttgtg ttatcaaccg aacacagaag aatcccaaat gatgaagctg
      121 agtctcatca aagtcgttaa tggctgtcgt ctaggaaaaa tacaaaacct gggcaaagca
      181 ggggactgca cggtggacat tccgggctgt cttctctaca ccaggactgg ctctgcccca
      241 cacctgacac atcagacgct gcgtaacatc cacggggtcc caggcatagc ccagctcaca
      301 ctctcatccc tagcagaaca tcatgaagtc ttggcagaat ataagaaagg agttggaagc
      361 tttataggca tgccggaatc actcttctat tgttccctgc acgatccagt cacccccggc
      421 ccagctggtt atgtaacaag taagtctgtg tccgtgtggg gttttggagg tcgagtggaa
      481 atgactgttt ccaagttcat ggcaattcag gaggccctgc agccagattg gttccagtgc
      541 ctctcggatg gggaagcatc ttgtgcagaa acaacttcca taaaacgggc caggaagtct
      601 gtggaccgct cgcttctgtt cctggacagc tgtttgcgac tacaggagga gtctgaggtc
      661 ctccagaaaa gtgtgatcat tggagtgatt gagggtggag atgtgatgga agagaggttg
      721 aggtcagcac gagagacagc caagcgaccc gtcgggggct tcctgctgga cggctttcaa
      781 ggggatccag cagtcacaga aaccagactg cacttgctgt catcagtcac tgcagagctg
      841 ccagaggaca aaccaaggct catctgcggt gtcagccggc cagacgaagt gctagagtgc
      901 atcgaaaggg gagtggactt gtttgagagt tttttcccat atcaagtgac cgagcggggc
      961 tgtgccctga ctttcacctt tgattgccag ctgaatcctg aggagacact attgcaacaa
     1021 aatggaatcc aagaaaaaat aaaaggcttg gatcaagcaa agaaaattga agcaactggt
     1081 tgcaaccaag agatgacgtc atttgaaatt aatctgaagg agaaaaagta ccaggaagac
     1141 tttgacccgc ttgtaagagg gtgctcctgt tactgctgta agaaccacac tcgtgcgtat
     1201 atccaccatc ttctgatgac caacgagctg ctggctggtg tcctccttat gatgcacaac
     1261 tttgagcact actttggatt tttctgctcc atccgagaag cactaaagaa tgacacactg
     1321 gcacagctga aagaactcat ttgcagacag atgttttgag aactggaaaa tataagcctg
     1381 tctcatcttc agaaacagtg aaatggcaga gatctgagct ctcagcggtt acggtgggac
     1441 caaagagcat ctgccccacc ctgcccacag gagtgtggag gaaggccttc tgcagatttc
     1501 ttggcccata tcgatcagaa ctgtgacttt atttttctag gtttattctt ctagtgagat
     1561 tcctttagtt gaagacaaaa gtattagata tgagagagcc ttgaaaggat ttgaggtttt
     1621 aggaaccagt gagatgggtg aggcccgagt ggagatggct gtcatagctg gaagcacagc
     1681 tattccctgg agaagtcatc tagctgattc cacaggcttt tatttgtttc tcctcatgct
     1741 ctcaggggct ttgggccata cctttgtctt cagggctacc acaacaacta ccacttaggg
     1801 ttctcctgcc ttaaacatgt tcatatgtcc caggaatatg gggctcaggc catgcttttg
     1861 tgatccgttg acgtcatttg gctacaagtc tttttgtgcc tgggtcttct gacaaccact
     1921 gtacttgccc atgaggaacc aaatattgcc tagctgctct gtctggttgt gcagatccag
     1981 ctaacagctt catcctctaa actgtcctgc tgtgtctgta atgactggct ctgtcacttg
     2041 gaggagattc ctttgctgtg tgttgatgtg gccccaatcc tggcctgaca gcagatcggt
     2101 ttccattcca cacagctgta agctcaggca aatgctgact tttctgtgtc cgtcccctcg
     2161 tgagtaaaca gggacaggca tcgcaggtgg aggcagaatg ttcagaagct gcgtcatact
     2221 ctccatcctt atttactaag ctctgtcggc ctcacccctt ccccacgttc tttctttttt
     2281 tgtttttgtt tgtctgtctg ttttgtttgt atccagccat aagattgtcc tgtggatttt
     2341 gaagtggttg gtgaattggc attcttctga ccctgaggct ggttgtccct ccggggttct
     2401 ctgtaattct gtatttttgt ggtggcatga cagggctttt tttttgtatg tatcttttct
     2461 atatttatca atttttttaa ggagtacaca aaacatatat gtatatacat gtagttttta
     2521 taaaaataat acaatttaaa agattcattt ttgtaggtgt aagaaatgca tttcttatat
     2581 ttgtttggtt tccaatttat agtggccatt actgaacatt gtatgtagga attatgtaat
     2641 tactgtactt ttatgtgctg gaaatccaac gttgtttttc ctttttgtgg tatgacttgt
     2701 tgatgaatgc aagggattca tagaatgcag acgcagagac agagtttctg ttctcagtga
     2761 tctgtgttga atggattttg tacttgttta tatgttttat ccttggccaa gaccaaaccc
     2821 attattgaag gattattagt aaatatctaa gaatccatat aaa
//
