LOCUS       NM_021888               1328 bp    mRNA    linear   ROD 01-OCT-2024
DEFINITION  Mus musculus queuine tRNA-ribosyltransferase catalytic subunit 1
            (Qtrt1), mRNA.
ACCESSION   NM_021888 XM_978348 XM_978378 XM_980968 XM_981004
VERSION     NM_021888.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1328)
  AUTHORS   Cirzi,C., Dyckow,J., Legrand,C., Schott,J., Guo,W., Perez
            Hernandez,D., Hisaoka,M., Parlato,R., Pitzer,C., van der Hoeven,F.,
            Dittmar,G., Helm,M., Stoecklin,G., Schirmer,L., Lyko,F. and
            Tuorto,F.
  TITLE     Queuosine-tRNA promotes sex-dependent learning and memory formation
            by maintaining codon-biased translation elongation speed
  JOURNAL   EMBO J 42 (19), e112507 (2023)
   PUBMED   37609797
REFERENCE   2  (bases 1 to 1328)
  AUTHORS   Zhang,J., Zhang,Y., McGrenaghan,C.J., Kelly,V.P., Xia,Y. and Sun,J.
  TITLE     Disruption to tRNA Modification by Queuine Contributes to
            Inflammatory Bowel Disease
  JOURNAL   Cell Mol Gastroenterol Hepatol 15 (6), 1371-1389 (2023)
   PUBMED   36801450
REFERENCE   3  (bases 1 to 1328)
  AUTHORS   Sebastiani,M., Behrens,C., Dorr,S., Gerber,H.D., Benazza,R.,
            Hernandez-Alba,O., Cianferani,S., Klebe,G., Heine,A. and Reuter,K.
  TITLE     Structural and Biochemical Investigation of the Heterodimeric
            Murine tRNA-Guanine Transglycosylase
  JOURNAL   ACS Chem Biol 17 (8), 2229-2247 (2022)
   PUBMED   35815944
  REMARK    GeneRIF: Structural and Biochemical Investigation of the
            Heterodimeric Murine tRNA-Guanine Transglycosylase.
REFERENCE   4  (bases 1 to 1328)
  AUTHORS   Muller,M., Legrand,C., Tuorto,F., Kelly,V.P., Atlasi,Y., Lyko,F.
            and Ehrenhofer-Murray,A.E.
  TITLE     Queuine links translational control in eukaryotes to a
            micronutrient from bacteria
  JOURNAL   Nucleic Acids Res 47 (7), 3711-3727 (2019)
   PUBMED   30715423
REFERENCE   5  (bases 1 to 1328)
  AUTHORS   Varghese,S., Cotter,M., Chevot,F., Fergus,C., Cunningham,C.,
            Mills,K.H., Connon,S.J., Southern,J.M. and Kelly,V.P.
  TITLE     In vivo modification of tRNA with an artificial nucleobase leads to
            full disease remission in an animal model of multiple sclerosis
  JOURNAL   Nucleic Acids Res 45 (4), 2029-2039 (2017)
   PUBMED   28204548
REFERENCE   6  (bases 1 to 1328)
  AUTHORS   Rakovich,T., Boland,C., Bernstein,I., Chikwana,V.M., Iwata-Reuyl,D.
            and Kelly,V.P.
  TITLE     Queuosine deficiency in eukaryotes compromises tyrosine production
            through increased tetrahydrobiopterin oxidation
  JOURNAL   J Biol Chem 286 (22), 19354-19363 (2011)
   PUBMED   21487017
REFERENCE   7  (bases 1 to 1328)
  AUTHORS   Boland,C., Hayes,P., Santa-Maria,I., Nishimura,S. and Kelly,V.P.
  TITLE     Queuosine formation in eukaryotic tRNA occurs via a
            mitochondria-localized heteromeric transglycosylase
  JOURNAL   J Biol Chem 284 (27), 18218-18227 (2009)
   PUBMED   19414587
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY291101.1, AB034632.1 and AI842405.1.
            
            On Oct 12, 2007 this sequence version replaced NM_021888.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC044811.1, AK011586.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-445               BY291101.1         1-445
            446-1230            AB034632.1         380-1164
            1231-1328           AI842405.1         9-106               c
FEATURES             Location/Qualifiers
     source          1..1328
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 7.79 cM"
     gene            1..1328
                     /gene="Qtrt1"
                     /gene_synonym="2610028E17Rik; Tgt"
                     /note="queuine tRNA-ribosyltransferase catalytic subunit
                     1"
                     /db_xref="GeneID:60507"
                     /db_xref="MGI:MGI:1931441"
     exon            1..261
                     /gene="Qtrt1"
                     /gene_synonym="2610028E17Rik; Tgt"
                     /inference="alignment:Splign:2.1.0"
     CDS             19..1230
                     /gene="Qtrt1"
                     /gene_synonym="2610028E17Rik; Tgt"
                     /EC_number="2.4.2.64"
                     /note="guanine insertion enzyme; tRNA-guanine
                     transglycosylase; queuine tRNA-ribosyltransferase 1"
                     /codon_start=1
                     /product="queuine tRNA-ribosyltransferase catalytic
                     subunit 1"
                     /protein_id="NP_068688.2"
                     /db_xref="CCDS:CCDS52735.1"
                     /db_xref="GeneID:60507"
                     /db_xref="MGI:MGI:1931441"
                     /translation="MAAVGSPGSLESAPRIMRLVAECSRSGARAGELRLPHGTVATPV
                     FMPVGTQATMKGITTEQLDSLGCRICLGNTYHLGLRPGPELIRKAQGLHGFMNWPHNL
                     LTDSGGFQMVSLFSLSEVTEEGVHFRSPYDGEETLLSPERSVEIQNALGSDIIMQLDH
                     VVSSTVTGPLVEEAMHRSVRWLDRCIAAHKHPDKQNLFAIIQGGLNADLRTTCLKEMT
                     KRDVPGFAIGGLSGGESKAQFWKMVALSTSMLPKDKPRYLMGVGYATDLVVCVALGCD
                     MFDCVYPTRTARFGSALVPTGNLQLKKKQYAKDFSPINPECPCPTCQTHSRAFLHALL
                     HSDNTTALHHLTVHNIAYQLQLLSAVRSSILEQRFPDFVRNFMRTMYGDHSLCPAWAV
                     EALASVGIMLT"
     exon            262..330
                     /gene="Qtrt1"
                     /gene_synonym="2610028E17Rik; Tgt"
                     /inference="alignment:Splign:2.1.0"
     exon            331..469
                     /gene="Qtrt1"
                     /gene_synonym="2610028E17Rik; Tgt"
                     /inference="alignment:Splign:2.1.0"
     exon            470..548
                     /gene="Qtrt1"
                     /gene_synonym="2610028E17Rik; Tgt"
                     /inference="alignment:Splign:2.1.0"
     exon            549..664
                     /gene="Qtrt1"
                     /gene_synonym="2610028E17Rik; Tgt"
                     /inference="alignment:Splign:2.1.0"
     exon            665..803
                     /gene="Qtrt1"
                     /gene_synonym="2610028E17Rik; Tgt"
                     /inference="alignment:Splign:2.1.0"
     exon            804..879
                     /gene="Qtrt1"
                     /gene_synonym="2610028E17Rik; Tgt"
                     /inference="alignment:Splign:2.1.0"
     exon            880..989
                     /gene="Qtrt1"
                     /gene_synonym="2610028E17Rik; Tgt"
                     /inference="alignment:Splign:2.1.0"
     exon            990..1077
                     /gene="Qtrt1"
                     /gene_synonym="2610028E17Rik; Tgt"
                     /inference="alignment:Splign:2.1.0"
     exon            1078..1321
                     /gene="Qtrt1"
                     /gene_synonym="2610028E17Rik; Tgt"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1284..1289
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Qtrt1"
                     /gene_synonym="2610028E17Rik; Tgt"
                     /note="hexamer: TATAAA"
     polyA_site      1321
                     /gene="Qtrt1"
                     /gene_synonym="2610028E17Rik; Tgt"
                     /note="major polyA site"
ORIGIN      
        1 gtggttccgg gactgaaaat ggcggcggta ggcagcccag gttcgcttga gtccgctcca
       61 cgaataatgc ggctggtcgc tgagtgcagt cgctccggag ctcgggcggg tgagctgcgg
      121 ctgccgcatg gaacggtagc cacccctgtg ttcatgcctg tgggtacaca ggccaccatg
      181 aagggtatca ccacggagca gctggactcc ctgggctgcc gcatctgctt gggcaacacc
      241 taccatctgg ggctgaggcc gggaccggag ctgatccgga aagcccaggg tcttcacggc
      301 ttcatgaatt ggccccacaa tctgctgacg gatagcggcg gcttccagat ggtgtccctc
      361 ttctccctgt ccgaggtgac ggaggagggc gtccacttcc gctcgcccta cgatggagaa
      421 gagacacttt tgagcccaga gaggtcggtg gagatccaga atgctctggg ctcggacatc
      481 atcatgcagt tagaccatgt ggtgagcagc acagtgacag gccctctagt ggaggaggcc
      541 atgcacaggt cagtccgctg gctggacaga tgcatcgcag cccataagca cccggacaag
      601 cagaacctct ttgccatcat ccagggtgga ctgaatgctg atcttcggac cacttgtctg
      661 aaagagatga ccaagagaga tgtgccgggc ttcgccatcg gaggtctgag tggaggagaa
      721 agcaaggcac agttctggaa gatggtggcg ttgagcacct ccatgctgcc taaggacaag
      781 ccacgatacc tgatgggggt tggctatgcc accgatttgg tggtctgcgt ggctcttgga
      841 tgtgacatgt tcgactgtgt gtaccccaca cggacagcgc gctttggatc cgcccttgtg
      901 cccactggga accttcagtt gaagaagaag cagtatgcca aggatttcag ccccataaac
      961 cctgagtgtc cctgtcccac ctgccagacg cacagccgag ccttcctgca tgccctgcta
     1021 cacagtgaca acactacagc actacaccac ctaaccgtgc acaacattgc ctatcagctg
     1081 cagctcctga gtgccgtgcg cagcagtatc ttggaacagc gctttcctga ctttgtacga
     1141 aacttcatgc gcactatgta tggtgaccac agcctctgtc ctgcctgggc cgttgaagca
     1201 ctggcctctg tgggaatcat gctcacatga cctggttgct gggaaggaca ctggggtatg
     1261 gggaattctg aaggattctt ttttataaaa gattttgtta ctactttttg ttttcattta
     1321 aaaaaaaa
//
