LOCUS       NM_001302956            3914 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus quiescin Q6 sulfhydryl oxidase 2 (Qsox2), transcript
            variant 1, mRNA.
ACCESSION   NM_001302956 XM_006497902
VERSION     NM_001302956.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3914)
  AUTHORS   Chen,S.Y., Wang,T.E., Lee,W.Y., Yang,Y.Y., Lai,H.C., Matsuda,F.,
            Kosek,H., Chen,Y.T., Li,S.H. and Tsai,P.S.
  TITLE     Cre-LoxP and tamoxifen-induced deletion of ovarian quiescin
            sulfhydryl oxidase 2 showed disruption of ovulatory activity in
            mice
  JOURNAL   J Ovarian Res 17 (1), 66 (2024)
   PUBMED   38504307
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3914)
  AUTHORS   Wang,T.E., Minabe,S., Matsuda,F., Li,S.H., Tsukamura,H.,
            Maeda,K.I., Smith,L., O'Hara,L., Gadella,B.M. and Tsai,P.S.
  TITLE     Testosterone regulation on quiescin sulfhydryl oxidase 2 synthesis
            in the epididymis
  JOURNAL   Reproduction 161 (5), 593-602 (2021)
   PUBMED   33784244
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3914)
  AUTHORS   Wang,T.E., Li,S.H., Minabe,S., Anderson,A.L., Dun,M.D., Maeda,K.I.,
            Matsuda,F., Chang,H.W., Nixon,B. and Tsai,P.J.
  TITLE     Mouse quiescin sulfhydryl oxidases exhibit distinct epididymal
            luminal distribution with segment-specific sperm surface
            associations
  JOURNAL   Biol Reprod 99 (5), 1022-1033 (2018)
   PUBMED   29800099
  REMARK    GeneRIF: our study provides the first comprehensive comparisons
            between QSOX1 and QSOX2 in the mouse epididymis, revealing their
            distinct epididymal distribution, cellular localization, mechanisms
            of secretion and sperm membrane association
REFERENCE   4  (bases 1 to 3914)
  AUTHORS   Wittke,I., Wiedemeyer,R., Pillmann,A., Savelyeva,L., Westermann,F.
            and Schwab,M.
  TITLE     Neuroblastoma-derived sulfhydryl oxidase, a new member of the
            sulfhydryl oxidase/Quiescin6 family, regulates sensitization to
            interferon gamma-induced cell death in human neuroblastoma cells
  JOURNAL   Cancer Res 63 (22), 7742-7752 (2003)
   PUBMED   14633699
REFERENCE   5  (bases 1 to 3914)
  AUTHORS   Thorpe,C., Hoober,K.L., Raje,S., Glynn,N.M., Burnside,J., Turi,G.K.
            and Coppock,D.L.
  TITLE     Sulfhydryl oxidases: emerging catalysts of protein disulfide bond
            formation in eukaryotes
  JOURNAL   Arch Biochem Biophys 405 (1), 1-12 (2002)
   PUBMED   12176051
  REMARK    Review article
REFERENCE   6  (bases 1 to 3914)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL773595.10 and AK140324.1.
            
            On Dec 6, 2014 this sequence version replaced XM_006497902.1.
            
            Summary: This gene encodes a member of the sulfhydryl oxidase
            protein family. Members of this family catalyze formation of
            disulfide bonds. A similar protein in humans may sensitize
            neuroblastoma cells to interferon gamma-induced cell death.
            Alternate splicing results in multiple transcript variants.
            [provided by RefSeq, Dec 2014].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK140324.1, AK165642.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-11                AL773595.10        96908-96918         c
            12-3907             AK140324.1         2-3897
            3908-3914           AL773595.10        68643-68649         c
FEATURES             Location/Qualifiers
     source          1..3914
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 18.45 cM"
     gene            1..3914
                     /gene="Qsox2"
                     /gene_synonym="Qscn6l1; Soxn"
                     /note="quiescin Q6 sulfhydryl oxidase 2"
                     /db_xref="GeneID:227638"
                     /db_xref="MGI:MGI:2387194"
     exon            1..357
                     /gene="Qsox2"
                     /gene_synonym="Qscn6l1; Soxn"
                     /inference="alignment:Splign:2.1.0"
     CDS             48..2126
                     /gene="Qsox2"
                     /gene_synonym="Qscn6l1; Soxn"
                     /EC_number="1.8.3.2"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; quiescin Q6-like 1; sulfhydryl oxidase 2"
                     /codon_start=1
                     /product="sulfhydryl oxidase 2 isoform 1 precursor"
                     /protein_id="NP_001289885.1"
                     /db_xref="GeneID:227638"
                     /db_xref="MGI:MGI:2387194"
                     /translation="MAAARAVARDPGAYARQPPSLRAARLPRLLFLLAVVAAVGPREG
                     GGARLYREGSDAVWLLDSGSVRSATGNSSAAWLVQFHSSWCGHCIGYAPTWRALAADV
                     RDWAAAIRVAALDCAEEKNQDVCRTYDIHFYPTFRYFKAFTKEFTTGENFKGPDRELR
                     TVRQTMIDFLQNHTEGTWPPACPPLDPIQSSDILSFMDSHSGQYHAIVFESNGSYVGR
                     EVILDLIPYENIMVSRALDTDKAFLGTLGITSVPSCYLIYPNGSHGLVNVAKPLRSFF
                     SSHLKSLPDVRKKSLFLPEKSNKEEKSEVVVWKEFDRAKLYTADLESGLHYLLRVELA
                     AHRSLAGAQLKTFRDFVTVVAKLFPGRPAVKKLLETLQEWLANLPLDKIPYNAILDLV
                     NNKMQISGIFLTSHVKWVGCQGSRLELRGYPCSLWKLFHTLTVQASTHPEALAGTGFE
                     GHPQAVLQAIRRYIRTFFGCKECGEHFEEMAKESMDSVKTPDQAVLWLWRKHNMVNSR
                     LAGHLSEDPKFPKVPWPTPDLCPACHEEIKGLDSWNEGQVLLFLKQHYSRDNLVDAYS
                     VDQGSPGEWEAQGREQEEGKGLNPSGKSWRHHDTGSLRPPHILGPRTDLSKSLHHRLD
                     LRLQSPQGPQALKEAKAVVPFLGVGFSSLDMSLCVVLYVASSLFLMIMYFFFRVRSKR
                     WKVRLYHPAV"
     exon            358..458
                     /gene="Qsox2"
                     /gene_synonym="Qscn6l1; Soxn"
                     /inference="alignment:Splign:2.1.0"
     exon            459..507
                     /gene="Qsox2"
                     /gene_synonym="Qscn6l1; Soxn"
                     /inference="alignment:Splign:2.1.0"
     exon            508..613
                     /gene="Qsox2"
                     /gene_synonym="Qscn6l1; Soxn"
                     /inference="alignment:Splign:2.1.0"
     exon            614..704
                     /gene="Qsox2"
                     /gene_synonym="Qscn6l1; Soxn"
                     /inference="alignment:Splign:2.1.0"
     exon            705..850
                     /gene="Qsox2"
                     /gene_synonym="Qscn6l1; Soxn"
                     /inference="alignment:Splign:2.1.0"
     exon            851..985
                     /gene="Qsox2"
                     /gene_synonym="Qscn6l1; Soxn"
                     /inference="alignment:Splign:2.1.0"
     exon            986..1115
                     /gene="Qsox2"
                     /gene_synonym="Qscn6l1; Soxn"
                     /inference="alignment:Splign:2.1.0"
     exon            1116..1238
                     /gene="Qsox2"
                     /gene_synonym="Qscn6l1; Soxn"
                     /inference="alignment:Splign:2.1.0"
     exon            1239..1389
                     /gene="Qsox2"
                     /gene_synonym="Qscn6l1; Soxn"
                     /inference="alignment:Splign:2.1.0"
     exon            1390..1578
                     /gene="Qsox2"
                     /gene_synonym="Qscn6l1; Soxn"
                     /inference="alignment:Splign:2.1.0"
     exon            1579..3914
                     /gene="Qsox2"
                     /gene_synonym="Qscn6l1; Soxn"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3888..3893
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Qsox2"
                     /gene_synonym="Qscn6l1; Soxn"
                     /note="hexamer: AATAAA"
     regulatory      3892..3897
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Qsox2"
                     /gene_synonym="Qscn6l1; Soxn"
                     /note="hexamer: AAGAAA"
     polyA_site      3908
                     /gene="Qsox2"
                     /gene_synonym="Qscn6l1; Soxn"
                     /note="major polyA site"
     polyA_site      3913
                     /gene="Qsox2"
                     /gene_synonym="Qscn6l1; Soxn"
ORIGIN      
        1 cgccggttgc cagggtgaaa ggtcaacgcg ccggcggcac tcccaacatg gctgccgccc
       61 gggctgtggc gcgggatcca ggagcttatg cgcggcagcc accgtctctt cgagccgcgc
      121 ggctgccgcg gctgctcttc ctgctggcgg tggtggcggc agtggggccc cgggagggcg
      181 gcggggcgcg gctctaccgc gagggctcag acgccgtgtg gttgctggac agcggcagcg
      241 tgcggtcggc cacgggcaac agctcagccg cgtggctggt gcagttccac tcgtcgtggt
      301 gcggccactg catcggctac gcacccacct ggcgagcgct ggcggcggac gtgcgagact
      361 gggctgctgc catccgtgtt gctgctctgg actgtgcaga agaaaagaac caggatgtgt
      421 gccgcacata tgacatccac ttctacccca ccttcaggta ttttaaagca tttacaaagg
      481 agtttacaac gggagaaaat tttaaaggac ctgacaggga gctgcggaca gtcaggcaga
      541 caatgatcga cttcctgcag aaccatactg agggcacctg gcctcctgca tgcccacccc
      601 tggaccctat tcagtccagt gacatccttt ccttcatgga tagccacagt ggccaatacc
      661 atgctattgt gtttgaaagc aatggttctt atgttggacg agaggtgatc ttagatttga
      721 ttccatatga aaacatcatg gtgagccgag cactggatac ggacaaagca tttctgggga
      781 cacttggcat tacttcagtg ccttcctgtt acttgattta cccaaatggg tctcatggac
      841 tggttaatgt tgcaaagcct ctacgatcgt ttttctcctc tcatttaaaa tccttaccag
      901 atgtaaggaa aaagtcactt ttcttgcctg aaaagtccaa caaagaagaa aaatcagagg
      961 tggtggtttg gaaagaattt gacagggcca agctgtatac tgcagacctg gagtcgggac
     1021 ttcactacct gctgagagtg gagctggctg ctcacaggtc cctggctgga gcccagttaa
     1081 agacattcag ggacttcgtg actgtcgttg ccaagctgtt ccctggccgg cctgcagtca
     1141 agaagctgtt ggagacactg caggagtggt tggccaacct ccccctggac aagattccat
     1201 ataatgccat cctagaccta gtcaacaaca aaatgcagat ttctggaatc tttcttacca
     1261 gccacgtaaa gtgggtggga tgtcaaggaa gtcgattgga gttgaggggc tacccatgct
     1321 ccctctggaa actgtttcac actttgacgg ttcaggcctc cacccatcca gaagcgctgg
     1381 ctggcacagg ctttgaaggc cacccccagg ctgtgttgca ggccatcagg agatacattc
     1441 gcacattctt tgggtgcaaa gaatgtggtg aacattttga ggaaatggct aaggagtcca
     1501 tggattctgt gaaaactcca gaccaagctg ttctctggct ttggagaaag cacaacatgg
     1561 taaacagccg cctggcaggc catttgagtg aggaccccaa gtttccaaag gttccatggc
     1621 ccactccaga cctctgccca gcctgccatg aggaaattaa aggcctggac agctggaatg
     1681 agggccaggt gcttctgttc ctgaaacagc actatagcag ggacaacctg gtggacgcat
     1741 actctgtgga ccagggcagt cctggtgagt gggaagccca gggcagagag caagaagaag
     1801 gcaaaggtct taacccctca gggaagtcct ggagacacca tgacactggg agtctccgtc
     1861 caccccatat cctgggtccc agaactgacc tttccaagag cctgcatcac aggctggacc
     1921 taagactcca gagccctcag gggccccagg cacttaagga ggccaaggca gttgtgccct
     1981 tccttggggt tggcttctcc agtctggaca tgagcctctg cgtggtgctc tacgtggcct
     2041 cctccttgtt cctgatgatc atgtacttct tcttcagagt gaggtccaag cgatggaaag
     2101 tccggctcta ccacccagct gtgtagagac cctggggcag tcatggcgat acagaggaag
     2161 ctttgaacca cccacacacc tgcagcttta atgttgggat cagggatttt gcaaatgtgc
     2221 ccagcatggt gtctggagga gcatgttttc tttttttttt tcctatggaa catttttgcc
     2281 ttgctgttac cttgtcctca ccttcccagc ctccatgtta gactagtgtg tatttggccc
     2341 tatatgctag aagggggcag gtccaaccca cagccacaca gccttccatg aagcctcaca
     2401 tctacatttg ttaccttccc acccaccccc tctctctggg cacagcatcc agagatgagc
     2461 agccaaagca cagaggcctc tacagacagc acacaccctg ccacagatgt gggctgtgtt
     2521 cctgcataag ccaaaagtgc tttcatgggg gctcagggtg ctctgaactt gaacaaggaa
     2581 gtctgatcat cttgtggggt acagggccta gaggccacta agttatgttg tagcttccct
     2641 gcgtcttaaa tacccaggtc aagctgtagt gcagtcttgg tctctgtggg gcagtgcagt
     2701 ctccaggaag cctctaaaga ccctgtcatg tctgtcatgt acactacaga agacactggt
     2761 ggtggcatgg gatgctaccc ctgtgtactt ggtctcctgg ccttgagggt aacttaaaaa
     2821 caacaacatc aacttaaata cattatttgt aaaatctcaa tggtaaactt gtgcctaaag
     2881 acttttaaca aatggactaa gtctacattt ctggaaacat tcttactgag accctccata
     2941 gctcaggagc ttccttttat ttggataaag caagctagtc tctctctgtg tgtgtgtgtg
     3001 tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg gtgagagcgc atgtgcgcat
     3061 gtgtgtgcat gtgtgtacat tccattttgc atattctatc ttttatattt gcatccttcc
     3121 caatgacagt tggtcacatg ggtaccattt aagaccctgt attatcgatg tccctgctgc
     3181 cacttaagaa aatggacagc tgtctccttg ggctgttatt aaccctcctt tcatcacatg
     3241 gcaggatcag ttctgagagc cagaccttgg ctggggcaga tggccagact cagccacgtg
     3301 aacctcctgc ctcacttccc tgtggaggaa gtttcttctt tgaaacctgg agtcctgtgc
     3361 ttaaaaacaa acaagcccag atcatcgtta ggtgtttcca aggatgaaca ctcctggtct
     3421 gtcagcttga gaattgggcc tatttaagga cagctccagt gaaatgtctg agcccgaagg
     3481 gtggccctgg ggctgccata gcaccccaca gtgcctggcg tggctgatgt ttgcagaagc
     3541 ccactctggg cagatcctac tttcagctgc tcttgtacag tcccaggtca tcccttctgg
     3601 gggacaagct tgccacggac atccctgttt gaactgttca ttctgcagtg aaaaggcttg
     3661 catccctcca gggacccatc tttgggccaa gtgtaaggtc tgttttaaag tctgaagttt
     3721 tatgagaggt attaagatta atatctagaa tagttcagta atttaaatgt ttatttattt
     3781 tttaatgcaa agattttgag taaaaagcaa ttggcatgaa aatgtcaatg aaatttctta
     3841 aggggtacat tttgtattta agtaaactct aatgtgcaca ttgtaagaat aaagaaattt
     3901 gacatttagt aaag
//
