LOCUS       NM_001024945            3399 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus quiescin Q6 sulfhydryl oxidase 1 (Qsox1), transcript
            variant 1, mRNA.
ACCESSION   NM_001024945
VERSION     NM_001024945.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3399)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3399)
  AUTHORS   Ilani,T., Reznik,N., Yeshaya,N., Feldman,T., Vilela,P., Lansky,Z.,
            Javitt,G., Shemesh,M., Brenner,O., Elkis,Y., Varsano,N.,
            Jaramillo,A.M., Evans,C.M. and Fass,D.
  TITLE     The disulfide catalyst QSOX1 maintains the colon mucosal barrier by
            regulating Golgi glycosyltransferases
  JOURNAL   EMBO J 42 (2), e111869 (2023)
   PUBMED   36245281
  REMARK    GeneRIF: The disulfide catalyst QSOX1 maintains the colon mucosal
            barrier by regulating Golgi glycosyltransferases.
REFERENCE   3  (bases 1 to 3399)
  AUTHORS   Yoo,D., Park,J., Lee,C., Song,I., Lee,Y.H., Yun,T., Lee,H.,
            Heguy,A., Han,J.Y., Dasen,J.S., Kim,H. and Baek,M.
  TITLE     Little skate genome provides insights into genetic programs
            essential for limb-based locomotion
  JOURNAL   Elife 11, e78345 (2022)
   PUBMED   36288084
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3399)
  AUTHORS   Balu,R., Ramachandran,S.S., Mathimaran,A., Jeyaraman,J. and
            Paramasivam,S.G.
  TITLE     Functional significance of mouse seminal vesicle sulfhydryl oxidase
            on sperm capacitation in vitro
  JOURNAL   Mol Hum Reprod 29 (9) (2022)
   PUBMED   35809071
  REMARK    GeneRIF: Functional significance of mouse seminal vesicle
            sulfhydryl oxidase on sperm capacitation in vitro.
REFERENCE   5  (bases 1 to 3399)
  AUTHORS   Wei,Y.S., Lin,W.Z., Wang,T.E., Lee,W.Y., Li,S.H., Lin,F.J.,
            Nixon,B., Sipila,P. and Tsai,P.S.
  TITLE     Polarized epithelium-sperm co-culture system reveals stimulatory
            factors for the secretion of mouse epididymal quiescin sulfhydryl
            oxidase 1
  JOURNAL   J Reprod Dev 68 (3), 198-208 (2022)
   PUBMED   35228412
  REMARK    GeneRIF: Polarized epithelium-sperm co-culture system reveals
            stimulatory factors for the secretion of mouse epididymal quiescin
            sulfhydryl oxidase 1.
REFERENCE   6  (bases 1 to 3399)
  AUTHORS   Portes,K.F., Ikegami,C.M., Getz,J., Martins,A.P., de Noronha,L.,
            Zischler,L.F., Klassen,G., Camargo,A.A., Zanata,S.M., Bevilacqua,E.
            and Nakao,L.S.
  TITLE     Tissue distribution of quiescin Q6/sulfhydryl oxidase (QSOX) in
            developing mouse
  JOURNAL   J Mol Histol 39 (2), 217-225 (2008)
   PUBMED   18034316
REFERENCE   7  (bases 1 to 3399)
  AUTHORS   Tury,A., Mairet-Coello,G., Esnard-Feve,A., Benayoun,B.,
            Risold,P.Y., Griffond,B. and Fellmann,D.
  TITLE     Cell-specific localization of the sulphydryl oxidase QSOX in rat
            peripheral tissues
  JOURNAL   Cell Tissue Res 323 (1), 91-103 (2006)
   PUBMED   16160860
  REMARK    GeneRIF: In seminiferous tubules, where a high level of expression
            was noticed, QSOX might play an important physiological role in
            sperm function and serve as a marker for the diagnosis of male
            infertility.
REFERENCE   8  (bases 1 to 3399)
  AUTHORS   Matsuba,S., Suga,Y., Ishidoh,K., Hashimoto,Y., Takamori,K.,
            Kominami,E., Wilhelm,B., Seitz,J. and Ogawa,H.
  TITLE     Sulfhydryl oxidase (SOx) from mouse epidermis: molecular cloning,
            nucleotide sequence, and expression of recombinant protein in the
            cultured cells
  JOURNAL   J Dermatol Sci 30 (1), 50-62 (2002)
   PUBMED   12354420
  REMARK    GeneRIF: cloned skin SOx cDNA and characterized it as one of the
            disulfide (S-S) cross-linking enzymes
REFERENCE   9  (bases 1 to 3399)
  AUTHORS   Thorpe,C., Hoober,K.L., Raje,S., Glynn,N.M., Burnside,J., Turi,G.K.
            and Coppock,D.L.
  TITLE     Sulfhydryl oxidases: emerging catalysts of protein disulfide bond
            formation in eukaryotes
  JOURNAL   Arch Biochem Biophys 405 (1), 1-12 (2002)
   PUBMED   12176051
  REMARK    Review article
REFERENCE   10 (bases 1 to 3399)
  AUTHORS   Coppock,D.L., Cina-Poppe,D. and Gilleran,S.
  TITLE     The quiescin Q6 gene (QSCN6) is a fusion of two ancient gene
            families: thioredoxin and ERV1
  JOURNAL   Genomics 54 (3), 460-468 (1998)
   PUBMED   9878249
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY334148.1, AK083938.1 and CK625426.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer protein (isoform a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK083938.1, BC076590.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-49                BY334148.1         98-146
            50-3357             AK083938.1         1-3308
            3358-3399           CK625426.1         1-42                c
FEATURES             Location/Qualifiers
     source          1..3399
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 67.64 cM"
     gene            1..3399
                     /gene="Qsox1"
                     /gene_synonym="1300003H02Rik; b2b2673Clo; Qscn6; QSOX;
                     SOx"
                     /note="quiescin Q6 sulfhydryl oxidase 1"
                     /db_xref="GeneID:104009"
                     /db_xref="MGI:MGI:1330818"
     exon            1..374
                     /gene="Qsox1"
                     /gene_synonym="1300003H02Rik; b2b2673Clo; Qscn6; QSOX;
                     SOx"
                     /inference="alignment:Splign:2.1.0"
     CDS             101..2347
                     /gene="Qsox1"
                     /gene_synonym="1300003H02Rik; b2b2673Clo; Qscn6; QSOX;
                     SOx"
                     /EC_number="1.8.3.2"
                     /note="isoform a precursor is encoded by transcript
                     variant 1; sulfhydryl oxidase 1; skin sulfhydryl oxidase"
                     /codon_start=1
                     /product="sulfhydryl oxidase 1 isoform a precursor"
                     /protein_id="NP_001020116.1"
                     /db_xref="CCDS:CCDS15386.1"
                     /db_xref="GeneID:104009"
                     /db_xref="MGI:MGI:1330818"
                     /translation="MRRCGRLSGPPSLLLLLLLLSPLLFSGPGAYAARLSVLYSSSDP
                     LTLLDADSVRPTVLGSSSAWAVEFFASWCGHCIAFAPTWKELANDVKDWRPALNLAVL
                     DCAEETNSAVCREFNIAGFPTVRFFQAFTKNGSGATLPGAGANVQTLRMRLIDALESH
                     RDTWPPACPPLEPAKLNDIDGFFTRNKADYLALVFEREDSYLGREVTLDLSQYHAVAV
                     RRVLNTESDLVNKFGVTDFPSCYLLLRNGSVSRVPVLVESRSFYTSYLRGLPGLTRDA
                     PPTTATPVTADKIAPTVWKFADRSKIYMADLESALHYILRVEVGKFSVLEGQRLVALK
                     KFVAVLAKYFPGQPLVQNFLHSINDWLQKQQKKRIPYSFFKAALDSRKEDAVLTEKVN
                     WVGCQGSEPHFRGFPCSLWVLFHFLTVQANRYSEAHPQEPADGQEVLQAMRSYVQFFF
                     GCRDCADHFEQMAAASMHQVRSPSNAILWLWTSHNRVNARLSGALSEDPHFPKVQWPP
                     RELCSACHNELNGQVPLWDLGATLNFLKAHFSPANIVIDSSASRHTGRRGSPEATPEL
                     VMDTLKLESRNSVLGHEQAASAESPGATALDVPAEKPEASGPQELYTGLRMGGASPGQ
                     GPPERMEDHQRDMQENAPGQQHLSKRDTEALFLPEVNHLQGPLELRRGGRSPKQLAPI
                     LEEEPEALAIQGQGQWLQVLGGGISHLDISLCVGLYSVSFMGLLAMYTYFRARLRTPK
                     GHASYPTA"
     exon            375..475
                     /gene="Qsox1"
                     /gene_synonym="1300003H02Rik; b2b2673Clo; Qscn6; QSOX;
                     SOx"
                     /inference="alignment:Splign:2.1.0"
     exon            476..521
                     /gene="Qsox1"
                     /gene_synonym="1300003H02Rik; b2b2673Clo; Qscn6; QSOX;
                     SOx"
                     /inference="alignment:Splign:2.1.0"
     exon            522..624
                     /gene="Qsox1"
                     /gene_synonym="1300003H02Rik; b2b2673Clo; Qscn6; QSOX;
                     SOx"
                     /inference="alignment:Splign:2.1.0"
     exon            625..715
                     /gene="Qsox1"
                     /gene_synonym="1300003H02Rik; b2b2673Clo; Qscn6; QSOX;
                     SOx"
                     /inference="alignment:Splign:2.1.0"
     exon            716..861
                     /gene="Qsox1"
                     /gene_synonym="1300003H02Rik; b2b2673Clo; Qscn6; QSOX;
                     SOx"
                     /inference="alignment:Splign:2.1.0"
     exon            862..996
                     /gene="Qsox1"
                     /gene_synonym="1300003H02Rik; b2b2673Clo; Qscn6; QSOX;
                     SOx"
                     /inference="alignment:Splign:2.1.0"
     exon            997..1126
                     /gene="Qsox1"
                     /gene_synonym="1300003H02Rik; b2b2673Clo; Qscn6; QSOX;
                     SOx"
                     /inference="alignment:Splign:2.1.0"
     exon            1127..1249
                     /gene="Qsox1"
                     /gene_synonym="1300003H02Rik; b2b2673Clo; Qscn6; QSOX;
                     SOx"
                     /inference="alignment:Splign:2.1.0"
     exon            1250..1397
                     /gene="Qsox1"
                     /gene_synonym="1300003H02Rik; b2b2673Clo; Qscn6; QSOX;
                     SOx"
                     /inference="alignment:Splign:2.1.0"
     exon            1398..1577
                     /gene="Qsox1"
                     /gene_synonym="1300003H02Rik; b2b2673Clo; Qscn6; QSOX;
                     SOx"
                     /inference="alignment:Splign:2.1.0"
     exon            1578..3361
                     /gene="Qsox1"
                     /gene_synonym="1300003H02Rik; b2b2673Clo; Qscn6; QSOX;
                     SOx"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3331..3336
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Qsox1"
                     /gene_synonym="1300003H02Rik; b2b2673Clo; Qscn6; QSOX;
                     SOx"
                     /note="hexamer: AATAAA"
     polyA_site      3358
                     /gene="Qsox1"
                     /gene_synonym="1300003H02Rik; b2b2673Clo; Qscn6; QSOX;
                     SOx"
                     /note="major polyA site"
ORIGIN      
        1 ctcctcctcc tcctccgggg cggaggctgt tggtgcgcgg caggctccgg atactgacta
       61 gtcacaaact tgaaggaggt ggacattcaa gccgcctagg atgaggaggt gcggccgcct
      121 ctcggggccg ccatcgctgc tgctactact gctgctgctc tcgcctctgc tcttctcggg
      181 gcccggcgct tacgcggccc ggctctcagt gctctactcg tcctctgacc cgctgacgct
      241 gctggatgct gattcggtgc gtcccactgt gctcggctcc agcagcgcct gggcggtgga
      301 gttcttcgcc tcctggtgtg gccactgcat cgccttcgcc ccgacgtgga aggagcttgc
      361 taacgacgtg aaagactgga ggccagcact caatcttgct gtcctggact gtgctgagga
      421 gaccaacagt gctgtctgca gagagttcaa catcgctggc ttcccgactg tgaggttttt
      481 tcaggccttt accaagaacg gttctggagc gacactgcca ggtgctggcg ctaatgtgca
      541 gactctgcgt atgaggctca tcgatgctct ggagtcccac cgtgacacat ggcccccagc
      601 ctgtccacct ctggaacctg ccaagctgaa tgatatcgac ggattcttta caagaaataa
      661 agcagattac ctggccctgg tctttgaaag ggaagactcc tacctgggta gagaggtaac
      721 tctggacctg tcccagtacc atgctgtggc agtgcgcagg gtcttgaata cagagagtga
      781 cctggtgaac aagtttggcg tcactgactt cccatcttgt tacctgctgc ttcggaatgg
      841 ctctgtctcc cgagtgcctg tgctggtgga gtccaggtct ttctatacat cctatcttcg
      901 ggggctacct ggactgacca gggatgctcc cccaaccaca gccaccccag tcactgctga
      961 taagatagca cccacagtgt ggaagtttgc agaccgctcc aagatctaca tggccgacct
     1021 ggagtccgca ctccactaca tcttgcgtgt agaagtgggg aagttctcag tgctggaggg
     1081 acagcgcctg gtggccctga aaaagtttgt ggcagtattg gccaagtact tccctgggca
     1141 gcctttggtc cagaacttct tgcattccat aaacgactgg cttcagaagc agcagaagaa
     1201 gaggatcccc tacagtttct tcaaagctgc tctggacagc aggaaggagg atgctgtcct
     1261 tactgagaag gtgaactggg tcggctgcca gggcagtgag ccacacttcc gggggtttcc
     1321 ctgctcactg tgggtcctct tccacttcct gacggtgcag gcaaaccgat atagtgaggc
     1381 ccacccacag gaaccagctg atggccagga ggtcctccaa gccatgagga gctatgttca
     1441 gttcttcttt ggctgtcgtg actgtgcgga ccattttgag cagatggctg cagcgtccat
     1501 gcaccaagtg agaagtccca gtaatgcgat tctttggctc tggactagcc acaacagggt
     1561 taacgctcgc ctctcaggtg ctctgagtga ggacccccac ttccccaagg tgcagtggcc
     1621 tccccgtgag ctgtgttctg cctgccataa tgaactcaac ggacaggtgc ctttgtggga
     1681 ccttggtgcc accctcaact ttctcaaggc tcacttctcc ccagcaaaca tcgtcataga
     1741 ctcttctgca tctagacaca caggccggag agggagtcca gaagctaccc ccgagctggt
     1801 aatggataca ttaaaactgg agagcagaaa ttcagtgttg ggccatgagc aggctgcttc
     1861 tgcagagtcc cctggagcca ctgccctaga tgtaccagct gagaagcctg aagcaagtgg
     1921 cccccaagaa ctatacacag gcctcagaat gggtggagct tcaccagggc agggccctcc
     1981 tgagcgcatg gaagaccacc agagggatat gcaggagaat gcccccgggc agcaacactt
     2041 gagcaagaga gacactgaag ccttatttct gcctgaggtg aaccacctcc aaggcccttt
     2101 agagctcagg cgagggggcc gcagccccaa gcaactagcc cccatacttg aagaggaacc
     2161 agaggcccta gctatacagg gccaaggcca gtggctgcag gttctaggag ggggcatttc
     2221 ccacctggac attagcctct gtgtggggct ctactccgtg tccttcatgg gcttactggc
     2281 catgtacacc tactttcggg ccaggctgag aaccccaaag ggccatgcta gttaccccac
     2341 agcctgaact gcctcggcag aggacagaca aggagctgct gatgtctggg gctttgggtt
     2401 tttttttttt ttttttggcc cactggcccc cttgcttcct ttctacccct tgttctgttg
     2461 tctagcttag gagagtggca agtccaagaa agtgagttgt ttcagtgaac cctggagtct
     2521 actgtgagag gattccctag acaaaacaga atcagggtgc cagtctcgcc tgaccagcat
     2581 ggggtaggag cagcctgacg caggggctca ggaggcttct gggaggctca ggccctggct
     2641 tcagcaccaa attctgtttt tcagctcttg tgaagtcctg ccccattcct gctgaagtct
     2701 caatgtgtcc tgcttggtct tggccttaga ttgaggcaga caagtccaga gtttccaagg
     2761 tttctcatcc agaggagtgt atgtgggccg ggtgggctgg agtggacctc ctcactgcat
     2821 tctgagactg tctactcccc tccctcacga catgaagaaa aagcatccct ccggccttct
     2881 ctggcctggc cagcttcagc acctcaggag tgggtggggc ttagcttcaa gaatgggtct
     2941 gggagcctca gaaaatgatt ctggtcaccc aggttcaaac tggggtttct gctgcaagag
     3001 tgtggtttgg caggctggga gggtgacagt tgctgcactg tagggtgtag tgcttgcttg
     3061 gtggtagggg caagggggtg ggtgatgctg gggtctgtag tgccttagtc ctgggctagc
     3121 tgggagaggg cagactcctc tctgagcggg ggtgcttgtc tcttactttg gtctctaaaa
     3181 tcaatgctaa ctttggggtg tggaaggtgc tgggtttagg gcagtgggca gagccctctc
     3241 tctcccgctt gggtccactg tgggcaggag ggggtggaga gaccagccca catttccttc
     3301 ccctgctcct gtggcttggg agggatgtgg aataaaatta tttttgttaa gtcacgcaga
     3361 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaa
//
