LOCUS       NM_001081054            1970 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus glutaminyl-tRNA synthase (glutamine-hydrolyzing)-like
            1 (Qrsl1), mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_001081054 XM_125586
VERSION     NM_001081054.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1970)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1970)
  AUTHORS   Zurkirchen,L., Varum,S., Giger,S., Klug,A., Hausel,J., Bossart,R.,
            Zemke,M., Cantu,C., Atak,Z.K., Zamboni,N., Basler,K. and Sommer,L.
  TITLE     Yin Yang 1 sustains biosynthetic demands during brain development
            in a stage-specific manner
  JOURNAL   Nat Commun 10 (1), 2192 (2019)
   PUBMED   31097699
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1970)
  AUTHORS   Varum,S., Baggiolini,A., Zurkirchen,L., Atak,Z.K., Cantu,C.,
            Marzorati,E., Bossart,R., Wouters,J., Hausel,J., Tuncer,E.,
            Zingg,D., Veen,D., John,N., Balz,M., Levesque,M.P., Basler,K.,
            Aerts,S., Zamboni,N., Dummer,R. and Sommer,L.
  TITLE     Yin Yang 1 Orchestrates a Metabolic Program Required for Both
            Neural Crest Development and Melanoma Formation
  JOURNAL   Cell Stem Cell 24 (4), 637-653 (2019)
   PUBMED   30951662
REFERENCE   4  (bases 1 to 1970)
  AUTHORS   Echevarria,L., Clemente,P., Hernandez-Sierra,R., Gallardo,M.E.,
            Fernandez-Moreno,M.A. and Garesse,R.
  TITLE     Glutamyl-tRNAGln amidotransferase is essential for mammalian
            mitochondrial translation in vivo
  JOURNAL   Biochem J 460 (1), 91-101 (2014)
   PUBMED   24579914
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK012351.1.
            
            On Jun 3, 2007 this sequence version replaced NM_001081054.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK012351.1, SRR1660815.57906.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164139, SAMN01164143
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1970              AK012351.1         2-1971
FEATURES             Location/Qualifiers
     source          1..1970
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 23.11 cM"
     gene            1..1970
                     /gene="Qrsl1"
                     /gene_synonym="2700038P16Rik; GatA"
                     /note="glutaminyl-tRNA synthase
                     (glutamine-hydrolyzing)-like 1"
                     /db_xref="GeneID:76563"
                     /db_xref="MGI:MGI:1923813"
     exon            1..123
                     /gene="Qrsl1"
                     /gene_synonym="2700038P16Rik; GatA"
                     /inference="alignment:Splign:2.1.0"
     CDS             100..1677
                     /gene="Qrsl1"
                     /gene_synonym="2700038P16Rik; GatA"
                     /EC_number="6.3.5.7"
                     /note="glutamyl-tRNA(Gln) amidotransferase subunit A
                     homolog; glutaminyl-tRNA synthase-like protein 1; glu-AdT
                     subunit A"
                     /codon_start=1
                     /product="glutamyl-tRNA(Gln) amidotransferase subunit A,
                     mitochondrial"
                     /protein_id="NP_001074523.1"
                     /db_xref="CCDS:CCDS35894.1"
                     /db_xref="GeneID:76563"
                     /db_xref="MGI:MGI:1923813"
                     /translation="MLGRTLREVSAALKQGQVTPTELCKNCLSLIKKTKYLNAYITVS
                     EEVALKQAEESEKRYKQGQSLGDLDGIPVAVKDNFSTTGIETTCASNMLKGYVPPYNA
                     TVVQKLLDQGALLMGKTNLDEFAMGSGSTDGVFGPVRNPWTYSKQYRERSRQDAGDDS
                     HWLITGGSSGGSAAAVAAFTCFAALGSDTGGSTRNPAAHCGIVGFKPSYGLVSRHGLI
                     PLVNSMDVPGILTRCVDDTAIVLGTLAGHDPKDSTTVRNPAQPASVPGGMDVSRLCIG
                     IPKEYLVPELSSEVRSLWSQAADLFESEGAKVIEVSLPHTCYSIVCYHVLCTSEVASN
                     MARFDGLQYGHRSGVDVSTEAMYAATRQEGFNDVVRGRILSGNFFLLKENYENYFVKA
                     QKVRRLIVKDFVDVFESGVDVLLTPTTLTEAVPYLEFIKEDNRTRSAQDDIFTQAVNM
                     AGLPAVSVPVALSNQGLPIGLQLIGRAFCDQQLLTVAKWFEKQVQFPVIQLQGLMDDG
                     SLVLENGKLTSASLTQR"
     exon            124..283
                     /gene="Qrsl1"
                     /gene_synonym="2700038P16Rik; GatA"
                     /inference="alignment:Splign:2.1.0"
     exon            284..382
                     /gene="Qrsl1"
                     /gene_synonym="2700038P16Rik; GatA"
                     /inference="alignment:Splign:2.1.0"
     exon            383..479
                     /gene="Qrsl1"
                     /gene_synonym="2700038P16Rik; GatA"
                     /inference="alignment:Splign:2.1.0"
     exon            480..647
                     /gene="Qrsl1"
                     /gene_synonym="2700038P16Rik; GatA"
                     /inference="alignment:Splign:2.1.0"
     exon            648..823
                     /gene="Qrsl1"
                     /gene_synonym="2700038P16Rik; GatA"
                     /inference="alignment:Splign:2.1.0"
     exon            824..936
                     /gene="Qrsl1"
                     /gene_synonym="2700038P16Rik; GatA"
                     /inference="alignment:Splign:2.1.0"
     exon            937..1129
                     /gene="Qrsl1"
                     /gene_synonym="2700038P16Rik; GatA"
                     /inference="alignment:Splign:2.1.0"
     exon            1130..1247
                     /gene="Qrsl1"
                     /gene_synonym="2700038P16Rik; GatA"
                     /inference="alignment:Splign:2.1.0"
     exon            1248..1453
                     /gene="Qrsl1"
                     /gene_synonym="2700038P16Rik; GatA"
                     /inference="alignment:Splign:2.1.0"
     exon            1454..1970
                     /gene="Qrsl1"
                     /gene_synonym="2700038P16Rik; GatA"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aagaggagcc aagatgtctg cgcccatgta acgccggtgg cagagattga ctccttcctc
       61 tgttccggga cccggtgcta ccggctgact ccgagggcta tgctgggccg gactctccga
      121 gaagtttctg cggcactgaa gcagggccag gttacaccaa cagagctctg caagaactgt
      181 ctctccctca tcaagaaaac caagtatcta aatgcttaca ttactgtatc agaagaggtc
      241 gctttaaagc aagctgaaga atcagagaaa agatacaagc aaggtcagtc tcttggagat
      301 ttagatggaa ttcctgttgc tgtgaaagac aactttagca caactggcat tgagacaaca
      361 tgtgcatcaa atatgttaaa aggttacgta ccaccttaca atgctacagt agttcagaag
      421 ctgttggatc agggtgccct actcatgggg aaaacaaatt tagatgagtt tgctatgggg
      481 tctggaagca cagatggtgt gtttgggcca gttagaaacc cctggactta ctcgaagcag
      541 tacagagaga gaagccggca ggatgcaggt gatgattccc actggctgat cactggcgga
      601 agctcgggcg gcagcgcagc agccgtggcc gcgttcacct gctttgcggc tctcggatcg
      661 gacactggtg ggtccaccag gaaccctgct gcccactgtg ggattgttgg tttcaaacca
      721 agctatggct tggtttcacg gcacggcctt attcccctgg tgaattcaat ggacgtgcca
      781 ggaatcctca ccagatgtgt ggacgacaca gcaattgtgt taggtacact ggctggacat
      841 gaccccaaag attccaccac agtgagaaac cctgctcagc cggcctcggt tcccggcggg
      901 atggatgtga gcaggctgtg tataggaatc ccaaaggaat atctagtacc agaattgtca
      961 agtgaagtac ggtctctctg gtcccaagct gctgacctct ttgagtctga aggagccaaa
     1021 gtgattgagg tgtctctgcc acacacctgt tactcaattg tctgctacca tgtcctgtgc
     1081 acatcagaag tagcatcgaa tatggcaaga tttgatgggc tccagtatgg tcataggtct
     1141 ggtgttgatg tgtccactga agccatgtac gccgcaacca gacaggaagg cttcaatgat
     1201 gtggtgagag gaagaattct ctcaggaaac tttttcttat taaaagaaaa ttatgagaat
     1261 tatttcgtca aggcacagaa agtgaggcgc ctcattgtga aggattttgt ggatgttttt
     1321 gagtctgggg tggatgtcct gctaaccccc accaccctga ctgaggcagt gccgtacctg
     1381 gagttcatca aagaagacaa caggacacgc agcgcccagg atgatatttt cactcaagct
     1441 gtcaatatgg caggcttgcc agcagtgagt gtccctgtgg ccctctcaaa ccaagggctg
     1501 ccaataggac tgcagttaat tggacgtgca ttttgtgacc agcaacttct gacagttgcc
     1561 aagtggtttg aaaaacaagt acagtttcct gttattcaac tgcagggcct catggatgat
     1621 ggctcgttgg ttcttgaaaa tggaaagtta acgtctgctt ctctgaccca gagatgatca
     1681 gaatctcgtg cagttgcctg gtggtaggat gctgggatct tacgctggcc tcaggcttgc
     1741 tctctgccac tggactgatc cccacctctg tatcatgcag ttaaaatgcc ccttagaagt
     1801 gctgttctct gagtgtcggt gatctcattc agccctgtga tcagggtcac tgtcaaccct
     1861 gtctgtcctg ggaatcattt gttcaaatcc ctatgatgct gtaaattgta atgttgtata
     1921 cattgtatat tgtaactatg gtattctata ttaaaatgtt ctataaacct
//
