LOCUS       NM_001033267            7261 bp    mRNA    linear   ROD 17-JUN-2024
DEFINITION  Mus musculus glutamine rich 2 (Qrich2), mRNA.
ACCESSION   NM_001033267 XM_011248954 XM_126800 XM_910690
VERSION     NM_001033267.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 7261)
  AUTHORS   Zhang,G., Xiong,D., Ye,F., Zhao,Y., Du,X., Zhi,W., Liu,F., Zeng,J.,
            Xu,W., Liu,W. and Shi,Y.
  TITLE     A Key regulatory protein QRICH2 governing sperm function with
            profound antioxidant properties, enhancing sperm viability
  JOURNAL   Reprod Biol 24 (2), 100881 (2024)
   PUBMED   38772286
  REMARK    GeneRIF: A Key regulatory protein QRICH2 governing sperm function
            with profound antioxidant properties, enhancing sperm viability.
REFERENCE   2  (bases 1 to 7261)
  AUTHORS   Zhang,G., Guo,J., Yang,H., Li,Q., Ye,F., Song,Y., Xiong,D.,
            Zeng,J., Zhi,W., Yuan,S., Lv,Y., Li,T., Wang,Y., Liao,L., Deng,D.,
            Liu,W. and Xu,W.
  TITLE     Metabolic profiling identifies Qrich2 as a novel glutamine sensor
            that regulates microtubule glutamylation and mitochondrial function
            in mouse sperm
  JOURNAL   Cell Mol Life Sci 81 (1), 170 (2024)
   PUBMED   38597976
  REMARK    GeneRIF: Metabolic profiling identifies Qrich2 as a novel glutamine
            sensor that regulates microtubule glutamylation and mitochondrial
            function in mouse sperm.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 7261)
  AUTHORS   Zhang,G., Li,D., Tu,C., Meng,L., Tan,Y., Ji,Z., Cheng,J., Lu,G.,
            Lin,G., Zhang,H., Sun,J., Wang,M., Du,J. and Xu,W.
  TITLE     Loss-of-function missense variant of AKAP4 induced male infertility
            through reduced interaction with QRICH2 during sperm flagella
            development
  JOURNAL   Hum Mol Genet 31 (2), 219-231 (2021)
   PUBMED   34415320
  REMARK    GeneRIF: Loss-of-function missense variant of AKAP4 induced male
            infertility through reduced interaction with QRICH2 during sperm
            flagella development.
REFERENCE   4  (bases 1 to 7261)
  AUTHORS   Shen,Y., Zhang,F., Li,F., Jiang,X., Yang,Y., Li,X., Li,W., Wang,X.,
            Cheng,J., Liu,M., Zhang,X., Yuan,G., Pei,X., Cai,K., Hu,F., Sun,J.,
            Yan,L., Tang,L., Jiang,C., Tu,W., Xu,J., Wu,H., Kong,W., Li,S.,
            Wang,K., Sheng,K., Zhao,X., Yue,H., Yang,X. and Xu,W.
  TITLE     Loss-of-function mutations in QRICH2 cause male infertility with
            multiple morphological abnormalities of the sperm flagella
  JOURNAL   Nat Commun 10 (1), 433 (2019)
   PUBMED   30683861
  REMARK    GeneRIF: The findings strongly suggest that the genetic mutations
            of QRICH2 can lead to male infertility with multiple morphological
            abnormalities of the flagella, and that QRICH2 is essential for
            sperm flagellar formation.
            Erratum:[Nat Commun. 2019 May 20;10(1):2289. doi:
            10.1038/s41467-019-10313-x. PMID: 31110204]
            Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL645851.8 and AL645861.12.
            
            On or before Feb 21, 2023 this sequence version replaced
            XM_011248954.3, NM_001033267.2.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMN00849374, SAMN00849375
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-785               AL645851.8         3062-3846           c
            786-851             AL645851.8         2881-2946           c
            852-911             AL645861.12        210058-210117       c
            912-1025            AL645861.12        209460-209573       c
            1026-5196           AL645861.12        203011-207181       c
            5197-5282           AL645861.12        202367-202452       c
            5283-5380           AL645861.12        202060-202157       c
            5381-5495           AL645861.12        201534-201648       c
            5496-5750           AL645861.12        196154-196408       c
            5751-5873           AL645861.12        195259-195381       c
            5874-5948           AL645861.12        195078-195152       c
            5949-6113           AL645861.12        194758-194922       c
            6114-6235           AL645861.12        194470-194591       c
            6236-6301           AL645861.12        193945-194010       c
            6302-6403           AL645861.12        193595-193696       c
            6404-6604           AL645861.12        192948-193148       c
            6605-6740           AL645861.12        192477-192612       c
            6741-6828           AL645861.12        191740-191827       c
            6829-7029           AL645861.12        190908-191108       c
            7030-7261           AL645861.12        189318-189549       c
FEATURES             Location/Qualifiers
     source          1..7261
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 81.3 cM"
     gene            1..7261
                     /gene="Qrich2"
                     /gene_synonym="Gm66"
                     /note="glutamine rich 2"
                     /db_xref="GeneID:217341"
                     /db_xref="MGI:MGI:2684912"
     exon            1..785
                     /gene="Qrich2"
                     /gene_synonym="Gm66"
                     /inference="alignment:Splign:2.1.0"
     exon            786..851
                     /gene="Qrich2"
                     /gene_synonym="Gm66"
                     /inference="alignment:Splign:2.1.0"
     exon            852..911
                     /gene="Qrich2"
                     /gene_synonym="Gm66"
                     /inference="alignment:Splign:2.1.0"
     exon            912..1025
                     /gene="Qrich2"
                     /gene_synonym="Gm66"
                     /inference="alignment:Splign:2.1.0"
     exon            1026..5196
                     /gene="Qrich2"
                     /gene_synonym="Gm66"
                     /inference="alignment:Splign:2.1.0"
     exon            5197..5282
                     /gene="Qrich2"
                     /gene_synonym="Gm66"
                     /inference="alignment:Splign:2.1.0"
     exon            5283..5380
                     /gene="Qrich2"
                     /gene_synonym="Gm66"
                     /inference="alignment:Splign:2.1.0"
     exon            5381..5495
                     /gene="Qrich2"
                     /gene_synonym="Gm66"
                     /inference="alignment:Splign:2.1.0"
     exon            5496..5750
                     /gene="Qrich2"
                     /gene_synonym="Gm66"
                     /inference="alignment:Splign:2.1.0"
     exon            5751..5873
                     /gene="Qrich2"
                     /gene_synonym="Gm66"
                     /inference="alignment:Splign:2.1.0"
     exon            5874..5948
                     /gene="Qrich2"
                     /gene_synonym="Gm66"
                     /inference="alignment:Splign:2.1.0"
     exon            5949..6113
                     /gene="Qrich2"
                     /gene_synonym="Gm66"
                     /inference="alignment:Splign:2.1.0"
     exon            6114..6235
                     /gene="Qrich2"
                     /gene_synonym="Gm66"
                     /inference="alignment:Splign:2.1.0"
     exon            6236..6301
                     /gene="Qrich2"
                     /gene_synonym="Gm66"
                     /inference="alignment:Splign:2.1.0"
     exon            6302..6403
                     /gene="Qrich2"
                     /gene_synonym="Gm66"
                     /inference="alignment:Splign:2.1.0"
     exon            6404..6604
                     /gene="Qrich2"
                     /gene_synonym="Gm66"
                     /inference="alignment:Splign:2.1.0"
     exon            6605..6740
                     /gene="Qrich2"
                     /gene_synonym="Gm66"
                     /inference="alignment:Splign:2.1.0"
     exon            6741..6828
                     /gene="Qrich2"
                     /gene_synonym="Gm66"
                     /inference="alignment:Splign:2.1.0"
     exon            6829..7029
                     /gene="Qrich2"
                     /gene_synonym="Gm66"
                     /inference="alignment:Splign:2.1.0"
     exon            7030..7261
                     /gene="Qrich2"
                     /gene_synonym="Gm66"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7241..7246
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Qrich2"
                     /gene_synonym="Gm66"
                     /note="hexamer: AATAAA"
     polyA_site      7261
                     /gene="Qrich2"
                     /gene_synonym="Gm66"
                     /note="major polyA site"
ORIGIN      
        1 gttccaaacg tccaccggcc aagagccggg ctggctagga gagcggagcc cagggctggc
       61 taggagagcg gagcccaggg ctccagctag gaagccacaa acccacaaac agggccacct
      121 gctgagaccc ctgctggccc cataagcctt ctgggaacga ggaggcgctt ggtctccctt
      181 cttccctgat tctgtgcctc cccaaagggc acacgatgcc gccctcattg gtggccaaca
      241 gggtctccct ccgggagcta gccgacctgg caattggcac tccagaggtg ggcgcggtga
      301 actttacggc cttgcacaca ctgatagtgt ccattctcaa gagcctcaac ctccaagaag
      361 ttcttatcga cttccactac ccatcgactg agactggccg cggaactgag tctctgcatg
      421 gcactcacag cgccccgcat ttgccaacca gcaaagagaa gcatcagagt ctacctaggc
      481 tgtcacagac tccacaagag ctagaaaacc aggtgaagga cttgggtaac caggtactgg
      541 acctcaccaa acagtttaaa actatggaca acaaagtaca gggcatggcc acacaaatag
      601 accagatctc agtccctgaa ctccagcagg aagaggagat agctctggtg acccaacagg
      661 tatccctaac aaagttctcc aagatctatg aatctgagga gatgatggag aagcctgagc
      721 ccacagtcaa gatgcccacc gagatggtac aactaaagcc ctcaaggact cccagcctga
      781 ccaagcccac gagtgtgctc caagacctca tagaagatgt gaaaattctg aagcaggctt
      841 ctgagctgca ggaactcctt caacgtttta atgaactgga gaaactagtt aaaagccgag
      901 aagaatacct ggatctatta agtcggaggc tgaatcttct tgctccgggt ggtgaagaaa
      961 tcaccatggt cacctgggaa gagctagaac aagtgattgg tgacggctgg agggcctcca
     1021 aagggagctc ggattcgtcc acagcaaccg ttggcaagca caaatttacc tcaagtgacc
     1081 tccttccgag tggaatgttt ctcagagctg ctgaccaggc tctggattcc actggtggta
     1141 tagaaagaat ctccagcaga gatcaaagca gatctactac tgcatttcgg gatatggccc
     1201 gtgagccatc ccaggtcata tccgagacag atcgccagac atatgcaaga agagatgagc
     1261 aactccctgg tcagactcaa cgtggtggga tacccaggac ggaaccattt ggcatggatc
     1321 agcctagatt gatagacgct gtgatgccca ccactacggg tcagcttggt gtaaagcccc
     1381 ccgaaatgta tggccaggaa ttagtacctg ttgataaagc tcagagtggt gggctgccac
     1441 catcaggacc tgacaaggaa ctgaaaaaac tgagtacaat ccagcttggt acagttccac
     1501 ctagcacgta tcagcaaggc atgatgcttc ctggaatgga ccgagagggc acggaacagg
     1561 ctgctgtgcg tgacagtggt cagggaccat ggcccacggc tcagcaaggg ttgatagcag
     1621 taggcgtaga tcagcatgga ttgccgatac caggcacagg ccagcaagga ctgcccccac
     1681 aacatatgga tcagcggggt ttggtaacac ctggtacaga ccaacgtgca ttctctccat
     1741 ctctttcaga tgaacgtacc ttggtgtcac ttggtttgat gcaagttagt acagatcaac
     1801 aaggttttag acagtccagc ttaacgtcac gctttataca acctggtgca gaacagctca
     1861 gggtagagca gcgtggtgta gcgcagcctg gtttagatcg gcgcagttca gtgcctgtag
     1921 ggacagaacg gcgggcttca ttgcaggctc ttgcagagaa acgtagttca gtgcccattg
     1981 aggtagaaca gcagagtctg gcacagtcta gggcaggtca gcaaggttta ggacaaccta
     2041 gcacagtttc gggtggtttg atacagcctg gcacagacca acatttggtg cctcctggtg
     2101 tagatcagcc tagcttgatt caacctggtg catttccact tagtttggca caacttggtg
     2161 cagatcagca aggtctaata caaacagaca cagggcagcc tgtttgggtt caaccaagca
     2221 cagatcagag tggcggggta cagcctggtg catatctgcc cggttgggta cagcctagtg
     2281 tagatcaacg tgacttagta caagttggaa tggatcagca ggagctgaga caacctggtg
     2341 cagttcagcc cgggctggtg cagccaggtg catatgcacc tgggttgatg caagttggtg
     2401 caagtcagga tggtttgctt caacctggaa tggatcagct tggtctggta cagcctggta
     2461 cagcctggag tttggtgcag cctgatgtag atcagcttga tatggcacaa ccacatggaa
     2521 ttctgcctgg cctggcacaa ccacgtggag ttctgcctgg catggtccaa ccaggtgcag
     2581 ttcagcctgg tgtgttgcaa ccaggtgcag ttcagcctgg tgtgttgcaa ccaggtgcag
     2641 ttcagcctgg tgtgttgcaa ccaggtgcag ctcagcctgg cttggtccag ccaggtgcag
     2701 ctcagcctgg cttggtccag ccaggtgcag ctcagcctgg tgtgttgcaa gcaggtgcag
     2761 ttcagcctgg tgtgttgcaa gcaggtgcag ttcagcctgg catggtccag cagggtccag
     2821 ttcagcctgg tgtgttgcaa gcaggtgcag ctcagcctgg catggtccat ccgggtgcag
     2881 ctcagcctgg catggtccag ccgggttcag ttcagcctgg catggtccag ctaggtgcag
     2941 ttcagcctgg cgtgttgcaa gcaggtgcag ttcagtttgg catggtccag ccgggtgcag
     3001 ttgagcctgg tgtgttgcga gccggtgcag ttcagcttgg catggtccag ccgggtgcag
     3061 ttcagcttgg tgtgtttcga gcaggtgcag ttcagcctgg tgtgttgcaa gcaggtgcag
     3121 ttcagcctgg catggtccag caaggtccag ttcagcctgg tgtgttgcaa gcaggtgcag
     3181 ttcagcctgg catggtccag caaggtccag ttcagcctgg tgtgttgcaa gcaggtgcag
     3241 ttcagcctgg catggtccag caaggtccag ttcagcctgg tgtgttgcaa gcaggtgcag
     3301 ttcagcctgg catggtccag caaggtccag ttcagcctgg tgtgttgcaa tcaggtgcag
     3361 ttcagcctgg catggtccag cctggtatac ttcctagtgg ttgggggcag cctgttgcat
     3421 actcacttgg cttgggccaa cctggtatag gtcagtatgg tttggttcag ccaagagttg
     3481 atcgatatgg ttttgtgcag cccggtgtag cacgtggttt actccaacct agtgacagtc
     3541 agcgcgcttt gatgcaacct ggagtaggtc aagttgagtg gatacaacct ggaatgagtc
     3601 gtcgtgattt agtacaacct ggtgcagatg agagtggttt agcccaaggt ggaatggctc
     3661 agcagggttt ggtacaatct ggcatggccc ggcagggttt ggcacaacct ggcatggccc
     3721 ggcagggtgt ggcacaccct ggcatggccc ggcagggtgt ggcacaccct ggcaaggccc
     3781 ggcagggtgt ggcacaccct ggcaaggccc ggcagggtgt ggcacaacct gacttggcac
     3841 aacctggagc acctagtgag gacaagtttg gcttggcaca gcctatagtg gaccagagtg
     3901 cttttatgca gcctggcatg gaccaacgtg gcttggtaca gcctagaatg taccagtatg
     3961 gttttgtgga cccttctgat cttcagcgta acttcttgca acccagagga gttttgccta
     4021 ggttagtcca gcctgtcgtg gatcagggtg gtccgctgca ggctggactg gctcagtcta
     4081 ggatggtgca gcctatcacg gatcagagag gcccggtgca gcctgaaact cttcagccta
     4141 ggcaggtgca gcctagtaca agccgtcgag gcctggtgca gtctctcctg actccgtatg
     4201 gcctgatgca gccaggtgca gctcaacttg gtttggtgca gcctggcatg gagcagctag
     4261 gggaagaaag gcgtggctta ctgcagcctg gcatggatca gcctggtttg ttgcagcctg
     4321 ggacagatca gcctggtttg ttgcagcctg gggcagatca gcctggtttg ttgcagcctg
     4381 gggcagatca gcctggtttg ttgcagcctg gggcagatca gcctggtttc ttacagcctg
     4441 gggcagatca gcctggtttc ttacagcctg gggcagctag gctggacagg atacagcctg
     4501 ggatggttga gcctggtgca ggccctcagg gtttgggtca gcctgacttg gccccacctc
     4561 cttttattca ccctggtata tttcctcgtg gtatatttca acctgctaca cttccacgtg
     4621 gtttcagaca acccactcca actcagccag actttgtaac accaagcata gaccttcgct
     4681 ttccaacaat ggaggttgaa cctcagcaac cacaattgcc ccagttatat cagcttccta
     4741 cagcactcca aaccaggcaa ggtatacttc ctgaaggggt ccatcggatc tcaggtcaaa
     4801 aagccaagac aaggacagtt gaagttcagt atgatataga agaggctggc ctgcctgaag
     4861 aagtccagag agttgaggtg gatacccagg tctcttggga gctaagtcac cttgactcgg
     4921 ctgccccaac tgccccagaa caagttatca ccgactccag gactcaggat tcctggaact
     4981 atctccagca gttctcatca gtaagcgaga ctcgtcgaga gcagcagcgg caggagtcac
     5041 tgcctccaag cttccccatg gcggtggaaa cactgcgcct gatcggggag ctcatctccc
     5101 tctatttaga actgaaggaa cagttgaaag acttggacga ggaactggcc ggccagactg
     5161 acttcgagaa aatccagtac ctgatcacaa tgatagtcaa aaagaccata ccccaggacc
     5221 tggcagagca gctgaagagc ctaaagacgt tgaacaagga agttcggcag gacaaggcaa
     5281 aactagagaa gatacagaag tttgtggaca gtgctgctga caccaccgga gggaagggag
     5341 tgaaacctaa ccatctgagc ttgcagctgg gcatcctcag agtcaccgtg tctgacatcg
     5401 agaaggagct gaacgagctg agagagagcc aggaccgagg caaggccacc atggagaact
     5461 ctgtctctga ggcgtctctt tacctacagg atcagctgga caagctcaga accatcattg
     5521 agagcatgct gggcagctcc tccacgctgc tctccatgag cataacccca cacaagtcca
     5581 ccgcctgcct agtgcccggc cagatcgacc ccgaggccac ctgtccggcc tgcagtctgg
     5641 atgtgagcca ccaagtcagt ctgctggtcc agcgctacga gcagctacag gacatggtca
     5701 gtggcctcgc tgcctccaga ccctccaaga aggccaagct gcagggccag gatgaggagc
     5761 tgctgggcca cgtgcagagc gccatcctac aagtccaggg tgactgtgag aagctcaaca
     5821 ttaccacgag caacctcatt gaggaccatc ggcagaagca gaaagacatt gaagtgctgt
     5881 atcaggggat agaaaggctg gataaggaaa aggccaacag agagcacctg gagatggaga
     5941 ttgatgagaa agccgacaag agcgctctgg catccaaagt gagccggatc cagtttgatg
     6001 ccactacaga gcagctgaac cacatgatgc aggaactggt ggccaagatg agcggacagg
     6061 agcaagactg gcagaaactt ctggataagc tcctggcaga gatggacagc aagctggacc
     6121 gcctggagct ggatccgttg aagcagatgc tggaggaccg ctggaaatca ctgcggcagc
     6181 agctcaaaga gcgccctcca ctctaccagg ccgacgaggc ggctgccatg cggaggcagc
     6241 tcttggctca tttccactgc ttgtcctgtg accgtccctt ggagacaact gtgactggac
     6301 aagtcatctc tgtgaccccc ataatttcga gcatgccagg gcaccgttcc gtccggcctt
     6361 acactgtgtt tgaactagag cagatccgac agcaaagcag aaacctgaag ctgggcagca
     6421 gcttccctcg ggttgacatg tcacagatgg agagaagcgt ggggcgtctg cacagcatgc
     6481 actcccggat gctgatggac atggagaagg tgcaggtcca cttcggaggc tctgtgaagg
     6541 ccagcagcca gatgatccga gagctgctgc acacccagtg cctcagccac ccatgctaca
     6601 aacggggagc agacacagca gattacagct actcgactgt atcccgtcgc tgtgggggca
     6661 gccacaccct cacctacccc taccggcgaa accgcccgca gcacctgtct ccactggagg
     6721 agatccagat cgccatgaag catgatgagg ttgacatcct gggcctcgac ggacacatct
     6781 acaagggacg gatggataca cggttgccag gcatcctagg gaaagatgcc ccaggagtga
     6841 caaaacacaa caaggctaag ctccagcagc tccaacaact gcagcagctg cagcagctcc
     6901 aacaactgca gcagctgcag caggcccagc atgcccggcc ccacgcacac aggcagccaa
     6961 gcctgggcaa catgatctcg ccaccctctc ggcctcagag tgcacagatg atagcggaca
     7021 gcaaagcagt tccttcaggg caaaagaaag acagaccagt ctcctctgag gggcgtctcc
     7081 tgcagtcgaa tgtgagccat tcatccatcc ctacagacat agccagtctg cagggtagcc
     7141 aacaggggct gaacatgcac attgacgtgc ctcccgggga ggggctggag gagcccaccc
     7201 ggggaccacg gtccaccgct gctcactgaa cggaggcata aataaacatt tttaaaaagg
     7261 a
//
