LOCUS       NM_175143               3238 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus glutamine-rich 1 (Qrich1), transcript variant 2, mRNA.
ACCESSION   NM_175143 XM_977539
VERSION     NM_175143.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3238)
  AUTHORS   You,K., Wang,L., Chou,C.H., Liu,K., Nakata,T., Jaiswal,A., Yao,J.,
            Lefkovith,A., Omar,A., Perrigoue,J.G., Towne,J.E., Regev,A.,
            Graham,D.B. and Xavier,R.J.
  TITLE     QRICH1 dictates the outcome of ER stress through transcriptional
            control of proteostasis
  JOURNAL   Science 371 (6524) (2021)
   PUBMED   33384352
  REMARK    GeneRIF: QRICH1 dictates the outcome of ER stress through
            transcriptional control of proteostasis.
REFERENCE   2  (bases 1 to 3238)
  AUTHORS   Lui,J.C., Jee,Y.H., Lee,A., Yue,S., Wagner,J., Donnelly,D.E.,
            Vogt,K.S. and Baron,J.
  TITLE     QRICH1 mutations cause a chondrodysplasia with developmental delay
  JOURNAL   Clin Genet 95 (1), 160-164 (2019)
   PUBMED   30281152
REFERENCE   3  (bases 1 to 3238)
  AUTHORS   San Agustin,J.T., Klena,N., Granath,K., Panigrahy,A., Stewart,E.,
            Devine,W., Strittmatter,L., Jonassen,J.A., Liu,X., Lo,C.W. and
            Pazour,G.J.
  TITLE     Genetic link between renal birth defects and congenital heart
            disease
  JOURNAL   Nat Commun 7, 11103 (2016)
   PUBMED   27002738
  REMARK    Erratum:[Nat Commun. 2016 Jun 08;7:11910. doi:
            10.1038/ncomms11910.. PMID: 27273704]
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3238)
  AUTHORS   Li,Y., Klena,N.T., Gabriel,G.C., Liu,X., Kim,A.J., Lemke,K.,
            Chen,Y., Chatterjee,B., Devine,W., Damerla,R.R., Chang,C., Yagi,H.,
            San Agustin,J.T., Thahir,M., Anderton,S., Lawhead,C., Vescovi,A.,
            Pratt,H., Morgan,J., Haynes,L., Smith,C.L., Eppig,J.T.,
            Reinholdt,L., Francis,R., Leatherbury,L., Ganapathiraju,M.K.,
            Tobita,K., Pazour,G.J. and Lo,C.W.
  TITLE     Global genetic analysis in mice unveils central role for cilia in
            congenital heart disease
  JOURNAL   Nature 521 (7553), 520-524 (2015)
   PUBMED   25807483
REFERENCE   5  (bases 1 to 3238)
  AUTHORS   Nakahara,M., Tateyama,H., Araki,M., Nakagata,N., Yamamura,K. and
            Araki,K.
  TITLE     Gene-trap mutagenesis using Mol/MSM-1 embryonic stem cells from
            MSM/Ms mice
  JOURNAL   Mamm Genome 24 (5-6), 228-239 (2013)
   PUBMED   23604909
REFERENCE   6  (bases 1 to 3238)
  AUTHORS   Wiese,C.B., Ireland,S., Fleming,N.L., Yu,J., Valerius,M.T.,
            Georgas,K., Chiu,H.S., Brennan,J., Armstrong,J., Little,M.H.,
            McMahon,A.P. and Southard-Smith,E.M.
  TITLE     A genome-wide screen to identify transcription factors expressed in
            pelvic Ganglia of the lower urinary tract
  JOURNAL   Front Neurosci 6, 130 (2012)
   PUBMED   22988430
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 3238)
  AUTHORS   Taniwaki,T., Haruna,K., Nakamura,H., Sekimoto,T., Oike,Y.,
            Imaizumi,T., Saito,F., Muta,M., Soejima,Y., Utoh,A., Nakagata,N.,
            Araki,M., Yamamura,K. and Araki,K.
  TITLE     Characterization of an exchangeable gene trap using pU-17 carrying
            a stop codon-beta geo cassette
  JOURNAL   Dev Growth Differ 47 (3), 163-172 (2005)
   PUBMED   15840001
REFERENCE   8  (bases 1 to 3238)
  AUTHORS   Cobellis,G., Nicolaus,G., Iovino,M., Romito,A., Marra,E.,
            Barbarisi,M., Sardiello,M., Di Giorgio,F.P., Iovino,N., Zollo,M.,
            Ballabio,A. and Cortese,R.
  TITLE     Tagging genes with cassette-exchange sites
  JOURNAL   Nucleic Acids Res 33 (4), e44 (2005)
   PUBMED   15741177
  REMARK    Publication Status: Online-Only
REFERENCE   9  (bases 1 to 3238)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   10 (bases 1 to 3238)
  AUTHORS   Araki,K., Imaizumi,T., Sekimoto,T., Yoshinobu,K., Yoshimuta,J.,
            Akizuki,M., Miura,K., Araki,M. and Yamamura,K.
  TITLE     Exchangeable gene trap using the Cre/mutated lox system
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 45 (5), 737-750 (1999)
   PUBMED   10512203
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB851544.1, BC120916.1, AK151491.1 and BF658891.1.
            
            On Jan 31, 2008 this sequence version replaced NM_175143.4.
            
            Transcript Variant: This variant lacks an exon in the 5' UTR
            compared to variant 1. Variants 1 and 2 encode the same protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC006738.1, SRR1660817.134442.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-69                BB851544.1         2-70
            70-1218             BC120916.1         1-1149
            1219-3231           AK151491.1         1317-3329
            3232-3238           BF658891.1         6-12                c
FEATURES             Location/Qualifiers
     source          1..3238
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 59.45 cM"
     gene            1..3238
                     /gene="Qrich1"
                     /gene_synonym="2610028H07Rik; b2b2404Clo"
                     /note="glutamine-rich 1"
                     /db_xref="GeneID:69232"
                     /db_xref="MGI:MGI:1916482"
     exon            1..154
                     /gene="Qrich1"
                     /gene_synonym="2610028H07Rik; b2b2404Clo"
                     /inference="alignment:Splign:2.1.0"
     exon            155..484
                     /gene="Qrich1"
                     /gene_synonym="2610028H07Rik; b2b2404Clo"
                     /inference="alignment:Splign:2.1.0"
     CDS             176..2509
                     /gene="Qrich1"
                     /gene_synonym="2610028H07Rik; b2b2404Clo"
                     /note="glutamine-rich protein 1"
                     /codon_start=1
                     /product="transcriptional regulator QRICH1"
                     /protein_id="NP_780352.2"
                     /db_xref="CCDS:CCDS52927.1"
                     /db_xref="GeneID:69232"
                     /db_xref="MGI:MGI:1916482"
                     /translation="MNNSLENTISFEEYIRVKARSVPQHRMKEFLDSLASKGPEALQE
                     FQQTATTTMVYQQGGNCIYTDSTEVAGSLLELACPVTTSVQPQTQQEQQIQVQQPQQV
                     QVQVQVQQSPQQVSAQQLSPQFTVHQPAEQPIQVQVQIQGQAPQSAAPSIQTPSLQSP
                     SPSQLQAAQIQVQHVQAAQQIQAAEIPEEHIPHQQIQAQLVAGQSLAGGQQIQIQTVG
                     ALSPPPSQQGSPREGERRVGTASVLQPVKKRKVDMPITVSYAISGQPVATVLAIPQGQ
                     QQSYVSLRPDLLTVDSAHLYSATGTITSPTGETWTIPVYSAQPRGDPQQQSITHIAIP
                     QEAYNAVHVSGSPTALAAVKLEDDKEKMVGTTSVVKNSHEEVVQTLANSLFPAQFMNG
                     NIHIPVAVQAVAGTYQNTAQTVHIWDPQQQPQQQTAQEQTPPPQQQQQQLQVTCSAQT
                     VQVAEVEPQSQPQPSPELLLPNSLKPEEGLEVWKNWAQTKNAELEKDAQNRLAPIGRR
                     QLLRFQEDLISSAVAELNYGLCLMTREARNGEGEPYDPDVLYYIFLCIQKYLFENGRV
                     DDIFSDLYYVRFTEWLHEVLKDVQPRVTPLGYVLPSHVTEEMLWECKQLGAHSPSTLL
                     TTLMFFNTKYFLLKTVDQHMKLAFSKVLRQTKKSPSNPKDKSTSIRYLKALGIHQTGQ
                     KVTDDMYAEQTENPENPLRCPIKLYDFYLFKCPQSVKGRNDTFYLTPEPVVAPNSPIW
                     YSVQPISREQMGQMLTRILVIREIQEAIAVANATTMH"
     exon            485..1516
                     /gene="Qrich1"
                     /gene_synonym="2610028H07Rik; b2b2404Clo"
                     /inference="alignment:Splign:2.1.0"
     exon            1517..1694
                     /gene="Qrich1"
                     /gene_synonym="2610028H07Rik; b2b2404Clo"
                     /inference="alignment:Splign:2.1.0"
     exon            1695..1849
                     /gene="Qrich1"
                     /gene_synonym="2610028H07Rik; b2b2404Clo"
                     /inference="alignment:Splign:2.1.0"
     exon            1850..1964
                     /gene="Qrich1"
                     /gene_synonym="2610028H07Rik; b2b2404Clo"
                     /inference="alignment:Splign:2.1.0"
     exon            1965..2073
                     /gene="Qrich1"
                     /gene_synonym="2610028H07Rik; b2b2404Clo"
                     /inference="alignment:Splign:2.1.0"
     exon            2074..2225
                     /gene="Qrich1"
                     /gene_synonym="2610028H07Rik; b2b2404Clo"
                     /inference="alignment:Splign:2.1.0"
     exon            2226..2316
                     /gene="Qrich1"
                     /gene_synonym="2610028H07Rik; b2b2404Clo"
                     /inference="alignment:Splign:2.1.0"
     exon            2317..3238
                     /gene="Qrich1"
                     /gene_synonym="2610028H07Rik; b2b2404Clo"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      3236
                     /gene="Qrich1"
                     /gene_synonym="2610028H07Rik; b2b2404Clo"
                     /note="major polyA site"
ORIGIN      
        1 attggccgtg agggctgaat gtaagatggc gcccagggag ctgtgaggag aaaatcctgt
       61 cggtctcgga gcggcgacgg cagaaccgag gccccgggcg gtgaagcggg gccggcgggt
      121 agaacggagg cagcggcggc ggtgacgtcg ccgggaaccc taaggactct gcaatatgaa
      181 taattctcta gagaacacca tctcatttga agagtacatc cgagtaaagg cgaggtctgt
      241 cccgcaacac aggatgaagg aatttctgga ctcactggct tctaagggac cagaagctct
      301 tcaggagttc cagcagactg ccaccaccac catggtgtac cagcagggtg ggaactgcat
      361 ttatacagac agcactgaag tggctgggtc tttgcttgaa cttgcttgtc cagtcacaac
      421 cagtgttcaa ccacaaactc agcaagagca gcagatccag gttcagcagc cacagcaggt
      481 tcaggtacag gtgcaggtgc agcagtctcc acaacaggtc tcagctcagc aactttcccc
      541 acagttcacc gttcaccagc ctgctgagca acccatccag gtccaggtgc agatccaggg
      601 ccaagcacca cagtccgcag ccccctccat tcagactcca tctctgcaga gccccagccc
      661 ctcacagctg caagcagctc agatccaggt gcagcacgtc caggcggccc aacagatcca
      721 ggctgcagaa atcccagagg agcatatccc acatcaacaa atccaggctc agttggtagc
      781 tggccaatct cttgctgggg gccagcaaat tcaaattcag actgtgggtg ctctttcccc
      841 accaccatcc cagcagggct cacccaggga aggggaacgg agggttggca cagccagtgt
      901 ccttcagcca gtgaagaaac gcaaagtgga catgcctatc accgtgtcct acgccatctc
      961 agggcagcca gtggccactg tgctggccat tccacaaggc cagcaacaga gttatgtgtc
     1021 tttgaggcca gacttactga cagtagacag tgcccacctg tacagtgcca ctgggaccat
     1081 aactagccct acaggagaaa cttggaccat ccctgtttat tctgcccagc cccgcgggga
     1141 tcctcagcag cagagcatta cgcacattgc cattccccag gaagcctaca atgcggttca
     1201 tgtcagtggc tcacctacgg ccctggcagc tgtaaagctg gaggatgaca aggagaagat
     1261 ggtgggcacc acatctgtag tgaaaaactc ccatgaagag gtagtgcaga cccttgcaaa
     1321 ctctctcttt ccagcacagt tcatgaatgg caacatccac attccagtgg ctgtgcaggc
     1381 tgtagcaggc acataccaga atacggctca gactgtacat atatgggacc cacagcagca
     1441 gccacaacag caaactgcac aagagcagac accaccacca caacagcagc agcagcagct
     1501 gcaggtcact tgttcagcac agactgttca ggttgctgaa gttgagccac agtcacaacc
     1561 acagccttca ccagagcttt tgcttccaaa ttctttgaag ccagaagaag ggcttgaagt
     1621 atggaaaaac tgggctcaga ccaagaatgc tgaactagaa aaggatgctc aaaacagatt
     1681 ggcccccatt gggaggcgac agttgctacg atttcaggaa gatctgatct cctctgctgt
     1741 ggctgaattg aattatggcc tttgtttaat gacacgagaa gctcggaatg gagaaggtga
     1801 accctatgac ccagatgtac tctactacat tttcctgtgt atacagaagt atctttttga
     1861 aaatggaaga gtagatgaca tattttctga tctttactat gttcgtttca ccgaatggct
     1921 acatgaagtt ctgaaggatg tacagcctcg ggtcactcca cttggctatg tgttgcccag
     1981 tcacgtgact gaagagatgc tgtgggaatg taagcagctt ggggcacatt ccccttccac
     2041 actgctgacc accctcatgt tctttaacac caagtacttc ctgttgaaga ctgtagatca
     2101 gcacatgaag ctggctttct ctaaggtcct ccgacagaca aagaagagcc cctcgaatcc
     2161 taaggataaa agcacgagca tccgctacct gaaggccctc ggaatacacc agactggcca
     2221 gaaagttaca gatgacatgt atgcagagca aacagagaat ccagagaatc cactaaggtg
     2281 tcccatcaag ctctacgatt tctacctctt taaatgccct cagagtgtga aaggccgaaa
     2341 tgacaccttt tacctgacac ctgagccagt tgtagctccc aacagcccaa tctggtactc
     2401 agtccagcct atcagcagag aacagatggg acagatgctg acccggatcc tggttatacg
     2461 agaaatccaa gaagccattg ccgtggccaa tgcaaccacc atgcactgag gtgcctcagc
     2521 tataggaaaa aagatccagg aaaaaccaga cagactttca cactaaagga gaggcctcca
     2581 catttttttt taatttgtag ttatgatgct tttcaggcta cttctgttca aaatgtaaaa
     2641 gacgatattg ccctctttgc atcttcataa aatgggcaga cccctggttc atagggatct
     2701 gggttttctg agaacctggt gtcctaggaa gtggttggct ttttcttttc tctttttttc
     2761 ttttgtctgg ggcgtgggga aaggaacttg gactgtatgg agagatacag acccttccct
     2821 tcctcaggga agatggagct gctgatgcat cagcctgtca ctcggaatcg gcaaacttta
     2881 ctgaccactc agagccacat ttgttttttg ttttttgttt tttttttttg taatgctcag
     2941 acataaactt aacatcttga tggaagaaga ataaggggaa cttcaattat gatttttatc
     3001 cagacaattt ctattacacc cttctttatg acaagtgaca taaaagttaa agtaaaaact
     3061 ttaccatgcg cttttttttt tttttggcct aacattgagg ccttaaaaat gaggctcctg
     3121 tgcctgatgg aattcttgta acatacactt gtgtatcata taaagatacc actctttctc
     3181 ttatgtattc ttattctagt tgtttattaa gaatgacaag cacgtctttt caacaagc
//
