LOCUS       NM_198192               1839 bp    mRNA    linear   ROD 06-NOV-2024
DEFINITION  Mus musculus pyroglutamylated RFamide peptide receptor (Qrfpr),
            mRNA.
ACCESSION   NM_198192 XM_355395
VERSION     NM_198192.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1839)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1839)
  AUTHORS   Cook,C., Nunn,N., Worth,A.A., Bechtold,D.A., Suter,T.,
            Gackeheimer,S., Foltz,L., Emmerson,P.J., Statnick,M.A. and
            Luckman,S.M.
  TITLE     The hypothalamic RFamide, QRFP, increases feeding and locomotor
            activity: The role of Gpr103 and orexin receptors
  JOURNAL   PLoS One 17 (10), e0275604 (2022)
   PUBMED   36251705
  REMARK    GeneRIF: The hypothalamic RFamide, QRFP, increases feeding and
            locomotor activity: The role of Gpr103 and orexin receptors.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1839)
  AUTHORS   Moreau,M.X., Saillour,Y., Cwetsch,A.W., Pierani,A. and Causeret,F.
  TITLE     Single-cell transcriptomics of the early developing mouse cerebral
            cortex disentangle the spatial and temporal components of neuronal
            fate acquisition
  JOURNAL   Development 148 (14) (2021)
   PUBMED   34170322
REFERENCE   4  (bases 1 to 1839)
  AUTHORS   Patel,S.K. and Singh,S.K.
  TITLE     Ontogeny of QRFP and its receptor expression in mouse testis during
            post-natal development
  JOURNAL   Int J Biol Macromol 122, 1217-1223 (2019)
   PUBMED   30219516
  REMARK    GeneRIF: Ontogeny of QRFP and its receptor expression in mouse
            testis during post-natal development
REFERENCE   5  (bases 1 to 1839)
  AUTHORS   Palotai,M. and Telegdy,G.
  TITLE     Anxiolytic effect of the GPR103 receptor agonist peptide P550
            (homolog of neuropeptide 26RFa) in mice. Involvement of
            neurotransmitters
  JOURNAL   Peptides 82, 20-25 (2016)
   PUBMED   27224020
  REMARK    GeneRIF: we treated mice with the synthetic GPR103 receptor agonist
            peptide P550 and the anxious behavior was investigated using an
            elevated plus-maze test.
REFERENCE   6  (bases 1 to 1839)
  AUTHORS   Mulumba,M., Jossart,C., Granata,R., Gallo,D., Escher,E., Ghigo,E.,
            Servant,M.J., Marleau,S. and Ong,H.
  TITLE     GPR103b functions in the peripheral regulation of adipogenesis
  JOURNAL   Mol Endocrinol 24 (8), 1615-1625 (2010)
   PUBMED   20534693
  REMARK    GeneRIF: Results suggest that GPR103b and QRFP work in an
            autocrine/paracrine manner to regulate adipogenesis.
REFERENCE   7  (bases 1 to 1839)
  AUTHORS   Takayasu,S., Sakurai,T., Iwasaki,S., Teranishi,H., Yamanaka,A.,
            Williams,S.C., Iguchi,H., Kawasawa,Y.I., Ikeda,Y., Sakakibara,I.,
            Ohno,K., Ioka,R.X., Murakami,S., Dohmae,N., Xie,J., Suda,T.,
            Motoike,T., Ohuchi,T., Yanagisawa,M. and Sakai,J.
  TITLE     A neuropeptide ligand of the G protein-coupled receptor GPR103
            regulates feeding, behavioral arousal, and blood pressure in mice
  JOURNAL   Proc Natl Acad Sci U S A 103 (19), 7438-7443 (2006)
   PUBMED   16648250
  REMARK    GeneRIF: QRFP and GPR103A/B may regulate diverse neuroendocrine and
            behavioral functions and implicate this neuropeptide system in
            metabolic syndrome
REFERENCE   8  (bases 1 to 1839)
  AUTHORS   Baribault,H., Danao,J., Gupte,J., Yang,L., Sun,B., Richards,W. and
            Tian,H.
  TITLE     The G-protein-coupled receptor GPR103 regulates bone formation
  JOURNAL   Mol Cell Biol 26 (2), 709-717 (2006)
   PUBMED   16382160
  REMARK    GeneRIF: Osteopenia in GPR103-/- mice may be mediated directly by
            the loss of GPR103 expression in bone.
REFERENCE   9  (bases 1 to 1839)
  AUTHORS   Fukusumi,S., Yoshida,H., Fujii,R., Maruyama,M., Komatsu,H.,
            Habata,Y., Shintani,Y., Hinuma,S. and Fujino,M.
  TITLE     A new peptidic ligand and its receptor regulating adrenal function
            in rats
  JOURNAL   J Biol Chem 278 (47), 46387-46395 (2003)
   PUBMED   12960173
REFERENCE   10 (bases 1 to 1839)
  AUTHORS   Jiang,Y., Luo,L., Gustafson,E.L., Yadav,D., Laverty,M., Murgolo,N.,
            Vassileva,G., Zeng,M., Laz,T.M., Behan,J., Qiu,P., Wang,L.,
            Wang,S., Bayne,M., Greene,J., Monsma,F. Jr. and Zhang,F.L.
  TITLE     Identification and characterization of a novel RF-amide peptide
            ligand for orphan G-protein-coupled receptor SP9155
  JOURNAL   J Biol Chem 278 (30), 27652-27657 (2003)
   PUBMED   12714592
  REMARK    GeneRIF: characterization and tissue distribution of SP9155
            (GPR103) ligand [GPR103/SP9155]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC102844.11.
            
            On Oct 5, 2022 this sequence version replaced NM_198192.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC096610.1, AK142880.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164139 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-414               AC102844.11        183317-183730       c
            415-573             AC102844.11        150869-151027       c
            574-635             AC102844.11        149573-149634       c
            636-871             AC102844.11        143871-144106       c
            872-969             AC102844.11        142362-142459       c
            970-1839            AC102844.11        140843-141712       c
FEATURES             Location/Qualifiers
     source          1..1839
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 17.41 cM"
     gene            1..1839
                     /gene="Qrfpr"
                     /gene_synonym="AQ27; Gpr103; Gpr103a; SP9155"
                     /note="pyroglutamylated RFamide peptide receptor"
                     /db_xref="GeneID:229214"
                     /db_xref="MGI:MGI:2677633"
     exon            1..414
                     /gene="Qrfpr"
                     /gene_synonym="AQ27; Gpr103; Gpr103a; SP9155"
                     /inference="alignment:Splign:2.1.0"
     CDS             75..1376
                     /gene="Qrfpr"
                     /gene_synonym="AQ27; Gpr103; Gpr103a; SP9155"
                     /note="G protein-coupled receptor 103; QRFP receptor;
                     orexigenic neuropeptide QRFP receptor"
                     /codon_start=1
                     /product="pyroglutamylated RF-amide peptide receptor"
                     /protein_id="NP_937835.1"
                     /db_xref="CCDS:CCDS17311.1"
                     /db_xref="GeneID:229214"
                     /db_xref="MGI:MGI:2677633"
                     /translation="MQALNITAEQFSRLLSAHNLTREQFIHRYGLRPLVYTPELPARA
                     KLAFALAGALIFALALFGNSLVIYVVTRSKAMRTVTNIFICSLALSDLLIAFFCIPVT
                     MLQNISDKWLGGAFICKMVPFVQSTAVVTEILTMTCIAVERHQGLIHPFKMKWQYTTR
                     RAFTILGVVWLAAIIVGSPMWHVQRLEIKYDFLYEKEHVCCLEEWASPMHQRIYTTFI
                     LVILFLLPLVVMLVLYSKIGYELWIKKRVGDSSALQTIHGKEMSKIARKKKRAVVMMV
                     TVVALFAACWAPFHVVHMMVEYSNFEKEYDDVTIKMVFAVAQTIGFFNSICNPFVYAF
                     MNENFKKNFLSAVCYCIVRETFSPGQKPGNSGISMMQKRAKLSRSQRPVAEAKGDLFS
                     DANVDVKLCEQPGEKRQLKRQLAFFSSELSENSTFGSGHEL"
     exon            415..573
                     /gene="Qrfpr"
                     /gene_synonym="AQ27; Gpr103; Gpr103a; SP9155"
                     /inference="alignment:Splign:2.1.0"
     exon            574..635
                     /gene="Qrfpr"
                     /gene_synonym="AQ27; Gpr103; Gpr103a; SP9155"
                     /inference="alignment:Splign:2.1.0"
     exon            636..871
                     /gene="Qrfpr"
                     /gene_synonym="AQ27; Gpr103; Gpr103a; SP9155"
                     /inference="alignment:Splign:2.1.0"
     exon            872..969
                     /gene="Qrfpr"
                     /gene_synonym="AQ27; Gpr103; Gpr103a; SP9155"
                     /inference="alignment:Splign:2.1.0"
     exon            970..1839
                     /gene="Qrfpr"
                     /gene_synonym="AQ27; Gpr103; Gpr103a; SP9155"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1575..1580
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Qrfpr"
                     /gene_synonym="AQ27; Gpr103; Gpr103a; SP9155"
                     /note="hexamer: AATAAA"
     polyA_site      1596
                     /gene="Qrfpr"
                     /gene_synonym="AQ27; Gpr103; Gpr103a; SP9155"
     regulatory      1659..1664
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Qrfpr"
                     /gene_synonym="AQ27; Gpr103; Gpr103a; SP9155"
                     /note="hexamer: ATTAAA"
     polyA_site      1681
                     /gene="Qrfpr"
                     /gene_synonym="AQ27; Gpr103; Gpr103a; SP9155"
     regulatory      1815..1820
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Qrfpr"
                     /gene_synonym="AQ27; Gpr103; Gpr103a; SP9155"
                     /note="hexamer: AATAAA"
     polyA_site      1839
                     /gene="Qrfpr"
                     /gene_synonym="AQ27; Gpr103; Gpr103a; SP9155"
                     /note="major polyA site"
ORIGIN      
        1 gagctctgca ctgtcaccag agccttagac ttggaacagc cagagcagga ggctggcagg
       61 actctgcgca cagcatgcag gcgctcaaca tcaccgcgga gcagttttcc cggctgctga
      121 gcgcgcacaa cctgactcgg gaacagttca ttcatcgcta tgggctgcga ccgctggtct
      181 acactccgga gctgcccgcg cgcgctaaac tggcctttgc gctggctgga gcactcattt
      241 ttgccctggc gctctttggc aactctctgg tcatctatgt ggtgacccgc agcaaggcca
      301 tgcgcaccgt caccaacatc ttcatctgct ctctggcact cagtgatctg ctcattgcct
      361 tcttctgcat ccccgtcacg atgctccaga acatctccga caagtggctg ggtggtgcct
      421 tcatctgcaa gatggtgccc ttcgtccagt ccactgctgt tgtgacggaa atcctcacca
      481 tgacttgcat cgctgttgag aggcaccaag gactcatcca tccttttaaa atgaagtggc
      541 agtacactac ccgaagggct ttcacaatct tgggtgtggt ctggttggca gccatcatcg
      601 taggatcacc catgtggcac gtacaacgcc tcgagattaa gtatgacttc ctctatgaga
      661 aagaacatgt ctgctgtttg gaagagtggg ccagccccat gcaccagaga atctacacca
      721 ccttcatcct cgtcatcctc ttcctcctgc cgcttgtggt gatgcttgtc ctctacagca
      781 agattggcta tgaactgtgg atcaagaaga gagttggaga cagttcagca cttcagacta
      841 tccacgggaa agaaatgtcc aaaatagcca ggaagaagaa gcgggctgtc gttatgatgg
      901 tgacagtggt ggctctcttc gctgcgtgct gggcaccttt ccatgttgtt cacatgatgg
      961 ttgagtacag taactttgaa aaagagtatg atgatgtcac aatcaagatg gtttttgctg
     1021 ttgcacaaac aattggcttt ttcaactcca tctgtaatcc ctttgtgtat gcatttatga
     1081 atgaaaactt caaaaagaat tttttgtctg cggtttgtta ttgcatagta agagaaacct
     1141 tctccccagg acagaagcct ggaaattctg ggatttcaat gatgcaaaag agagcaaagt
     1201 tatcacgatc acagcgtcca gtggcggaag ccaaaggaga cttattcagc gatgccaacg
     1261 ttgatgtcaa attgtgtgag cagccagggg agaaaaggca actcaagcga cagcttgcct
     1321 tctttagttc tgaactttct gaaaactcta ctttcggcag tggacatgaa ctgtaatgat
     1381 atcctcatag ctaatatcat ttgtatggaa agttatttta agcaaaggtc aggactattt
     1441 tttttaaatg acaagaagag aaacaagaca tgttttccat ttaaatgaac ataatacata
     1501 acactgtaac tttgaaaaat tattataaca gctttgtaga tgataaaagt agatttttga
     1561 aagtcttcgt acataataaa gcagtggttt tggcagcagt tttatccatg tagtcaatgt
     1621 aatgtgactt ttatgtattg ctacactgga tgaaaattat taaaattgtg tcatcatcct
     1681 tgaatattaa acatctgaac atcataatgt agtttgtagt gtgctgtaaa cgtttgtaaa
     1741 atcagccttt ggaactgaca tctgtgccat aattaaaaaa tcaaggagga tgaagaatca
     1801 ggcaagtgac aactaataaa agttaagaga taaatgtca
//
