LOCUS       NM_183424               2925 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus pyroglutamylated RFamide peptide (Qrfp), mRNA.
ACCESSION   NM_183424
VERSION     NM_183424.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2925)
  AUTHORS   Takahashi,T.M., Sakurai,T. and Hirano,A.
  TITLE     Measuring body temperature of freely moving mice under an
            optogenetics-induced long-term hypothermic state
  JOURNAL   STAR Protoc 4 (2), 102321 (2023)
   PUBMED   37267111
  REMARK    Publication Status: Available-Online prior to print
REFERENCE   2  (bases 1 to 2925)
  AUTHORS   El Mehdi,M., Takhlidjt,S., Devere,M., Arabo,A., Le Solliec,M.A.,
            Maucotel,J., Benani,A., Nedelec,E., Duparc,C., Lefranc,B.,
            Leprince,J., Anouar,Y., Prevost,G., Chartrel,N. and Picot,M.
  TITLE     The 26RFa (QRFP)/GPR103 neuropeptidergic system in mice relays
            insulin signalling into the brain to regulate glucose homeostasis
  JOURNAL   Diabetologia 65 (7), 1198-1211 (2022)
   PUBMED   35476025
REFERENCE   3  (bases 1 to 2925)
  AUTHORS   Patel,S.K. and Singh,S.K.
  TITLE     Role of pyroglutamylated RFamide peptide43 in germ cell dynamics in
            mice testes in relation to energy metabolism
  JOURNAL   Biochimie 175, 146-158 (2020)
   PUBMED   32504656
  REMARK    GeneRIF: Role of pyroglutamylated RFamide peptide43 in germ cell
            dynamics in mice testes in relation to energy metabolism.
REFERENCE   4  (bases 1 to 2925)
  AUTHORS   Takahashi,T.M., Sunagawa,G.A., Soya,S., Abe,M., Sakurai,K.,
            Ishikawa,K., Yanagisawa,M., Hama,H., Hasegawa,E., Miyawaki,A.,
            Sakimura,K., Takahashi,M. and Sakurai,T.
  TITLE     A discrete neuronal circuit induces a hibernation-like state in
            rodents
  JOURNAL   Nature 583 (7814), 109-114 (2020)
   PUBMED   32528181
REFERENCE   5  (bases 1 to 2925)
  AUTHORS   El-Mehdi,M., Takhlidjt,S., Khiar,F., Prevost,G., do Rego,J.L., do
            Rego,J.C., Benani,A., Nedelec,E., Godefroy,D., Arabo,A.,
            Lefranc,B., Leprince,J., Anouar,Y., Chartrel,N. and Picot,M.
  TITLE     Glucose homeostasis is impaired in mice deficient in the
            neuropeptide 26RFa (QRFP)
  JOURNAL   BMJ Open Diabetes Res Care 8 (1) (2020)
   PUBMED   32114486
  REMARK    GeneRIF: Glucose homeostasis is impaired in mice deficient in the
            neuropeptide 26RFa (QRFP).
REFERENCE   6  (bases 1 to 2925)
  AUTHORS   Zhang,Q., Qiu,P., Arreaza,M.G., Simon,J.S., Golovko,A., Laverty,M.,
            Vassileva,G., Gustafson,E.L., Rojas-Triana,A., Bober,L.A.,
            Hedrick,J.A., Monsma,F.J. Jr., Greene,J.R., Bayne,M.L. and
            Murgolo,N.J.
  TITLE     P518/Qrfp sequence polymorphisms in SAMP6 osteopenic mouse
  JOURNAL   Genomics 90 (5), 629-635 (2007)
   PUBMED   17869477
  REMARK    GeneRIF: Qrfp polymorphisms is associated with osteopenia
REFERENCE   7  (bases 1 to 2925)
  AUTHORS   Takayasu,S., Sakurai,T., Iwasaki,S., Teranishi,H., Yamanaka,A.,
            Williams,S.C., Iguchi,H., Kawasawa,Y.I., Ikeda,Y., Sakakibara,I.,
            Ohno,K., Ioka,R.X., Murakami,S., Dohmae,N., Xie,J., Suda,T.,
            Motoike,T., Ohuchi,T., Yanagisawa,M. and Sakai,J.
  TITLE     A neuropeptide ligand of the G protein-coupled receptor GPR103
            regulates feeding, behavioral arousal, and blood pressure in mice
  JOURNAL   Proc Natl Acad Sci U S A 103 (19), 7438-7443 (2006)
   PUBMED   16648250
REFERENCE   8  (bases 1 to 2925)
  AUTHORS   Chartrel,N., Bruzzone,F., Dujardin,C., Leprince,J., Tollemer,H.,
            Anouar,Y., Vallarino,M., Costentin,J. and Vaudry,H.
  TITLE     Identification of 26RFa from frog brain: a novel hypothalamic
            neuropeptide with orexigenic activity in mammals
  JOURNAL   Ann N Y Acad Sci 1040, 80-83 (2005)
   PUBMED   15891009
  REMARK    GeneRIF: P518/26RFa is a neuropeptide that stimulates food intake
            in mice.
REFERENCE   9  (bases 1 to 2925)
  AUTHORS   Fukusumi,S., Yoshida,H., Fujii,R., Maruyama,M., Komatsu,H.,
            Habata,Y., Shintani,Y., Hinuma,S. and Fujino,M.
  TITLE     A new peptidic ligand and its receptor regulating adrenal function
            in rats
  JOURNAL   J Biol Chem 278 (47), 46387-46395 (2003)
   PUBMED   12960173
REFERENCE   10 (bases 1 to 2925)
  AUTHORS   Jiang,Y., Luo,L., Gustafson,E.L., Yadav,D., Laverty,M., Murgolo,N.,
            Vassileva,G., Zeng,M., Laz,T.M., Behan,J., Qiu,P., Wang,L.,
            Wang,S., Bayne,M., Greene,J., Monsma,F. Jr. and Zhang,F.L.
  TITLE     Identification and characterization of a novel RF-amide peptide
            ligand for orphan G-protein-coupled receptor SP9155
  JOURNAL   J Biol Chem 278 (30), 27652-27657 (2003)
   PUBMED   12714592
  REMARK    GeneRIF: Characterization and tissue distribution of SP9155
            (GPR103) ligand.
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BB634210.1 and AK029144.1.
            
            On Sep 26, 2015 this sequence version replaced NM_183424.3.
            
            Summary: This gene encodes a preproprotein that is proteolytically
            processed to generate multiple protein products. The encoded
            products are members of the RFamide family of neuropeptides,
            characterized by their common protein C-terminus consisting of an
            arginine (R) and an amidated phenylalanine (F). These products
            include the neuropeptides QRFP-26 (26RFa) and the N-terminally
            extended form, QRFP-43 (43RFa). Both of these neuropeptides bind to
            the pyroglutamylated RFamide peptide receptor (QRFPR) and may
            regulate blood pressure, reproduction and food intake. [provided by
            RefSeq, Sep 2015].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK029144.1, BB613620.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849378
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-62                BB634210.1         1-62
            63-2293             AK029144.1         2-2232
            2294-2780           AK029144.1         2234-2720
            2781-2925           AK029144.1         2722-2866
FEATURES             Location/Qualifiers
     source          1..2925
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 21.89 cM"
     gene            1..2925
                     /gene="Qrfp"
                     /gene_synonym="P518"
                     /note="pyroglutamylated RFamide peptide"
                     /db_xref="GeneID:227717"
                     /db_xref="MGI:MGI:3630329"
     exon            1..174
                     /gene="Qrfp"
                     /gene_synonym="P518"
                     /inference="alignment:Splign:2.1.0"
     exon            175..2925
                     /gene="Qrfp"
                     /gene_synonym="P518"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1448..1453
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Qrfp"
                     /gene_synonym="P518"
                     /note="hexamer: AATAAA"
     polyA_site      1475
                     /gene="Qrfp"
                     /gene_synonym="P518"
                     /note="major polyA site"
ORIGIN      
        1 atcctggggc taggaatgca tagcaatcag gcaggctggg gctcgcctct ccagggagct
       61 ttataaagcg ggggaacccc agagccatgc ctgctggacc gggacctgag cagctctgcc
      121 tgacaactgg ggtccaggga ctcacctgcc cttcttagag cagccctcag cacaatgagg
      181 ggcttccggc ctttgctttc cctacttctc cctctgagtg cctgctttcc cctgctggac
      241 agaaggggac ccacagacat cggtgacatc ggagccagga tgaactgggc ccagctggct
      301 gagggacatc cccccaactc ggttcaaaat ccacagccac aggccctgct tgtggtggcc
      361 agggagcagc aggcctccca cagggagcac accggcttcc gtctagggag gcaagacggt
      421 agcagtgagg ccgcagggtt cctgcccgcc gactcggaga aggccagcgg ccctctgggg
      481 actctggcag aggagctgag cagctacagc cggaggaagg gaggcttcag cttccgcttt
      541 ggacggtgag ggcctgcgtg gactctgccc cgtctgaccg tctactgttg ccccggcccc
      601 aacctcagga acccagaccc ggagagagta tcacagtgca ctagtggtgg tgaataggtg
      661 tgttcacatt ttcatttcca actttgctaa agtgagaaat ctgggtggtg ttcaagaaaa
      721 aaaaaaaaaa ccaaacaaac aaacaaaaaa ccaaaatgag caatcccctc tcctccctcc
      781 accccaccct actcctgaaa ccctgcacac aggaggacca agcttgtctt ggtcagtaag
      841 acaatgtgtc cttatcctag cccatgactc gggctgctgt ctgtctcagc ctccgacttt
      901 ccccagtggt ctgactggag cagtccccgg tccccagtgg cagcgcattg aggctgtgct
      961 ggggccgtgg atacaacagg cctctggctc tgttgttcat ttgtcggtag gtggactgag
     1021 agattacagc tggaaatcaa agttctgaca gtctccgaag ggacactggt agctgacatc
     1081 tgaaggggcg cgctgtgaaa gagcgcactc cgctgtgtat aaaatgtgag tctgaaagta
     1141 gagaaatgaa ggagaagaaa ataacccaga cacaaacaaa cccaaaacag tcagtgtgtt
     1201 ctccatccca ttagcacaag acgcctctgg caagaaagcc agcagtggca ccaagctgcc
     1261 cactgaatgg cctgtgcatc ccctctggct gcccatcgcc ccttgtccat ggtagtatta
     1321 gccaacttaa gggcctcatg gggactgaac tctgaaaggg tggggttttt tgtttgtttt
     1381 tgtttttgtg ctaagcaagg ttgagtttca aatacccaaa ctaggaattg ccatgtgtat
     1441 cttttgaaat aaaagttgta acaactgcag catcataatg ggatgctggc ctcttccttc
     1501 caggtcctct gggccccaga aacttctttt cttgagttcc tgaagccttc actttgggga
     1561 gatggaaatc aggctgcctg taccccgtac acctctccga gcagcccctt aattggcaac
     1621 tgggcgaagg gagagaagga acaggctgtt tccctctcca cttccctgtt ccctatgttt
     1681 ctcagaacga gtgtgagagg gaaaaaaaac gacatctcca cctgggggag gcaaggggag
     1741 gtgtgtgtag ggggacaggc tcagtctggg ctgtgtgccg gcctggggcc agcagaacat
     1801 ccctttcaaa ggctgccgag tctcctacat cccatcctgg gtcacacaca gccgtcagaa
     1861 gcagctcact ccagggctgg ctgtgactgc tgagatgaga acttatattg atgtttctat
     1921 ggcaacatct cccctcctcc ttgcgagtag cggcttgccc ccgttcacaa ttgaataatt
     1981 ttccattgag ctgtcacaat taattggtgg atttttatta gccttttaga accacactgg
     2041 gccaggccca gcttggcacc tcacagtatt ctggtgtttt ccattctatt agtgacttac
     2101 gtcctcagta gcagctttca atcctcagca gccaggaagc cacttcatta aggttgacag
     2161 atcagagcca caaaaggacc atgttgactg gggagcaggg ctgggaggtg aactgaggag
     2221 ggggccagag ccaaacacct gacacagtgg tgcactgact ccccccagag ccaccttggg
     2281 ctccccaggg gccttgcaca tgggtcctgg gctgcagtca cagggacaag acaagcacac
     2341 tgtaaggcac atcactctgc cgtccttacc atctcaggaa gatgtgacgg agggtgtgtc
     2401 cagcaaagga atgctactgc tctcctctag tgtggacatc atgggcacca ccacactcct
     2461 ttgggacagt cctgagaaca caggtcatct gtggacacag agaggtggct gtggtttccc
     2521 cagctccctc accagccagg gatgcccacc tgcttctgtg gggcagtacc ctggctcatt
     2581 catacacata tgagacaggc tgagacagaa gaccacaagc cagggctgaa gggcaccctg
     2641 gagcctgggc cctggcaccc actcacgcca tgaggctgca caccctcact cactctgggg
     2701 gtaggtaggg ctcattttga gttttcgtct tttttgatgc tgaggttcca gctcaggccc
     2761 tcatgcatgc taggcaagtg ccctggcact gggcttcacc ccgagcctgg caggttctta
     2821 atttagcagg attagattaa cctcgacgga gagggctgag atgaaggggg aggccttcaa
     2881 aggaacgcat ctgctgtcat tacctttaat cattaaaaga aaacc
//
