LOCUS       NM_133686               1211 bp    mRNA    linear   ROD 11-DEC-2024
DEFINITION  Mus musculus quinolinate phosphoribosyltransferase (Qprt), mRNA.
ACCESSION   NM_133686
VERSION     NM_133686.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1211)
  AUTHORS   Clark,A.J., Saade,M.C., Vemireddy,V., Vu,K.Q., Flores,B.M.,
            Etzrodt,V., Ciampa,E.J., Huang,H., Takakura,A., Zandi-Nejad,K.,
            Zsengeller,Z.K. and Parikh,S.M.
  TITLE     Hepatocyte nuclear factor 4alpha mediated quinolinate
            phosphoribosylltransferase (QPRT) expression in the kidney
            facilitates resilience against acute kidney injury
  JOURNAL   Kidney Int 104 (6), 1150-1163 (2023)
   PUBMED   37783445
  REMARK    GeneRIF: Hepatocyte nuclear factor 4alpha mediated quinolinate
            phosphoribosylltransferase (QPRT) expression in the kidney
            facilitates resilience against acute kidney injury.
REFERENCE   2  (bases 1 to 1211)
  AUTHORS   Chung,T., Bopp,T., Ward,C., Notarangelo,F.M., Schwarcz,R.,
            Westbrook,R., Xue,Q.L., Walston,J. and Hoke,A.
  TITLE     Deletion of quinolinate phosphoribosyltransferase gene accelerates
            frailty phenotypes and neuromuscular decline with aging in a
            sex-specific pattern
  JOURNAL   Aging Cell 22 (7), e13849 (2023)
   PUBMED   37078472
  REMARK    GeneRIF: Deletion of quinolinate phosphoribosyltransferase gene
            accelerates frailty phenotypes and neuromuscular decline with aging
            in a sex-specific pattern.
REFERENCE   3  (bases 1 to 1211)
  AUTHORS   Liu,C.L., Cheng,S.P., Chen,M.J., Lin,C.H., Chen,S.N., Kuo,Y.H. and
            Chang,Y.C.
  TITLE     Quinolinate Phosphoribosyltransferase Promotes Invasiveness of
            Breast Cancer Through Myosin Light Chain Phosphorylation
  JOURNAL   Front Endocrinol (Lausanne) 11, 621944 (2021)
   PUBMED   33613454
  REMARK    GeneRIF: Quinolinate Phosphoribosyltransferase Promotes
            Invasiveness of Breast Cancer Through Myosin Light Chain
            Phosphorylation.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1211)
  AUTHORS   Minhas,P.S., Liu,L., Moon,P.K., Joshi,A.U., Dove,C., Mhatre,S.,
            Contrepois,K., Wang,Q., Lee,B.A., Coronado,M., Bernstein,D.,
            Snyder,M.P., Migaud,M., Majeti,R., Mochly-Rosen,D., Rabinowitz,J.D.
            and Andreasson,K.I.
  TITLE     Macrophage de novo NAD+ synthesis specifies immune function in
            aging and inflammation
  JOURNAL   Nat Immunol 20 (1), 50-63 (2019)
   PUBMED   30478397
REFERENCE   5  (bases 1 to 1211)
  AUTHORS   Poyan Mehr,A., Tran,M.T., Ralto,K.M., Leaf,D.E., Washco,V.,
            Messmer,J., Lerner,A., Kher,A., Kim,S.H., Khoury,C.C., Herzig,S.J.,
            Trovato,M.E., Simon-Tillaux,N., Lynch,M.R., Thadhani,R.I.,
            Clish,C.B., Khabbaz,K.R., Rhee,E.P., Waikar,S.S., Berg,A.H. and
            Parikh,S.M.
  TITLE     De novo NAD+ biosynthetic impairment in acute kidney injury in
            humans
  JOURNAL   Nat Med 24 (9), 1351-1359 (2018)
   PUBMED   30127395
REFERENCE   6  (bases 1 to 1211)
  AUTHORS   Wang,Z., Gao,Y., Zhang,C., Hu,H., Guo,D., Xu,Y., Xu,Q., Zhang,W.,
            Deng,S., Lv,P., Yang,Y., Ding,Y., Li,Q., Weng,C., Chen,X., Gong,S.,
            Chen,H., Niu,J. and Tang,H.
  TITLE     Quinolinate Phosphoribosyltransferase is an Antiviral Host Factor
            Against Hepatitis C Virus Infection
  JOURNAL   Sci Rep 7 (1), 5876 (2017)
   PUBMED   28724915
  REMARK    GeneRIF: Hepatic QPRT thus likely served as a cellular factor that
            dampened productive hepatitis c virus replication.
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 1211)
  AUTHORS   Liu,X., Jiao,Y., Cao,Y., Deng,N., Ma,Y., Hasty,K.A., Kang,A.,
            Chen,H., Stuart,J.M. and Gu,W.
  TITLE     Decreased expression levels of Ifi genes is associated to the
            increased resistance to spontaneous arthritis disease in mice
            deficiency of IL-1RA
  JOURNAL   BMC Immunol 17 (1), 25 (2016)
   PUBMED   27480124
  REMARK    Publication Status: Online-Only
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC011191.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC011191.1, AK019119.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1211
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="FVB/N"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 69.33 cM"
     gene            1..1211
                     /gene="Qprt"
                     /gene_synonym="2410027J01Rik; QPRTase"
                     /note="quinolinate phosphoribosyltransferase"
                     /db_xref="GeneID:67375"
                     /db_xref="MGI:MGI:1914625"
     exon            1..57
                     /gene="Qprt"
                     /gene_synonym="2410027J01Rik; QPRTase"
                     /inference="alignment:Splign:2.1.0"
     CDS             45..944
                     /gene="Qprt"
                     /gene_synonym="2410027J01Rik; QPRTase"
                     /EC_number="2.4.2.19"
                     /note="QAPRTase; nicotinate-nucleotide pyrophosphorylase"
                     /codon_start=1
                     /product="nicotinate-nucleotide pyrophosphorylase
                     [carboxylating]"
                     /protein_id="NP_598447.1"
                     /db_xref="CCDS:CCDS40138.1"
                     /db_xref="GeneID:67375"
                     /db_xref="MGI:MGI:1914625"
                     /translation="MDPEGLQLLLPPTTLAALANSWLQEDCPGLNFASLVTGSAPSQA
                     VLWAKSPGVLAGRPFFDAIFTQLNCQVSWFLPEGSKLVPVVKVAEVKGPAHHLLLGER
                     VALNTLARCSGIASAAATAVEVARSTGWTGHVAGTRKTTPGFRLVEKYGLQVGGAACH
                     RYDLGGMVMVKDNHVVAAGSMERAVLKARQAAGFSLKVEVECSSLEEAFRAAEAGADL
                     VMLDNFKPEELHPTAATLKARFPSVSVEASGGVTLDNLTQFCGTHIDVISLGMLTQAA
                     PALDFSLKLFAEGDTPVPHARRF"
     exon            58..593
                     /gene="Qprt"
                     /gene_synonym="2410027J01Rik; QPRTase"
                     /inference="alignment:Splign:2.1.0"
     exon            594..725
                     /gene="Qprt"
                     /gene_synonym="2410027J01Rik; QPRTase"
                     /inference="alignment:Splign:2.1.0"
     exon            726..1197
                     /gene="Qprt"
                     /gene_synonym="2410027J01Rik; QPRTase"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1152..1157
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Qprt"
                     /gene_synonym="2410027J01Rik; QPRTase"
                     /note="hexamer: AATAAA"
     polyA_site      1197
                     /gene="Qprt"
                     /gene_synonym="2410027J01Rik; QPRTase"
                     /note="major polyA site"
ORIGIN      
        1 gaactgtggt gaacacactg acccgctggc tgctccaagt caccatggac cctgaaggcc
       61 tgcagctcct gttaccccct acaaccttgg cagccctggc gaacagctgg ctgcaagagg
      121 actgcccggg cctcaatttt gcatccttgg ttaccgggtc ggcaccctcg caggctgtgc
      181 tgtgggccaa atctcctggg gttctggcag ggcgaccctt ctttgacgcc atcttcactc
      241 aactcaactg ccaagtgtcc tggttcctcc cggagggatc gaagctggta cctgtggtca
      301 aggtggcaga ggtcaaggga cctgcccacc acctgctctt gggggaacgg gtggctctta
      361 acaccctggc ccgctgcagt gggattgcca gcgcggcagc gacagctgtg gaggtggcca
      421 ggagcaccgg ctggactgga cacgtggcgg gcacgaggaa gacgacacct gggttccgac
      481 tggtggagaa gtatgggctc caagtaggcg gggcagcatg ccaccgctac gacctgggag
      541 ggatggtgat ggtgaaagac aaccatgtag tggcggccgg cagcatggaa agggcagtgc
      601 tgaaggctcg gcaggcagcc gggttttccc tgaaggtaga ggtggaatgt agcagcctgg
      661 aggaggcctt tcgggcagca gaggctgggg ctgacctggt aatgctggac aactttaagc
      721 ctgaggagct gcaccccaca gcagctacac ttaaagccag attccccagc gtgtcggtgg
      781 aagccagtgg gggcgtcaca ctggacaacc tcacccagtt ctgtgggaca cacattgacg
      841 tcatctcgtt gggaatgctg acccaggctg ctccagccct ggatttttcc ctcaaactgt
      901 ttgctgaagg agatacccca gtgcctcacg ctcgccggtt ctaaagccga agaagatgcc
      961 accagaatgg actactgcgg cttgttgggc accttgggtc acatgtcttt agattcagag
     1021 gccaatagga catatctagg ctttttacct aggcttccca ctagctctgc catctccagc
     1081 ttgtgtgact tgccagggct gactttgatt ttgcttgcct cggttttctc atctgtgaaa
     1141 taggtctaat aaataaaatc aacagcctta ctgggctgtt gatgataata actactaaaa
     1201 aaaaaaaaaa a
//
