LOCUS       NM_027455               2059 bp    mRNA    linear   ROD 01-AUG-2024
DEFINITION  Mus musculus glutaminyl-peptide cyclotransferase (glutaminyl
            cyclase) (Qpct), transcript variant 1, mRNA.
ACCESSION   NM_027455 XM_001005187 XM_898493 XM_987319 XM_987493
VERSION     NM_027455.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2059)
  AUTHORS   Barreira da Silva,R., Leitao,R.M., Pechuan-Jorge,X., Werneke,S.,
            Oeh,J., Javinal,V., Wang,Y., Phung,W., Everett,C., Nonomiya,J.,
            Arnott,D., Lu,C., Hsiao,Y.C., Koerber,J.T., Hotzel,I., Ziai,J.,
            Modrusan,Z., Pillow,T.H., Roose-Girma,M., Schartner,J.M.,
            Merchant,M., Rutz,S., Eidenschenk,C., Mellman,I. and Albert,M.L.
  TITLE     Loss of the intracellular enzyme QPCTL limits chemokine function
            and reshapes myeloid infiltration to augment tumor immunity
  JOURNAL   Nat Immunol 23 (4), 568-580 (2022)
   PUBMED   35314846
REFERENCE   2  (bases 1 to 2059)
  AUTHORS   Guo,J., He,H., Liu,Q., Zhang,F., Lv,J., Zeng,T., Gu,N. and Wu,Q.
  TITLE     Identification and Epigenetic Analysis of a Maternally Imprinted
            Gene Qpct
  JOURNAL   Mol Cells 38 (10), 859-865 (2015)
   PUBMED   26447138
  REMARK    GeneRIF: Authors identified a placenta-specific imprinted gene
            Qpct. Results show that Qpct is widely expressed during early
            embryonic development and can be detected in the telencephalon,
            midbrain, and rhombencephalon at E9.5-E11.5.
REFERENCE   3  (bases 1 to 2059)
  AUTHORS   Waniek,A., Hartlage-Rubsamen,M., Hofling,C., Kehlen,A.,
            Schilling,S., Demuth,H.U. and Rossner,S.
  TITLE     Identification of thyrotropin-releasing hormone as hippocampal
            glutaminyl cyclase substrate in neurons and reactive astrocytes
  JOURNAL   Biochim Biophys Acta 1852 (1), 146-155 (2015)
   PUBMED   25446989
  REMARK    GeneRIF: co-regulation of the enzyme glutaminyl cyclase and its
            substrate TRH was reflected by a co-induction of both proteins in
            reactive astrocytes in proximity of Abeta deposits
REFERENCE   4  (bases 1 to 2059)
  AUTHORS   Hofling,C., Indrischek,H., Hopcke,T., Waniek,A., Cynis,H., Koch,B.,
            Schilling,S., Morawski,M., Demuth,H.U., Rossner,S. and
            Hartlage-Rubsamen,M.
  TITLE     Mouse strain and brain region-specific expression of the glutaminyl
            cyclases QC and isoQC
  JOURNAL   Int J Dev Neurosci 36, 64-73 (2014)
   PUBMED   24886834
  REMARK    GeneRIF: This study provide a thorough comparative characterization
            of the glutaminyl cyclases QC and isoQC in defined brain regions of
            different inbred and outbred mouse strains
REFERENCE   5  (bases 1 to 2059)
  AUTHORS   Alexandru,A., Jagla,W., Graubner,S., Becker,A., Bauscher,C.,
            Kohlmann,S., Sedlmeier,R., Raber,K.A., Cynis,H., Ronicke,R.,
            Reymann,K.G., Petrasch-Parwez,E., Hartlage-Rubsamen,M., Waniek,A.,
            Rossner,S., Schilling,S., Osmand,A.P., Demuth,H.U. and von
            Horsten,S.
  TITLE     Selective hippocampal neurodegeneration in transgenic mice
            expressing small amounts of truncated Abeta is induced by
            pyroglutamate-Abeta formation
  JOURNAL   J Neurosci 31 (36), 12790-12801 (2011)
   PUBMED   21900558
REFERENCE   6  (bases 1 to 2059)
  AUTHORS   Hartlage-Rubsamen,M., Staffa,K., Waniek,A., Wermann,M.,
            Hoffmann,T., Cynis,H., Schilling,S., Demuth,H.U. and Rossner,S.
  TITLE     Developmental expression and subcellular localization of glutaminyl
            cyclase in mouse brain
  JOURNAL   Int J Dev Neurosci 27 (8), 825-835 (2009)
   PUBMED   19699792
  REMARK    GeneRIF: Results describe the expression of glutaminyl cyclase
            throughout the mouse brain during early postnatal development.
REFERENCE   7  (bases 1 to 2059)
  AUTHORS   Stephan,A., Wermann,M., von Bohlen,A., Koch,B., Cynis,H.,
            Demuth,H.U. and Schilling,S.
  TITLE     Mammalian glutaminyl cyclases and their isoenzymes have identical
            enzymatic characteristics
  JOURNAL   FEBS J 276 (22), 6522-6536 (2009)
   PUBMED   19804409
  REMARK    GeneRIF: Murine isoQC proteins displayed a broad substrate
            specificity and preference for hydrophobic substrates, similar to
            the related QC.
REFERENCE   8  (bases 1 to 2059)
  AUTHORS   Ye,J.T., Pi,R.B., Mao,X.X., Chen,X.H., Qin,J., Xu,S.W. and Liu,P.Q.
  TITLE     Alterations in mRNA expression of BACE1, cathepsin B, and
            glutaminyl cyclase in mice ischemic brain
  JOURNAL   Neuroreport 20 (16), 1456-1460 (2009)
   PUBMED   19809370
  REMARK    GeneRIF: The observations of this study indicated that brain
            ischemia might be a pathogenic factor of alzheimer disease through
            increasing BACE1, cathepsin B, and glutaminyl cyclase.
REFERENCE   9  (bases 1 to 2059)
  AUTHORS   Boon,A.C., deBeauchamp,J., Hollmann,A., Luke,J., Kotb,M., Rowe,S.,
            Finkelstein,D., Neale,G., Lu,L., Williams,R.W. and Webby,R.J.
  TITLE     Host genetic variation affects resistance to infection with a
            highly pathogenic H5N1 influenza A virus in mice
  JOURNAL   J Virol 83 (20), 10417-10426 (2009)
   PUBMED   19706712
REFERENCE   10 (bases 1 to 2059)
  AUTHORS   Schilling,S., Cynis,H., von Bohlen,A., Hoffmann,T., Wermann,M.,
            Heiser,U., Buchholz,M., Zunkel,K. and Demuth,H.U.
  TITLE     Isolation, catalytic properties, and competitive inhibitors of the
            zinc-dependent murine glutaminyl cyclase
  JOURNAL   Biochemistry 44 (40), 13415-13424 (2005)
   PUBMED   16201766
  REMARK    GeneRIF: QC is a zinc-dependent catalyst
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK045974.1 and AK148394.1.
            
            On Oct 24, 2015 this sequence version replaced NM_027455.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK148394.1, AK045974.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1924              AK045974.1         2-1925
            1925-2059           AK148394.1         1597-1731
FEATURES             Location/Qualifiers
     source          1..2059
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 49.83 cM"
     gene            1..2059
                     /gene="Qpct"
                     /gene_synonym="5730422A13Rik"
                     /note="glutaminyl-peptide cyclotransferase (glutaminyl
                     cyclase)"
                     /db_xref="GeneID:70536"
                     /db_xref="MGI:MGI:1917786"
     exon            1..483
                     /gene="Qpct"
                     /gene_synonym="5730422A13Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             361..1449
                     /gene="Qpct"
                     /gene_synonym="5730422A13Rik"
                     /EC_number="2.3.2.5"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; QC; glutaminyl cyclase; glutaminyl-tRNA
                     cyclotransferase"
                     /codon_start=1
                     /product="glutaminyl-peptide cyclotransferase isoform 1
                     precursor"
                     /protein_id="NP_081731.1"
                     /db_xref="CCDS:CCDS28983.1"
                     /db_xref="GeneID:70536"
                     /db_xref="MGI:MGI:1917786"
                     /translation="MAGSEDKLVVGTLHLLLLQATVLSLTAGNLSLVSAAWTQEKNHH
                     QPAHLNSSSLQQVAEGTSISEMWQNDLRPLLIERYPGSPGSYSARQHIMQRIQRLQAE
                     WVVEVDTFLSRTPYGYRSFSNIISTLNPEAKRHLVLACHYDSKYFPRWDSRVFVGATD
                     SAVPCAMMLELARALDKKLHSLKDVSGSKPDLSLRLIFFDGEEAFHHWSPQDSLYGSR
                     HLAQKMASSPHPPGSRGTNQLDGMDLLVLLDLIGAANPTFPNFFPKTTRWFNRLQAIE
                     KELYELGLLKDHSLERKYFQNFGYGNIIQDDHIPFLRKGVPVLHLIASPFPEVWHTMD
                     DNEENLHASTIDNLNKIIQVFVLEYLHL"
     exon            484..630
                     /gene="Qpct"
                     /gene_synonym="5730422A13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            631..909
                     /gene="Qpct"
                     /gene_synonym="5730422A13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            910..1086
                     /gene="Qpct"
                     /gene_synonym="5730422A13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1087..1186
                     /gene="Qpct"
                     /gene_synonym="5730422A13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1187..1303
                     /gene="Qpct"
                     /gene_synonym="5730422A13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1304..2059
                     /gene="Qpct"
                     /gene_synonym="5730422A13Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1878..1883
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Qpct"
                     /gene_synonym="5730422A13Rik"
                     /note="hexamer: ATTAAA"
     polyA_site      1900
                     /gene="Qpct"
                     /gene_synonym="5730422A13Rik"
                     /note="major polyA site"
ORIGIN      
        1 ccttccttcc ttccttcctt ccttccttcc ttccttcctt ctttcctccc tctctctccc
       61 tccctccctc ccttcctttt ttccctccat cctttctaaa ataaggaagt gttttctttg
      121 tcccttggat tccaaagctc ctgtcaccca gggaagctca gtcccctggc ttccaggctt
      181 ctgggagagg actgctggtt tgtgcttgcg ctgcacagcg ggaggccaca ggaggcgact
      241 gggaggcaga cacaatcaat ccaggggtgg agaagggaga aggcagggcg accggcgcgc
      301 gttcccgggc tcgtgaccgc tggcggcccc gggaatccac gcccacacac tcttgcagag
      361 atggcaggca gcgaagacaa gctcgtcgtg ggcactctcc acctgctgct actgcaggcg
      421 accgtcctgt ctctgacagc tgggaatctg agtctggtct ccgctgcctg gacgcaggag
      481 aagaaccacc accaaccagc acatttgaat tcttcatctc ttcagcaagt tgcagaaggc
      541 actagcattt ctgaaatgtg gcaaaacgac ttgagaccat tgctgataga acgatatcct
      601 ggatcgcccg gaagctattc tgctcggcag cacatcatgc aacgaattca gagacttcag
      661 gctgagtggg tcgtggaagt tgacaccttc ctgagtagga ctccctatgg ctatcggtcc
      721 ttctcaaata tcatcagcac tcttaacccg gaagcgaaac gacacctggt cctcgcctgc
      781 cactacgact ccaaatattt tcctcgatgg gacagcagag tgtttgtggg agccacggat
      841 tcagctgtgc catgtgcaat gatgttggaa cttgcccgtg ccttagacaa gaaactccat
      901 tccttgaagg atgtctctgg ttccaagcca gatctctcac tccggctaat tttctttgat
      961 ggtgaagagg cttttcatca ctggtcccct caagattctc tgtatgggtc tcggcactta
     1021 gctcagaaga tggcatcaag ccctcaccct cctggatcaa gaggcaccaa ccaactggat
     1081 ggcatggatc tgttggtctt actagattta attggagcag caaatccaac attccctaat
     1141 tttttcccca agactaccag atggtttaat agacttcaag caattgaaaa ggaactctat
     1201 gaattgggat tactcaagga tcattctttg gagaggaagt attttcagaa ttttggctat
     1261 ggaaatatta tccaggatga ccacattcca tttttaagaa aaggtgtccc agttcttcac
     1321 ctgatagctt ctcctttccc tgaagtctgg cacaccatgg atgacaatga agaaaatcta
     1381 catgcgtcaa ccattgacaa tctcaacaaa atcattcaag tctttgtgtt ggaatatctt
     1441 cacttgtaat gtttggattt agtttctggt aattgcttct acagcaactt caagacacca
     1501 tttatacaat ctgcttccag ataaatgtgt gtagacttct gtcctataga ttcattctgt
     1561 aggtgttttt gaatatgtga tcagcgaact gtagaattct atgatgcctt cactaatttt
     1621 cctctagaga tgagaaagaa acatgtaaag aaataaaata ataataattt ttaaaattct
     1681 tttggattaa aactttaaca taaagttaga tttatttacc aataccatag atttgtaaac
     1741 aatacttaga tacaatgatg ctgtatggta tagtggtagt tttatatgtg atattatata
     1801 gtgtgttata taatatgtaa taaaacacag gcatatactt tgacagcctt taagtttctt
     1861 taaaaaaagc tttggaaatt aaagtctgaa ttaaattgca tattgtgaat ttattttcat
     1921 gtccataaat gagaaagtgt ctgttttaat gcatggtcca gttttctaga tttttatacc
     1981 tataattttt ttttgtaaag atgatagagt tggtgacaaa accttcagaa aaggatacaa
     2041 aatataatcc cattgcatt
//
