LOCUS       NP_081731                362 aa            linear   ROD 01-AUG-2024
DEFINITION  glutaminyl-peptide cyclotransferase isoform 1 precursor [Mus
            musculus].
ACCESSION   NP_081731 XP_001005187 XP_903586 XP_992413 XP_992587
VERSION     NP_081731.1
DBSOURCE    REFSEQ: accession NM_027455.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 362)
  AUTHORS   Barreira da Silva,R., Leitao,R.M., Pechuan-Jorge,X., Werneke,S.,
            Oeh,J., Javinal,V., Wang,Y., Phung,W., Everett,C., Nonomiya,J.,
            Arnott,D., Lu,C., Hsiao,Y.C., Koerber,J.T., Hotzel,I., Ziai,J.,
            Modrusan,Z., Pillow,T.H., Roose-Girma,M., Schartner,J.M.,
            Merchant,M., Rutz,S., Eidenschenk,C., Mellman,I. and Albert,M.L.
  TITLE     Loss of the intracellular enzyme QPCTL limits chemokine function
            and reshapes myeloid infiltration to augment tumor immunity
  JOURNAL   Nat Immunol 23 (4), 568-580 (2022)
   PUBMED   35314846
REFERENCE   2  (residues 1 to 362)
  AUTHORS   Guo,J., He,H., Liu,Q., Zhang,F., Lv,J., Zeng,T., Gu,N. and Wu,Q.
  TITLE     Identification and Epigenetic Analysis of a Maternally Imprinted
            Gene Qpct
  JOURNAL   Mol Cells 38 (10), 859-865 (2015)
   PUBMED   26447138
  REMARK    GeneRIF: Authors identified a placenta-specific imprinted gene
            Qpct. Results show that Qpct is widely expressed during early
            embryonic development and can be detected in the telencephalon,
            midbrain, and rhombencephalon at E9.5-E11.5.
REFERENCE   3  (residues 1 to 362)
  AUTHORS   Waniek,A., Hartlage-Rubsamen,M., Hofling,C., Kehlen,A.,
            Schilling,S., Demuth,H.U. and Rossner,S.
  TITLE     Identification of thyrotropin-releasing hormone as hippocampal
            glutaminyl cyclase substrate in neurons and reactive astrocytes
  JOURNAL   Biochim Biophys Acta 1852 (1), 146-155 (2015)
   PUBMED   25446989
  REMARK    GeneRIF: co-regulation of the enzyme glutaminyl cyclase and its
            substrate TRH was reflected by a co-induction of both proteins in
            reactive astrocytes in proximity of Abeta deposits
REFERENCE   4  (residues 1 to 362)
  AUTHORS   Hofling,C., Indrischek,H., Hopcke,T., Waniek,A., Cynis,H., Koch,B.,
            Schilling,S., Morawski,M., Demuth,H.U., Rossner,S. and
            Hartlage-Rubsamen,M.
  TITLE     Mouse strain and brain region-specific expression of the glutaminyl
            cyclases QC and isoQC
  JOURNAL   Int J Dev Neurosci 36, 64-73 (2014)
   PUBMED   24886834
  REMARK    GeneRIF: This study provide a thorough comparative characterization
            of the glutaminyl cyclases QC and isoQC in defined brain regions of
            different inbred and outbred mouse strains
REFERENCE   5  (residues 1 to 362)
  AUTHORS   Alexandru,A., Jagla,W., Graubner,S., Becker,A., Bauscher,C.,
            Kohlmann,S., Sedlmeier,R., Raber,K.A., Cynis,H., Ronicke,R.,
            Reymann,K.G., Petrasch-Parwez,E., Hartlage-Rubsamen,M., Waniek,A.,
            Rossner,S., Schilling,S., Osmand,A.P., Demuth,H.U. and von
            Horsten,S.
  TITLE     Selective hippocampal neurodegeneration in transgenic mice
            expressing small amounts of truncated Abeta is induced by
            pyroglutamate-Abeta formation
  JOURNAL   J Neurosci 31 (36), 12790-12801 (2011)
   PUBMED   21900558
REFERENCE   6  (residues 1 to 362)
  AUTHORS   Hartlage-Rubsamen,M., Staffa,K., Waniek,A., Wermann,M.,
            Hoffmann,T., Cynis,H., Schilling,S., Demuth,H.U. and Rossner,S.
  TITLE     Developmental expression and subcellular localization of glutaminyl
            cyclase in mouse brain
  JOURNAL   Int J Dev Neurosci 27 (8), 825-835 (2009)
   PUBMED   19699792
  REMARK    GeneRIF: Results describe the expression of glutaminyl cyclase
            throughout the mouse brain during early postnatal development.
REFERENCE   7  (residues 1 to 362)
  AUTHORS   Stephan,A., Wermann,M., von Bohlen,A., Koch,B., Cynis,H.,
            Demuth,H.U. and Schilling,S.
  TITLE     Mammalian glutaminyl cyclases and their isoenzymes have identical
            enzymatic characteristics
  JOURNAL   FEBS J 276 (22), 6522-6536 (2009)
   PUBMED   19804409
  REMARK    GeneRIF: Murine isoQC proteins displayed a broad substrate
            specificity and preference for hydrophobic substrates, similar to
            the related QC.
REFERENCE   8  (residues 1 to 362)
  AUTHORS   Ye,J.T., Pi,R.B., Mao,X.X., Chen,X.H., Qin,J., Xu,S.W. and Liu,P.Q.
  TITLE     Alterations in mRNA expression of BACE1, cathepsin B, and
            glutaminyl cyclase in mice ischemic brain
  JOURNAL   Neuroreport 20 (16), 1456-1460 (2009)
   PUBMED   19809370
  REMARK    GeneRIF: The observations of this study indicated that brain
            ischemia might be a pathogenic factor of alzheimer disease through
            increasing BACE1, cathepsin B, and glutaminyl cyclase.
REFERENCE   9  (residues 1 to 362)
  AUTHORS   Boon,A.C., deBeauchamp,J., Hollmann,A., Luke,J., Kotb,M., Rowe,S.,
            Finkelstein,D., Neale,G., Lu,L., Williams,R.W. and Webby,R.J.
  TITLE     Host genetic variation affects resistance to infection with a
            highly pathogenic H5N1 influenza A virus in mice
  JOURNAL   J Virol 83 (20), 10417-10426 (2009)
   PUBMED   19706712
REFERENCE   10 (residues 1 to 362)
  AUTHORS   Schilling,S., Cynis,H., von Bohlen,A., Hoffmann,T., Wermann,M.,
            Heiser,U., Buchholz,M., Zunkel,K. and Demuth,H.U.
  TITLE     Isolation, catalytic properties, and competitive inhibitors of the
            zinc-dependent murine glutaminyl cyclase
  JOURNAL   Biochemistry 44 (40), 13415-13424 (2005)
   PUBMED   16201766
  REMARK    GeneRIF: QC is a zinc-dependent catalyst
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK045974.1 and AK148394.1.
            
            On or before Jul 24, 2006 this sequence version replaced
            XP_001005187.1, XP_903586.2, XP_992587.1, XP_992413.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK148394.1, AK045974.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..362
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 49.83 cM"
     Protein         1..362
                     /product="glutaminyl-peptide cyclotransferase isoform 1
                     precursor"
                     /EC_number="2.3.2.5"
                     /note="QC; glutaminyl cyclase; glutaminyl-tRNA
                     cyclotransferase"
                     /calculated_mol_wt=37558
     sig_peptide     1..35
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=3536
     Site            29
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9CYK2.2)"
     mat_peptide     36..362
                     /product="Glutaminyl-peptide cyclotransferase.
                     /id=PRO_0000022196"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9CYK2.2)"
                     /calculated_mol_wt=37558
     Site            50
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000269|PubMed:21671571,
                     ECO:0007744|PDB:3SI1, ECO:0007744|PDB:3SI2; propagated
                     from UniProtKB/Swiss-Prot (Q9CYK2.2)"
     Region          54..359
                     /region_name="M28_QC_like"
                     /note="M28 Zn-peptidase glutaminyl cyclase; cd03880"
                     /db_xref="CDD:349876"
     Site            order(160,202..204,208,213..214,249..250,304..305,322,326,
                     330..331)
                     /site_type="active"
                     /db_xref="CDD:349876"
     CDS             1..362
                     /gene="Qpct"
                     /gene_synonym="5730422A13Rik"
                     /coded_by="NM_027455.3:361..1449"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1"
                     /db_xref="CCDS:CCDS28983.1"
                     /db_xref="GeneID:70536"
                     /db_xref="MGI:MGI:1917786"
ORIGIN      
        1 magsedklvv gtlhllllqa tvlsltagnl slvsaawtqe knhhqpahln ssslqqvaeg
       61 tsisemwqnd lrpllieryp gspgsysarq himqriqrlq aewvvevdtf lsrtpygyrs
      121 fsniistlnp eakrhlvlac hydskyfprw dsrvfvgatd savpcammle laraldkklh
      181 slkdvsgskp dlslrliffd geeafhhwsp qdslygsrhl aqkmassphp pgsrgtnqld
      241 gmdllvlldl igaanptfpn ffpkttrwfn rlqaiekely elgllkdhsl erkyfqnfgy
      301 gniiqddhip flrkgvpvlh liaspfpevw htmddneenl hastidnlnk iiqvfvleyl
      361 hl
//
