LOCUS       NM_001159517            4522 bp    mRNA    linear   ROD 14-OCT-2024
DEFINITION  Mus musculus quaking, KH domain containing RNA binding (Qki),
            transcript variant 1, mRNA.
ACCESSION   NM_001159517
VERSION     NM_001159517.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4522)
  AUTHORS   Hayakawa-Yano,Y., Furukawa,T., Matsuo,T., Ogasawara,T., Nogami,M.,
            Yokoyama,K., Yugami,M., Shinozaki,M., Nakamoto,C., Sakimura,K.,
            Koyama,A., Ogi,K., Onodera,O., Takebayashi,H., Okano,H. and Yano,M.
  TITLE     Qki5 safeguards spinal motor neuron function by defining the motor
            neuron-specific transcriptome via pre-mRNA processing
  JOURNAL   Proc Natl Acad Sci U S A 121 (37), e2401531121 (2024)
   PUBMED   39226364
  REMARK    GeneRIF: Qki5 safeguards spinal motor neuron function by defining
            the motor neuron-specific transcriptome via pre-mRNA processing.
REFERENCE   2  (bases 1 to 4522)
  AUTHORS   Montanes-Agudo,P., van der Made,I., Aufiero,S., Tijsen,A.J.,
            Pinto,Y.M. and Creemers,E.E.
  TITLE     Quaking regulates circular RNA production in cardiomyocytes
  JOURNAL   J Cell Sci 136 (13) (2023)
   PUBMED   37272356
REFERENCE   3  (bases 1 to 4522)
  AUTHORS   Yan,Z., Ruan,B., Wang,S., Du,T., Shao,X., Chen,G., Wang,L.,
            Zhai,D., Zhu,S., Lu,Z. and Cao,X.
  TITLE     RNA-binding Protein QKI Inhibits Osteogenic Differentiation Via
            Suppressing Wnt Pathway
  JOURNAL   Arch Med Res 54 (5), 102853 (2023)
   PUBMED   37460362
  REMARK    GeneRIF: RNA-binding Protein QKI Inhibits Osteogenic
            Differentiation Via Suppressing Wnt Pathway.
REFERENCE   4  (bases 1 to 4522)
  AUTHORS   Montanes-Agudo,P., Aufiero,S., Schepers,E.N., van der Made,I.,
            Cocera-Ortega,L., Ernault,A.C., Richard,S., Kuster,D.W.D.,
            Christoffels,V.M., Pinto,Y.M. and Creemers,E.E.
  TITLE     The RNA-binding protein QKI governs a muscle-specific alternative
            splicing program that shapes the contractile function of
            cardiomyocytes
  JOURNAL   Cardiovasc Res 119 (5), 1161-1174 (2023)
   PUBMED   36627242
  REMARK    GeneRIF: The RNA-binding protein QKI governs a muscle-specific
            alternative splicing program that shapes the contractile function
            of cardiomyocytes.
REFERENCE   5  (bases 1 to 4522)
  AUTHORS   Zhai,D., Wang,W., Ye,Z., Xue,K., Chen,G., Hu,S., Yan,Z., Guo,Y.,
            Wang,F., Li,X., Xiang,A., Li,X., Lu,Z. and Wang,L.
  TITLE     QKI degradation in macrophage by RNF6 protects mice from MRSA
            infection via enhancing PI3K p110beta dependent autophagy
  JOURNAL   Cell Biosci 12 (1), 154 (2022)
   PUBMED   36088389
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4522)
  AUTHORS   Mikoshiba,K., Nagaike,K., Aoki,E. and Tsukada,Y.
  TITLE     Biochemical and immunohistochemical studies on dysmyelination of
            quaking mutant mice in vivo and in vitro
  JOURNAL   Brain Res 177 (2), 287-299 (1979)
   PUBMED   227533
REFERENCE   7  (bases 1 to 4522)
  AUTHORS   Greenfield,S., Williams,N.I., White,M., Brostoff,S.W. and
            Hogan,E.L.
  TITLE     Proteolipid protein: synthesis and assembly into quaking mouse
            myelin
  JOURNAL   J Neurochem 32 (6), 1647-1651 (1979)
   PUBMED   448358
REFERENCE   8  (bases 1 to 4522)
  AUTHORS   Fagg,G.E.
  TITLE     The quaking mouse: regional variations in the content and protein
            composition of myelin isolated from the central nervous system
  JOURNAL   Neuroscience 4 (7), 973-978 (1979)
   PUBMED   552615
REFERENCE   9  (bases 1 to 4522)
  AUTHORS   Suzuki,K. and Zagoren,J.C.
  TITLE     Quaking mouse: an ultrastructural study of the peripheral nerves
  JOURNAL   J Neurocytol 6 (1), 71-84 (1977)
   PUBMED   190360
REFERENCE   10 (bases 1 to 4522)
  AUTHORS   Friedrich,V.L. Jr.
  TITLE     Hyperplasia of oligodendrocytes in quaking mice
  JOURNAL   Anat Embryol (Berl) 147 (3), 259-271 (1975)
   PUBMED   174456
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC154238.2 and AC113114.9.
            
            On Nov 25, 2022 this sequence version replaced NM_001159517.1.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC056346.1, SRR7652917.560618.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164135
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-574               AC154238.2         32594-33167         c
            575-717             AC113114.9         27091-27233
            718-834             AC113114.9         36009-36125
            835-978             AC113114.9         71036-71179
            979-1066            AC113114.9         92269-92356
            1067-1366           AC113114.9         93613-93912
            1367-1441           AC113114.9         96639-96713
            1442-4522           AC113114.9         100441-103521
FEATURES             Location/Qualifiers
     source          1..4522
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 7.75 cM"
     gene            1..4522
                     /gene="Qki"
                     /gene_synonym="1110003F05Rik; 1500005P18; l(17)-1Wis;
                     l17Wis1; Qk"
                     /note="quaking, KH domain containing RNA binding"
                     /db_xref="GeneID:19317"
                     /db_xref="MGI:MGI:97837"
     exon            1..574
                     /gene="Qki"
                     /gene_synonym="1110003F05Rik; 1500005P18; l(17)-1Wis;
                     l17Wis1; Qk"
                     /inference="alignment:Splign:2.1.0"
     CDS             433..1458
                     /gene="Qki"
                     /gene_synonym="1110003F05Rik; 1500005P18; l(17)-1Wis;
                     l17Wis1; Qk"
                     /note="isoform 1 is encoded by transcript variant 1;
                     protein quaking; lethal, Chr 17, U Wisconsin 1; QKI-5
                     protein; QKI-6 protein; KH domain-containing RNA-binding
                     protein QKI; QKI-7b protein; QKI-7 protein"
                     /codon_start=1
                     /product="KH domain-containing RNA-binding protein QKI
                     isoform 1"
                     /protein_id="NP_001152989.1"
                     /db_xref="CCDS:CCDS49947.1"
                     /db_xref="GeneID:19317"
                     /db_xref="MGI:MGI:97837"
                     /translation="MVGEMETKEKPKPTPDYLMQLMNDKKLMSSLPNFCGIFNHLERL
                     LDEEISRVRKDMYNDTLNGSTEKRSAELPDAVGPIVQLQEKLYVPVKEYPDFNFVGRI
                     LGPRGLTAKQLEAETGCKIMVRGKGSMRDKKKEEQNRGKPNWEHLNEDLHVLITVEDA
                     QNRAEIKLKRAVEEVKKLLVPAAEGEDSLKKMQLMELAILNGTYRDANIKSPALAFSL
                     AATAQAAPRIITGPAPVLPPAALRTPTPAGPTIMPLIRQIQTAVMPNGTPHPTAAIVP
                     PGPEAGLIYTPYEYPYTLAPATSILEYPIEPSGVLGAVATKVRRHDMRVHPYQRIVTA
                     DRAATGN"
     exon            575..717
                     /gene="Qki"
                     /gene_synonym="1110003F05Rik; 1500005P18; l(17)-1Wis;
                     l17Wis1; Qk"
                     /inference="alignment:Splign:2.1.0"
     exon            718..834
                     /gene="Qki"
                     /gene_synonym="1110003F05Rik; 1500005P18; l(17)-1Wis;
                     l17Wis1; Qk"
                     /inference="alignment:Splign:2.1.0"
     exon            835..978
                     /gene="Qki"
                     /gene_synonym="1110003F05Rik; 1500005P18; l(17)-1Wis;
                     l17Wis1; Qk"
                     /inference="alignment:Splign:2.1.0"
     exon            979..1066
                     /gene="Qki"
                     /gene_synonym="1110003F05Rik; 1500005P18; l(17)-1Wis;
                     l17Wis1; Qk"
                     /inference="alignment:Splign:2.1.0"
     exon            1067..1366
                     /gene="Qki"
                     /gene_synonym="1110003F05Rik; 1500005P18; l(17)-1Wis;
                     l17Wis1; Qk"
                     /inference="alignment:Splign:2.1.0"
     exon            1367..1441
                     /gene="Qki"
                     /gene_synonym="1110003F05Rik; 1500005P18; l(17)-1Wis;
                     l17Wis1; Qk"
                     /inference="alignment:Splign:2.1.0"
     exon            1442..4522
                     /gene="Qki"
                     /gene_synonym="1110003F05Rik; 1500005P18; l(17)-1Wis;
                     l17Wis1; Qk"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4495..4500
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Qki"
                     /gene_synonym="1110003F05Rik; 1500005P18; l(17)-1Wis;
                     l17Wis1; Qk"
                     /note="hexamer: AATAAA"
     polyA_site      4522
                     /gene="Qki"
                     /gene_synonym="1110003F05Rik; 1500005P18; l(17)-1Wis;
                     l17Wis1; Qk"
                     /note="major polyA site"
ORIGIN      
        1 gcagtcggag cgcggcggcg gcggcggcgg cggtaacgcg gagcgccgcg gcggacagca
       61 ccgcagactc gcgagctccg gcgcaggcgg cgcgaccggc cgacgagcgg ccccccggct
      121 cctcgcggcg cagcggcccc gcgccgcgct cggcccgaga cccgcctctg ccgccggcct
      181 cgcgagggga gccgcgccgg gcggccgagg agcggcggcc gcggcgcgtc gggccgggcg
      241 aaagtgcctg cggggggcgg gcgggcgcgc ggagccggcc gccccggggc tcggcgcggg
      301 agccggagcg ggagccggcg cggagcggga cgccgcgtcc cgagcggccg gcggccggag
      361 ctcgcccccg cccctccctc ctctcctccg gcggcggcgg cggcgggcgg agtgagctgc
      421 ggagcctgga atatggtcgg ggaaatggaa acgaaggaga agccgaagcc caccccagat
      481 tatttgatgc agctgatgaa cgacaagaag ctcatgagca gcctgcccaa cttctgcggg
      541 atcttcaacc acctcgagcg gctgctggac gaagaaatta gcagagtacg gaaagacatg
      601 tacaatgaca cgttaaatgg cagtacagag aaaagaagtg cagaattgcc tgacgcggtg
      661 ggacccattg ttcagttaca agagaaactt tatgtgcctg taaaagaata ccctgatttt
      721 aattttgttg ggagaatcct tggacctaga ggacttacag ctaaacaact tgaagcagaa
      781 acgggatgta aaataatggt ccgaggcaaa ggctcaatga gggataaaaa gaaggaggag
      841 caaaatagag gcaagcccaa ttgggagcat ctaaatgaag acttacatgt actaatcact
      901 gtggaagatg ctcagaacag agcagaaatc aagctgaaga gagcggttga agaagtgaag
      961 aagttactgg tacctgcggc tgaaggtgaa gacagcctga agaagatgca gctgatggag
     1021 cttgcaattc tgaatggcac ctacagagac gccaacatta aatcaccagc ccttgccttt
     1081 tctcttgcag caactgccca ggctgctcca aggatcatca ctgggcctgc gcctgtcctc
     1141 ccaccagctg ctctgcgtac acctacgcca gctggcccta ccataatgcc tttgatcaga
     1201 caaatacaga ccgctgtcat gccaaacgga actcctcacc caactgctgc aatagtccct
     1261 ccagggcctg aagctgggtt aatctacaca ccctatgaat acccctacac attggcacca
     1321 gctacatcaa tccttgagta ccctattgaa cccagtggtg tgttaggtgc ggtggctact
     1381 aaagttcgaa ggcacgatat gcgtgtccat ccttaccaaa ggattgtgac cgcagaccga
     1441 gccgccaccg gcaactaacc tatgaccttc tgacctctga actcttcacc caatgatgac
     1501 ctgaccatgc ctgcctgctg atcagttaac tggtaatcgc ctttgcttgc ctgtcgtcag
     1561 tgcagcgagc tgaggcactt gtccgttcgt cttaccatct aaccaaacaa aagacaaaga
     1621 aattgtcctc caactcagct tttccccccc tgtttgggtg aaagtggttc tagaacctgc
     1681 actgaatagt agtaaagcaa taaggcccga ttcatcccac agcactgatc atctctcaat
     1741 gccccacccc aagcgaacgg taagaaggcc tctcttaaga aggggagaca gatggcccta
     1801 actactcagt gacagaggca gttactgtga gagacttgta ggaatttttt tcttctccta
     1861 gcgaagtcaa agctctctct gaatgtactg tgtgacaatg catcatgcat gaaccttcgg
     1921 tcagggatgt cgttggggaa gtgacttcaa aagtattcaa aatttgacat gctgtttgtt
     1981 tagtcactac agtgccctca aagggcagac attgcagcct ttttatattg cctgccaaaa
     2041 tttgaagtat tagaacaaag tgtgccatga gagaaaaact taacaaggag ttttgaaaag
     2101 aaatgcaaag aacaaaacta caacactatt ttttaaaaag ttgagtatct gagttaaaat
     2161 ttccaaatct ttattttaca ccaccttaaa aattatatga gaacaaggta catgcattat
     2221 gtgtcacatt actgggcaaa ctgttcaaat atttttttta aacctccctg tatagaaaat
     2281 atcattaagg atgtaaaagc catgcttgcc tatttgctgt atacatgtaa tgaaattgta
     2341 gataaagtgt agtgcattga aacaaatgaa caaaaaagta gatactttta ctatacaagg
     2401 gtgctggtgc agaaaaaaat atatatattt ttggaaatgt agcattttat actttcaagt
     2461 gttataaaaa aaaagaaaaa gaacaaagaa accctttatt tcattaaatg attttttctg
     2521 gtggttgtca agaaacaaaa gaccaaaaga gcctttttgt ctttcttttt tattttttaa
     2581 gtattggaat aagtctaatg aaaaagaaag tgccttattt ttcttcatgg tcatttagtc
     2641 aagtgtcctg taagatcagc tcctccctca gaataaagtt actgcatgtt cctcagtcgc
     2701 ccagtatgtg aaaggagata tgagaggaga caaatgagtt gatggtctaa attataagat
     2761 ttgtgtcaca ttatcttgat gccagtttgc caaatctgat actgtgaaaa aatttgatag
     2821 cttttctaat gtctgactag taaattttaa aatgtcattc ttttacaaat cataattagt
     2881 acttttggtt attaccgtct tcagtgttag cccaaagatt ctgaggttta gaaaaaaatt
     2941 atgtaagatc tgaacatcag tttgcagaca aaattaaatt agagctttat tttatttgga
     3001 gaagagggat acaatggaat ttttccttac caattagaaa taattgtaat gcctaaaaaa
     3061 ctttttcaca aaaatgaatc tttgaaattt tttattgttg aaaaagtgtt aagtaacata
     3121 aatctaatca gatatcttat gtagtccatc tctgctggct ttagtaactg ctcctaaact
     3181 ttttaactct aaaggagcgt ggaaagcccg catcacagtg ttcagtgact gctctgctcc
     3241 attctttctc ctctccagtt tctctcttga aagtcaaaca gttttgtagt tgaagcagtc
     3301 cgtgtgcaaa gcctgcatct aaacacttgc gttaataagt cattaaccgc tcagtaccag
     3361 atgtggcaaa tctcaagtga ttgtggactc ctggctcatc aactcatgcc ctcttccata
     3421 ccctcatggc ttcacagtca aggtcagcag gaagctcatt ggtcaccttc atggtgacct
     3481 ctccattatt ctgtctcact tggaaccatt ttcagtttat ttactatgca atagacagtc
     3541 cttgttttgt actcagctag ctttgattta atgtaccact gctttgtctt tctgttacac
     3601 atatggtttt gatttattta caatatatgc tgtgccattt tgatttttat tttggttggt
     3661 tggttgaata aatatgcgac actcagaaca cttgaggtga tagttttaaa aaaaacaaac
     3721 aaacagtacc agtatttgat ccagtctcat ctcagctgtg ttatacctgg acaatttaga
     3781 tgtttatcaa aggtctttta tggggaagaa agcaaatgtg taaaacagta gacgtgtgac
     3841 gtttatgagt aatgctggct ctgaacaaac ttttgaaaac ttagttgaca gtgttttgag
     3901 tcaactgaaa aaaagcatga cttttggaat ctctgaatgc cttggttctc agtattatca
     3961 ctctattgaa tttttttttc ttattaaagt atgtagttta aaagtaagac ttttttcctg
     4021 acagtattat gtaattttta gcgtgggtag atgggagtgt cgcttgtatg ttaccataca
     4081 gctgacatgt attttttgtc tattctttat tatcttagta gtttcatgct gtgtatgtac
     4141 cataaccaac ctattgccta tgagaaacat gtaagataat gtatttacag ccattgttac
     4201 aagtttataa tgtatttttc tatcttgttt tatatgtatg ttatataaca ttcaaaagaa
     4261 tttttttctt gattgagaaa aggatacaaa atgcaaaatc cacaattttg ataactgaaa
     4321 attgccaatt gttttgcagt actttattat attgggtgtc ttgtctttct tgggctttta
     4381 gttagctgat gaatgaatac attagacact tctgggtttt agttgggatt ttacatagct
     4441 tgcattttag ttctttggtt ctttgctgtt tctattaacc catagcatta ttttaataaa
     4501 tgttataata ccaacctact aa
//
