LOCUS       NM_024236               1394 bp    mRNA    linear   ROD 03-JUN-2024
DEFINITION  Mus musculus quinoid dihydropteridine reductase (Qdpr), mRNA.
ACCESSION   NM_024236
VERSION     NM_024236.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1394)
  AUTHORS   Suganuma,Y., Sumi-Ichinose,C., Kano,T., Ikemoto,K., Matsui,T.,
            Ichinose,H. and Kondo,K.
  TITLE     Quinonoid dihydropteridine reductase, a
            tetrahydrobiopterin-recycling enzyme, contributes to
            5-hydroxytryptamine-associated platelet aggregation in mice
  JOURNAL   J Pharmacol Sci 150 (3), 173-179 (2022)
   PUBMED   36184122
  REMARK    GeneRIF: Quinonoid dihydropteridine reductase, a
            tetrahydrobiopterin-recycling enzyme, contributes to
            5-hydroxytryptamine-associated platelet aggregation in mice.
REFERENCE   2  (bases 1 to 1394)
  AUTHORS   Xu,F., Sudo,Y., Sanechika,S., Yamashita,J., Shimaguchi,S.,
            Honda,S., Sumi-Ichinose,C., Mori-Kojima,M., Nakata,R., Furuta,T.,
            Sakurai,M., Sugimoto,M., Soga,T., Kondo,K. and Ichinose,H.
  TITLE     Disturbed biopterin and folate metabolism in the Qdpr-deficient
            mouse
  JOURNAL   FEBS Lett 588 (21), 3924-3931 (2014)
   PUBMED   25240194
  REMARK    GeneRIF: wide alterations in folate-associated metabolism in the
            Qdpr(-/-) mice
REFERENCE   3  (bases 1 to 1394)
  AUTHORS   Wang,D.Y., Abbasi,C., El-Rass,S., Li,J.Y., Dawood,F., Naito,K.,
            Sharma,P., Bousette,N., Singh,S., Backx,P.H., Cox,B., Wen,X.Y.,
            Liu,P.P. and Gramolini,A.O.
  TITLE     Endoplasmic reticulum resident protein 44 (ERp44) deficiency in
            mice and zebrafish leads to cardiac developmental and functional
            defects
  JOURNAL   J Am Heart Assoc 3 (5), e001018 (2014)
   PUBMED   25332179
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1394)
  AUTHORS   Thompson,C.L., Ng,L., Menon,V., Martinez,S., Lee,C.K.,
            Glattfelder,K., Sunkin,S.M., Henry,A., Lau,C., Dang,C.,
            Garcia-Lopez,R., Martinez-Ferre,A., Pombero,A., Rubenstein,J.L.R.,
            Wakeman,W.B., Hohmann,J., Dee,N., Sodt,A.J., Young,R., Smith,K.,
            Nguyen,T.N., Kidney,J., Kuan,L., Jeromin,A., Kaykas,A., Miller,J.,
            Page,D., Orta,G., Bernard,A., Riley,Z., Smith,S., Wohnoutka,P.,
            Hawrylycz,M.J., Puelles,L. and Jones,A.R.
  TITLE     A high-resolution spatiotemporal atlas of gene expression of the
            developing mouse brain
  JOURNAL   Neuron 83 (2), 309-323 (2014)
   PUBMED   24952961
REFERENCE   5  (bases 1 to 1394)
  AUTHORS   Golini,L., Chouabe,C., Berthier,C., Cusimano,V., Fornaro,M.,
            Bonvallet,R., Formoso,L., Giacomello,E., Jacquemond,V. and
            Sorrentino,V.
  TITLE     Junctophilin 1 and 2 proteins interact with the L-type Ca2+ channel
            dihydropyridine receptors (DHPRs) in skeletal muscle
  JOURNAL   J Biol Chem 286 (51), 43717-43725 (2011)
   PUBMED   22020936
  REMARK    GeneRIF: JP1 and JP2 can facilitate the assembly of DHPR with other
            proteins of the excitation-contraction coupling machinery
REFERENCE   6  (bases 1 to 1394)
  AUTHORS   Altherr,M.R., Wasmuth,J.J., Seldin,M.F., Nadeau,J.H., Baehr,W. and
            Pittler,S.J.
  TITLE     Chromosome mapping of the rod photoreceptor cGMP phosphodiesterase
            beta-subunit gene in mouse and human: tight linkage to the
            Huntington disease region (4p16.3)
  JOURNAL   Genomics 12 (4), 750-754 (1992)
   PUBMED   1315306
REFERENCE   7  (bases 1 to 1394)
  AUTHORS   Pittler,S.J., Lee,A.K., Altherr,M.R., Howard,T.A., Seldin,M.F.,
            Hurwitz,R.L., Wasmuth,J.J. and Baehr,W.
  TITLE     Primary structure and chromosomal localization of human and mouse
            rod photoreceptor cGMP-gated cation channel
  JOURNAL   J Biol Chem 267 (9), 6257-6262 (1992)
   PUBMED   1372902
REFERENCE   8  (bases 1 to 1394)
  AUTHORS   Koizumi,T., MacDonald,M., Bucan,M., Hopwood,J.J., Morris,C.P.,
            Scott,H.S., Gusella,J.F. and Nadeau,J.H.
  TITLE     Linkage, but not gene order, of homologous loci, including
            alpha-L-iduronidase (Idua), is conserved in the Huntington disease
            region of the mouse and human genomes
  JOURNAL   Mamm Genome 3 (1), 23-27 (1992)
   PUBMED   1533802
REFERENCE   9  (bases 1 to 1394)
  AUTHORS   Cheng,S.V., Martin,G.R., Nadeau,J.H., Haines,J.L., Bucan,M.,
            Kozak,C.A., MacDonald,M.E., Lockyer,J.L., Ledley,F.D., Woo,S.L. et
            al.
  TITLE     Synteny on mouse chromosome 5 of homologs for human DNA loci linked
            to the Huntington disease gene
  JOURNAL   Genomics 4 (3), 419-426 (1989)
   PUBMED   2523855
REFERENCE   10 (bases 1 to 1394)
  AUTHORS   MacDonald,M.E., Anderson,M.A., Lockyer,J.L., Milstien,S.,
            Hobbs,W.J., Faryniarz,A.G., Kaufman,S., Ledley,F.D., Woo,S.L. and
            Gusella,J.F.
  TITLE     Physical and genetic localization of quinonoid dihydropteridine
            reductase gene (QDPR) on short arm of chromosome 4
  JOURNAL   Somat Cell Mol Genet 13 (5), 569-574 (1987)
   PUBMED   2889272
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC092711.14 and AK166694.1.
            
            On Aug 26, 2009 this sequence version replaced NM_024236.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC002107.1, AK166694.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-47                AC092711.14        99358-99404         c
            48-1372             AK166694.1         2-1326
            1373-1394           AC092711.14        83207-83228         c
FEATURES             Location/Qualifiers
     source          1..1394
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 24.9 cM"
     gene            1..1394
                     /gene="Qdpr"
                     /gene_synonym="2610008L04Rik; D5Ertd371e; Dhpr; PKU2"
                     /note="quinoid dihydropteridine reductase"
                     /db_xref="GeneID:110391"
                     /db_xref="MGI:MGI:97836"
     exon            1..223
                     /gene="Qdpr"
                     /gene_synonym="2610008L04Rik; D5Ertd371e; Dhpr; PKU2"
                     /inference="alignment:Splign:2.1.0"
     CDS             128..853
                     /gene="Qdpr"
                     /gene_synonym="2610008L04Rik; D5Ertd371e; Dhpr; PKU2"
                     /EC_number="1.5.1.34"
                     /note="HDHPR"
                     /codon_start=1
                     /product="dihydropteridine reductase"
                     /protein_id="NP_077198.1"
                     /db_xref="CCDS:CCDS19272.1"
                     /db_xref="GeneID:110391"
                     /db_xref="MGI:MGI:97836"
                     /translation="MAASGEARRVLVYGGRGALGSRCVQAFRARNWWVASIDVVENEE
                     ASASVVVKMTDSFTEQADQVTADVGKLLGDQKVDAILCVAGGWAGGNAKSKSLFKNCD
                     MMWKQSMWTSTISSHLATKHLKEGGLLTLAGAKAALDGTPGMIGYGMAKGAVHQLCQS
                     LAGKNSGMPPGAAAIAVLPVTLDTPMNRKSMPEADFSSWTPLEFLVETFHDWITGNKR
                     PNSGSLIQVVTTDGKTELTPAYF"
     exon            224..316
                     /gene="Qdpr"
                     /gene_synonym="2610008L04Rik; D5Ertd371e; Dhpr; PKU2"
                     /inference="alignment:Splign:2.1.0"
     exon            317..413
                     /gene="Qdpr"
                     /gene_synonym="2610008L04Rik; D5Ertd371e; Dhpr; PKU2"
                     /inference="alignment:Splign:2.1.0"
     exon            414..554
                     /gene="Qdpr"
                     /gene_synonym="2610008L04Rik; D5Ertd371e; Dhpr; PKU2"
                     /inference="alignment:Splign:2.1.0"
     exon            555..663
                     /gene="Qdpr"
                     /gene_synonym="2610008L04Rik; D5Ertd371e; Dhpr; PKU2"
                     /inference="alignment:Splign:2.1.0"
     exon            664..747
                     /gene="Qdpr"
                     /gene_synonym="2610008L04Rik; D5Ertd371e; Dhpr; PKU2"
                     /inference="alignment:Splign:2.1.0"
     exon            748..1394
                     /gene="Qdpr"
                     /gene_synonym="2610008L04Rik; D5Ertd371e; Dhpr; PKU2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1354..1359
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Qdpr"
                     /gene_synonym="2610008L04Rik; D5Ertd371e; Dhpr; PKU2"
                     /note="hexamer: AATAAA"
     polyA_site      1373
                     /gene="Qdpr"
                     /gene_synonym="2610008L04Rik; D5Ertd371e; Dhpr; PKU2"
                     /note="major polyA site"
ORIGIN      
        1 ggcggggcac aggcaggggc gggtgttctg ggcaaccttt ctgagttcct tcctcccagg
       61 gaagctgcga gcctcgaagt gcgtttgggc tcgccgttca gtaccgcgcg agtctgtcag
      121 gagcaggatg gcggcttcag gcgaggcgcg ccgggtgctg gtgtacggcg gcaggggcgc
      181 tctgggctcg cgctgcgtac aggccttccg ggcccgcaac tggtgggttg ccagcatcga
      241 tgtggtggag aacgaagagg ccagtgccag cgtggttgtt aagatgacag attcattcac
      301 agagcaggct gaccaggtca ctgctgatgt tggaaagctc ctaggtgacc agaaggtgga
      361 tgcaattctc tgtgtggctg gaggatgggc cgggggcaat gccaaatcca agtcgctttt
      421 taaaaactgt gacatgatgt ggaagcagag tatgtggaca tccactatct ccagccactt
      481 ggccacaaag cacctgaagg aaggaggcct cttgaccctg gctggggcca aagctgcctt
      541 ggatgggact cctgggatga tcggctatgg catggccaag ggagccgtcc atcagctctg
      601 ccagagcctg gcagggaaga acagtggcat gccccctggg gctgctgcca ttgctgtgct
      661 ccccgttacc ctggataccc cgatgaacag gaaatcaatg cctgaggcag acttcagctc
      721 ctggacaccc ttagagttcc tggtggaaac cttccatgac tggatcactg ggaacaaacg
      781 gccaaactca ggaagcctaa tccaggtggt aaccacagat gggaagacag agcttactcc
      841 agcatatttc taagctgcat ctcagtgcct gggagagccc tctcgaaaca tcactaacct
      901 gtctgtattg ccgaatctgg ccccatgttt tctgtattcc tgtttgtggt aggagataac
      961 cagtcttgtt tgtttcttac atggcattcc tttgttgtcc tgggatggtg aggtatgttt
     1021 atgggaaatg agcagaggcc tgtaggtagc acctgagggt ccagggaggt atatggacag
     1081 gcctgcatca cagcatccta gacttctttg gagacccgtt tgatagtact ttcagttttt
     1141 ggcatttggg gtactttgaa atccaacttg tttttaaatt ccatgttggt gccatagatg
     1201 tagtttttac agcctgaaaa ttaactgcca tgaacattct ttggtgatgt aagcaagtaa
     1261 aacccaatgg actctgttgt gatatccttt tgtgttccag cctaggctaa gtgtttgtga
     1321 aagccatttg tgagtgcttg gagtgttctt cctaataaac acacttcatg tcttgtgttg
     1381 tctttttcac tcaa
//
