LOCUS       NM_133794               2501 bp    mRNA    linear   ROD 24-DEC-2024
DEFINITION  Mus musculus glutaminyl-tRNA synthetase 1 (Qars1), mRNA.
ACCESSION   NM_133794 XM_486261
VERSION     NM_133794.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2501)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2501)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2501)
  AUTHORS   Zhang,X., Ling,J., Barcia,G., Jing,L., Wu,J., Barry,B.J.,
            Mochida,G.H., Hill,R.S., Weimer,J.M., Stein,Q., Poduri,A.,
            Partlow,J.N., Ville,D., Dulac,O., Yu,T.W., Lam,A.T.,
            Servattalab,S., Rodriguez,J., Boddaert,N., Munnich,A., Colleaux,L.,
            Zon,L.I., Soll,D., Walsh,C.A. and Nabbout,R.
  TITLE     Mutations in QARS, encoding glutaminyl-tRNA synthetase, cause
            progressive microcephaly, cerebral-cerebellar atrophy, and
            intractable seizures
  JOURNAL   Am J Hum Genet 94 (4), 547-558 (2014)
   PUBMED   24656866
REFERENCE   4  (bases 1 to 2501)
  AUTHORS   Chen,J., Melton,C., Suh,N., Oh,J.S., Horner,K., Xie,F., Sette,C.,
            Blelloch,R. and Conti,M.
  TITLE     Genome-wide analysis of translation reveals a critical role for
            deleted in azoospermia-like (Dazl) at the oocyte-to-zygote
            transition
  JOURNAL   Genes Dev 25 (7), 755-766 (2011)
   PUBMED   21460039
REFERENCE   5  (bases 1 to 2501)
  AUTHORS   Kim,J.Y., Kang,Y.S., Lee,J.W., Kim,H.J., Ahn,Y.H., Park,H., Ko,Y.G.
            and Kim,S.
  TITLE     p38 is essential for the assembly and stability of macromolecular
            tRNA synthetase complex: implications for its physiological
            significance
  JOURNAL   Proc Natl Acad Sci U S A 99 (12), 7912-7916 (2002)
   PUBMED   12060739
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY131964.1, AK155759.1 and CT010508.10.
            
            On Nov 26, 2009 this sequence version replaced NM_133794.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC079854.1, AK155759.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-52                BY131964.1         2-53
            53-2494             AK155759.1         2-2443
            2495-2501           CT010508.10        165698-165704
FEATURES             Location/Qualifiers
     source          1..2501
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 59.44 cM"
     gene            1..2501
                     /gene="Qars1"
                     /gene_synonym="1110018N24Rik; 1200016L19Rik; GLNRS; Qars"
                     /note="glutaminyl-tRNA synthetase 1"
                     /db_xref="GeneID:97541"
                     /db_xref="MGI:MGI:1915851"
     exon            1..195
                     /gene="Qars1"
                     /gene_synonym="1110018N24Rik; 1200016L19Rik; GLNRS; Qars"
                     /inference="alignment:Splign:2.1.0"
     CDS             79..2406
                     /gene="Qars1"
                     /gene_synonym="1110018N24Rik; 1200016L19Rik; GLNRS; Qars"
                     /EC_number="6.1.1.18"
                     /note="glutamine-tRNA ligase"
                     /codon_start=1
                     /product="glutamine--tRNA ligase"
                     /protein_id="NP_598555.2"
                     /db_xref="CCDS:CCDS23530.1"
                     /db_xref="GeneID:97541"
                     /db_xref="MGI:MGI:1915851"
                     /translation="MATPDSLALFTGLGLSENKARETLKNEALSTQLREAATQAHQIL
                     GSTIDKATGVLLYDLVSRLRDTRRRSFLVSYIANKKIHTGLQLSAALEYVRSHPQDPI
                     DTKDFEQECGVGVVVTPEQIEEAVESTINKHQLQLLAERYRFNMGLLMGEARAALRWA
                     DGKMIKNEVDMQVLHLLGPKMEADLVKKPKVAKARLEETDRKTAKDVVEKGEVAGQTL
                     SLMEQLRGEALKFHKPGENYKTPGYVITPYTMDLLKQHLEITGGQVRTRFPPEPNGIL
                     HIGHAKAINFNFGYAKANNGICFLRFDDTNPEKEEAKFFTAIYDMVTWLGYTPYKVTY
                     ASDYFDQLYAWAVELIHGGLAYVCHQRVEELKGHNPLPSPWRDRPKEESLLLFEAMRK
                     GKFAEGEATLRMKLVMEDGKMDPVAYRVKYTPHHRTGDKWCIYPTYDYTHCLCDSIEH
                     ITHSLCTKEFQARRSSYFWLCNALKVYCPVQWEYGRLNLHYAVVSKRKILQLVAAGAV
                     RDWDDPRLFTLTALRRRGFPPEAINNFCARVGVTVAQTTMEPHLLEACVRDVLNDAAP
                     RAMAVLEPLQVVITNFPAPKPLDIRVPNFPADETKGFHQVPFASTVFIERSDFKEESE
                     PGYKRLASGQPVGLRHTGYVIELQNIVRGSSGCVERLEVTCRRADAGEKPKAFIHWVS
                     QPLVCEIRLYECLFQHKNPEDPVEVPGGFLSDLNPASLQVVEGALVDCSVALAKPFDK
                     FQFERLGYFSVDPDSHQGQIVFNRTVTLKEDPGKI"
     exon            196..343
                     /gene="Qars1"
                     /gene_synonym="1110018N24Rik; 1200016L19Rik; GLNRS; Qars"
                     /inference="alignment:Splign:2.1.0"
     exon            344..453
                     /gene="Qars1"
                     /gene_synonym="1110018N24Rik; 1200016L19Rik; GLNRS; Qars"
                     /inference="alignment:Splign:2.1.0"
     exon            454..529
                     /gene="Qars1"
                     /gene_synonym="1110018N24Rik; 1200016L19Rik; GLNRS; Qars"
                     /inference="alignment:Splign:2.1.0"
     exon            530..594
                     /gene="Qars1"
                     /gene_synonym="1110018N24Rik; 1200016L19Rik; GLNRS; Qars"
                     /inference="alignment:Splign:2.1.0"
     exon            595..648
                     /gene="Qars1"
                     /gene_synonym="1110018N24Rik; 1200016L19Rik; GLNRS; Qars"
                     /inference="alignment:Splign:2.1.0"
     exon            649..709
                     /gene="Qars1"
                     /gene_synonym="1110018N24Rik; 1200016L19Rik; GLNRS; Qars"
                     /inference="alignment:Splign:2.1.0"
     exon            710..781
                     /gene="Qars1"
                     /gene_synonym="1110018N24Rik; 1200016L19Rik; GLNRS; Qars"
                     /inference="alignment:Splign:2.1.0"
     exon            782..867
                     /gene="Qars1"
                     /gene_synonym="1110018N24Rik; 1200016L19Rik; GLNRS; Qars"
                     /inference="alignment:Splign:2.1.0"
     exon            868..954
                     /gene="Qars1"
                     /gene_synonym="1110018N24Rik; 1200016L19Rik; GLNRS; Qars"
                     /inference="alignment:Splign:2.1.0"
     exon            955..1054
                     /gene="Qars1"
                     /gene_synonym="1110018N24Rik; 1200016L19Rik; GLNRS; Qars"
                     /inference="alignment:Splign:2.1.0"
     exon            1055..1133
                     /gene="Qars1"
                     /gene_synonym="1110018N24Rik; 1200016L19Rik; GLNRS; Qars"
                     /inference="alignment:Splign:2.1.0"
     exon            1134..1242
                     /gene="Qars1"
                     /gene_synonym="1110018N24Rik; 1200016L19Rik; GLNRS; Qars"
                     /inference="alignment:Splign:2.1.0"
     exon            1243..1373
                     /gene="Qars1"
                     /gene_synonym="1110018N24Rik; 1200016L19Rik; GLNRS; Qars"
                     /inference="alignment:Splign:2.1.0"
     exon            1374..1466
                     /gene="Qars1"
                     /gene_synonym="1110018N24Rik; 1200016L19Rik; GLNRS; Qars"
                     /inference="alignment:Splign:2.1.0"
     exon            1467..1604
                     /gene="Qars1"
                     /gene_synonym="1110018N24Rik; 1200016L19Rik; GLNRS; Qars"
                     /inference="alignment:Splign:2.1.0"
     exon            1605..1692
                     /gene="Qars1"
                     /gene_synonym="1110018N24Rik; 1200016L19Rik; GLNRS; Qars"
                     /inference="alignment:Splign:2.1.0"
     exon            1693..1836
                     /gene="Qars1"
                     /gene_synonym="1110018N24Rik; 1200016L19Rik; GLNRS; Qars"
                     /inference="alignment:Splign:2.1.0"
     exon            1837..1941
                     /gene="Qars1"
                     /gene_synonym="1110018N24Rik; 1200016L19Rik; GLNRS; Qars"
                     /inference="alignment:Splign:2.1.0"
     exon            1942..2034
                     /gene="Qars1"
                     /gene_synonym="1110018N24Rik; 1200016L19Rik; GLNRS; Qars"
                     /inference="alignment:Splign:2.1.0"
     exon            2035..2162
                     /gene="Qars1"
                     /gene_synonym="1110018N24Rik; 1200016L19Rik; GLNRS; Qars"
                     /inference="alignment:Splign:2.1.0"
     exon            2163..2229
                     /gene="Qars1"
                     /gene_synonym="1110018N24Rik; 1200016L19Rik; GLNRS; Qars"
                     /inference="alignment:Splign:2.1.0"
     exon            2230..2355
                     /gene="Qars1"
                     /gene_synonym="1110018N24Rik; 1200016L19Rik; GLNRS; Qars"
                     /inference="alignment:Splign:2.1.0"
     exon            2356..2501
                     /gene="Qars1"
                     /gene_synonym="1110018N24Rik; 1200016L19Rik; GLNRS; Qars"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2476..2481
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Qars1"
                     /gene_synonym="1110018N24Rik; 1200016L19Rik; GLNRS; Qars"
                     /note="hexamer: AATAAA"
     polyA_site      2496
                     /gene="Qars1"
                     /gene_synonym="1110018N24Rik; 1200016L19Rik; GLNRS; Qars"
                     /note="major polyA site"
ORIGIN      
        1 gtactcctat tggtcaatga gcaaaggtcg ctgttcagat gaggcccaaa gtttcttttg
       61 gtttccggtg tgcctgctat ggctactcca gattcgctag cgctgttcac cggccttggc
      121 cttagcgaga acaaggcccg cgagacgctc aagaacgagg ctctgagcac tcagctgcgc
      181 gaggcggcga cccaggcaca ccagattctg ggttctacca tcgacaaggc tactggggtc
      241 ctcctatatg acttggtctc ccgactcagg gatactcggc gtcgttcttt ccttgtgagc
      301 tatatagcca ataagaagat tcacacggga ctccagctga gcgctgctct tgaatatgtt
      361 cggagtcatc cccaggatcc cattgatacc aaggacttcg agcaggagtg tggcgtcggt
      421 gtggtggtga caccggagca gattgaggaa gctgtggagt ccaccataaa taagcatcag
      481 ttgcagctcc tagcggaacg gtaccgtttc aacatggggc tgctaatggg agaggctcgg
      541 gctgcgctca gatgggcaga cggcaaaatg atcaagaacg aggtggatat gcaggtgctt
      601 caccttttgg ggcccaagat ggaagctgat ctggtgaaga agcccaaggt ggcaaaggca
      661 cggctggaag aaacagaccg gaagacagca aaagatgtgg tggagaaagg tgaagtggct
      721 ggccagaccc tgtctctgat ggagcagctc cggggggagg cacttaagtt tcataagcca
      781 ggtgagaact acaagacgcc aggctatgtg atcactccat ataccatgga tctgctgaag
      841 cagcacctgg agatcactgg gggacaggta cgtacgcggt tccctccaga gcccaatgga
      901 atcctgcata ttggacacgc caaagccatc aatttcaact ttggttatgc caaggccaac
      961 aatggtatct gttttctgcg ctttgatgac accaaccctg agaaagaaga agcaaaattc
     1021 ttcactgcta tttatgacat ggtgacctgg ctgggttata caccttacaa agtgacatat
     1081 gcttctgact attttgacca gctgtatgcc tgggccgtgg aactcatcca tgggggtctt
     1141 gcttatgtgt gtcaccagag agtggaagag ctcaaaggcc ataacccttt accttctcca
     1201 tggagggaca ggcctaagga agaatcattg ctgctctttg aggcaatgcg caagggcaaa
     1261 tttgcagaag gagaggccac acttcgaatg aagttggtga tggaagatgg caagatggac
     1321 cccgtggcct atcgagtcaa gtacacgcca caccatcgca caggggacaa atggtgcatc
     1381 taccccacct atgactacac acattgtctg tgtgactcca ttgagcacat tacccactcg
     1441 ttgtgtacca aggagttcca ggctcgacgg tcttcctact tttggttatg taacgctctg
     1501 aaagtctatt gtcctgttca gtgggaatat ggtcgcctca atttgcacta tgctgttgtc
     1561 tcaaagcgca agattctcca gcttgtagca gctggtgctg ttcgggactg ggacgatcca
     1621 cggctcttca cactcactgc cctacgacga cggggttttc caccagaggc tatcaacaac
     1681 ttctgtgctc gggttggggt cacagtggca cagaccacaa tggaacctca tcttctggaa
     1741 gcctgtgtgc gtgatgtgct gaatgatgca gccccacgtg ccatggctgt tctagagcca
     1801 ctacaagttg tcatcaccaa ctttcctgct cccaagccct tggacatccg agtgccaaat
     1861 ttcccagctg atgagaccaa gggtttccac caggttcctt ttgcttccac tgtcttcatt
     1921 gagagaagcg actttaagga ggagtcagaa ccaggctata agcgcctagc ttcgggccag
     1981 cctgtgggcc tgagacacac tggttatgtc attgaactgc agaatattgt caggggctcc
     2041 agtggctgtg tggaacgctt ggaggtgacc tgtagacgag ctgatgctgg agagaagccc
     2101 aaggccttta ttcactgggt atcacagcct ttggtgtgtg agattcgcct ctatgagtgc
     2161 ctattccagc acaagaaccc cgaagaccct gttgaagtgc ctggtggatt cctaagtgac
     2221 ctgaacccgg cgtcactaca agtggtagaa ggagcattag tggactgctc tgtggctttg
     2281 gcaaagccct ttgacaagtt ccagtttgag cgccttgggt acttctctgt ggatccagac
     2341 agccatcaag gacagattgt cttcaaccga actgtcacac taaaagaaga cccaggcaaa
     2401 atatgaactg aatacatgtg gccctacctc atcctggagg ctgggggtgc ccttcagcac
     2461 tccacactcc gtttcaataa agaataacta aatccctctg g
//
