LOCUS       NP_598555                775 aa            linear   ROD 24-DEC-2024
DEFINITION  glutamine--tRNA ligase [Mus musculus].
ACCESSION   NP_598555 XP_486261
VERSION     NP_598555.2
DBSOURCE    REFSEQ: accession NM_133794.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 775)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (residues 1 to 775)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 775)
  AUTHORS   Zhang,X., Ling,J., Barcia,G., Jing,L., Wu,J., Barry,B.J.,
            Mochida,G.H., Hill,R.S., Weimer,J.M., Stein,Q., Poduri,A.,
            Partlow,J.N., Ville,D., Dulac,O., Yu,T.W., Lam,A.T.,
            Servattalab,S., Rodriguez,J., Boddaert,N., Munnich,A., Colleaux,L.,
            Zon,L.I., Soll,D., Walsh,C.A. and Nabbout,R.
  TITLE     Mutations in QARS, encoding glutaminyl-tRNA synthetase, cause
            progressive microcephaly, cerebral-cerebellar atrophy, and
            intractable seizures
  JOURNAL   Am J Hum Genet 94 (4), 547-558 (2014)
   PUBMED   24656866
REFERENCE   4  (residues 1 to 775)
  AUTHORS   Chen,J., Melton,C., Suh,N., Oh,J.S., Horner,K., Xie,F., Sette,C.,
            Blelloch,R. and Conti,M.
  TITLE     Genome-wide analysis of translation reveals a critical role for
            deleted in azoospermia-like (Dazl) at the oocyte-to-zygote
            transition
  JOURNAL   Genes Dev 25 (7), 755-766 (2011)
   PUBMED   21460039
REFERENCE   5  (residues 1 to 775)
  AUTHORS   Kim,J.Y., Kang,Y.S., Lee,J.W., Kim,H.J., Ahn,Y.H., Park,H., Ko,Y.G.
            and Kim,S.
  TITLE     p38 is essential for the assembly and stability of macromolecular
            tRNA synthetase complex: implications for its physiological
            significance
  JOURNAL   Proc Natl Acad Sci U S A 99 (12), 7912-7916 (2002)
   PUBMED   12060739
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY131964.1, AK155759.1 and CT010508.10.
            
            On Nov 26, 2009 this sequence version replaced NP_598555.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC079854.1, AK155759.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..775
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 59.44 cM"
     Protein         1..775
                     /product="glutamine--tRNA ligase"
                     /EC_number="6.1.1.18"
                     /note="glutamine-tRNA ligase"
                     /calculated_mol_wt=87546
     Region          2..774
                     /region_name="PLN02859"
                     /note="glutamine-tRNA ligase"
                     /db_xref="CDD:178450"
     Site            2
                     /site_type="acetylation"
                     /note="N-acetylalanine.
                     /evidence=ECO:0000250|UniProtKB:P47897; propagated from
                     UniProtKB/Swiss-Prot (Q8BML9.1)"
     Site            70
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:17242355,
                     ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q8BML9.1)"
     Site            309
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:P47897; propagated from
                     UniProtKB/Swiss-Prot (Q8BML9.1)"
     Site            495
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P47897; propagated from
                     UniProtKB/Swiss-Prot (Q8BML9.1)"
     CDS             1..775
                     /gene="Qars1"
                     /gene_synonym="1110018N24Rik; 1200016L19Rik; GLNRS; Qars"
                     /coded_by="NM_133794.2:79..2406"
                     /db_xref="CCDS:CCDS23530.1"
                     /db_xref="GeneID:97541"
                     /db_xref="MGI:MGI:1915851"
ORIGIN      
        1 matpdslalf tglglsenka retlkneals tqlreaatqa hqilgstidk atgvllydlv
       61 srlrdtrrrs flvsyiankk ihtglqlsaa leyvrshpqd pidtkdfeqe cgvgvvvtpe
      121 qieeavesti nkhqlqllae ryrfnmgllm gearaalrwa dgkmiknevd mqvlhllgpk
      181 meadlvkkpk vakarleetd rktakdvvek gevagqtlsl meqlrgealk fhkpgenykt
      241 pgyvitpytm dllkqhleit ggqvrtrfpp epngilhigh akainfnfgy akanngicfl
      301 rfddtnpeke eakfftaiyd mvtwlgytpy kvtyasdyfd qlyawaveli hgglayvchq
      361 rveelkghnp lpspwrdrpk eeslllfeam rkgkfaegea tlrmklvmed gkmdpvayrv
      421 kytphhrtgd kwciyptydy thclcdsieh ithslctkef qarrssyfwl cnalkvycpv
      481 qweygrlnlh yavvskrkil qlvaagavrd wddprlftlt alrrrgfppe ainnfcarvg
      541 vtvaqttmep hlleacvrdv lndaaprama vleplqvvit nfpapkpldi rvpnfpadet
      601 kgfhqvpfas tvfiersdfk eesepgykrl asgqpvglrh tgyvielqni vrgssgcver
      661 levtcrrada gekpkafihw vsqplvceir lyeclfqhkn pedpvevpgg flsdlnpasl
      721 qvvegalvdc svalakpfdk fqferlgyfs vdpdshqgqi vfnrtvtlke dpgki
//
