LOCUS       NM_007376               4681 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus PZP, alpha-2-macroglobulin like (Pzp), mRNA.
ACCESSION   NM_007376
VERSION     NM_007376.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4681)
  AUTHORS   Jiang,X., Lin,J., Dong,M., Liu,X., Huang,Y., Zhang,H., Ye,R.,
            Zhou,H., Yan,C., Yuan,S., Chen,L., Jiang,R., Zheng,K. and Jin,W.
  TITLE     Overexpression of Pregnancy Zone Protein in Fat Antagonizes
            Diet-Induced Obesity Under an Intermittent Fasting Regime
  JOURNAL   Front Physiol 13, 950619 (2022)
   PUBMED   36051914
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4681)
  AUTHORS   Krause,K., Azouz,F., Nakano,E., Nerurkar,V.R. and Kumar,M.
  TITLE     Deletion of Pregnancy Zone Protein and Murinoglobulin-1 Restricts
            the Pathogenesis of West Nile Virus Infection in Mice
  JOURNAL   Front Microbiol 10, 259 (2019)
   PUBMED   30814992
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4681)
  AUTHORS   Naba,A., Clauser,K.R., Mani,D.R., Carr,S.A. and Hynes,R.O.
  TITLE     Quantitative proteomic profiling of the extracellular matrix of
            pancreatic islets during the angiogenic switch and insulinoma
            progression
  JOURNAL   Sci Rep 7, 40495 (2017)
   PUBMED   28071719
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4681)
  AUTHORS   Naba,A., Clauser,K.R., Hoersch,S., Liu,H., Carr,S.A. and Hynes,R.O.
  TITLE     The matrisome: in silico definition and in vivo characterization by
            proteomics of normal and tumor extracellular matrices
  JOURNAL   Mol Cell Proteomics 11 (4), M111.014647 (2012)
   PUBMED   22159717
REFERENCE   5  (bases 1 to 4681)
  AUTHORS   Bernhard,O.K., Kapp,E.A. and Simpson,R.J.
  TITLE     Enhanced analysis of the mouse plasma proteome using
            cysteine-containing tryptic glycopeptides
  JOURNAL   J Proteome Res 6 (3), 987-995 (2007)
   PUBMED   17330941
REFERENCE   6  (bases 1 to 4681)
  AUTHORS   Koo,P.H. and Qiu,W.S.
  TITLE     Monoamine-activated alpha 2-macroglobulin binds trk receptor and
            inhibits nerve growth factor-stimulated trk phosphorylation and
            signal transduction
  JOURNAL   J Biol Chem 269 (7), 5369-5376 (1994)
   PUBMED   7508936
REFERENCE   7  (bases 1 to 4681)
  AUTHORS   van Leuven,F., Torrekens,S., Overbergh,L., Lorent,K., de
            Strooper,B. and van den Berghe,H.
  TITLE     The primary sequence and the subunit structure of mouse
            alpha-2-macroglobulin, deduced from protein sequencing of the
            isolated subunits and from molecular cloning of the cDNA
  JOURNAL   Eur J Biochem 210 (1), 319-327 (1992)
   PUBMED   1280217
REFERENCE   8  (bases 1 to 4681)
  AUTHORS   Koo,P.H. and Liebl,D.J.
  TITLE     Inhibition of nerve growth factor-stimulated neurite outgrowth by
            methylamine-modified alpha 2-macroglobulin
  JOURNAL   J Neurosci Res 31 (4), 678-692 (1992)
   PUBMED   1374478
REFERENCE   9  (bases 1 to 4681)
  AUTHORS   Hilliker,C., Overbergh,L., Petit,P., Van Leuven,F. and Van den
            Berghe,H.
  TITLE     Assignment of mouse alpha-2-macroglobulin gene to chromosome 6 band
            F1-G3
  JOURNAL   Mamm Genome 3 (8), 469-471 (1992)
   PUBMED   1379499
REFERENCE   10 (bases 1 to 4681)
  AUTHORS   Greene,N.D., Damian,R.T. and Hubbard,W.J.
  TITLE     The identification of alpha-2-macroglobulin in the mouse
  JOURNAL   Biochim Biophys Acta 236 (3), 659-663 (1971)
   PUBMED   5559967
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC123060.4.
            
            On Jan 29, 2007 this sequence version replaced NM_007376.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC057983.2, M93264.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849386, SAMN01164135
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-142               AC123060.4         149704-149845       c
            143-326             AC123060.4         148240-148423       c
            327-480             AC123060.4         147095-147248       c
            481-533             AC123060.4         146902-146954       c
            534-554             AC123060.4         145865-145885       c
            555-723             AC123060.4         145141-145309       c
            724-808             AC123060.4         144226-144310       c
            809-932             AC123060.4         142517-142640       c
            933-1047            AC123060.4         139941-140055       c
            1048-1157           AC123060.4         139198-139307       c
            1158-1319           AC123060.4         136861-137022       c
            1320-1547           AC123060.4         135281-135508       c
            1548-1611           AC123060.4         133470-133533       c
            1612-1754           AC123060.4         129861-130003       c
            1755-1904           AC123060.4         126598-126747       c
            1905-2069           AC123060.4         125301-125465       c
            2070-2157           AC123060.4         122084-122171       c
            2158-2332           AC123060.4         119704-119878       c
            2333-2561           AC123060.4         119025-119253       c
            2562-2688           AC123060.4         118318-118444       c
            2689-2810           AC123060.4         117833-117954       c
            2811-2862           AC123060.4         117553-117604       c
            2863-2946           AC123060.4         115282-115365       c
            2947-3123           AC123060.4         114621-114797       c
            3124-3214           AC123060.4         114290-114380       c
            3215-3371           AC123060.4         113648-113804       c
            3372-3446           AC123060.4         113144-113218       c
            3447-3624           AC123060.4         112807-112984       c
            3625-3866           AC123060.4         112031-112272       c
            3867-4085           AC123060.4         111006-111224       c
            4086-4216           AC123060.4         110528-110658       c
            4217-4307           AC123060.4         110018-110108       c
            4308-4376           AC123060.4         109243-109311       c
            4377-4479           AC123060.4         108683-108785       c
            4480-4521           AC123060.4         107989-108030       c
            4522-4681           AC123060.4         106692-106851       c
FEATURES             Location/Qualifiers
     source          1..4681
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 63.02 cM"
     gene            1..4681
                     /gene="Pzp"
                     /gene_synonym="A1m; A2m; MAM"
                     /note="PZP, alpha-2-macroglobulin like"
                     /db_xref="GeneID:11287"
                     /db_xref="MGI:MGI:87854"
     exon            1..142
                     /gene="Pzp"
                     /gene_synonym="A1m; A2m; MAM"
                     /inference="alignment:Splign:2.1.0"
     CDS             57..4544
                     /gene="Pzp"
                     /gene_synonym="A1m; A2m; MAM"
                     /note="alpha 1 macroglobulin; alpha-2-macroglobulin;
                     alpha-2-M; pregnancy zone protein"
                     /codon_start=1
                     /product="pregnancy zone protein precursor"
                     /protein_id="NP_031402.3"
                     /db_xref="CCDS:CCDS39650.1"
                     /db_xref="GeneID:11287"
                     /db_xref="MGI:MGI:87854"
                     /translation="MRRNQLPTPAFLLLFLLLPRDATTATAKPQYVVLVPSEVYSGVP
                     EKACVSLNHVNETVMLSLTLEYAMQQTKLLTDQAVDKDSFYCSPFTISGSPLPYTFIT
                     VEIKGPTQRFIKKKSIQIIKAESPVFVQTDKPIYKPGQIVKFRVVSVDISFRPLNETF
                     PVVYIETPKRNRIFQWQNIHLAGGLHQLSFPLSVEPALGIYKVVVQKDSGKKIEHSFE
                     VKEYVLPKFEVIIKMQKTMAFLEEELPITACGVYTYGKPVPGLVTLRVCRKYSRYRST
                     CHNQNSMSICEEFSQQADDKGCFRQVVKTKVFQLRQKGHDMKIEVEAKIKEEGTGIEL
                     TGIGSCEIANALSKLKFTKVNTNYRPGLPFSGQVLLVDEKGKPIPNKNITSVVSPLGY
                     LSIFTTDEHGLANISIDTSNFTAPFLRVVVTYKQNHVCYDNWWLDEFHTQADHSATLV
                     FSPSQSYIQLELVFGTLACGQTQEIRIHYLLNEDIMKNEKDLTFYYLIKARGSIFNLG
                     SHVLSLEQGNMKGVFSLPIQVEPGMAPEAQLLIYAILPNEELVADAQNFEIEKCFANK
                     VNLSFPSAQSLPASDTHLKVKAAPLSLCALTAVDQSVLLLKPEAKLSPQSIYNLLPGK
                     TVQGAFFGVPVYKDHENCISGEDITHNGIVYTPKHSLGDNDAHSIFQSVGINIFTNSK
                     IHKPRFCQEFQHYPAMGGVAPQALAVAASGPGSSFRAMGVPMMGLDYSDEINQVVEVR
                     ETVRKYFPETWIWDLVPLDVSGDGELAVKVPDTITEWKASAFCLSGTTGLGLSSTISL
                     QAFQPFFLELTLPYSVVRGEAFTLKATVLNYMSHCIQIRVDLEISPDFLAVPVGGHEN
                     SHCICGNERKTVSWAVTPKSLGEVNFTATAEALQSPELCGNKLTEVPALVHKDTVVKS
                     VIVEPEGIEKEQTYNTLLCPQDTELQDNWSLELPPNVVEGSARATHSVLGDILGSAMQ
                     NLQNLLQMPYGCGEQNMVLFVPNIYVLNYLNETQQLTEAIKSKAINYLISGYQRQLNY
                     QHSDGSYSTFGNHGGGNTPGNTWLTAFVLKAFAQAQSHIFIEKTHITNAFNWLSMKQK
                     ENGCFQQSGYLLNNAMKGGVDDEVTLSAYITIALLEMPLPVTHSAVRNALFCLETAWA
                     SISQSQESHVYTKALLAYAFALAGNKAKRSELLESLNKDAVKEEDSLHWQRPGDVQKV
                     KALSFYQPRAPSAEVEMTAYVLLAYLTSESSRPTRDLSSSDLSTASKIVKWISKQQNS
                     HGGFSSTQDTVVALQALSKYGAATFTRSQKEVLVTIESSGTFSKTFHVNSGNRLLLQE
                     VRLPDLPGNYVTKGSGSGCVYLQTSLKYNILPVADGKAPFALQVNTLPLNFDKAGDHR
                     TFQIRINVSYTGERPSSNMVIVDVKMVSGFIPMKPSVKKLQDQPNIQRTEVNTNHVLI
                     YIEKLTNQTLGFSFAVEQDIPVKNLKPAPIKVYDYYETDEFTVEEYSAPFSDGSEQGN
                     A"
     exon            143..326
                     /gene="Pzp"
                     /gene_synonym="A1m; A2m; MAM"
                     /inference="alignment:Splign:2.1.0"
     exon            327..480
                     /gene="Pzp"
                     /gene_synonym="A1m; A2m; MAM"
                     /inference="alignment:Splign:2.1.0"
     exon            481..533
                     /gene="Pzp"
                     /gene_synonym="A1m; A2m; MAM"
                     /inference="alignment:Splign:2.1.0"
     exon            534..554
                     /gene="Pzp"
                     /gene_synonym="A1m; A2m; MAM"
                     /inference="alignment:Splign:2.1.0"
     exon            555..723
                     /gene="Pzp"
                     /gene_synonym="A1m; A2m; MAM"
                     /inference="alignment:Splign:2.1.0"
     exon            724..808
                     /gene="Pzp"
                     /gene_synonym="A1m; A2m; MAM"
                     /inference="alignment:Splign:2.1.0"
     exon            809..932
                     /gene="Pzp"
                     /gene_synonym="A1m; A2m; MAM"
                     /inference="alignment:Splign:2.1.0"
     exon            933..1047
                     /gene="Pzp"
                     /gene_synonym="A1m; A2m; MAM"
                     /inference="alignment:Splign:2.1.0"
     exon            1048..1157
                     /gene="Pzp"
                     /gene_synonym="A1m; A2m; MAM"
                     /inference="alignment:Splign:2.1.0"
     exon            1158..1319
                     /gene="Pzp"
                     /gene_synonym="A1m; A2m; MAM"
                     /inference="alignment:Splign:2.1.0"
     exon            1320..1547
                     /gene="Pzp"
                     /gene_synonym="A1m; A2m; MAM"
                     /inference="alignment:Splign:2.1.0"
     exon            1548..1611
                     /gene="Pzp"
                     /gene_synonym="A1m; A2m; MAM"
                     /inference="alignment:Splign:2.1.0"
     exon            1612..1754
                     /gene="Pzp"
                     /gene_synonym="A1m; A2m; MAM"
                     /inference="alignment:Splign:2.1.0"
     exon            1755..1904
                     /gene="Pzp"
                     /gene_synonym="A1m; A2m; MAM"
                     /inference="alignment:Splign:2.1.0"
     exon            1905..2069
                     /gene="Pzp"
                     /gene_synonym="A1m; A2m; MAM"
                     /inference="alignment:Splign:2.1.0"
     exon            2070..2157
                     /gene="Pzp"
                     /gene_synonym="A1m; A2m; MAM"
                     /inference="alignment:Splign:2.1.0"
     exon            2158..2332
                     /gene="Pzp"
                     /gene_synonym="A1m; A2m; MAM"
                     /inference="alignment:Splign:2.1.0"
     exon            2333..2561
                     /gene="Pzp"
                     /gene_synonym="A1m; A2m; MAM"
                     /inference="alignment:Splign:2.1.0"
     exon            2562..2688
                     /gene="Pzp"
                     /gene_synonym="A1m; A2m; MAM"
                     /inference="alignment:Splign:2.1.0"
     exon            2689..2810
                     /gene="Pzp"
                     /gene_synonym="A1m; A2m; MAM"
                     /inference="alignment:Splign:2.1.0"
     exon            2811..2862
                     /gene="Pzp"
                     /gene_synonym="A1m; A2m; MAM"
                     /inference="alignment:Splign:2.1.0"
     exon            2863..2946
                     /gene="Pzp"
                     /gene_synonym="A1m; A2m; MAM"
                     /inference="alignment:Splign:2.1.0"
     exon            2947..3123
                     /gene="Pzp"
                     /gene_synonym="A1m; A2m; MAM"
                     /inference="alignment:Splign:2.1.0"
     exon            3124..3214
                     /gene="Pzp"
                     /gene_synonym="A1m; A2m; MAM"
                     /inference="alignment:Splign:2.1.0"
     exon            3215..3371
                     /gene="Pzp"
                     /gene_synonym="A1m; A2m; MAM"
                     /inference="alignment:Splign:2.1.0"
     exon            3372..3446
                     /gene="Pzp"
                     /gene_synonym="A1m; A2m; MAM"
                     /inference="alignment:Splign:2.1.0"
     exon            3447..3624
                     /gene="Pzp"
                     /gene_synonym="A1m; A2m; MAM"
                     /inference="alignment:Splign:2.1.0"
     exon            3625..3866
                     /gene="Pzp"
                     /gene_synonym="A1m; A2m; MAM"
                     /inference="alignment:Splign:2.1.0"
     exon            3867..4085
                     /gene="Pzp"
                     /gene_synonym="A1m; A2m; MAM"
                     /inference="alignment:Splign:2.1.0"
     exon            4086..4216
                     /gene="Pzp"
                     /gene_synonym="A1m; A2m; MAM"
                     /inference="alignment:Splign:2.1.0"
     exon            4217..4307
                     /gene="Pzp"
                     /gene_synonym="A1m; A2m; MAM"
                     /inference="alignment:Splign:2.1.0"
     exon            4308..4376
                     /gene="Pzp"
                     /gene_synonym="A1m; A2m; MAM"
                     /inference="alignment:Splign:2.1.0"
     exon            4377..4479
                     /gene="Pzp"
                     /gene_synonym="A1m; A2m; MAM"
                     /inference="alignment:Splign:2.1.0"
     exon            4480..4521
                     /gene="Pzp"
                     /gene_synonym="A1m; A2m; MAM"
                     /inference="alignment:Splign:2.1.0"
     exon            4522..4681
                     /gene="Pzp"
                     /gene_synonym="A1m; A2m; MAM"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4657..4662
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pzp"
                     /gene_synonym="A1m; A2m; MAM"
                     /note="hexamer: AATAAA"
     polyA_site      4675
                     /gene="Pzp"
                     /gene_synonym="A1m; A2m; MAM"
                     /note="major polyA site"
ORIGIN      
        1 caaggatcag agttcggggg ctgagggctc agacgttctt ctctgccctc tccaccatga
       61 ggagaaacca gctgcccaca ccagcttttc ttttactgtt cctgcttctt cccagagatg
      121 ccaccacagc tactgcaaaa ccacaatatg tggtgctggt cccgtcagag gtctattcag
      181 gagtccctga aaaggcctgt gtcagcctca accatgtgaa tgagactgtg atgctcagct
      241 taactctaga gtatgcaatg cagcaaacga agctcctcac agaccaggct gtggataagg
      301 actccttcta ctgcagcccc ttcacgatct caggttcacc tttaccctac acattcatta
      361 ctgtggagat aaaaggacca acgcagcgct tcataaagaa gaagtcaata caaataataa
      421 aagctgagag cccagtcttt gtccagacag acaaacccat atacaaacca ggacagatag
      481 tgaaattccg agttgtttct gtggacatca gttttcgccc gttgaatgaa acgttccctg
      541 tcgtttatat tgagactccc aagaggaacc gaatttttca atggcaaaat atccatctgg
      601 caggaggact ccaccagctc tctttcccac tgtctgttga gccagctctg ggtatctaca
      661 aggttgtagt gcagaaggac tcagggaaga aaatagaaca ctcctttgag gtgaaggaat
      721 acgttttacc caaatttgag gtgataataa aaatgcagaa gactatggct ttcctggaag
      781 aggaacttcc tataactgct tgtggcgtat acacatatgg aaagcctgtt cccggtctgg
      841 tgacattgag agtgtgcaga aaatattcac gataccgctc cacctgccat aaccaaaact
      901 caatgagtat ctgtgaagaa ttcagccaac aggcagatga taaaggatgt ttcagacaag
      961 ttgtaaaaac caaagtattc cagctcagac aaaaaggcca cgacatgaag atagaggtgg
     1021 aagccaaaat caaagaggaa ggaacaggaa tagaactaac tggtattgga tcatgtgaaa
     1081 tagcaaatgc cttaagcaaa ctgaaattta ctaaagtaaa tacaaattac aggcctgggc
     1141 tacctttctc tggacaggtt cttcttgttg atgagaaggg taaaccaatc cccaacaaaa
     1201 acataacttc cgtcgtgtct ccacttgggt acctgtccat ttttactacg gatgagcatg
     1261 gcttggctaa catttccatt gacacttcca acttcacagc tccgtttttg agagttgtgg
     1321 tcacctacaa gcagaaccat gtctgctatg ataactggtg gcttgatgaa tttcacacac
     1381 aggcagacca ttctgcaact ctagtctttt ctccaagcca gagttatatt caacttgaac
     1441 ttgtttttgg tactttggcc tgtgggcaaa ctcaggagat tcggatacac tacctcttga
     1501 atgaagatat catgaagaat gaaaaagact taacctttta ctatctgatc aaagcaaggg
     1561 gaagcatctt caacttagga agccatgtgt tgtcgcttga acaaggaaac atgaaaggag
     1621 tcttttccct cccaattcaa gtggagccag gcatggctcc cgaggctcag ctgctcattt
     1681 atgctatttt acctaatgaa gaacttgtcg ctgatgctca gaattttgaa atcgagaagt
     1741 gttttgccaa caaggtaaat ttgagtttcc catcagcaca gagcctgcca gcctctgaca
     1801 cccacctgaa ggtcaaagcc gcgcctctgt ccctctgtgc cctcactgca gtagaccaga
     1861 gtgtgctgct actgaagccc gaagccaagc tctcacctca gtcaatctac aatttgctgc
     1921 caggaaagac tgtccagggt gccttctttg gtgtcccagt gtacaaagac catgagaact
     1981 gcatcagcgg agaagacatc actcacaatg ggatcgtgta cacgccaaag cactctctgg
     2041 gcgataatga tgcacacagc atttttcagt ctgtaggaat aaatattttt accaactcca
     2101 aaatccacaa accacgcttt tgtcaagagt ttcaacacta tccggcaatg ggaggagtgg
     2161 cacctcaagc cttagctgtg gctgcttcag gcccaggatc cagcttcaga gcaatgggcg
     2221 tgccgatgat ggggttggac tactctgatg aaattaatca ggtggtggaa gtaagagaga
     2281 cagtgcggaa gtacttccct gagacctgga tctgggacct ggtgccactg gacgtatccg
     2341 gggacggtga attggcggta aaggtccccg acaccatcac tgagtggaag gccagtgcat
     2401 tctgcttgtc tggaaccact ggccttggcc tctcctccac catctccctt caagccttcc
     2461 agcccttctt cttggagctc actctcccat actctgtggt gcgaggggaa gcctttaccc
     2521 tcaaagccac cgtgctcaat tacatgtctc actgcattca gatccgagtg gacctagaga
     2581 tttctcctga tttcctggca gtcccagtgg ggggccatga aaactctcat tgcatctgtg
     2641 gaaatgaaag gaaaaccgtg tcctgggctg tgaccccaaa gtcgctgggg gaggtgaact
     2701 tcacagctac cgcagaagcc ttgcagtctc cagaattgtg tggcaataag ttgacagaag
     2761 tgccagccct tgtacacaag gacactgtgg tgaagtccgt aatagttgag cctgaaggaa
     2821 ttgagaagga gcaaacgtac aacacactgt tatgcccaca agatactgag ttacaagata
     2881 attggtcact ggagcttcca cccaatgtgg ttgaaggatc tgccagggct acacattccg
     2941 ttttgggtga tatactgggc tctgcaatgc aaaacctcca gaatcttctc cagatgccct
     3001 atggctgtgg ggaacaaaac atggtccttt ttgtccctaa catctatgtt ctgaactatc
     3061 tgaacgagac acagcagctg acagaggcga tcaagtccaa agccattaac tacctcatca
     3121 gtgggtacca gaggcagctg aactatcagc acagtgatgg ctcgtacagc acattcggga
     3181 accatggtgg tggcaacact ccgggaaata cttggctcac tgcgtttgtg ctcaaggcct
     3241 ttgctcaagc tcagtcgcac atctttatag agaagacaca catcacaaat gctttcaact
     3301 ggctctccat gaaacaaaag gagaatggct gtttccaaca gtctggatat ctgcttaaca
     3361 atgcgatgaa gggtggtgtg gatgatgaag tgactctctc tgcctacatc accattgctc
     3421 tgctggagat gcctctgcct gtcacgcaca gtgctgtgcg aaatgctcta ttttgcctgg
     3481 aaacggcctg ggcctccatc tcacagagcc aggaaagtca tgtctatacc aaggcattgc
     3541 tggcctatgc cttcgccctg gcaggaaaca aggccaagag aagcgaactg cttgaatccc
     3601 taaacaaaga tgctgtgaag gaagaggatt cgctgcactg gcaacgccct ggggatgttc
     3661 agaaagtgaa ggccttatct ttctatcaac ctcgggcccc ttctgccgaa gtggagatga
     3721 cagcttacgt gcttctcgcc tatctaacct ctgagtcttc ccggcccaca cgggacctgt
     3781 cttcatcaga cctgtccaca gcatccaaga ttgtgaagtg gatcagcaag caacaaaact
     3841 cccacggggg cttctcctcc actcaggata cagtggtggc tctccaagcc ctctccaaat
     3901 atggagctgc cacttttacg agaagtcaga aagaagtgtt ggtcaccatc gagtcttcag
     3961 ggaccttctc taagactttc catgttaaca gtggcaatcg cctgctgctg caggaagtca
     4021 ggctgccaga tctgcccgga aattacgtca ccaaagggtc aggatcagga tgtgtgtacc
     4081 ttcagacatc tctaaagtac aacatcctcc cagtggcaga tggaaaagca cccttcgctc
     4141 tgcaagtcaa cactctcccc ctaaactttg acaaggcagg agatcacaga acattccaga
     4201 ttcgcatcaa cgtaagctac actggagaac gacccagctc caacatggtc attgttgatg
     4261 tgaagatggt atcaggcttc atacctatga agccatccgt gaaaaagctc caagaccagc
     4321 ctaacattca gaggactgaa gtgaacacca accatgttct aatctacatt gaaaagctaa
     4381 ccaatcaaac cctcggtttc tccttcgcgg tggaacaaga catcccagta aagaacttaa
     4441 aaccagcccc cataaaagtc tatgattatt atgagacaga tgaattcacc gttgaagaat
     4501 acagtgcccc tttcagtgat ggctctgaac aaggaaatgc ttaaaagtcg gaacctatag
     4561 atgtcctcag aaggactcct ccacacatga agaaccaaga agaaagacag caagataaac
     4621 ggaagggaat taaaaaacca taacatttat atgttgaata aagttatgac atttacatct
     4681 g
//
