LOCUS       NM_145435                511 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus peptide YY (Pyy), transcript variant 1, mRNA.
ACCESSION   NM_145435
VERSION     NM_145435.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 511)
  AUTHORS   Shepherd,A., Feinstein,L., Sabel,S., Rastelli,D., Mezhibovsky,E.,
            Matthews,L., Muppirala,A., Robinson,A., Sharma,K.R., ElSeht,A.,
            Zeve,D., Breault,D.T., Gershon,M.D. and Rao,M.
  TITLE     RET Signaling Persists in the Adult Intestine and Stimulates
            Motility by Limiting PYY Release From Enteroendocrine Cells
  JOURNAL   Gastroenterology 166 (3), 437-449 (2024)
   PUBMED   37995867
  REMARK    GeneRIF: RET Signaling Persists in the Adult Intestine and
            Stimulates Motility by Limiting PYY Release From Enteroendocrine
            Cells.
REFERENCE   2  (bases 1 to 511)
  AUTHORS   Zahedi,B., Daley,E.J., Brooks,D.J., Bruce,M., Townsend,R.L.,
            Berthoud,H.R., Bouxsein,M.L. and Yu,E.W.
  TITLE     The PYY/Y2R-deficient male mouse is not protected from bone loss
            due to Roux-en-Y gastric bypass
  JOURNAL   Bone 167, 116608 (2023)
   PUBMED   36368466
  REMARK    GeneRIF: The PYY/Y2R-deficient male mouse is not protected from
            bone loss due to Roux-en-Y gastric bypass.
REFERENCE   3  (bases 1 to 511)
  AUTHORS   Farzi,A., Ip,C.K., Reed,F., Enriquez,R., Zenz,G., Durdevic,M.,
            Zhang,L., Holzer,P. and Herzog,H.
  TITLE     Lack of peptide YY signaling in mice disturbs gut microbiome
            composition in response to high-fat diet
  JOURNAL   FASEB J 35 (4), e21435 (2021)
   PUBMED   33749879
  REMARK    GeneRIF: Lack of peptide YY signaling in mice disturbs gut
            microbiome composition in response to high-fat diet.
REFERENCE   4  (bases 1 to 511)
  AUTHORS   Paton,C.M., Son,Y., Vaughan,R.A. and Cooper,J.A.
  TITLE     Free Fatty Acid-Induced Peptide YY Expression Is Dependent on TG
            Synthesis Rate and Xbp1 Splicing
  JOURNAL   Int J Mol Sci 21 (9), 3368 (2020)
   PUBMED   32397573
  REMARK    GeneRIF: Free Fatty Acid-Induced Peptide YY Expression Is Dependent
            on TG Synthesis Rate and Xbp1 Splicing.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 511)
  AUTHORS   Yang,H., Liu,H., Jiao,Y. and Qian,J.
  TITLE     Roux-en-Y Gastrointestinal Bypass Promotes Activation of TGR5 and
            Peptide YY
  JOURNAL   Endocr Metab Immune Disord Drug Targets 20 (8), 1262-1267 (2020)
   PUBMED   32600238
  REMARK    GeneRIF: Roux-en-Y Gastrointestinal Bypass Promotes Activation of
            TGR5 and Peptide YY.
REFERENCE   6  (bases 1 to 511)
  AUTHORS   Schwitzgebel,V.M., Scheel,D.W., Conners,J.R., Kalamaras,J.,
            Lee,J.E., Anderson,D.J., Sussel,L., Johnson,J.D. and German,M.S.
  TITLE     Expression of neurogenin3 reveals an islet cell precursor
            population in the pancreas
  JOURNAL   Development 127 (16), 3533-3542 (2000)
   PUBMED   10903178
REFERENCE   7  (bases 1 to 511)
  AUTHORS   Berg,B.M., Croom,J., Fernandez,J.M., Spears,J.W., Eisen,E.J.,
            Taylor,I.L., Daniel,L.R., Coles,B.A., Boeheim,F. and Mannon,P.J.
  TITLE     Peptide YY administration decreases brain aluminum in the Ts65Dn
            Down syndrome mouse model
  JOURNAL   Growth Dev Aging 64 (1-2), 3-19 (2000)
   PUBMED   10969882
REFERENCE   8  (bases 1 to 511)
  AUTHORS   Apelqvist,A., Li,H., Sommer,L., Beatus,P., Anderson,D.J., Honjo,T.,
            Hrabe de Angelis,M., Lendahl,U. and Edlund,H.
  TITLE     Notch signalling controls pancreatic cell differentiation
  JOURNAL   Nature 400 (6747), 877-881 (1999)
   PUBMED   10476967
REFERENCE   9  (bases 1 to 511)
  AUTHORS   Jackerott,M., Oster,A. and Larsson,L.I.
  TITLE     PYY in developing murine islet cells: comparisons to development of
            islet hormones, NPY, and BrdU incorporation
  JOURNAL   J Histochem Cytochem 44 (8), 809-817 (1996)
   PUBMED   8756753
REFERENCE   10 (bases 1 to 511)
  AUTHORS   Upchurch,B.H., Aponte,G.W. and Leiter,A.B.
  TITLE     Expression of peptide YY in all four islet cell types in the
            developing mouse pancreas suggests a common peptide YY-producing
            progenitor
  JOURNAL   Development 120 (2), 245-252 (1994)
   PUBMED   8149907
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC010821.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC010821.1, BB654143.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849389 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..511
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="FVB/N"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 65.48 cM"
     gene            1..511
                     /gene="Pyy"
                     /note="peptide YY"
                     /db_xref="GeneID:217212"
                     /db_xref="MGI:MGI:99924"
     exon            1..36
                     /gene="Pyy"
                     /inference="alignment:Splign:2.1.0"
     CDS             37..333
                     /gene="Pyy"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; Peptide tyrosine tyrosine"
                     /codon_start=1
                     /product="peptide YY isoform 1 precursor"
                     /protein_id="NP_663410.1"
                     /db_xref="CCDS:CCDS36339.1"
                     /db_xref="GeneID:217212"
                     /db_xref="MGI:MGI:99924"
                     /translation="MVAVRRPWPVTVAMLLILLACLGALVDAYPAKPEAPGEDASPEE
                     LSRYYASLRHYLNLVTRQRYGKRDVPAALFSKLLFTDDSDSENLPFRPEGLDQW"
     exon            37..224
                     /gene="Pyy"
                     /inference="alignment:Splign:2.1.0"
     exon            225..308
                     /gene="Pyy"
                     /inference="alignment:Splign:2.1.0"
     exon            309..499
                     /gene="Pyy"
                     /inference="alignment:Splign:2.1.0"
     regulatory      475..480
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pyy"
                     /note="hexamer: AATAAA"
     polyA_site      499
                     /gene="Pyy"
                     /note="major polyA site"
ORIGIN      
        1 cctcctgctc atcttgcttc ggaagctgta gctgctatgg tggcggtgcg caggccttgg
       61 cccgtcacgg tcgcaatgct gctaatcctg ctcgcctgtc tgggagccct ggtggacgcc
      121 taccctgcca aaccagaggc tcccggcgaa gacgcctccc cggaggagct gagccgctac
      181 tacgcctccc tgcgccacta cctcaacctg gtcacccggc agcggtatgg aaaaagagat
      241 gtccccgcag ctctgttctc caaactgctc ttcacagacg acagcgacag cgagaacctc
      301 cccttcaggc cagaaggttt ggaccagtgg tgaagactcc cccaaggcct cctgcgagat
      361 gtgttaacta caccgacttc acttgcatgt ttggtttaag aagagggcac ttcatatctc
      421 ggtgtctcgg acacccagac tggagggctg tgtgtgttca tttccctgtc cctaaataaa
      481 aagcaaattt cgcacaaaaa aaaaaaaaaa a
//
