LOCUS       NM_183165               1728 bp    mRNA    linear   ROD 14-FEB-2025
DEFINITION  Mus musculus pyridine nucleotide-disulphide oxidoreductase domain 1
            (Pyroxd1), transcript variant 1, mRNA.
ACCESSION   NM_183165
VERSION     NM_183165.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1728)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1728)
  AUTHORS   Asanovic,I., Strandback,E., Kroupova,A., Pasajlic,D., Meinhart,A.,
            Tsung-Pin,P., Djokovic,N., Anrather,D., Schuetz,T.,
            Suskiewicz,M.J., Sillamaa,S., Kocher,T., Beveridge,R., Nikolic,K.,
            Schleiffer,A., Jinek,M., Hartl,M., Clausen,T., Penninger,J.,
            Macheroux,P., Weitzer,S. and Martinez,J.
  TITLE     The oxidoreductase PYROXD1 uses NAD(P)+ as an antioxidant to
            sustain tRNA ligase activity in pre-tRNA splicing and unfolded
            protein response
  JOURNAL   Mol Cell 81 (12), 2520-2532 (2021)
   PUBMED   33930333
REFERENCE   3  (bases 1 to 1728)
  AUTHORS   Saha,M., Reddy,H.M., Salih,M.A., Estrella,E., Jones,M.D.,
            Mitsuhashi,S., Cho,K.A., Suzuki-Hatano,S., Rizzo,S.A., Hamad,M.H.,
            Mukhtar,M.M., Hamed,A.A., Elseed,M.A., Lek,M., Valkanas,E.,
            MacArthur,D.G., Kunkel,L.M., Pacak,C.A., Draper,I. and Kang,P.B.
  TITLE     Impact of PYROXD1 deficiency on cellular respiration and
            correlations with genetic analyses of limb-girdle muscular
            dystrophy in Saudi Arabia and Sudan
  JOURNAL   Physiol Genomics 50 (11), 929-939 (2018)
   PUBMED   30345904
  REMARK    GeneRIF: Pyroxd1 role in the proliferation, migration, and
            differentiation of murine myoblasts.
REFERENCE   4  (bases 1 to 1728)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC102125.13.
            
            On Aug 29, 2022 this sequence version replaced NM_183165.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK165677.1, AK148411.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849382
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-153               AC102125.13        34582-34734         c
            154-234             AC102125.13        32751-32831         c
            235-354             AC102125.13        31747-31866         c
            355-483             AC102125.13        29199-29327         c
            484-557             AC102125.13        26791-26864         c
            558-718             AC102125.13        25604-25764         c
            719-819             AC102125.13        23806-23906         c
            820-952             AC102125.13        22877-23009         c
            953-1065            AC102125.13        21878-21990         c
            1066-1188           AC102125.13        21231-21353         c
            1189-1326           AC102125.13        19393-19530         c
            1327-1728           AC102125.13        18234-18635         c
FEATURES             Location/Qualifiers
     source          1..1728
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 73.9 cM"
     gene            1..1728
                     /gene="Pyroxd1"
                     /note="pyridine nucleotide-disulphide oxidoreductase
                     domain 1"
                     /db_xref="GeneID:232491"
                     /db_xref="MGI:MGI:2676395"
     exon            1..153
                     /gene="Pyroxd1"
                     /inference="alignment:Splign:2.1.0"
     CDS             79..1575
                     /gene="Pyroxd1"
                     /EC_number="1.8.1.-"
                     /note="isoform a is encoded by transcript variant 1;
                     pyridine nucleotide-disulfide oxidoreductase
                     domain-containing protein 1"
                     /codon_start=1
                     /product="pyridine nucleotide-disulfide oxidoreductase
                     domain-containing protein 1 isoform a"
                     /protein_id="NP_898988.2"
                     /db_xref="CCDS:CCDS20681.1"
                     /db_xref="GeneID:232491"
                     /db_xref="MGI:MGI:2676395"
                     /translation="MEAPRPAGTFVVVGGGIAGVTCAEQLAVSFPEEDILLVTASPVI
                     KAVTNFRQVSKVLEEFDVEEQPGTMLESRFPNIKVIESGVKQLKSEDHCIFTEDGREF
                     VYKKLCLCAGAKPKLIYEGNPRVLGIRDTDSAQEFQKELAKARRIMIVGNGGIALELA
                     YEIEGCEVVWAIKDNAIGNTFFDAGAAEFLTSKLMSEKSEAKIAHKRTIYTVEEAKKE
                     TRTKSKADYVGSALGPDWHGGLALKGTEEFSHSVHIETRCEVKKIYLEEEFKIMKKKS
                     LAFPKDHHKSVTADKEMWPVYVELTNGTIYGCDFLVSATGVTPNVHPFLHRNNFALGE
                     DGGLRVDDQMRTSLPDIYAAGDICTACWQPSPVWQQMRLWTQARQMGYYAAKCMAAAS
                     MGHPIDMDFSFELFAHVTKFFNYKVVLLGKYNAQGLGADHELMLRCTRGQEYVKVVMQ
                     NGRMMGAVLIGETDLEETFENLILNQMDLSSYGEDLLDPNIDIEDYFD"
     exon            154..234
                     /gene="Pyroxd1"
                     /inference="alignment:Splign:2.1.0"
     exon            235..354
                     /gene="Pyroxd1"
                     /inference="alignment:Splign:2.1.0"
     exon            355..483
                     /gene="Pyroxd1"
                     /inference="alignment:Splign:2.1.0"
     exon            484..557
                     /gene="Pyroxd1"
                     /inference="alignment:Splign:2.1.0"
     exon            558..718
                     /gene="Pyroxd1"
                     /inference="alignment:Splign:2.1.0"
     exon            719..819
                     /gene="Pyroxd1"
                     /inference="alignment:Splign:2.1.0"
     exon            820..952
                     /gene="Pyroxd1"
                     /inference="alignment:Splign:2.1.0"
     exon            953..1065
                     /gene="Pyroxd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1066..1188
                     /gene="Pyroxd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1189..1326
                     /gene="Pyroxd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1327..1728
                     /gene="Pyroxd1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1709..1714
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pyroxd1"
                     /note="hexamer: AAGAAA"
     polyA_site      1728
                     /gene="Pyroxd1"
                     /note="major polyA site"
ORIGIN      
        1 gtgggcagcg tctcttccgg gtagaaaata gctggaactt tcaccagtgt tcagtctgcc
       61 gccagccccc ggggaactat ggaggccccg cgaccggcag ggacattcgt ggtggtagga
      121 ggtggcatcg ctggcgtcac gtgtgccgag cagctggctg tcagtttccc agaggaagac
      181 attctcctag tcacagcctc tcctgttatc aaagccgtta caaacttcag acaggtttct
      241 aaagtactgg aagaatttga tgttgaagaa cagccaggta ctatgctgga aagtcgcttt
      301 cccaacatta aggtcatcga atctggagta aagcagttga aaagtgaaga ccattgcatc
      361 ttcacagaag acggtcgtga atttgtatat aagaaactct gtctgtgtgc tggagctaag
      421 ccaaagttaa tctacgaggg aaatccacgt gtactgggaa tccgtgatac agacagtgct
      481 caggaatttc agaaagagct tgcaaaagcc aggaggataa tgattgtcgg gaatggtggc
      541 attgctctgg agctagcgta tgaaattgaa ggctgtgaag tagtttgggc cataaaggat
      601 aacgccattg ggaatacatt ctttgacgcg ggtgcagcag agtttctgac ttccaagctc
      661 atgtctgaaa aatcagaggc taaaattgca cataaaagaa ctatatatac agttgaagaa
      721 gcaaagaagg aaaccagaac caaatctaaa gctgattatg tgggcagtgc ccttggacca
      781 gactggcacg gaggcttggc tttgaaagga actgaagagt tttctcacag tgttcacatt
      841 gaaaccagat gtgaagtaaa gaaaatctac cttgaagagg aatttaagat tatgaagaaa
      901 aagtccttgg cttttccaaa ggaccaccat aagtcagtta cagctgataa agaaatgtgg
      961 cctgtgtatg tggaactgac caatgggaca atatacggct gtgatttcct tgtcagcgct
     1021 acaggagtca ccccaaacgt acaccctttt cttcatagaa acaattttgc tctaggagaa
     1081 gatggcggcc tgagagtgga tgaccagatg cgcacgtcac ttcctgatat ctatgctgct
     1141 ggagacatct gcactgcgtg ctggcagccg agtccagtct ggcagcagat gaggttgtgg
     1201 acacaggccc ggcagatggg gtattatgca gccaagtgca tggccgcagc tagcatggga
     1261 catcctattg acatggattt cagctttgaa ctgtttgctc atgtcacaaa gttttttaac
     1321 tataaggttg tattgctggg aaaatacaac gcacaaggcc tgggcgcaga ccatgagttg
     1381 atgctgaggt gcaccagagg acaagagtat gtcaaagtcg ttatgcagaa tggacgcatg
     1441 atgggagccg tcttaattgg tgaaacggac ttagaggaaa catttgaaaa tttaatctta
     1501 aaccaaatgg acctttcatc atacggggag gatctcctag atccaaatat cgacatagag
     1561 gattattttg attgaaattg aaatctcttc aggaatacaa agtacaaaat aaagagaaaa
     1621 gaaagtacat ggggaaacat aaccacacgg agtgcatggg cactcaagta gagaatgcag
     1681 acaccagact ggatgttgga aagaaataaa gaaaattctt cagatgaa
//
