LOCUS       NM_001293768            3262 bp    mRNA    linear   ROD 29-AUG-2023
DEFINITION  Mus musculus pygopus 2 (Pygo2), transcript variant 1, mRNA.
ACCESSION   NM_001293768 XM_006502003
VERSION     NM_001293768.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3262)
  AUTHORS   Zhu Y, Zhao Y, Wen J, Liu S, Huang T, Hatial I, Peng X, Al Janabi
            H, Huang G, Mittlesteadt J, Cheng M, Bhardwaj A, Ashfeld BL, Kao
            KR, Maeda DY, Dai X, Wiest O, Blagg BSJ, Lu X, Cheng L, Wan J and
            Lu X.
  TITLE     Targeting the chromatin effector Pygo2 promotes cytotoxic T cell
            responses and overcomes immunotherapy resistance in prostate cancer
  JOURNAL   Sci Immunol 8 (81), eade4656 (2023)
   PUBMED   36897957
REFERENCE   2  (bases 1 to 3262)
  AUTHORS   Li J, Zuo L, Geng Z, Li Q, Cheng Y, Yang Z, Shi R, Zhou Y, Nie W,
            Wang Y, Zhang X, Ge S, Song X and Hu J.
  TITLE     Pygopus2 ameliorates mesenteric adipocyte poor differentiation to
            alleviate Crohn's disease -like colitis via the Axin2/GSK3beta
            pathway
  JOURNAL   Cell Prolif 55 (10), e13292 (2022)
   PUBMED   35707871
  REMARK    GeneRIF: Pygopus2 ameliorates mesenteric adipocyte poor
            differentiation to alleviate Crohn's disease -like colitis via the
            Axin2/GSK3beta pathway.
REFERENCE   3  (bases 1 to 3262)
  AUTHORS   Shull LC, Lencer ES, Kim HM, Goyama S, Kurokawa M, Costello JC,
            Jones K and Artinger KB.
  TITLE     PRDM paralogs antagonistically balance Wnt/beta-catenin activity
            during craniofacial chondrocyte differentiation
  JOURNAL   Development 149 (4) (2022)
   PUBMED   35132438
REFERENCE   4  (bases 1 to 3262)
  AUTHORS   Lin L, Xu W, Li Y, Zhu P, Yuan W, Liu M, Shi Y, Chen Y, Liang J,
            Chen J, Yang B, Cai W, Wen Y, Zhu X, Peng X, Zhou Z, Mo X, Wan Y,
            Yuan H, Li F, Ye X, Jiang Z, Wang Y, Zhuang J, Fan X and Wu X.
  TITLE     Pygo1 regulates pathological cardiac hypertrophy via a
            beta-catenin-dependent mechanism
  JOURNAL   Am J Physiol Heart Circ Physiol 320 (4), H1634-H1645 (2021)
   PUBMED   33635162
REFERENCE   5  (bases 1 to 3262)
  AUTHORS   Zimmerli D, Borrelli C, Jauregi-Miguel A, Soderholm S, Brutsch S,
            Doumpas N, Reichmuth J, Murphy-Seiler F, Aguet M, Basler K, Moor AE
            and Cantu C.
  TITLE     TBX3 acts as tissue-specific component of the Wnt/beta-catenin
            transcriptional complex
  JOURNAL   Elife 9, e58123 (2020)
   PUBMED   32808927
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3262)
  AUTHORS   Jonckheere N, Mayes E, Shih HP, Li B, Lioubinski O, Dai X and
            Sander M.
  TITLE     Analysis of mPygo2 mutant mice suggests a requirement for
            mesenchymal Wnt signaling in pancreatic growth and differentiation
  JOURNAL   Dev Biol 318 (2), 224-235 (2008)
   PUBMED   18452912
  REMARK    GeneRIF: Study finds canonical Wnt signaling to be predominantly
            active in the mesenchyme at the time when mPygo2 is required and
            demonstrate the dependence of Wnt signal transduction on mPygo2.
REFERENCE   7  (bases 1 to 3262)
  AUTHORS   Li B, Rheaume C, Teng A, Bilanchone V, Munguia JE, Hu M, Jessen S,
            Piccolo S, Waterman ML and Dai X.
  TITLE     Developmental phenotypes and reduced Wnt signaling in mice
            deficient for pygopus 2
  JOURNAL   Genesis 45 (5), 318-325 (2007)
   PUBMED   17458864
  REMARK    GeneRIF: ablation of pygo2 expression causes defects in
            morphogenesis of both ectodermally and endodermally derived
            tissues, including brain, eyes, hair follicles, and lung
REFERENCE   8  (bases 1 to 3262)
  AUTHORS   Song N, Schwab KR, Patterson LT, Yamaguchi T, Lin X, Potter SS and
            Lang RA.
  TITLE     pygopus 2 has a crucial, Wnt pathway-independent function in lens
            induction
  JOURNAL   Development 134 (10), 1873-1885 (2007)
   PUBMED   17428831
  REMARK    GeneRIF: Pygo2 can function in the Wnt pathway, but its activity in
            lens development is Wnt pathway-independent
REFERENCE   9  (bases 1 to 3262)
  AUTHORS   Schwab KR, Patterson LT, Hartman HA, Song N, Lang RA, Lin X and
            Potter SS.
  TITLE     Pygo1 and Pygo2 roles in Wnt signaling in mammalian kidney
            development
  JOURNAL   BMC Biol 5, 15 (2007)
   PUBMED   17425782
  REMARK    GeneRIF: In mammals, the Pygo1/Pygo2 genes are not absolutely
            required for canonical Wnt signaling in most developing systems,
            but rather function as quantitative transducers, or modulators, of
            Wnt signal intensity
            Publication Status: Online-Only
REFERENCE   10 (bases 1 to 3262)
  AUTHORS   Li B, Mackay DR, Ma J and Dai X.
  TITLE     Cloning and developmental expression of mouse pygopus 2, a putative
            Wnt signaling component
  JOURNAL   Genomics 84 (2), 398-405 (2004)
   PUBMED   15234002
  REMARK    GeneRIF: Mouse pygo2 expression was detected in the developing
            epidermis and hair follicles, which suggests that mpygo2 might
            mediate the effect of this signaling pathway in mouse skin.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY009144.1, AC171273.1 and AI843615.1.
            
            [WARNING] On Apr 6, 2024 this sequence was replaced by
            NM_001293768.2.
            
            On Jun 20, 2014 this sequence version replaced XM_006502003.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC025640.2, AY486147.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-47                BY009144.1         1-47
            48-516              AC171273.1         111444-111912       c
            517-566             AC171273.1         110997-111046       c
            567-3245            AC171273.1         107045-109723       c
            3246-3262           AI843615.1         1-17                c
FEATURES             Location/Qualifiers
     source          1..3262
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 39.12 cM"
     gene            1..3262
                     /gene="Pygo2"
                     /gene_synonym="1190004M21Rik"
                     /note="pygopus 2"
                     /db_xref="GeneID:68911"
                     /db_xref="MGI:MGI:1916161"
     exon            1..516
                     /gene="Pygo2"
                     /gene_synonym="1190004M21Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             414..1631
                     /gene="Pygo2"
                     /gene_synonym="1190004M21Rik"
                     /note="isoform a is encoded by transcript variant 1"
                     /codon_start=1
                     /product="pygopus homolog 2 isoform a"
                     /protein_id="NP_001280697.1"
                     /db_xref="CCDS:CCDS79952.1"
                     /db_xref="GeneID:68911"
                     /db_xref="MGI:MGI:1916161"
                     /translation="MAASAPPPPDKLEGGSGPAPPPAPPSTGRKQGKAGLQMKSPEKK
                     RRKSNTQGPAYSHLTEFAPPPTPMVDHLVASNPFEDDFGAPKVGGAGPPFLGSPVPFG
                     GFRVQGGMAGQVPPGYGTGGGGGPQPLRRQPPPFPPNPMGPAFNMPPQGPGYPPPGNM
                     NFPSQPFNQSLGQNFSPPGGQVMPGPVGGFGPMISPTMGQPPRGELGPPPLPQRFTQP
                     GAPFGPSLQRPGQGLPSLPPNTSPFPGPDPGFPGPGGEDGGKPLNPPAPTAFPQEPHS
                     GSPAAAVNGNQPSFPPSSSGRGGGTPDANSLAPPGKAGGGSGPQPPPGLVYPCGACRS
                     EVNDDQDAILCEASCQKWFHRECTGMTESAYGLLTTEASAVWACDLCLKTKEIQSVYI
                     REGMGQLVAANDG"
     exon            517..566
                     /gene="Pygo2"
                     /gene_synonym="1190004M21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            567..3248
                     /gene="Pygo2"
                     /gene_synonym="1190004M21Rik"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggcgtgtccg gaccgccccc aggcccaccc gcagctcgca cggcccctgt cgagtggtgc
       61 gttccactct gctaccgggc tagctgggcg gcgacaggcg cacttcggag gagtggcgtg
      121 gcgaggccca gccttcctgg gtgcggcgtc tgggcccttc cctgctttcc ctccccaccg
      181 cgttccgtgg tggtgaccca ttggagttcc ggttccggtt gctgtggctg cgggcgggcg
      241 gtgagtctgg agcaggcgcg cagttggtgc aacggctctg tgctttcccc ctcggcgtgg
      301 ctagggcttg ctgctgctcg ggggggctgc gctgcccctg actcccctcc gggcgatggt
      361 gcggcccgag gacgcctcca tcccccgccg acgctgactc gggtccccaa tccatggccg
      421 cctcggcgcc gcccccaccg gacaagctgg agggaggcag cggccccgca ccgccccccg
      481 cgccgcccag caccgggagg aagcagggca aggccggtct gcaaatgaag agccctgaaa
      541 agaagcgaag aaagtccaat actcagggtc ctgcatattc acatctgacg gagttcgccc
      601 cacccccgac ccccatggtg gatcatctgg tcgcttctaa cccttttgag gatgatttcg
      661 gagcccctaa agtggggggc gcaggccctc cgttcctcgg cagtccggtg ccctttggag
      721 gctttcgtgt acaggggggc atggcaggcc aggtaccccc aggctacggc actggaggag
      781 gagggggtcc ccagccactt cgtcggcagc cccctccttt tccccccaac cctatgggtc
      841 cagcttttaa tatgccccct cagggccctg gctacccgcc ccctggcaac atgaactttc
      901 ccagtcaacc cttcaaccag tctctgggcc aaaactttag cccacctggt gggcaggtga
      961 tgccaggccc agtaggcgga tttggtccca tgatctcacc gaccatggga cagcctccta
     1021 gaggggagct gggtcctcct cctctccccc aacgctttac ccaaccagga gcaccttttg
     1081 gtccttctct tcagagacct ggtcagggac tccccagcct gccccccaac acaagtccct
     1141 tccctggtcc agaccctggt tttcctggcc ctggcggtga ggatggtggg aagcccttga
     1201 acccaccggc tcccaccgcc tttccccagg agccccattc gggctccccc gctgctgctg
     1261 tcaatgggaa tcagcccagt ttccccccta gcagcagtgg tcgaggtggg ggcactccag
     1321 atgccaacag tctggcaccc cccggcaagg cagggggagg ctcagggccc cagcctcccc
     1381 caggcctggt gtacccctgc ggtgcctgcc gtagtgaggt aaatgatgac caggatgcca
     1441 ttctgtgtga ggcctcctgc cagaagtggt ttcaccgcga gtgcaccggc atgaccgaga
     1501 gtgcctacgg cctgctgacc accgaggcct ctgccgtctg ggcctgtgat ctttgcctca
     1561 agaccaagga gatccagtct gtctacatcc gagagggcat gggccagttg gtggctgcta
     1621 acgatgggtg actctagtac catggcctgg gaaagtgcac cttttccacc gtgctcctgc
     1681 agagtggctc tctttctttc cttgtcttcc accactggca tcccatctcc atggagcaga
     1741 aacatgtttc ctggaagcag aaaaggaact gaggcggaca ggcagaaaag cctgggttgc
     1801 ttgtcttctg ttgttgttgg ttttgttttt gtttttttct gggaacttgt gcactgagta
     1861 ccttcagaga tccaggaagc taaagcctgg ttgagcagag ccattcctag agtctaacca
     1921 gaggctgcaa gagaaaatgg gctggaggaa gttttagaga gcaaggatgt cctgtgcgca
     1981 gatgacccca acacccgtgc ctacaatacc tgtatagccc catggctgct gctgtagctc
     2041 ttggagtcga atgttcaagg ttccttggct ccctgaggta gagccccttt ccttgggttc
     2101 aggagacaaa tggggatttc tttctttttc tctgtgtccc tttgcttccc ctgcacctga
     2161 cttactccat tcccctcgga gcaccaaata ccttgaggaa ataggagagt tcctgactag
     2221 ggcagttgtc tgggcttcaa gactgtaggt aagagatgct gagaggacgt cttcctcata
     2281 ccaaagtcat tgtcctctct cagcttctct tgtggttgtt tctctcagtg accatgtttt
     2341 gccaaaaatt ggtatatgtg gtctgagtga ccagagtatt tgaagttggg gctcccctag
     2401 aagtctggac tgcaggtgta acccccccca atctggtgca cagtgggaca gtgctacttt
     2461 tcagctcttg gtgccctcat atcctctgtc tccagaaaac atttgggaag gcacgaagcc
     2521 cttatacctc actccttccc ctgatgaaag gatccaaggg aggccctgcc atggctttgg
     2581 ggacatgggg ccgagcagca ggaccctcaa agccatggta ccgcaagctg gaagaacctg
     2641 aagtggtctg cttagtcttt tttatcctgc gatgtcatcg tgggcctggc gatccagcaa
     2701 ttaggctagg tttatttttg gttttgtagc actccctgcc agagatggga tcgaggcctg
     2761 atcaggagcc tctctcagct gctcttcttt ccagctaacc caaaagtcca ttcctcaaat
     2821 gggtggggaa ggcaggcttg ggtgtggccc tcctgagagt cggaggtgcc cagcttgacc
     2881 gcgaaggctg ccctctggga tgtcccgtct cagccctcac gctccctgca tggggagaga
     2941 gaagactcaa gagttggcag ccttggaagc tgaggagggc gagggtggac ctgcttctta
     3001 ctctgccccc caattcctaa actacacgag gcagcccctc tacttagctt tgtgttgtgc
     3061 tatggttttg ttcgcccatg ttacctgccg ctacttttgt gttgtctcca tggtttgtaa
     3121 aatgctcccg gggagggccc atccccttgt tcttctctgc taccttttgg aagaaagtgg
     3181 gttggcaggg atgtggttac aggatctttt tgtacggttg gattaataaa atgacttgaa
     3241 aatccaaaaa aaaaaaaaaa aa
//
