LOCUS       NM_028116               8321 bp    mRNA    linear   ROD 08-JUN-2024
DEFINITION  Mus musculus pygopus 1 (Pygo1), mRNA.
ACCESSION   NM_028116 XM_134865 XM_918029 XM_982776
VERSION     NM_028116.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 8321)
  AUTHORS   Lin,L., Xu,W., Li,Y., Zhu,P., Yuan,W., Liu,M., Shi,Y., Chen,Y.,
            Liang,J., Chen,J., Yang,B., Cai,W., Wen,Y., Zhu,X., Peng,X.,
            Zhou,Z., Mo,X., Wan,Y., Yuan,H., Li,F., Ye,X., Jiang,Z., Wang,Y.,
            Zhuang,J., Fan,X. and Wu,X.
  TITLE     Pygo1 regulates pathological cardiac hypertrophy via a
            beta-catenin-dependent mechanism
  JOURNAL   Am J Physiol Heart Circ Physiol 320 (4), H1634-H1645 (2021)
   PUBMED   33635162
  REMARK    GeneRIF: Pygo1 regulates pathological cardiac hypertrophy via a
            beta-catenin-dependent mechanism.
REFERENCE   2  (bases 1 to 8321)
  AUTHORS   Zimmerli,D., Borrelli,C., Jauregi-Miguel,A., Soderholm,S.,
            Brutsch,S., Doumpas,N., Reichmuth,J., Murphy-Seiler,F., Aguet,M.,
            Basler,K., Moor,A.E. and Cantu,C.
  TITLE     TBX3 acts as tissue-specific component of the Wnt/beta-catenin
            transcriptional complex
  JOURNAL   Elife 9, e58123 (2020)
   PUBMED   32808927
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 8321)
  AUTHORS   Mieszczanek,J., van Tienen,L.M., Ibrahim,A.E.K., Winton,D.J. and
            Bienz,M.
  TITLE     Bcl9 and Pygo synergise downstream of Apc to effect intestinal
            neoplasia in FAP mouse models
  JOURNAL   Nat Commun 10 (1), 724 (2019)
   PUBMED   30760710
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 8321)
  AUTHORS   Cantu,C., Felker,A., Zimmerli,D., Prummel,K.D., Cabello,E.M.,
            Chiavacci,E., Mendez-Acevedo,K.M., Kirchgeorg,L., Burger,S.,
            Ripoll,J., Valenta,T., Hausmann,G., Vilain,N., Aguet,M., Burger,A.,
            Panakova,D., Basler,K. and Mosimann,C.
  TITLE     Mutations in Bcl9 and Pygo genes cause congenital heart defects by
            tissue-specific perturbation of Wnt/beta-catenin signaling
  JOURNAL   Genes Dev 32 (21-22), 1443-1458 (2018)
   PUBMED   30366904
REFERENCE   5  (bases 1 to 8321)
  AUTHORS   Cantu,C., Pagella,P., Shajiei,T.D., Zimmerli,D., Valenta,T.,
            Hausmann,G., Basler,K. and Mitsiadis,T.A.
  TITLE     A cytoplasmic role of Wnt/beta-catenin transcriptional cofactors
            Bcl9, Bcl9l, and Pygopus in tooth enamel formation
  JOURNAL   Sci Signal 10 (465) (2017)
   PUBMED   28174279
  REMARK    GeneRIF: Transcriptional cofactors Bcl9, Bcl9l and Pygo1/2 act
            independently of beta-catenin to ensure proper enamel formation.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 8321)
  AUTHORS   Nakamura,Y., Umehara,T., Hamana,H., Hayashizaki,Y., Inoue,M.,
            Kigawa,T., Shirouzu,M., Terada,T., Tanaka,A., Padmanabhan,B. and
            Yokoyama,S.
  TITLE     Crystal structure analysis of the PHD domain of the transcription
            co-activator Pygopus
  JOURNAL   J Mol Biol 370 (1), 80-92 (2007)
   PUBMED   17499269
  REMARK    GeneRIF: These results suggest that the Pygopus1 plant homeodomain
            (PHD) dimerization is functionally important for Lgs/Bcl9
            recognition as well as for the regulation of the Wnt/beta-catenin
            signaling pathway.
REFERENCE   7  (bases 1 to 8321)
  AUTHORS   Song,N., Schwab,K.R., Patterson,L.T., Yamaguchi,T., Lin,X.,
            Potter,S.S. and Lang,R.A.
  TITLE     pygopus 2 has a crucial, Wnt pathway-independent function in lens
            induction
  JOURNAL   Development 134 (10), 1873-1885 (2007)
   PUBMED   17428831
REFERENCE   8  (bases 1 to 8321)
  AUTHORS   Schwab,K.R., Patterson,L.T., Hartman,H.A., Song,N., Lang,R.A.,
            Lin,X. and Potter,S.S.
  TITLE     Pygo1 and Pygo2 roles in Wnt signaling in mammalian kidney
            development
  JOURNAL   BMC Biol 5, 15 (2007)
   PUBMED   17425782
  REMARK    GeneRIF: In mammals, the Pygo1/Pygo2 genes are not absolutely
            required for canonical Wnt signaling in most developing systems,
            but rather function as quantitative transducers, or modulators, of
            Wnt signal intensity
            Publication Status: Online-Only
REFERENCE   9  (bases 1 to 8321)
  AUTHORS   Adachi,S., Jigami,T., Yasui,T., Nakano,T., Ohwada,S., Omori,Y.,
            Sugano,S., Ohkawara,B., Shibuya,H., Nakamura,T. and Akiyama,T.
  TITLE     Role of a BCL9-related beta-catenin-binding protein, B9L, in
            tumorigenesis induced by aberrant activation of Wnt signaling
  JOURNAL   Cancer Res 64 (23), 8496-8501 (2004)
   PUBMED   15574752
REFERENCE   10 (bases 1 to 8321)
  AUTHORS   Li,B., Mackay,D.R., Ma,J. and Dai,X.
  TITLE     Cloning and developmental expression of mouse pygopus 2, a putative
            Wnt signaling component
  JOURNAL   Genomics 84 (2), 398-405 (2004)
   PUBMED   15234002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC158997.2.
            
            On Jan 25, 2019 this sequence version replaced NM_028116.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK011208.1, BC116631.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-316               AC158997.2         67753-68068
            317-402             AC158997.2         85028-85113
            403-8321            AC158997.2         86776-94694
FEATURES             Location/Qualifiers
     source          1..8321
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 40.08 cM"
     gene            1..8321
                     /gene="Pygo1"
                     /gene_synonym="2600014C22Rik"
                     /note="pygopus 1"
                     /db_xref="GeneID:72135"
                     /db_xref="MGI:MGI:1919385"
     exon            1..316
                     /gene="Pygo1"
                     /gene_synonym="2600014C22Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             268..1521
                     /gene="Pygo1"
                     /gene_synonym="2600014C22Rik"
                     /codon_start=1
                     /product="pygopus homolog 1"
                     /protein_id="NP_082392.1"
                     /db_xref="CCDS:CCDS23332.1"
                     /db_xref="GeneID:72135"
                     /db_xref="MGI:MGI:1919385"
                     /translation="MSAEQDKEPIALKRVRGGDSGLDGLGGPNIQLGSPDKKKRKANT
                     QGSSFPPLSEYAPPPNPNSDHLVAANPFDDSYNTISYKPLPSSNPYLGPGYPGFGGYS
                     TFRMPPHVPPRMSSPYCGPYSLRNQPHPFPQNPLGMGFNRPHAFNFGPHDNSNFGNPP
                     YNNVLTQDINMPGQHFRQGSAENFSQIPPQNVGQVSNPDLASNFAPGNNSNFTSPLET
                     NHSFIPPPNAFGQAKAPLPKQDFTQGATKTPNQNSSTHPPHLNMEDPVNQSNVELKNV
                     NRNNVVQENSRSGSAEATNNHANGTQNKPRQPRGAADLCTPDKSRKFSLLPSRHGHSS
                     SDPVYPCGICTNEVNDDQDAILCEASCQKWFHRICTGMTETAYGLLTAEASAVWGCDT
                     CMADKDVQLMRTREAFGPPAVGGDA"
     exon            317..402
                     /gene="Pygo1"
                     /gene_synonym="2600014C22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            403..8321
                     /gene="Pygo1"
                     /gene_synonym="2600014C22Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1727..1732
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pygo1"
                     /gene_synonym="2600014C22Rik"
                     /note="hexamer: AATAAA"
     polyA_site      1755
                     /gene="Pygo1"
                     /gene_synonym="2600014C22Rik"
                     /note="major polyA site"
     regulatory      4846..4851
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pygo1"
                     /gene_synonym="2600014C22Rik"
                     /note="hexamer: AAGAAA"
     polyA_site      4855
                     /gene="Pygo1"
                     /gene_synonym="2600014C22Rik"
                     /note="major polyA site"
     polyA_site      4868
                     /gene="Pygo1"
                     /gene_synonym="2600014C22Rik"
     regulatory      7660..7665
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pygo1"
                     /gene_synonym="2600014C22Rik"
                     /note="hexamer: ATTAAA"
     polyA_site      7682
                     /gene="Pygo1"
                     /gene_synonym="2600014C22Rik"
     regulatory      7866..7871
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pygo1"
                     /gene_synonym="2600014C22Rik"
                     /note="hexamer: AATAAA"
     polyA_site      7892
                     /gene="Pygo1"
                     /gene_synonym="2600014C22Rik"
     polyA_site      7916
                     /gene="Pygo1"
                     /gene_synonym="2600014C22Rik"
ORIGIN      
        1 aggccgcggc cctgagcccg gcggagcccg gcggagcccg gctaagcccc gcgagcgcac
       61 ggagccccga ggcctcggct gcctcccaaa cttttcaaag tcggcccgcg gctcggccgg
      121 cctgggctcc gagctcggcc gggaggactc cagggaccga gaggaggacc cggaggatca
      181 ggaggaggac ccagaggagg aggggccgcc gcatcaaaga caccggcttc ccgcggcccg
      241 ggggcgagcc atgcgcggcg gtcggtaatg tcagcggaac aggacaagga gcccatcgcg
      301 ctgaagagag ttagaggtgg tgacagtgga ctggatgggt taggagggcc caatatacaa
      361 ctcggaagcc cagataagaa aaaacgcaag gccaacacac agggatcttc ctttcctccg
      421 ctgtcagagt acgcgccacc accgaatcca aactccgacc atctagtggc tgccaatccg
      481 ttcgatgaca gctacaacac catttcctat aaaccactgc cttcatctaa tccatatctt
      541 ggccctgggt atcctggctt tggaggctac agcacattca gaatgccacc ccacgtccct
      601 ccaagaatgt cttctcccta ctgtggtcct tactcactca ggaatcagcc ccacccattt
      661 cctcagaatc cgttgggcat gggctttaac cggcctcatg cttttaactt tgggccgcat
      721 gataattcga attttggaaa cccaccttat aataatgtac tgactcagga cattaacatg
      781 cccggtcagc attttagaca aggctctgct gaaaacttca gtcagattcc cccgcagaat
      841 gttggccaag tgtctaaccc tgacctcgca tctaattttg cccctgggaa taattcaaat
      901 tttacctctc cgttagaaac gaatcattcg tttattccac ccccaaacgc gtttggccaa
      961 gcaaaagctc cacttcccaa acaagacttc actcaagggg caaccaaaac cccgaatcag
     1021 aattcgtcca ctcacccacc tcacctaaat atggaggatc cagtcaatca gagtaacgtc
     1081 gagttaaaaa atgtcaacag aaacaacgtt gtccaagaga acagccgttc gggcagcgca
     1141 gaggccacca acaaccatgc gaatgggacc cagaacaagc cccggcagcc caggggcgca
     1201 gctgacctgt gcacccccga caaaagccgc aagttctccc tgctccccag ccggcatggc
     1261 cattcctcct ctgaccctgt gtacccgtgc gggatttgta caaatgaagt gaatgacgat
     1321 caggacgcca ttctgtgtga agcctcttgt cagaagtggt ttcatcgcat ctgcactgga
     1381 atgaccgaaa cagcctacgg gctcctgaca gcggaagcat ccgcagtgtg gggctgtgac
     1441 acgtgcatgg ctgacaagga tgtccagctc atgcgcacta gagaggcctt tggtccacct
     1501 gccgtgggcg gcgatgccta agtacggctg tcggctaacg tgggttcatt gttctgtgta
     1561 gaacagagat ttggtgacat aggattttaa tgtttgacat tattttttta aaggcataca
     1621 caaaaatatt acattttagt tcttactaac aatgcttcat tttattgttt tttgtttgtt
     1681 gtcttgaaat gagattaatg ggggggttgc tgtagagaca tttacaaata aatgttcatt
     1741 gttatttatc ataaacacaa aagcctcttg aagcttcaaa ataatatatg acaaaaatag
     1801 gcaggttgta acttttaaaa gttagagtca ttgaaaaaaa tgtatatttc agtgctaaac
     1861 tttgaccctg tgaacgtaca tatatggttc aagagtagac caatttaaca tgttctctga
     1921 atacaatctg tgtggggata acataggggg atgtgtatct ttaatagatt ttaaatggct
     1981 tttttttttc acttcattgt tagaatttga cacctgattc ttcctcttct agggtctttg
     2041 aaatatgtga atttcattgt gtaaaatcag tctttccagg atatctatgt agttactaga
     2101 cagacactgg tcatagcata tagtctattc caagcagtag ctgctaatta actggtgggc
     2161 tgtgccacat gaaattgcta atatcagctc gctggtttta gtaaagttgg cataacacgt
     2221 ttccacatgt gtcgtttaga attatgctgg cattgtgttc tctattttta aattactctt
     2281 gtttctgcta atgttttcca cataataatg cagagtgctc agacttgtga acactttctt
     2341 ccacacactt ctaaactggg acagtctgca aagagagggg cagaagtggc catgtggtct
     2401 tacagggctc cgctgctctg agaactaagc actggtggtt ggaggaatgt tctggagttc
     2461 tgagcctgta agatgaacct cagggaagtt caaaatccac ttaaagtaaa ggccggtgaa
     2521 gaggcaaggc caaagcttcc ttggggcttt gcttcaggct tagtggtttc tggtgtaact
     2581 ggggatggtg tgagaaggta cctgagagga ccttacctcc agagggatgc tctaagatcc
     2641 tccaaactga cacacagata ttttaggaga ggatcataac ctgtgacttt aataaacaaa
     2701 tggtgtatag gacagtaggt agcaatttag acaacagtgg ggtattgatg accattccta
     2761 ataatgcttt gatattcatt atcagtgtga ccataaaaag ttctgaatgt ggggctggta
     2821 gcctggcact gtatacaaga gccattgctg ctcttgcaaa ggacctggat tcagttccct
     2881 gaagccacag tggtcaatgt acaaccacct gtatctccag ttccagggaa tctgatgccc
     2941 tcttctggcc tttataggca ctgcacacac aaagtgcaca tatatatgtt tgtgcatgca
     3001 cagatacaca taaaataaaa acatcttaaa acataataat caaagggatt aaaatgtaaa
     3061 aaccctgagc actctgctgc tcttaaagag gataattact acaggaagct tgaggggaag
     3121 gacacccgtg acagcagccc catgttatca agaaacttaa ggtatgtgaa gatttttgac
     3181 ttaagggctg gagagatggc ccagcagtta agggagcaag ctgatttttc tgaaggacca
     3241 gagtttgatt cccagaaccc atgcggcagc tcacaaccgt ccataattcc agttccagaa
     3301 gatcccatac catcttctaa cctccttgtg agggacacag gcatacatgc agacaaaaca
     3361 ctcatacacc taagaataaa taaaaagata ttttgactta aaaaatcttt ttgttaatga
     3421 acagaaacca taccttgaca cagtaggcca ctttatgtgt gtcttgggtc tcaatgtgct
     3481 gagtcacagt taactgatga accatgggct ttctcaccca ccctcatccc tagaccatta
     3541 attaatggaa agctagcttt ttacaatttg tgcttgtttt ctaggaaaca gcatgttcca
     3601 attaagaagt agtaactata gggcttgaat aatttacaca gttgacaaaa tgattaattg
     3661 tgtgaatatt agacctctga taccctgttg gtagaaaaca gtgtttctga tgtagatcat
     3721 tattgactta aattttttaa aaaatatata gtgctttgga gtgggggaaa atacagtgct
     3781 ttaattttga cataatagtt tcgtacaata caatgtacgc acggttttct cccgctaccc
     3841 ttgactggct agaactgtgt aattatataa taaatattgt cacaatttta ggaaatgaaa
     3901 tgataatgag ctttgtaact aacgtctctt cgggtgcagg aaggcctgtg aggtgggggg
     3961 ctacctgcca tgtgctggag ttcagtggct ccatgatctc aggcgggtgg tttttgttag
     4021 agctaacttt ctaaatgttt aaagatctgg ttatgttttt cttgaaattc ttttgagtgc
     4081 tgactttttg aagatgtatc ttggttttaa ttctgtgtat ctgcatgtgg gtgtccacag
     4141 aggccaggag agggcatcag atcccctgct gggattaaca ggcagttgta ggcagcctgt
     4201 ggtgggtact gggaagcaag ctctggacca cacacttaac gcttagcctc gcagccacct
     4261 ctagccattg agtcccgact cagggggagt tatggacttc atgccgtgtg ctcactccta
     4321 gcatcaggtc gtgactctga ctgaatggaa caagatggct ggtgctctca ggagttaaca
     4381 cctcagtgtg gtagtattga tttggtaatt gttaaagatg ggttatgtag ttcgataagc
     4441 catttcttgc tgacggtttt agtggttagc tttctttgtg tagaagtgac ctccagggac
     4501 atcatgtgat ttatttcact ttatttctaa ggcactgctt taaaaaacaa taccgttgaa
     4561 tttcaagtgc tttacactta ccaagcatca tagtaagtat ctctaaatat gagaaaaaca
     4621 gcggacgctc gcctttaatc ccagcaccca ggaggcaggg gcgggcggat ctctgagttc
     4681 caggccagcc tggtctacag agtgagttcc gggacagcca ggctccacag agaaaccctg
     4741 tctcacaaaa caaaaacaag aacagaaaag aaaaaccact ggaggtggag acaggaggct
     4801 ctctaggaat ttcaggatac atattgagac cctaacttta caaaaaagaa aggaaggaag
     4861 gaaggaaaga aggaagaaag aaagaaagaa agaaagaaag aaagaaagaa agaaagaaag
     4921 aaagaaagaa agaaagaaag aaagaaagga aaaagaaagg aagaaagaaa agaaaaagaa
     4981 aagtcttacc tttgtttcag ccatgagtca cggctgagct tcggcaatca cagctgacga
     5041 atatcttcac acgtttgaat taattttctt actagttaac acattcgtct gtgcaaaata
     5101 ctgtcaaaat tataagacat atagagatac atttggcgat gtaaaggatg aattatgagt
     5161 atagccagaa aatttgtctc attttacaca aagatgtctg ttacacagct ttgacagagc
     5221 tttcttagga aacatgatta aaaaaaaaca ctcccaactt caaaaatgta tcaggtgaag
     5281 aggcatgggc agaattgtgt cttttctggt ctgaccctct ttcttcactg acaggcctcc
     5341 tctcctacac actacaaacc tagctcactg tttatacctg ggctcgctca acaaagccaa
     5401 gttcctgatg aagttgtaaa tcatcagttt ctacgctggg atatgaccca gctgtgaaca
     5461 cttcctgctc tagagaagcc agcttctgtt cccatggcaa ctcacaagca tgtgtaactc
     5521 caggtgtggg ggatctgata ccctcttttg agcgcactgc atgtgtatgt gtgtgtgaat
     5581 tctgagctac cacgtgggag ctgagatttg aacctgggtc ctctagaaga gaagccagtg
     5641 ctcttaaccc ctgagccatc tctccatcga tgtctgcaaa atttgaaact cggagcatgc
     5701 acacgcacaa attagttatt ttctgagaag tttccttgct tgttcagtag agggtttctg
     5761 aaccccgtgc ttcagatatt acaggataca caaatactga agcaacttag ataattgaag
     5821 aaaatacatc tgccttcaaa tagagtgctt agagttagat ttgtgatcag tgtcttctag
     5881 ctggaatagt gctgctcttg tggttcttgc tacccaaatt agaaggttac gtacaggaat
     5941 ccaggctttc ctgcactggt gatttatttt gtgtaaatac acaaaacata acgacagcca
     6001 ggtttgagtt ttgctttttg ttgatgtttg gtttttgggg gtggggagat tggtttgatt
     6061 tcggttggtt gttttttcag acatccagtt ctgcctagtg atagaaaaac ctcttagtga
     6121 tattggtcac catgcaatct gatgatttac catcataaaa atatctcccc ccccccaaat
     6181 atcaaacaac ttcatctaat agtctttcaa ccttatttgt cttgaacaaa ttagcatgcc
     6241 agcatttctc tcacacccag gctgatagga cattaagcag atacacgagc agatctttaa
     6301 aggggggttc taagtgtgta gagcttcgtt tttgtaatgt agagaggttt tgtgtgcatg
     6361 tacagttgtg ctgttttatg ctttcctaat ttaaaaagtt gaaaaatcaa ccagacccac
     6421 agagctcatt tgtaaataat agtctggaaa gtcaatatga gatggttaga ttcttaggga
     6481 agcccgtgaa ggcttaaaac tctcttaaat gacacgttag tgtaagagag aaagcggtgg
     6541 ccttccgtgc tcccgatgtg ctgatgaagt tgactggcat gggcggttcc tacttgcccg
     6601 cttagcttct gctgtagaag gaagtttgtc ttcactcctc caggatgctc caactatcca
     6661 tctttcctct gatcagaagt tactttgtga gctatggatg tggctcaggt agtaaagcgc
     6721 ttgcctggca tgcatgaaat ctggattcca tccccaggac cacaaaaaaa atgggccacg
     6781 gtggttggta gccacctgta atcccagcac ttggcagatg gaagtcagag aatcagaaac
     6841 tcagcgccat cctcagctgt ggaacaagtt tgaggctagc ctggggtaca taagactatc
     6901 tcagaaagtg gggcagggga gaaagaaaga aaagcagtga ctttgtcctg tgttgttagg
     6961 tgtctaggtt ttaagagaag agcattttct gccgggatac aaatgaagat agtcgtgaca
     7021 ttatgttacc tttttcaaag agtctttgga atctttaaca cctaacattt ccgacaatgt
     7081 ggctgcatcc caggtcccac aggaagcagt actttttgca gaccagctgc cctgtctttg
     7141 gaccacttcc ttcagactgt ctggactttt cgcagctttc ctgtgctctg aggttcccta
     7201 ctcatcccca gacttcagta actttctctc gctctctctc ctattcctca ggagagcagt
     7261 ataagattgc atctgcattt accggttctg acataggaat tcggaggtac tggagcccgg
     7321 aggccaggaa gagccctctc ggctcccaaa gcagatggtc aaagagagat ggaagaagga
     7381 agttatgtat aagccagaac ctcaacacat tggacacttg cctgtgtgtc attcaaaact
     7441 caataaaaac cacgggtggg aaacctggcc tgtgtccagt tttaccaata acacattacg
     7501 tgcagttata tcaaacagtt ctgcaagtac ctgtaccttt cttgttctgt ggacatgtac
     7561 gtggtattgc ttgttagtta aaatgttatc ttttatttaa aaaaaaaaaa agagtcctgc
     7621 ttcttatcat gatgtatgtg acttgaacag ttgtttcata ttaaaactct ctctttccca
     7681 tgtactgttg tcatatgcct cttctgggga aatcagttaa gtacttttat acaatcccaa
     7741 gtgtgttcca cattggtgac atgtattttg gcagtaggtt gtccttttgt tcttagtgtg
     7801 tgtcttaagt catacatgca ccagtgctgt ggtctgtggc aaaattactg taattcaaat
     7861 tggaaaataa aaagtttcca gactttgtcc aacctttatt cccatgacaa aggaaattac
     7921 tgtgtaattc taatgatttt tgtctgctgg tacattctaa ggtattctag gaggtaacgg
     7981 agacatcagt atttatgggt tagtttgtaa tggctctgat gtctttgagg attaaaattt
     8041 ggtgttagct catggcattc ataatacata aatacatcta aaagtagtgt aattaattaa
     8101 tctcagtgtt tagtacctga accgggaggc tctggagttg gaggccatcc tgggctgctt
     8161 agcaagactg tctcaagagg aaaagagtct atctacctgt ggacatgatt tctaagggat
     8221 tctcttagct gacacacaca gatgactcct aacggaaagc aatactcatt gtactataag
     8281 caaaagaatg gttcttcatt aataaagaac ttattgagaa a
//
