LOCUS       NM_011224               2887 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus muscle glycogen phosphorylase (Pygm), mRNA.
ACCESSION   NM_011224
VERSION     NM_011224.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2887)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2887)
  AUTHORS   Xiang,J., Pompetti,A.J., Faranda,A.P., Wang,Y., Novo,S.G., Li,D.W.
            and Duncan,M.K.
  TITLE     ATF4 May Be Essential for Adaption of the Ocular Lens to Its
            Avascular Environment
  JOURNAL   Cells 12 (22), 2636 (2023)
   PUBMED   37998373
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2887)
  AUTHORS   Wang,T., Zhou,Y.Q., Wang,Y., Zhang,L., Zhu,X., Wang,X.Y.,
            Wang,J.H., Han,L.K., Meng,J., Zhang,X., Luo,H., Ma,Q.L., Wang,Z.X.
            and Zhang,Y.W.
  TITLE     Long-term potentiation-based screening identifies neuronal PYGM as
            a synaptic plasticity regulator participating in Alzheimer's
            disease
  JOURNAL   Zool Res 44 (5), 867-881 (2023)
   PUBMED   37537141
  REMARK    GeneRIF: Long-term potentiation-based screening identifies neuronal
            PYGM as a synaptic plasticity regulator participating in
            Alzheimer's disease.
REFERENCE   4  (bases 1 to 2887)
  AUTHORS   Rodriguez-Lopez,C., Santalla,A., Valenzuela,P.L., Real-Martinez,A.,
            Villarreal-Salazar,M., Rodriguez-Gomez,I., Pinos,T., Ara,I. and
            Lucia,A.
  TITLE     Muscle glycogen unavailability and fat oxidation rate during
            exercise: Insights from McArdle disease
  JOURNAL   J Physiol 601 (3), 551-566 (2023)
   PUBMED   36370371
REFERENCE   5  (bases 1 to 2887)
  AUTHORS   Villarreal-Salazar,M., Santalla,A., Real-Martinez,A.,
            Nogales-Gadea,G., Valenzuela,P.L., Fiuza-Luces,C., Andreu,A.L.,
            Rodriguez-Aguilera,J.C., Martin,M.A., Arenas,J., Vissing,J.,
            Lucia,A., Krag,T.O. and Pinos,T.
  TITLE     Low aerobic capacity in McArdle disease: A role for mitochondrial
            network impairment?
  JOURNAL   Mol Metab 66, 101648 (2022)
   PUBMED   36455789
REFERENCE   6  (bases 1 to 2887)
  AUTHORS   Johnson,K.R., Lane,P.W., Ward-Bailey,P. and Davisson,M.T.
  TITLE     Mapping the mouse dactylaplasia mutation, Dac, and a gene that
            controls its expression, mdac
  JOURNAL   Genomics 29 (2), 457-464 (1995)
   PUBMED   8666395
REFERENCE   7  (bases 1 to 2887)
  AUTHORS   Cook,S.A., Johnson,K.R., Bronson,R.T. and Davisson,M.T.
  TITLE     Neuromuscular degeneration (nmd): a mutation on mouse chromosome 19
            that causes motor neuron degeneration
  JOURNAL   Mamm Genome 6 (3), 187-191 (1995)
   PUBMED   7749225
REFERENCE   8  (bases 1 to 2887)
  AUTHORS   Johnson,K.R., Cook,S.A. and Davisson,M.T.
  TITLE     Identification and genetic mapping of 151 dispersed members of 16
            ribosomal protein multigene families in the mouse
  JOURNAL   Mamm Genome 5 (11), 670-687 (1994)
   PUBMED   7873877
REFERENCE   9  (bases 1 to 2887)
  AUTHORS   Szepetowski,P., Simon,M.P., Grosgeorge,J., Huebner,K., Bastard,C.,
            Evans,G.A., Tsujimoto,Y., Birnbaum,D., Theillet,C. and Gaudray,P.
  TITLE     Localization of 11q13 loci with respect to regional chromosomal
            breakpoints
  JOURNAL   Genomics 12 (4), 738-744 (1992)
   PUBMED   1572647
REFERENCE   10 (bases 1 to 2887)
  AUTHORS   Glaser,T., Matthews,K.E., Hudson,J.W., Seth,P., Housman,D.E. and
            Crerar,M.M.
  TITLE     Localization of the muscle, liver, and brain glycogen phosphorylase
            genes on linkage maps of mouse chromosomes 19, 12, and 2,
            respectively
  JOURNAL   Genomics 5 (3), 510-521 (1989)
   PUBMED   2575583
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC167245.2 and AI849927.1.
            
            On Dec 1, 2015 this sequence version replaced NM_011224.1.
            
            Summary: This gene encodes a glycolysis enzyme found in muscle.
            Highly similar enzymes encoded by different genes are found in
            liver and brain. The encoded protein is involved in regulating the
            breakdown of glycogen to glucose-1-phosphate, which is necessary
            for ATP generation. [provided by RefSeq, Dec 2015].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF124787.1, BC012961.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-314               AC167245.2         45577-45890
            315-416             AC167245.2         46854-46955
            417-495             AC167245.2         47035-47113
            496-599             AC167245.2         47193-47296
            600-731             AC167245.2         47543-47674
            732-843             AC167245.2         49232-49343
            844-926             AC167245.2         49436-49518
            927-1070            AC167245.2         49906-50049
            1071-1163           AC167245.2         50329-50421
            1164-1310           AC167245.2         50625-50771
            1311-1474           AC167245.2         50942-51105
            1475-1589           AC167245.2         51500-51614
            1590-1691           AC167245.2         52109-52210
            1692-1839           AC167245.2         52502-52649
            1840-1898           AC167245.2         53848-53906
            1899-2040           AC167245.2         54017-54158
            2041-2248           AC167245.2         54885-55092
            2249-2383           AC167245.2         58747-58881
            2384-2450           AC167245.2         59035-59101
            2451-2865           AC167245.2         59214-59628
            2866-2887           AI849927.1         1-22                c
FEATURES             Location/Qualifiers
     source          1..2887
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 4.53 cM"
     gene            1..2887
                     /gene="Pygm"
                     /gene_synonym="PG"
                     /note="muscle glycogen phosphorylase"
                     /db_xref="GeneID:19309"
                     /db_xref="MGI:MGI:97830"
     exon            1..314
                     /gene="Pygm"
                     /gene_synonym="PG"
                     /inference="alignment:Splign:2.1.0"
     CDS             72..2600
                     /gene="Pygm"
                     /gene_synonym="PG"
                     /EC_number="2.4.1.1"
                     /note="myophosphorylase"
                     /codon_start=1
                     /product="glycogen phosphorylase, muscle form"
                     /protein_id="NP_035354.1"
                     /db_xref="CCDS:CCDS29504.1"
                     /db_xref="GeneID:19309"
                     /db_xref="MGI:MGI:97830"
                     /translation="MSRPLSDQDKRKQISVRGLAGVENVSELKKNFNRHLHFTLVKDR
                     NVATPRDYYFALAHTVRDHLVGRWIRTQQHYYEKDPKRIYYLSLEFYMGRTLQNTMVN
                     LALENACDEATYQLGLDMEELEEIEEDAGLGNGGLGRLAACFLDSMATLGLAAYGYGI
                     RYEFGIFNQKICGGWQMEEADDWLRYGNPWEKARPEFTLPVHFYGRVEHTSQGAKWVD
                     TQVVLAMPYDTPVPGYRNNVVNTMRLWSAKAPNDFNLKDFNVGGYIQAVLDRNLAENI
                     SRVLYPNDNFFEGKELRLKQEYFVVAATLQDIIRRFKSSKFGSRDPVRTNFDAFPDKV
                     AIQLNDTHPSLAIPELMRILVDLERLDWDKAWDVTVKTCAYTNHTVLPEALERWPVHL
                     METLLPRHLQIIYEINQRFLNRVAAAFPGDVDRLRRMSLVEEGAVKRINMAHLCIAGS
                     HAVNGVARIHSEILKKTIFKDFYELEPHKFQNKTNGITPRRWLVLCNPGLAEVIAERI
                     GEDYISDLDQLRKLLSYVDDEAFIRDVAKVKQENKLKFSAYLEREYKVHINPNSLFDV
                     QVKRIHEYKRQLLNCLHIITLYNRIKREPNRFMVPRTIMIGGKAAPGYHMAKMIIKLI
                     TAIGDVVNHDPAVGDRLRVIFLENYRVSLAEKVIPAADLSEQISTAGTEASGTGNMKF
                     MLNGALTIGTMDGANVEMAEEAGEENFFIFGMRVEDVERLDQRGYNAQEYYDRIPELR
                     QIIEQLSSGFFSPKQPDLFKDIVNMLMHHDRFKVFADYEEYIKCQDKVSELYKNPREW
                     TRMVIRNIATSGKFSSDRTIAQYAREIWGVEPSRQRLPAPDEKI"
     exon            315..416
                     /gene="Pygm"
                     /gene_synonym="PG"
                     /inference="alignment:Splign:2.1.0"
     exon            417..495
                     /gene="Pygm"
                     /gene_synonym="PG"
                     /inference="alignment:Splign:2.1.0"
     exon            496..599
                     /gene="Pygm"
                     /gene_synonym="PG"
                     /inference="alignment:Splign:2.1.0"
     exon            600..731
                     /gene="Pygm"
                     /gene_synonym="PG"
                     /inference="alignment:Splign:2.1.0"
     exon            732..843
                     /gene="Pygm"
                     /gene_synonym="PG"
                     /inference="alignment:Splign:2.1.0"
     exon            844..926
                     /gene="Pygm"
                     /gene_synonym="PG"
                     /inference="alignment:Splign:2.1.0"
     exon            927..1070
                     /gene="Pygm"
                     /gene_synonym="PG"
                     /inference="alignment:Splign:2.1.0"
     exon            1071..1163
                     /gene="Pygm"
                     /gene_synonym="PG"
                     /inference="alignment:Splign:2.1.0"
     exon            1164..1310
                     /gene="Pygm"
                     /gene_synonym="PG"
                     /inference="alignment:Splign:2.1.0"
     exon            1311..1474
                     /gene="Pygm"
                     /gene_synonym="PG"
                     /inference="alignment:Splign:2.1.0"
     exon            1475..1589
                     /gene="Pygm"
                     /gene_synonym="PG"
                     /inference="alignment:Splign:2.1.0"
     exon            1590..1691
                     /gene="Pygm"
                     /gene_synonym="PG"
                     /inference="alignment:Splign:2.1.0"
     exon            1692..1839
                     /gene="Pygm"
                     /gene_synonym="PG"
                     /inference="alignment:Splign:2.1.0"
     exon            1840..1898
                     /gene="Pygm"
                     /gene_synonym="PG"
                     /inference="alignment:Splign:2.1.0"
     exon            1899..2040
                     /gene="Pygm"
                     /gene_synonym="PG"
                     /inference="alignment:Splign:2.1.0"
     exon            2041..2248
                     /gene="Pygm"
                     /gene_synonym="PG"
                     /inference="alignment:Splign:2.1.0"
     exon            2249..2383
                     /gene="Pygm"
                     /gene_synonym="PG"
                     /inference="alignment:Splign:2.1.0"
     exon            2384..2450
                     /gene="Pygm"
                     /gene_synonym="PG"
                     /inference="alignment:Splign:2.1.0"
     exon            2451..2870
                     /gene="Pygm"
                     /gene_synonym="PG"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2837..2842
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pygm"
                     /gene_synonym="PG"
                     /note="hexamer: AATAAA"
     polyA_site      2865
                     /gene="Pygm"
                     /gene_synonym="PG"
                     /note="major polyA site"
ORIGIN      
        1 cagctccact ccctggttgg aggcagctag gaggccatca tctgtccagt tcggcccacc
       61 ctctcacagc catgtccagg cctctttcag accaggataa gagaaagcaa atcagcgttc
      121 gtggcttagc cggagtggaa aatgtgtcgg agctaaaaaa gaacttcaac cgccacctgc
      181 atttcacctt ggtcaaggat cgcaatgtgg ctactccgag agattactat tttgcactgg
      241 cccacactgt ccgggaccac ctcgtgggac gctggatccg cacacagcag cattactacg
      301 aaaaggaccc caagaggatc tactacctgt ctttggagtt ctacatgggc cggacactgc
      361 agaacaccat ggtgaacctg gccttggaga acgcctgtga tgaggccact taccagctgg
      421 gcttggacat ggaggagttg gaggagatcg aggaggatgc agggttgggc aatgggggcc
      481 tgggacgcct ggcagcttgc tttttggact ccatggccac cctggggctc gctgcctatg
      541 gctatgggat ccgctatgag tttgggattt ttaatcagaa gatctgtggg ggctggcaga
      601 tggaagaagc tgatgactgg cttcgctatg gcaacccctg ggagaaggcc cgcccagagt
      661 tcacgctgcc tgtgcacttc tatggccgag tggagcacac cagccagggt gccaagtggg
      721 tggacacaca ggtagtgctg gctatgccct atgacactcc tgtgcccggc tatcggaaca
      781 acgtcgtcaa caccatgcgc ctctggtcgg ccaaggcacc taacgacttc aacctcaagg
      841 acttcaatgt tggcggctac atccaggctg tgctggaccg aaacctggcc gagaacatct
      901 cgcgtgtttt gtaccccaat gataatttct ttgaagggaa ggagctgcgg ctgaagcagg
      961 agtactttgt ggtggctgcc accctccagg acatcatccg acgtttcaag tcctccaagt
     1021 ttggcagccg tgatcctgtg cgcacaaact tcgatgcctt ccctgataag gtggccatcc
     1081 agctcaatga cacccacccc tctttggcca tcccagagct gatgaggatt ctggtggacc
     1141 tggaacgact ggactgggac aaggcctggg acgtaacagt gaagacctgt gcctacacca
     1201 accacacggt gctgcctgaa gccctggagc gctggccagt gcacctcatg gagacactgc
     1261 tgccccgcca cttgcagatc atttacgaga tcaaccagcg tttccttaac cgggtggcgg
     1321 ctgcattccc tggggacgta gataggctgc ggcgcatgtc actcgtggag gaaggagcag
     1381 tgaaacgcat caacatggca cacctgtgca ttgctggctc gcacgctgtc aacggcgtgg
     1441 ctcgcatcca ttcggagatc ctcaagaaaa ccatcttcaa ggacttttat gagctggagc
     1501 ctcacaagtt ccagaacaag accaatggca tcactcctcg gcgctggctg gttctgtgta
     1561 accctgggct ggcagaggtc attgctgagc gcattggtga ggactacatc tcagacctgg
     1621 accagctgcg caagctgctc tcctatgtgg atgatgaagc ctttatccgt gatgtggcca
     1681 aagtgaaaca ggaaaacaag ttgaagttct ctgcatacct cgagagggaa tacaaagtcc
     1741 acatcaaccc caactcgctc tttgacgtcc aggtgaaaag gattcatgag tacaagcggc
     1801 agctcctcaa ctgcctgcac atcatcacct tgtataaccg catcaaaagg gagcccaata
     1861 ggtttatggt gccgaggact atcatgattg gaggcaaggc tgcacccggg taccacatgg
     1921 ctaagatgat catcaagctt atcactgcca ttggggatgt ggtcaaccac gaccctgcgg
     1981 taggagaccg cctccgagtg atcttcctgg agaactaccg agtctccctt gctgagaaag
     2041 ttattcccgc cgccgacctc tcagagcaga tctccaccgc gggcaccgag gcctcgggca
     2101 ctggcaacat gaagttcatg ctcaatgggg ctctgaccat cggcaccatg gacggtgcca
     2161 acgtggagat ggcagaggag gcgggggagg agaacttctt catcttcggc atgcgagtgg
     2221 aggacgtgga aaggctggac cagagagggt acaatgccca ggagtactac gaccgaattc
     2281 ctgagcttcg gcagatcatc gaacagctaa gcagcggctt cttctccccc aagcagcctg
     2341 acctgttcaa ggacattgtc aatatgctca tgcaccatga ccggtttaaa gtctttgcag
     2401 attatgagga atacattaaa tgccaggaca aagtcagtga gttgtacaag aacccaagag
     2461 agtggacacg gatggtgatc aggaacatag ccacctctgg caagttttcc agtgaccgca
     2521 ccattgccca gtatgcccgg gagatctggg gtgttgaacc ttctcgccag cgcctgccag
     2581 ccccagatga gaagatctga gcttccacat cagaccccat acccgccctt gagtctgttt
     2641 gcaattcctg ggatcaggcc cactccagga ggtgggcctc tggaattaca tctctaccct
     2701 acccactttg gaacccactt tccccagtct ctaggtcctg atgcctagtg tgatgaagac
     2761 cttgccctct tcatttccct caactcccta ctccttttat gtatggatgg ggtctaacca
     2821 agtgcaccca ctccccaata aatcgactct tcctgctctt ccttactctt aaaaaaaaaa
     2881 aaaaaaa
//
