LOCUS       NM_133198               2821 bp    mRNA    linear   ROD 26-JUN-2024
DEFINITION  Mus musculus liver glycogen phosphorylase (Pygl), mRNA.
ACCESSION   NM_133198
VERSION     NM_133198.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2821)
  AUTHORS   Zhang,D., Deng,W., Jiang,T., Zhao,Y., Bai,D., Tian,Y., Kong,S.,
            Zhang,L., Wang,H., Gao,S. and Lu,Z.
  TITLE     Maternal Ezh1/2 deficiency impairs the function of mitochondria in
            mouse oocytes and early embryos
  JOURNAL   J Cell Physiol 239 (6), e31244 (2024)
   PUBMED   38529784
REFERENCE   2  (bases 1 to 2821)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 2821)
  AUTHORS   Arends,C.J., Wilson,L.H., Estrella,A., Kwon,O.S., Weinstein,D.A.
            and Lee,Y.M.
  TITLE     A Mouse Model of Glycogen Storage Disease Type IX-Beta: A Role for
            Phkb in Glycogenolysis
  JOURNAL   Int J Mol Sci 23 (17), 9944 (2022)
   PUBMED   36077341
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2821)
  AUTHORS   Kawakubo-Yasukochi,T., Yano,E., Kimura,S., Nishinakagawa,T.,
            Mizokami,A., Hayashi,Y., Hatakeyama,Y., Ohe,K., Yasukochi,A.,
            Nakamura,S., Jimi,E. and Hirata,M.
  TITLE     Hepatic glycogenolysis is determined by maternal high-calorie diet
            via methylation of Pygl and it is modified by oteocalcin
            administration in mice
  JOURNAL   Mol Metab 54, 101360 (2021)
   PUBMED   34673295
  REMARK    GeneRIF: Hepatic glycogenolysis is determined by maternal
            high-calorie diet via methylation of Pygl and it is modified by
            oteocalcin administration in mice.
REFERENCE   5  (bases 1 to 2821)
  AUTHORS   Roberts,G.A.G. and Tunster,S.J.
  TITLE     Characterising the dynamics of placental glycogen stores in the
            mouse
  JOURNAL   Placenta 99, 131-140 (2020)
   PUBMED   32798765
REFERENCE   6  (bases 1 to 2821)
  AUTHORS   Liu,S.P., Li,Y.S., Chen,Y.J., Chiang,E.P., Li,A.F., Lee,Y.H.,
            Tsai,T.F., Hsiao,M., Huang,S.F. and Chen,Y.M.
  TITLE     Glycine N-methyltransferase-/- mice develop chronic hepatitis and
            glycogen storage disease in the liver
  JOURNAL   Hepatology 46 (5), 1413-1425 (2007)
   PUBMED   17937387
  REMARK    Erratum:[Hepatology. 2008 Feb;47(2):769. Hwang, Shiu-Feng
            [corrected to Huang, Shiu-Feng]]
REFERENCE   7  (bases 1 to 2821)
  AUTHORS   McInerney,M., Serrano Rodriguez,G., Pawlina,W., Hurt,C.B.,
            Fletcher,B.S., Laipis,P.J. and Frost,S.C.
  TITLE     Glycogen phosphorylase is activated in response to glucose
            deprivation but is not responsible for enhanced glucose transport
            activity in 3T3-L1 adipocytes
  JOURNAL   Biochim Biophys Acta 1570 (1), 53-62 (2002)
   PUBMED   11960689
REFERENCE   8  (bases 1 to 2821)
  AUTHORS   Billingsley,G.D., Cox,D.W., Duncan,A.M., Goodfellow,P.J. and
            Grzeschik,K.H.
  TITLE     Regional localization of loci on chromosome 14 using somatic cell
            hybrids
  JOURNAL   Cytogenet Cell Genet 66 (1), 33-38 (1994)
   PUBMED   8275705
REFERENCE   9  (bases 1 to 2821)
  AUTHORS   Glaser,T., Matthews,K.E., Hudson,J.W., Seth,P., Housman,D.E. and
            Crerar,M.M.
  TITLE     Localization of the muscle, liver, and brain glycogen phosphorylase
            genes on linkage maps of mouse chromosomes 19, 12, and 2,
            respectively
  JOURNAL   Genomics 5 (3), 510-521 (1989)
   PUBMED   2575583
REFERENCE   10 (bases 1 to 2821)
  AUTHORS   Aldrich,C.J., Rodgers,J.R. and Rich,R.R.
  TITLE     Regulation of Qa-1 expression and determinant modification by an
            H-2D-linked gene, Qdm
  JOURNAL   Immunogenetics 28 (5), 334-344 (1988)
   PUBMED   2459056
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK145989.1 and BY435276.1.
            
            On Nov 19, 2009 this sequence version replaced NM_133198.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK145989.1, AK140321.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2817              AK145989.1         2-2818
            2818-2821           BY435276.1         411-414
FEATURES             Location/Qualifiers
     source          1..2821
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 29.01 cM"
     gene            1..2821
                     /gene="Pygl"
                     /note="liver glycogen phosphorylase"
                     /db_xref="GeneID:110095"
                     /db_xref="MGI:MGI:97829"
     exon            1..343
                     /gene="Pygl"
                     /inference="alignment:Splign:2.1.0"
     CDS             101..2653
                     /gene="Pygl"
                     /EC_number="2.4.1.1"
                     /codon_start=1
                     /product="glycogen phosphorylase, liver form"
                     /protein_id="NP_573461.2"
                     /db_xref="CCDS:CCDS25957.1"
                     /db_xref="GeneID:110095"
                     /db_xref="MGI:MGI:97829"
                     /translation="MAKPLTDQEKRRQISIRGIVGVENVAELKKGFNRHLHFTLVKDR
                     NVATPRDYYFALAHTVRDHLVGRWIRTQQHYYDKCPKRVYYLSLEFYMGRTLQNTMIN
                     LGLQNACDEAIYQLGLDMEELEEIEEDAGLGNGGLGRLAACFLDSMATLGLAAYGYGI
                     RYEYGIFNQKIREGWQVEEADDWLRHGNPWEKARPEFMLPVHFYGRVEHTQTGTKWVD
                     TQVVLALPYDTPVPGYMNNTVNTMRLWSARAPNDFNLQDFNVGDYIQAVLDRNLAENI
                     SRVLYPNDNFFEGKELRLKQEYFVVAATLQDVIRRFKASKFGSKDGMGTVFDAFPDQV
                     AIQLNDTHPALAIPELMRIFVDIEKLPWAKAWEITKKTFAYTNHTVLPEALERWPVEL
                     VEKLLPRHLEIIYEINQKHLDRIVALFPKDISRMRRMSLIEEEGGKRINMAHLCIVGC
                     HAVNGVAKIHSDIVKTQVFKDFSELEPDKFQNKTNGITPRRWLLLCNPGLADLIAEKI
                     GEDYVKDLSQLTKLHSFVSDDIFLREIAKVKQENKLKFSQFLEKEYKVKINPSSMFDV
                     HVKRIHEYKRQLLNCLHVITMYNRIKKDPKKFFVPRTVIIGGKAAPGYHMAKMIIKLI
                     TSVAEVVNNDPMVGSKLKVIFLENYRVSLAEKVIPATDLSEQISTAGTEASGTGNMKF
                     MLNGALTIGTMDGANVEMAEEAGEENLFIFGMRVDDVAALDKKGYEAKEYYEALPELK
                     LVIDQIDNGFFSPNQPDLFKDIINMLFYHDRFKVFADYEAYVKCQEKVSQLYMNQKAW
                     NTMVLKNIAASGKFSSDRTIKEYAKDIWNMEPSDLKISLSNESSNGVSANGK"
     exon            344..445
                     /gene="Pygl"
                     /inference="alignment:Splign:2.1.0"
     exon            446..524
                     /gene="Pygl"
                     /inference="alignment:Splign:2.1.0"
     exon            525..628
                     /gene="Pygl"
                     /inference="alignment:Splign:2.1.0"
     exon            629..760
                     /gene="Pygl"
                     /inference="alignment:Splign:2.1.0"
     exon            761..872
                     /gene="Pygl"
                     /inference="alignment:Splign:2.1.0"
     exon            873..955
                     /gene="Pygl"
                     /inference="alignment:Splign:2.1.0"
     exon            956..1099
                     /gene="Pygl"
                     /inference="alignment:Splign:2.1.0"
     exon            1100..1192
                     /gene="Pygl"
                     /inference="alignment:Splign:2.1.0"
     exon            1193..1339
                     /gene="Pygl"
                     /inference="alignment:Splign:2.1.0"
     exon            1340..1503
                     /gene="Pygl"
                     /inference="alignment:Splign:2.1.0"
     exon            1504..1618
                     /gene="Pygl"
                     /inference="alignment:Splign:2.1.0"
     exon            1619..1720
                     /gene="Pygl"
                     /inference="alignment:Splign:2.1.0"
     exon            1721..1868
                     /gene="Pygl"
                     /inference="alignment:Splign:2.1.0"
     exon            1869..1927
                     /gene="Pygl"
                     /inference="alignment:Splign:2.1.0"
     exon            1928..2069
                     /gene="Pygl"
                     /inference="alignment:Splign:2.1.0"
     exon            2070..2277
                     /gene="Pygl"
                     /inference="alignment:Splign:2.1.0"
     exon            2278..2412
                     /gene="Pygl"
                     /inference="alignment:Splign:2.1.0"
     exon            2413..2479
                     /gene="Pygl"
                     /inference="alignment:Splign:2.1.0"
     exon            2480..2821
                     /gene="Pygl"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2793..2798
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pygl"
     polyA_site      2819
                     /gene="Pygl"
ORIGIN      
        1 ggatccccaa ctccccagcg tctcaaaagc agcaagtaag gaagggagga ggccagtcct
       61 gcagcccgga gaccgttctg tgctccctcc gcccgcaacc atggcaaagc ccctgaccga
      121 ccaggagaag cgacggcaga tcagcatccg aggcatcgtg ggcgtagaga atgtggccga
      181 gctgaaaaag ggtttcaacc gtcacctgca cttcactctg gtcaaggacc gcaatgtggc
      241 caccccccgc gactactact tcgcccttgc gcacacagtg cgcgaccacc tggtggggcg
      301 ctggatccgt acacagcagc actactacga caagtgtccc aagagggtgt attacctctc
      361 tctggaattt tacatgggcc gaacattaca gaacaccatg atcaaccttg gcttacaaaa
      421 tgcctgcgat gaggccattt accagcttgg attggacatg gaagagttag aagaaattga
      481 agaagatgcc ggccttggca atggcggtct tgggaggctt gctgcctgct tcctggactc
      541 catggcaacc ctgggacttg cagcctatgg ctacggcatt cgttatgaat acggaatctt
      601 caatcagaag atccgagagg gatggcaggt agaagaggca gatgactggc tcaggcatgg
      661 aaacccttgg gagaaggctc gccctgaatt catgctgccc gtgcatttct acggaagagt
      721 agagcacacc cagacgggga caaagtgggt cgacacccag gtggtcctgg ctctgcctta
      781 cgacaccccc gtgcctggat atatgaacaa cactgtgaac actatgcgcc tctggtcggc
      841 tcgagcacca aatgacttta accttcaaga ttttaatgtt ggagactaca ttcaggctgt
      901 gctggaccgg aacctggctg agaatatctc cagagtgctc taccccaatg ataacttctt
      961 tgaagggaag gagttgcggc tgaaacagga gtactttgtg gtggctgcca ccctgcagga
     1021 tgtcatccgg cgcttcaagg cctccaagtt cggctccaag gatggcatgg gaaccgtgtt
     1081 tgatgccttt ccagatcagg tagccatcca gctgaatgac acacatcctg cactcgccat
     1141 tccagagctg atgaggattt ttgtggacat tgaaaaactg ccctgggcca aggcatggga
     1201 gatcacgaag aagaccttcg cctacaccaa ccacacggtg ctcccggagg ccctggagcg
     1261 ctggccggtg gaactggtgg agaagctgct gcctcgacac ttggagatca tttatgagat
     1321 caatcagaaa catttagaca gaattgtggc cttgtttcct aaagacatca gccgcatgcg
     1381 gagaatgtct ctcattgagg aggaaggagg caaacggatc aacatggccc acctctgcat
     1441 cgtgggctgc cacgcggtga acggtgtagc aaagatccac tcggacatcg tgaagaccca
     1501 agtattcaag gacttcagcg agctagaacc agacaagttc cagaataaaa ccaacgggat
     1561 taccccgagg cgctggctcc tactctgcaa cccagggctg gctgacttga tagcggagaa
     1621 aattggagag gattatgtga aagacctgag ccagctgacg aagctccaca gttttgtgag
     1681 tgatgacatc ttcctccggg aaatagccaa agtgaaacag gaaaataagc tgaaattctc
     1741 ccagttcctg gagaaggaat acaaggtgaa gatcaaccca tcctccatgt ttgatgtcca
     1801 tgtgaagcgg atccacgagt ataaaaggca gcttctgaac tgcctgcatg tgatcaccat
     1861 gtacaatcgc atcaagaaag accctaagaa attcttcgtg ccaaggacag tcataattgg
     1921 tggcaaagct gccccaggat atcacatggc caaaatgatc ataaagctga tcacctctgt
     1981 ggcagaagtg gtgaacaatg accccatggt cggcagcaag ttgaaagtca tcttcttgga
     2041 gaactacaga gtgtctcttg ccgaaaaagt cattccagcc acagacctat cggagcagat
     2101 ctccacggca ggcacggaag cctccgggac aggcaacatg aagttcatgc tgaacggggc
     2161 cctgaccatc gggactatgg atggggccaa tgtggagatg gcagaggaag ctggggagga
     2221 gaacctgttc atctttggca tgagagtaga tgatgtggct gctttggata agaaggggta
     2281 tgaggccaaa gaatattacg aggcccttcc agaactgaag ttggtcatcg accaaatcga
     2341 caatggcttc ttttctccca atcagccaga cctcttcaaa gacatcatca acatgttatt
     2401 ttatcatgac agatttaaag tctttgcaga ctacgaagcc tatgtcaagt gtcaagaaaa
     2461 agtcagtcag ctgtatatga atcaaaaagc ctggaacaca atggtactca aaaacatagc
     2521 tgcctcaggg aagttctcca gtgaccgaac aattaaggag tatgccaagg acatctggaa
     2581 catggagcct tcggatctga agatttccct atccaacgag tccagcaatg gggtcagtgc
     2641 caatgggaag tgaatgctaa aatgtactct tattcaatga cttcttatgg aacttgagtg
     2701 ttttagagct tccctgattc tgtttttgtc attgaatagt taagtgtctc cggggatggg
     2761 aagggaaaat gtatgtctgt attagagcta aaaataaaat gtcaacttcc agttgtcaat
     2821 c
//
