LOCUS       NP_573461                850 aa            linear   ROD 26-JUN-2024
DEFINITION  glycogen phosphorylase, liver form [Mus musculus].
ACCESSION   NP_573461
VERSION     NP_573461.2
DBSOURCE    REFSEQ: accession NM_133198.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 850)
  AUTHORS   Zhang,D., Deng,W., Jiang,T., Zhao,Y., Bai,D., Tian,Y., Kong,S.,
            Zhang,L., Wang,H., Gao,S. and Lu,Z.
  TITLE     Maternal Ezh1/2 deficiency impairs the function of mitochondria in
            mouse oocytes and early embryos
  JOURNAL   J Cell Physiol 239 (6), e31244 (2024)
   PUBMED   38529784
REFERENCE   2  (residues 1 to 850)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (residues 1 to 850)
  AUTHORS   Arends,C.J., Wilson,L.H., Estrella,A., Kwon,O.S., Weinstein,D.A.
            and Lee,Y.M.
  TITLE     A Mouse Model of Glycogen Storage Disease Type IX-Beta: A Role for
            Phkb in Glycogenolysis
  JOURNAL   Int J Mol Sci 23 (17), 9944 (2022)
   PUBMED   36077341
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 850)
  AUTHORS   Kawakubo-Yasukochi,T., Yano,E., Kimura,S., Nishinakagawa,T.,
            Mizokami,A., Hayashi,Y., Hatakeyama,Y., Ohe,K., Yasukochi,A.,
            Nakamura,S., Jimi,E. and Hirata,M.
  TITLE     Hepatic glycogenolysis is determined by maternal high-calorie diet
            via methylation of Pygl and it is modified by oteocalcin
            administration in mice
  JOURNAL   Mol Metab 54, 101360 (2021)
   PUBMED   34673295
  REMARK    GeneRIF: Hepatic glycogenolysis is determined by maternal
            high-calorie diet via methylation of Pygl and it is modified by
            oteocalcin administration in mice.
REFERENCE   5  (residues 1 to 850)
  AUTHORS   Roberts,G.A.G. and Tunster,S.J.
  TITLE     Characterising the dynamics of placental glycogen stores in the
            mouse
  JOURNAL   Placenta 99, 131-140 (2020)
   PUBMED   32798765
REFERENCE   6  (residues 1 to 850)
  AUTHORS   Liu,S.P., Li,Y.S., Chen,Y.J., Chiang,E.P., Li,A.F., Lee,Y.H.,
            Tsai,T.F., Hsiao,M., Huang,S.F. and Chen,Y.M.
  TITLE     Glycine N-methyltransferase-/- mice develop chronic hepatitis and
            glycogen storage disease in the liver
  JOURNAL   Hepatology 46 (5), 1413-1425 (2007)
   PUBMED   17937387
  REMARK    Erratum:[Hepatology. 2008 Feb;47(2):769. Hwang, Shiu-Feng
            [corrected to Huang, Shiu-Feng]]
REFERENCE   7  (residues 1 to 850)
  AUTHORS   McInerney,M., Serrano Rodriguez,G., Pawlina,W., Hurt,C.B.,
            Fletcher,B.S., Laipis,P.J. and Frost,S.C.
  TITLE     Glycogen phosphorylase is activated in response to glucose
            deprivation but is not responsible for enhanced glucose transport
            activity in 3T3-L1 adipocytes
  JOURNAL   Biochim Biophys Acta 1570 (1), 53-62 (2002)
   PUBMED   11960689
REFERENCE   8  (residues 1 to 850)
  AUTHORS   Billingsley,G.D., Cox,D.W., Duncan,A.M., Goodfellow,P.J. and
            Grzeschik,K.H.
  TITLE     Regional localization of loci on chromosome 14 using somatic cell
            hybrids
  JOURNAL   Cytogenet Cell Genet 66 (1), 33-38 (1994)
   PUBMED   8275705
REFERENCE   9  (residues 1 to 850)
  AUTHORS   Glaser,T., Matthews,K.E., Hudson,J.W., Seth,P., Housman,D.E. and
            Crerar,M.M.
  TITLE     Localization of the muscle, liver, and brain glycogen phosphorylase
            genes on linkage maps of mouse chromosomes 19, 12, and 2,
            respectively
  JOURNAL   Genomics 5 (3), 510-521 (1989)
   PUBMED   2575583
REFERENCE   10 (residues 1 to 850)
  AUTHORS   Aldrich,C.J., Rodgers,J.R. and Rich,R.R.
  TITLE     Regulation of Qa-1 expression and determinant modification by an
            H-2D-linked gene, Qdm
  JOURNAL   Immunogenetics 28 (5), 334-344 (1988)
   PUBMED   2459056
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK145989.1 and BY435276.1.
            
            On Nov 19, 2009 this sequence version replaced NP_573461.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK145989.1, AK140321.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..850
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 29.01 cM"
     Protein         1..850
                     /product="glycogen phosphorylase, liver form"
                     /EC_number="2.4.1.1"
                     /calculated_mol_wt=97332
     Site            2
                     /site_type="acetylation"
                     /note="N-acetylalanine. /evidence=ECO:0000269|Ref.3;
                     propagated from UniProtKB/Swiss-Prot (Q9ET01.4)"
     Site            15
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by PHK, in form phosphorylase a.
                     /evidence=ECO:0000250|UniProtKB:P06737; propagated from
                     UniProtKB/Swiss-Prot (Q9ET01.4)"
     Region          29..827
                     /region_name="GT35_Glycogen_Phosphorylase"
                     /note="glycogen phosphorylase and similar proteins;
                     cd04300"
                     /db_xref="CDD:340853"
     Site            order(29,31,33..34,36..38,61..63,194,283,286)
                     /site_type="other"
                     /note="homodimer interface [polypeptide binding]"
                     /db_xref="CDD:340853"
     Site            order(89,91,135..137,281,284,286,293,340,342,378..379,383,
                     485,492,569..570,572..575,609,614,616,650..651,673,
                     675..678,681)
                     /site_type="active"
                     /note="active site pocket [active]"
                     /db_xref="CDD:340853"
     Site            109
                     /site_type="other"
                     /note="Involved in the association of subunits.
                     /evidence=ECO:0000250|UniProtKB:P00489; propagated from
                     UniProtKB/Swiss-Prot (Q9ET01.4)"
     Site            143
                     /site_type="other"
                     /note="Involved in the association of subunits.
                     /evidence=ECO:0000250|UniProtKB:P00489; propagated from
                     UniProtKB/Swiss-Prot (Q9ET01.4)"
     Site            156
                     /site_type="other"
                     /note="May be involved in allosteric control.
                     /evidence=ECO:0000250|UniProtKB:P00489; propagated from
                     UniProtKB/Swiss-Prot (Q9ET01.4)"
     Site            470
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:P06737; propagated from
                     UniProtKB/Swiss-Prot (Q9ET01.4)"
     Site            524
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q9ET01.4)"
     Site            527
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q9ET01.4)"
     Site            561
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P09811; propagated from
                     UniProtKB/Swiss-Prot (Q9ET01.4)"
     Site            639
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P06737; propagated from
                     UniProtKB/Swiss-Prot (Q9ET01.4)"
     Site            796
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:P06737; propagated from
                     UniProtKB/Swiss-Prot (Q9ET01.4)"
     CDS             1..850
                     /gene="Pygl"
                     /coded_by="NM_133198.2:101..2653"
                     /db_xref="CCDS:CCDS25957.1"
                     /db_xref="GeneID:110095"
                     /db_xref="MGI:MGI:97829"
ORIGIN      
        1 makpltdqek rrqisirgiv gvenvaelkk gfnrhlhftl vkdrnvatpr dyyfalahtv
       61 rdhlvgrwir tqqhyydkcp krvyylslef ymgrtlqntm inlglqnacd eaiyqlgldm
      121 eeleeieeda glgngglgrl aacfldsmat lglaaygygi ryeygifnqk iregwqveea
      181 ddwlrhgnpw ekarpefmlp vhfygrveht qtgtkwvdtq vvlalpydtp vpgymnntvn
      241 tmrlwsarap ndfnlqdfnv gdyiqavldr nlaenisrvl ypndnffegk elrlkqeyfv
      301 vaatlqdvir rfkaskfgsk dgmgtvfdaf pdqvaiqlnd thpalaipel mrifvdiekl
      361 pwakaweitk ktfaytnhtv lpealerwpv elvekllprh leiiyeinqk hldrivalfp
      421 kdisrmrrms lieeeggkri nmahlcivgc havngvakih sdivktqvfk dfselepdkf
      481 qnktngitpr rwlllcnpgl adliaekige dyvkdlsqlt klhsfvsddi flreiakvkq
      541 enklkfsqfl ekeykvkinp ssmfdvhvkr iheykrqlln clhvitmynr ikkdpkkffv
      601 prtviiggka apgyhmakmi iklitsvaev vnndpmvgsk lkviflenyr vslaekvipa
      661 tdlseqista gteasgtgnm kfmlngalti gtmdganvem aeeageenlf ifgmrvddva
      721 aldkkgyeak eyyealpelk lvidqidngf fspnqpdlfk diinmlfyhd rfkvfadyea
      781 yvkcqekvsq lymnqkawnt mvlkniaasg kfssdrtike yakdiwnmep sdlkislsne
      841 ssngvsangk
//
