LOCUS       NM_153781               3860 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus brain glycogen phosphorylase (Pygb), mRNA.
ACCESSION   NM_153781
VERSION     NM_153781.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3860)
  AUTHORS   Roberts,G.A.G. and Tunster,S.J.
  TITLE     Characterising the dynamics of placental glycogen stores in the
            mouse
  JOURNAL   Placenta 99, 131-140 (2020)
   PUBMED   32798765
REFERENCE   2  (bases 1 to 3860)
  AUTHORS   Cai,Y., Guo,H., Fan,Z., Zhang,X., Wu,D., Tang,W., Gu,T., Wang,S.,
            Yin,A., Tao,L., Ji,X., Dong,H., Li,Y. and Xiong,L.
  TITLE     Glycogenolysis Is Crucial for Astrocytic Glycogen Accumulation and
            Brain Damage after Reperfusion in Ischemic Stroke
  JOURNAL   iScience 23 (5), 101136 (2020)
   PUBMED   32446205
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3860)
  AUTHORS   Muller,M.S., Pedersen,S.E., Walls,A.B., Waagepetersen,H.S. and
            Bak,L.K.
  TITLE     Isoform-selective regulation of glycogen phosphorylase by energy
            deprivation and phosphorylation in astrocytes
  JOURNAL   Glia 63 (1), 154-162 (2015)
   PUBMED   25130497
REFERENCE   4  (bases 1 to 3860)
  AUTHORS   Cheong,H., Wu,J., Gonzales,L.K., Guttentag,S.H., Thompson,C.B. and
            Lindsten,T.
  TITLE     Analysis of a lung defect in autophagy-deficient mouse strains
  JOURNAL   Autophagy 10 (1), 45-56 (2014)
   PUBMED   24275123
REFERENCE   5  (bases 1 to 3860)
  AUTHORS   Tamplin,O.J., Kinzel,D., Cox,B.J., Bell,C.E., Rossant,J. and
            Lickert,H.
  TITLE     Microarray analysis of Foxa2 mutant mouse embryos reveals novel
            gene expression and inductive roles for the gastrula organizer and
            its derivatives
  JOURNAL   BMC Genomics 9, 511 (2008)
   PUBMED   18973680
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3860)
  AUTHORS   Garcia-Frigola,C., Burgaya,F., Calbet,M., Lopez-Domenech,G., de
            Lecea,L. and Soriano,E.
  TITLE     A collection of cDNAs enriched in upper cortical layers of the
            embryonic mouse brain
  JOURNAL   Brain Res Mol Brain Res 122 (2), 133-150 (2004)
   PUBMED   15010206
REFERENCE   7  (bases 1 to 3860)
  AUTHORS   Nanda,N., Iismaa,S.E., Copeland,N.G., Gilbert,D.J., Jenkins,N.,
            Graham,R.M. and Sutrave,P.
  TITLE     Organization and chromosomal mapping of mouse Gh/tissue
            transglutaminase gene (Tgm2)
  JOURNAL   Arch Biochem Biophys 366 (1), 151-156 (1999)
   PUBMED   10334875
REFERENCE   8  (bases 1 to 3860)
  AUTHORS   Valenzuela,D.M., Griffiths,J.A., Rojas,J., Aldrich,T.H.,
            Jones,P.F., Zhou,H., McClain,J., Copeland,N.G., Gilbert,D.J.,
            Jenkins,N.A., Huang,T., Papadopoulos,N., Maisonpierre,P.C.,
            Davis,S. and Yancopoulos,G.D.
  TITLE     Angiopoietins 3 and 4: diverging gene counterparts in mice and
            humans
  JOURNAL   Proc Natl Acad Sci U S A 96 (5), 1904-1909 (1999)
   PUBMED   10051567
REFERENCE   9  (bases 1 to 3860)
  AUTHORS   Marini,J.C., Nelson,K.K., Battey,J. and Siracusa,L.D.
  TITLE     The pituitary hormones arginine vasopressin-neurophysin II and
            oxytocin-neurophysin I show close linkage with interleukin-1 on
            mouse chromosome 2
  JOURNAL   Genomics 15 (1), 200-202 (1993)
   PUBMED   8432536
REFERENCE   10 (bases 1 to 3860)
  AUTHORS   Glaser,T., Matthews,K.E., Hudson,J.W., Seth,P., Housman,D.E. and
            Crerar,M.M.
  TITLE     Localization of the muscle, liver, and brain glycogen phosphorylase
            genes on linkage maps of mouse chromosomes 19, 12, and 2,
            respectively
  JOURNAL   Genomics 5 (3), 510-521 (1989)
   PUBMED   2575583
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC035283.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC035283.1, BC031457.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3860
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="FVB/N"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 74.74 cM"
     gene            1..3860
                     /gene="Pygb"
                     /note="brain glycogen phosphorylase"
                     /db_xref="GeneID:110078"
                     /db_xref="MGI:MGI:97828"
     exon            1..315
                     /gene="Pygb"
                     /inference="alignment:Splign:2.1.0"
     CDS             73..2604
                     /gene="Pygb"
                     /EC_number="2.4.1.1"
                     /codon_start=1
                     /product="glycogen phosphorylase, brain form"
                     /protein_id="NP_722476.1"
                     /db_xref="CCDS:CCDS16862.1"
                     /db_xref="GeneID:110078"
                     /db_xref="MGI:MGI:97828"
                     /translation="MAKPLTDSERQKQISVRGIAGLGDVAEVRKSFNRHLHFTLVKDR
                     NVATPRDYFFALAHTVRDHLVGRWIRTQQHYYERDPKRIYYLSLEFYMGRTLQNTMVN
                     LGLQTACDEATYQLGLDLEELEEIEEDAGLGNGGLGRLAACFLDSMATLGLAAYGYGI
                     RYEFGIFNQKIVNGWQVEEADDWLRYGNPWEKARPEYMLPVHFYGRVEHTPDGVLWLD
                     TQVVLAMPYDTPVPGYKNNTVNTMRLWSAKAPNDFKLKDFNVGDYIEAVLDRNLAENI
                     SRVLYPNDNFFEGKELRLKQEYFVVAATLQDIIRRFKSSRFGCRDPVRTCFETFPDKV
                     AIQLNDTHPALSIPELMRILVDVEKVDWDKAWEITKKTCAYTNHTVLPEALERWPVSM
                     FEKLLPRHLEIIYAINQRHLDHVAALFPGDVDRLRRMSVIEEGDCKRINMAHLCVIGS
                     HAVNGVARIHSEIVKQSVFKDFYELEPEKFQNKTNGITPRRWLLLCNPGLAEIIVERI
                     GEGFLTDLSQLKKLLSLVDDEAFIRDVAKVKQENKLKFSAQLEKEYKVKINPASMFDV
                     HVKRIHEYKRQLLNCLHIITLYNRIKKDPAKAFVPRTVMIGGKAAPGYHMAKMIIKLV
                     TSIGDVVNHDPVVGDRLRVIFLENYRVSLAEKVIPAADLSQQISTAGTEASGTGNMKF
                     MLNGALTIGTMDGANVEMAEEAGEENLFIFGMRVEDVEALDQKGYNAREFYERLPELR
                     QAVDQISSGFFSPKDPDCFKDVVNMLMYHDRFKVFADYEAYIQCQAQVDRLYRNSKEW
                     TKKVIRNIACSGKFSSDRTITEYAREIWGVEPSDLQIPPPNLPKD"
     exon            316..417
                     /gene="Pygb"
                     /inference="alignment:Splign:2.1.0"
     exon            418..496
                     /gene="Pygb"
                     /inference="alignment:Splign:2.1.0"
     exon            497..600
                     /gene="Pygb"
                     /inference="alignment:Splign:2.1.0"
     exon            601..732
                     /gene="Pygb"
                     /inference="alignment:Splign:2.1.0"
     exon            733..844
                     /gene="Pygb"
                     /inference="alignment:Splign:2.1.0"
     exon            845..927
                     /gene="Pygb"
                     /inference="alignment:Splign:2.1.0"
     exon            928..1071
                     /gene="Pygb"
                     /inference="alignment:Splign:2.1.0"
     exon            1072..1164
                     /gene="Pygb"
                     /inference="alignment:Splign:2.1.0"
     exon            1165..1311
                     /gene="Pygb"
                     /inference="alignment:Splign:2.1.0"
     exon            1312..1475
                     /gene="Pygb"
                     /inference="alignment:Splign:2.1.0"
     exon            1476..1590
                     /gene="Pygb"
                     /inference="alignment:Splign:2.1.0"
     exon            1591..1692
                     /gene="Pygb"
                     /inference="alignment:Splign:2.1.0"
     exon            1693..1840
                     /gene="Pygb"
                     /inference="alignment:Splign:2.1.0"
     exon            1841..1899
                     /gene="Pygb"
                     /inference="alignment:Splign:2.1.0"
     exon            1900..2041
                     /gene="Pygb"
                     /inference="alignment:Splign:2.1.0"
     exon            2042..2249
                     /gene="Pygb"
                     /inference="alignment:Splign:2.1.0"
     exon            2250..2384
                     /gene="Pygb"
                     /inference="alignment:Splign:2.1.0"
     exon            2385..2451
                     /gene="Pygb"
                     /inference="alignment:Splign:2.1.0"
     exon            2452..3838
                     /gene="Pygb"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3821..3826
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pygb"
                     /note="hexamer: ATTAAA"
     polyA_site      3838
                     /gene="Pygb"
                     /note="major polyA site"
ORIGIN      
        1 gcagcatccc agcgctagag tcttctctgc tcgctccagg gccgtaccct gtcctctgcc
       61 tcttctggcg ccatggcgaa gccgttgacg gacagtgaga ggcagaagca gatcagcgtg
      121 cgtggcatcg cggggctggg cgacgtggcc gaggtgcgga agagcttcaa cagacacctg
      181 catttcacgc tggtcaagga ccgcaatgtg gccacgcccc gcgactactt cttcgctctg
      241 gcacacacag ttcgcgacca cctagtgggc cgctggatcc gcacgcagca gcattactat
      301 gagcgggacc ccaagcgcat ctattacctt tccctggaat tctacatggg ccgcacgctg
      361 cagaatacca tggtgaacct gggccttcag actgcatgcg acgaagccac ttatcagttg
      421 gggttggact tggaagagct agaggagata gaggaggatg ctggtcttgg gaatggcggc
      481 ctggggcgcc tggcagcctg cttccttgat tcaatggcca ccctgggtct ggctgcatac
      541 ggctatggaa tccgatatga atttgggatt ttcaaccaaa agattgtcaa tggctggcag
      601 gttgaagaag ctgatgactg gctacgctat ggaaacccct gggagaaggc acggccggag
      661 tacatgctgc cggtgcattt ctacgggagg gtggagcaca cccctgacgg ggtcctctgg
      721 ctggacacgc aggtggtact cgctatgccc tacgacaccc cagtgcctgg gtataagaac
      781 aacacagtca acaccatgag gctctggtct gccaaggcac ccaatgactt caagctgaag
      841 gacttcaacg ttggggacta catcgaagct gtcctggata ggaacttggc tgagaacatc
      901 tccagggtcc tgtatcccaa tgacaatttc ttcgagggga aggagctgcg gctgaagcag
      961 gagtactttg tggtggctgc caccctccag gacatcattc gaaggttcaa gtcttccagg
     1021 tttggctgcc gggacccagt gagaacctgt ttcgagacat tcccagacaa ggtagccatc
     1081 cagctgaatg acacccaccc cgcgctctcc atccctgagc tcatgcggat cctggtggac
     1141 gtggagaagg tggactggga taaggcctgg gagatcacca agaagacctg tgcctacacc
     1201 aaccacacgg tgctgcccga ggccctggag cgctggccag tgtctatgtt tgagaagctg
     1261 cttccgcggc acctggaaat aatctatgcc atcaaccaga ggcacttgga ccacgtggct
     1321 gccctgtttc ctggggacgt ggaccgactg aggaggatgt ccgtgattga ggaaggggac
     1381 tgcaagagaa tcaacatggc acacctgtgt gtgattgggt cccacgctgt gaacggggtg
     1441 gcaaggattc actctgagat cgtgaagcag tctgtcttta aggactttta cgaactggag
     1501 ccagagaagt tccagaacaa gacaaatggc atcacgcccc gacggtggct gctgttgtgt
     1561 aacccggggc tggcagaaat cattgtagag agaatcgggg aaggtttcct gaccgatctg
     1621 agccaactga agaagctgct gtcactggtt gatgatgagg ccttcatcag agacgtagcc
     1681 aaggttaagc aggaaaacaa gctgaagttc tctgcccagc tagagaagga gtacaaggtg
     1741 aagatcaacc ctgcatccat gtttgatgtg cacgtgaaga ggatccacga atataagcga
     1801 cagctgctca actgcctaca cattatcacc ctgtacaacc gaataaagaa ggatccagcc
     1861 aaggcctttg tgcccaggac tgttatgatt gggggcaagg cagctcctgg ttaccacatg
     1921 gctaagatga tcatcaagct ggtcacatcc attggagatg ttgtcaatca tgatccagtt
     1981 gtgggcgaca ggctcagagt gatcttcctg gagaactacc gtgtgtcttt agctgagaaa
     2041 gtgatcccag cggctgacct gtcccagcag atctccactg cgggcactga agcctcgggc
     2101 acaggcaaca tgaagttcat gctcaatgga gcgctcacca tcggcaccat ggatggtgcc
     2161 aacgtggaga tggccgagga ggccggggag gagaacctct tcatctttgg tatgcgggtg
     2221 gaagatgtcg aggccctgga ccagaaaggg tacaatgcca gagaattcta tgagcgcctg
     2281 cctgagctga ggcaggctgt ggatcagatc agcagtggct tcttttctcc caaagatcca
     2341 gactgcttca aggacgtggt taacatgctg atgtaccacg acagattcaa ggtatttgca
     2401 gactatgaag cctacatcca atgccaggcc caggtggacc gtctataccg gaattccaag
     2461 gagtggacta aaaaggtgat caggaatata gcctgctctg gcaagttctc cagtgaccgg
     2521 accatcactg aatacgcccg ggagatctgg ggtgtggagc cctctgacct gcagatccca
     2581 ccccccaacc tccccaagga ctaattaatt atcccacaca gtgagagcag tggcttgctt
     2641 agctgactgt gcccacgcca gtcttcaggc actgcaagca gccgctggtc cctgctatcc
     2701 gaagtgccat gcttccagga aggaccatgg gaatggtttt gaggacctgg atgaggaaga
     2761 aggcgtggca tcctcctggc ttcttacaga agaactgttg cagagttcac agcacagatg
     2821 ggcagagatg gtccccacag cttcagccca tcatcatccc cagaggccga gcagggaggg
     2881 agtggagctg agcccctgaa atcctgcacg tagctgagtg agcttaagcc tttagtttgg
     2941 ggtgtgaata gggatctgtg gtagccagtg ttcctatgtt ctgctagtac ctgggtcacc
     3001 agccataggg tacagccagc cccagtgtgt ggtcttgttg gcctgctggg tagaaccttt
     3061 gcttcaggct tcatgctcac agcttcctgt cctttgccct tgactgtact gagtatgtgg
     3121 gtggttgacc catataggcc atgcctctag ccatctgtgg aaccctgtgg gtgtcaagta
     3181 gaacccagaa cccctggaga ggagcactga agagagagag acctttatcc cgtaactgag
     3241 accttggttg aggactggca attttataga gggttggttt agttctttgc tttttcaaca
     3301 ggaaataaca cttcaggagg aactgaaact agctaagcct tcctttttag caagtaaacc
     3361 ttgaacttgg tcagtgtgga tatttctgct aggctgacga ctaagctgct ggccctgcag
     3421 agggtccagt gtacactcca ctctgctaca gcagcatggt gaggacccac cacaggagct
     3481 gtgctcctca gagggcagaa tctacattaa gtgccgccca aaggagagtg cgttgtcata
     3541 gaaaccacat aaaactatcc ttccagaggc ttcaccacct tgcactgctc tatctggttg
     3601 ggggtgggca ggagaacccc tcgctttccc caccatggga gcatttgctg ggaagtgtct
     3661 tttcaggact taaatcaccg gagccactgt ggtagcttgt gggggtgggt gggcaggttc
     3721 tagggctggt catctgctgc cctgtgcatg aggtcccctg aagccgcaat acatgaccac
     3781 ccttctacta cttgctatta cctccttgta tgagaaatgg attaaacttc tatgcctaaa
     3841 aaaaaaaaaa aaaaaaaaaa
//
