LOCUS       NM_025412               1302 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus pyrroline-5-carboxylate reductase 3 (Pycr3), mRNA.
ACCESSION   NM_025412
VERSION     NM_025412.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1302)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1302)
  AUTHORS   Suzuki,H., Fukunishi,Y., Kagawa,I., Saito,R., Oda,H., Endo,T.,
            Kondo,S., Bono,H., Okazaki,Y. and Hayashizaki,Y.
  TITLE     Protein-protein interaction panel using mouse full-length cDNAs
  JOURNAL   Genome Res 11 (10), 1758-1765 (2001)
   PUBMED   11591653
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC116520.14.
            
            On Jan 10, 2023 this sequence version replaced NM_025412.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC026536.1, AK002912.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849382, SAMN01164134
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-145               AC116520.14        110221-110365       c
            146-210             AC116520.14        108074-108138       c
            211-390             AC116520.14        107518-107697       c
            391-603             AC116520.14        107097-107309       c
            604-696             AC116520.14        106082-106174       c
            697-1302            AC116520.14        105319-105924       c
FEATURES             Location/Qualifiers
     source          1..1302
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 35.09 cM"
     gene            1..1302
                     /gene="Pycr3"
                     /gene_synonym="1110058B13Rik; 2700073G24Rik; Pycrl"
                     /note="pyrroline-5-carboxylate reductase 3"
                     /db_xref="GeneID:66194"
                     /db_xref="MGI:MGI:1913444"
     exon            1..145
                     /gene="Pycr3"
                     /gene_synonym="1110058B13Rik; 2700073G24Rik; Pycrl"
                     /inference="alignment:Splign:2.1.0"
     CDS             55..879
                     /gene="Pycr3"
                     /gene_synonym="1110058B13Rik; 2700073G24Rik; Pycrl"
                     /EC_number="1.5.1.2"
                     /note="P5CR 3; P5C reductase 3; pyrroline-5-carboxylate
                     reductase-like protein"
                     /codon_start=1
                     /product="pyrroline-5-carboxylate reductase 3"
                     /protein_id="NP_079688.2"
                     /db_xref="CCDS:CCDS37109.1"
                     /db_xref="GeneID:66194"
                     /db_xref="MGI:MGI:1913444"
                     /translation="MAATMSEPRRVGFVGAGRMAEAIARGLIQAGKVEAKQVLASAPT
                     DNNLCHFRALGCQTTHSNHEVLQNCPLVIFATKPQVLPTVLAEVAPIVTTEHIIVSVA
                     AGISLSTMEGLLPPNTRVLRVSPNLPCVVQEGAMVMARGHHAGNDDAELLQNLLEACG
                     QCIEVPESYVDIHTGLSGSGVAFVCTFSEALAEGAIKMGMPSGLAHRIAAQTLLGTAK
                     MLQQEGKHPAQLRTDVLTPAGTTIHGLHALERGGFRAATMSAVEAATCRAKELSKK"
     exon            146..210
                     /gene="Pycr3"
                     /gene_synonym="1110058B13Rik; 2700073G24Rik; Pycrl"
                     /inference="alignment:Splign:2.1.0"
     exon            211..390
                     /gene="Pycr3"
                     /gene_synonym="1110058B13Rik; 2700073G24Rik; Pycrl"
                     /inference="alignment:Splign:2.1.0"
     exon            391..603
                     /gene="Pycr3"
                     /gene_synonym="1110058B13Rik; 2700073G24Rik; Pycrl"
                     /inference="alignment:Splign:2.1.0"
     exon            604..696
                     /gene="Pycr3"
                     /gene_synonym="1110058B13Rik; 2700073G24Rik; Pycrl"
                     /inference="alignment:Splign:2.1.0"
     exon            697..1302
                     /gene="Pycr3"
                     /gene_synonym="1110058B13Rik; 2700073G24Rik; Pycrl"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1281..1286
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pycr3"
                     /gene_synonym="1110058B13Rik; 2700073G24Rik; Pycrl"
                     /note="hexamer: AATAAA"
     polyA_site      1302
                     /gene="Pycr3"
                     /gene_synonym="1110058B13Rik; 2700073G24Rik; Pycrl"
                     /note="major polyA site"
ORIGIN      
        1 ctagtgggcg ggacccgctg ccgcaaggac gagagaaggc cagctcagag caggatggcg
       61 gcgacaatgt ctgaacctcg gcgtgtgggc ttcgtgggtg caggccgcat ggcggaggcc
      121 attgcccgag gcctcatcca agcaggcaaa gtagaagcta aacaagtgct ggccagtgca
      181 ccaacggaca acaacctctg ccacttcagg gctctgggtt gccagactac tcactccaac
      241 catgaggtgc tgcaaaactg cccacttgtc atctttgcca ccaaacccca agtcctgcca
      301 actgtcctgg cggaagtggc ccccatagtc accactgagc acatcatcgt atctgtggct
      361 gctgggatct ctctgagcac aatggagggg ctgttacccc cgaacacacg agtattgcga
      421 gtctctccca atctaccctg cgttgtccag gagggggcca tggtgatggc ccggggccac
      481 catgctggga acgatgacgc agagctccta cagaacttgc tggaagcctg tgggcagtgc
      541 atagaggttc ccgagtccta cgtagatatc cacaccggtc tcagtggcag tggtgtggcc
      601 tttgtgtgta cattttcaga ggccctggct gaaggtgcca tcaaaatggg catgcccagt
      661 ggcctggccc accgcattgc tgctcagacc ctgctgggga cagccaagat gctgcagcag
      721 gaagggaagc acccagccca gcttcggaca gatgtgctca caccagctgg aaccaccatc
      781 catgggttgc atgccctaga gcggggcggt tttcgagcgg ctaccatgag tgcggtggaa
      841 gcagctacct gccgggctaa ggagctcagc aagaagtaag gcaggcctca gatgagacta
      901 cgggctcctt gcccagctgc agcctctgtg gtgagaatag ccctggacgg gagatgtagt
      961 gggcagtcct ctaagtggaa tggctaattt atccaagaag cggtgactac ttgtaagatg
     1021 ctatcaagac ggggttgcct tgactgtgac attcagtcaa ggaagaatcg cttgcccctt
     1081 acctgagatt ccagatcctc ccttctgcac ctcctggcca gttgcagttg tgtcctcatg
     1141 gtcacaggag ctggtagaat atgtctcctg tggaggtggt agacatcatc ctccatgctg
     1201 gcgtgagacg tctttggttg tggctgcttt gggatcaccc acactccgta agcagcgccc
     1261 cgtccatatt ctctaagccc aataaactca ttggttctct aa
//
