LOCUS       NM_001379087            2127 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus pyrroline-5-carboxylate reductase 1 (Pycr1),
            transcript variant 5, mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_001379087
VERSION     NM_001379087.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2127)
  AUTHORS   Wang,Z., Jia,X., Sun,W., Wang,M., Yuan,Q., Xu,T., Liu,Y., Chen,Z.,
            Huang,M., Ji,N. and Zhang,M.
  TITLE     A micropeptide TREMP encoded by lincR-PPP2R5C promotes Th2 cell
            differentiation by interacting with PYCR1 in allergic airway
            inflammation
  JOURNAL   Allergol Int 73 (4), 587-602 (2024)
   PUBMED   39025723
  REMARK    GeneRIF: A micropeptide TREMP encoded by lincR-PPP2R5C promotes Th2
            cell differentiation by interacting with PYCR1 in allergic airway
            inflammation.
REFERENCE   2  (bases 1 to 2127)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 2127)
  AUTHORS   Wang,H. and He,D.
  TITLE     LINC01123 acts as an oncogenic driver in lung adenocarcinoma by
            regulating the miR-4766-5p/PYCR1 axis
  JOURNAL   Histol Histopathol 38 (12), 1475-1486 (2023)
   PUBMED   36994814
  REMARK    GeneRIF: LINC01123 acts as an oncogenic driver in lung
            adenocarcinoma by regulating the miR-4766-5p/PYCR1 axis.
REFERENCE   4  (bases 1 to 2127)
  AUTHORS   Li,Z., Jiang,Y., Liu,J., Fu,H., Yang,Q., Song,W. and Li,Y.
  TITLE     Exosomes from PYCR1 knockdown bone marrow mesenchymal stem inhibits
            aerobic glycolysis and the growth of bladder cancer cells via
            regulation of the EGFR/PI3K/AKT pathway
  JOURNAL   Int J Oncol 63 (1) (2023)
   PUBMED   37293856
  REMARK    GeneRIF: Exosomes from PYCR1 knockdown bone marrow mesenchymal stem
            inhibits aerobic glycolysis and the growth of bladder cancer cells
            via regulation of the EGFR/PI3K/AKT pathway.
REFERENCE   5  (bases 1 to 2127)
  AUTHORS   Xue,Z., Pan,Y., Kong,X., Zhang,J., Wu,D. and Zhou,B.
  TITLE     Metabolomic and transcriptomic studies of improvements in
            myocardial infarction due to Pycr1 deletion
  JOURNAL   J Cell Mol Med 27 (1), 89-100 (2023)
   PUBMED   36495058
  REMARK    GeneRIF: Metabolomic and transcriptomic studies of improvements in
            myocardial infarction due to Pycr1 deletion.
REFERENCE   6  (bases 1 to 2127)
  AUTHORS   Jin,H., Komita,M., Koseki,H. and Aoe,T.
  TITLE     Sublethal endoplasmic reticulum stress caused by the mutation of
            immunoglobulin heavy chain-binding protein induces the synthesis of
            a mitochondrial protein, pyrroline-5-carboxylate reductase 1
  JOURNAL   Cell Stress Chaperones 22 (1), 77-85 (2017)
   PUBMED   27796797
REFERENCE   7  (bases 1 to 2127)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   8  (bases 1 to 2127)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   9  (bases 1 to 2127)
  AUTHORS   Yasuda,T., Kaji,Y., Agatsuma,T., Niki,T., Arisawa,M., Shuto,S.,
            Ariga,H. and Iguchi-Ariga,S.M.
  TITLE     DJ-1 cooperates with PYCR1 in cell protection against oxidative
            stress
  JOURNAL   Biochem Biophys Res Commun 436 (2), 289-294 (2013)
   PUBMED   23743200
REFERENCE   10 (bases 1 to 2127)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL663030.12.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7652917.1119374.1,
                                           SRR7345562.2420876.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164135, SAMN01164137
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-46                AL663030.12        99517-99562         c
            47-117              AL663030.12        98706-98776         c
            118-297             AL663030.12        97929-98108         c
            298-519             AL663030.12        97464-97685         c
            520-612             AL663030.12        97243-97335         c
            613-776             AL663030.12        96956-97119         c
            777-2127            AL663030.12        94812-96162         c
FEATURES             Location/Qualifiers
     source          1..2127
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 84.37 cM"
     gene            1..2127
                     /gene="Pycr1"
                     /gene_synonym="P5CR 1; P5CR1"
                     /note="pyrroline-5-carboxylate reductase 1"
                     /db_xref="GeneID:209027"
                     /db_xref="MGI:MGI:2384795"
     exon            1..46
                     /gene="Pycr1"
                     /gene_synonym="P5CR 1; P5CR1"
                     /inference="alignment:Splign:2.1.0"
     CDS             19..909
                     /gene="Pycr1"
                     /gene_synonym="P5CR 1; P5CR1"
                     /EC_number="1.5.1.2"
                     /note="isoform c precursor is encoded by transcript
                     variant 5; pyrroline-5-carboxylate reductase 1,
                     mitochondrial; P5C reductase 1"
                     /codon_start=1
                     /product="pyrroline-5-carboxylate reductase 1,
                     mitochondrial isoform c precursor"
                     /protein_id="NP_001366016.1"
                     /db_xref="GeneID:209027"
                     /db_xref="MGI:MGI:2384795"
                     /translation="MQEGLGCLLCVLAAHKIMASSPDMDQATVSALRKIGVNLTPHNK
                     ETVRHSDVLFLAVKPHIIPFILDEIGANIEDRHIVVSCAAGVTINSIEKKLTAFQPAP
                     KVIRCMTNTPVVVREGVTVYATGTHAQVEDGRLVEQLMGSVGFCTEVEEDLIDAVTGL
                     SGSGPAYAFTALDALADGGVKMGLPRRLAVRLGAQALLGAAKMLLDSEQHPSQLKDNV
                     CSPGGATIHALHVLESGGFRSLLINAVEASCIRTRELQTMADQETISPAAIKKTVLDK
                     VKLDSSAGASLSSDHVKPLP"
     exon            47..117
                     /gene="Pycr1"
                     /gene_synonym="P5CR 1; P5CR1"
                     /inference="alignment:Splign:2.1.0"
     exon            118..297
                     /gene="Pycr1"
                     /gene_synonym="P5CR 1; P5CR1"
                     /inference="alignment:Splign:2.1.0"
     exon            298..519
                     /gene="Pycr1"
                     /gene_synonym="P5CR 1; P5CR1"
                     /inference="alignment:Splign:2.1.0"
     exon            520..612
                     /gene="Pycr1"
                     /gene_synonym="P5CR 1; P5CR1"
                     /inference="alignment:Splign:2.1.0"
     exon            613..776
                     /gene="Pycr1"
                     /gene_synonym="P5CR 1; P5CR1"
                     /inference="alignment:Splign:2.1.0"
     exon            777..2127
                     /gene="Pycr1"
                     /gene_synonym="P5CR 1; P5CR1"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      2127
                     /gene="Pycr1"
                     /gene_synonym="P5CR 1; P5CR1"
                     /note="major polyA site"
ORIGIN      
        1 gcgggtgccg cgtggcgaat gcaagaaggg ctgggctgtc tgttgtgtgt tctggctgca
       61 cacaagataa tggccagctc cccagacatg gaccaagcta cggtctcggc cctccggaag
      121 ataggggtga acctgacacc ccacaacaaa gagactgtgc gccacagtga tgtgctcttc
      181 ctggctgtga agccacacat catccccttc atcctggatg aaattggggc gaacattgag
      241 gacaggcaca ttgtggtgtc ttgtgcggca ggggtcacca tcaactccat cgaaaagaag
      301 ctgacagcgt tccaacctgc ccccaaagtc atccgatgta tgactaacac cccggtcgtg
      361 gtacgggagg gggtcactgt gtatgccaca ggtactcacg ctcaggtgga agatggcagg
      421 cttgtggagc agctcatggg cagcgtgggc ttctgcacag aggtggagga agatctgatc
      481 gatgctgtca cagggctcag tggcagcggc cctgcctatg ctttcacagc cctggatgct
      541 ctggctgacg gtggtgtgaa aatggggctt cccagacgcc tggcagtccg cctcggggcc
      601 caggccctcc tgggggcagc caagatgcta ctagactcag aacagcatcc cagccagctc
      661 aaggataatg tctgctctcc gggtggggcc accatccatg ccttgcatgt gctggagagc
      721 gggggctttc gctccttgct tatcaacgct gtggaagcct cctgcatccg tacacgggag
      781 ctgcagacca tggctgacca ggagaccatc tctcctgctg ccataaagaa gactgtactg
      841 gataaggtga agctggactc ctctgctggg gcctctctgt cttctgacca tgtcaagcca
      901 ctgccctgaa acctggtccc agcaggcaag gaatgatttg tctgccagcc ttcctcctgt
      961 tccctacttt cctttccttt cctctcctct cctctcctct cctctcctct cctctcctct
     1021 ccagcagggt tttgcagtgt actccaggtt agctctgaac tagtcatccc ccactcttgt
     1081 gtcccaagtg ctgggatcat ggataagtgt taacatgcca ggatcctctt ctatctttaa
     1141 gtctaagata gtgacttgat gttgcccaga caagacttga acttacaggc tcagggcata
     1201 ctctgatttc aattcccgtt aggtacacaa cacctgagag actcagttct tctctttctt
     1261 cttttcttgc ttgaagcttc tgtcccaacg ctctcaaaca acaccgaata tccccatagc
     1321 aggcccttgc ccacagccag gtcagcaagg aaggggatat cacttacaac tggggacctc
     1381 cattgatact caagtgccag ctagacacta ggtggcttct cagacctccc cctcttcagc
     1441 atcctctgga gctcaggcct gtggggtctt tactctccct agtttcaggg tcagctagct
     1501 agttagccat ggcctctccc tttctgtgat gaccagctgg cccaagacat cgtgtacctc
     1561 cttctaggga cttaacgctt tagcaatgat tccctaggca ctggggaaaa gaacttctcg
     1621 ggtagctgac acgactcctg catcttcccc aactcaccaa actgctactg ctcttcctat
     1681 cctttcagtt gaataaaaaa agaaaaaaaa atcccccaga gctccagtca acctatttgt
     1741 cagctatgga gagaggcctg cctgtacagg gggagtatga caccgaagga gaagccagga
     1801 acacgggtcc tataaagccg gctgcagcca ggctgaggtg ctccagagaa cagagggcta
     1861 cagatcctcc gtgcctgtgc catagctgac ctgcctgaag actggcactg tacacaggcc
     1921 ctggcacaca tatgtagtga ggggcaccaa cctctttagt acctgtccat atagcttgcc
     1981 cagggagatg tttagctggc tgactcaggc tgtgcaggcc aagttcctgg tgaggaggaa
     2041 acctttagag gaactgttgg agtttcctag atgggcagat tcaagagcca tgacacaggg
     2101 gaaatcctgt ctggaaaaag aaagaaa
//
