LOCUS       NM_001289647            2954 bp    mRNA    linear   ROD 17-SEP-2024
DEFINITION  Mus musculus 2-phosphoxylose phosphatase 1 (Pxylp1), transcript
            variant 4, mRNA.
ACCESSION   NM_001289647 XM_006511135
VERSION     NM_001289647.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2954)
  AUTHORS   Butts,J.C., Wu,S.R., Durham,M.A., Dhindsa,R.S., Revelli,J.P.,
            Ljungberg,M.C., Saulnier,O., McLaren,M.E., Taylor,M.D. and
            Zoghbi,H.Y.
  TITLE     A single-cell transcriptomic map of the developing Atoh1 lineage
            identifies neural fate decisions and neuronal diversity in the
            hindbrain
  JOURNAL   Dev Cell 59 (16), 2171-2188 (2024)
   PUBMED   39106860
REFERENCE   2  (bases 1 to 2954)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 2954)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2954)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2954)
  AUTHORS   Shalom-Barak,T., Zhang,X., Chu,T., Timothy Schaiff,W., Reddy,J.K.,
            Xu,J., Sadovsky,Y. and Barak,Y.
  TITLE     Placental PPARgamma regulates spatiotemporally diverse genes and a
            unique metabolic network
  JOURNAL   Dev Biol 372 (1), 143-155 (2012)
   PUBMED   22967998
REFERENCE   6  (bases 1 to 2954)
  AUTHORS   Tang,T., Li,L., Tang,J., Li,Y., Lin,W.Y., Martin,F., Grant,D.,
            Solloway,M., Parker,L., Ye,W., Forrest,W., Ghilardi,N., Oravecz,T.,
            Platt,K.A., Rice,D.S., Hansen,G.M., Abuin,A., Eberhart,D.E.,
            Godowski,P., Holt,K.H., Peterson,A., Zambrowicz,B.P. and de
            Sauvage,F.J.
  TITLE     A mouse knockout library for secreted and transmembrane proteins
  JOURNAL   Nat Biotechnol 28 (7), 749-755 (2010)
   PUBMED   20562862
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC120869.12 and AK082059.1.
            
            On Jan 25, 2014 this sequence version replaced XM_006511135.1.
            
            Transcript Variant: This variant (4) differs in the 5' UTR compared
            to variant 1. Variants 1, 2, 3 and 4 encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC036342.1, AK084605.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164138, SAMN01164139
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-45                AC120869.12        110216-110260
            46-2951             AK082059.1         2-2907
            2952-2954           AC120869.12        176345-176347
FEATURES             Location/Qualifiers
     source          1..2954
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 50.71 cM"
     gene            1..2954
                     /gene="Pxylp1"
                     /gene_synonym="9430094M07Rik; Acpl2; C130099A20Rik"
                     /note="2-phosphoxylose phosphatase 1"
                     /db_xref="GeneID:235534"
                     /db_xref="MGI:MGI:2442444"
     exon            1..116
                     /gene="Pxylp1"
                     /gene_synonym="9430094M07Rik; Acpl2; C130099A20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            117..248
                     /gene="Pxylp1"
                     /gene_synonym="9430094M07Rik; Acpl2; C130099A20Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             170..1612
                     /gene="Pxylp1"
                     /gene_synonym="9430094M07Rik; Acpl2; C130099A20Rik"
                     /EC_number="3.1.3.2"
                     /note="acid phosphatase-like protein 2; acid
                     phosphatase-like 2"
                     /codon_start=1
                     /product="2-phosphoxylose phosphatase 1"
                     /protein_id="NP_001276576.1"
                     /db_xref="CCDS:CCDS23418.1"
                     /db_xref="GeneID:235534"
                     /db_xref="MGI:MGI:2442444"
                     /translation="MLHRNRFLVLLALAGLLAFLSLSLQFFHLIPVSATKNGGSSKSR
                     KRIMPDPVTEPPTVDPVYEALLYCNIPSVAEHSMEGHAPHHYKLVSVHVFIRHGDRYP
                     LYAIPKTKRPEIDCTLVASRKPYHPKLEAFISHMLKGSGASFESPLNSLPLYPNHPLC
                     ETGELTQTGVVQHLLNGQLLRDIYLRKHKLLPNNWSSDQLYLESTGKSRTLQSGLALL
                     YGFLPEFDWKKVYFKHQPSALFCSGSCYCPLRNQYLEKEQRRQYLLRLKNSDLERTYG
                     EMAKIVDIPTKQLRAANPIDSMLCHFCHNVSFPCSRSGCLGMEHFKVIKTHQIEDERE
                     RHEKLLYFGYSLLGAHPILNQTVNRMQRAASGWRDELFTLYSAHDVTLSPILSALGLL
                     EARFPRFAARLVFELWQDRQKPSEHSVRILYNGADVTFHTSFCHDFHKRSPKPMCPLE
                     NLVRFVKRDMFVALDGSSTNYYDACHGEGA"
     exon            249..407
                     /gene="Pxylp1"
                     /gene_synonym="9430094M07Rik; Acpl2; C130099A20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            408..534
                     /gene="Pxylp1"
                     /gene_synonym="9430094M07Rik; Acpl2; C130099A20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            535..674
                     /gene="Pxylp1"
                     /gene_synonym="9430094M07Rik; Acpl2; C130099A20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            675..2954
                     /gene="Pxylp1"
                     /gene_synonym="9430094M07Rik; Acpl2; C130099A20Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2933..2938
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pxylp1"
                     /gene_synonym="9430094M07Rik; Acpl2; C130099A20Rik"
                     /note="hexamer: AATAAA"
     polyA_site      2954
                     /gene="Pxylp1"
                     /gene_synonym="9430094M07Rik; Acpl2; C130099A20Rik"
                     /note="major polyA site"
ORIGIN      
        1 gcggaacccc gagtttggcg gcctgcgcgc gccaccgccg cctgcactcc cgccaggagg
       61 agctggctgc gggtggagat ccctacgcac agcgacggag gccgggaccg taggcggacg
      121 ggttcccgat tggaggtgaa accatgaaga gaacgtaggc cacacaacaa tgcttcaccg
      181 taatcgcttc ttggtgctgc tggccctggc tgggctcttg gctttcctga gcctcagcct
      241 gcagttcttc cacttgatcc cagtgtctgc cacaaagaat ggaggaagca gcaagagtcg
      301 aaagaggatc atgcctgacc cagtgacaga gcctcccacc gtagacccgg tttatgaagc
      361 tcttctgtac tgcaacattc caagcgtagc ggagcacagc atggaaggtc atgccccgca
      421 tcattataag ctggtctccg ttcatgtgtt cattcgccat ggggacaggt acccactgta
      481 tgccattccc aaaacaaagc ggccagaaat cgactgcact ctagtggcta gcaggaagcc
      541 gtatcaccct aaactagaag ctttcattag tcacatgttg aaaggatccg gagcctcttt
      601 tgaaagcccc ttaaattccc tgcctctcta tcctaaccat cctctgtgtg agacgggaga
      661 gctcacgcag acaggagtcg tgcagcatct gctgaatggc cagctgctga gggacatcta
      721 tctgaggaaa cacaaacttc tgcccaacaa ctggtcctca gaccagcttt acctggagag
      781 cacggggaag agccgcaccc tgcagagcgg gctagccctg ctctacggct tcctcccaga
      841 gtttgactgg aagaaggttt atttcaagca ccagccaagt gccctgttct gctctggaag
      901 ctgctactgc ccgctgagaa accagtatct ggagaaggaa cagcgacgcc agtacctgct
      961 acgtttgaag aacagcgacc tagagaggac ctacggggag atggccaaga ttgtggacat
     1021 ccccacgaag cagctccgcg cggccaaccc catcgattcc atgctctgcc acttctgcca
     1081 caatgtcagc ttcccctgca gcagaagcgg ctgccttggc atggagcact tcaaggtgat
     1141 caagacgcac cagatagagg atgagaggga gcgccacgag aagctcctgt actttgggta
     1201 ctccctcctc ggggcccacc ccatcctaaa tcagacggtc aaccggatgc agcgcgctgc
     1261 ctcgggctgg agggatgagc tgttcaccct ctactctgct catgacgtca ccctgtcacc
     1321 catcctcagt gccttgggtc ttttggaagc caggttcccg aggtttgccg ccaggctggt
     1381 ttttgagctc tggcaagacc gtcaaaagcc cagtgaacat tcggtccgaa ttctttataa
     1441 cggggctgat gttaccttcc acacctcctt ctgccatgac ttccacaagc gctctcccaa
     1501 gcctatgtgt cctcttgaga acttggtccg ctttgtcaaa cgggatatgt ttgtggccct
     1561 ggatggcagt agtactaact attacgatgc ctgtcatggg gaaggggcct aagcggtgtt
     1621 cagcacagca gtgttttatt gctggttctg tctgttgcta agatgtcaag gtatggagtt
     1681 ctaatggatg cagattaggt ggggtcttca tgctcattgg ttgagacaga caggaagcac
     1741 ataacaggat gttacttggt acaaaatagc cggttcacag aggaaagaag gtacgttttc
     1801 atggccgtgt gcagcttaga gtgccagcat aaggctcagt actcaacagc caaccttata
     1861 taacttttga cctgccatgg aaccagcaaa cctctgccaa aaatcttctt aatctccgac
     1921 atttacctta acctcgtcga gtggaaaatt ttccagagtg atgagttcac agtgtgcttg
     1981 gcttggcagc ctttctctgg gggcggggac cagaaggtca gtatcttagg ctctgtagac
     2041 ctaaaggtca cagagaatct ctgtcatatc ttctcagctg tgctctggtg gtgtggcgac
     2101 gcataagtgg ccatgtgtga gcaaacagag tgagtggcag ccagctcggg ctctctggcc
     2161 gtgtctgctg actcatcttt aaaagcagcc tgaaccgctg tgcttccagc actttgaagg
     2221 ccaaacgacc gctgttcttc aggtccttca gtaacgtctg ctagaagcac agcgttgggt
     2281 ctgtatctga cgtggtaaca cgcccagggg aacgaacacc aggtcagaaa gcacgcagga
     2341 aattactaca gtacttgatg ctcgtgagga tcgtggcaca aaatagcttt aagtgtgtct
     2401 tagatacttg tctgccgtag tctattggct gcatatgctg gaatttttgt attccattta
     2461 gtatttttat agtctaggga aatattttct gaggccagtt ttagatgtgt ttggattcct
     2521 atagaaatac tcggtttact gcacctgctt ggtggttgga aggaggccaa agctcaattc
     2581 agacactcgt tttccctcca aaaataaata atgacctgtt ccctttgaca agctgtagaa
     2641 ctgggtccat ttttaaacca ttttcatcaa tttcaaatgc caatttccaa ttgattttta
     2701 aagaggtttg tagaaagaaa aaaagaacaa ctttgttact ccatagttaa ataatctttc
     2761 taaagtgttt tctatattag gcgtgattgc agctaacgcc gtggttcctg ggttaacggt
     2821 gcttgttcgt tccgcagaca tggcccatgc aggtgggttc tccagcttca gcattccagc
     2881 ctttctcttc ctttgtgtct ggtgttgcac tcgaacacgt tttgttttta gaaataaaca
     2941 ttttggaatt ctta
//
